Mateus-Pinheiro A.,University of Minho
Translational psychiatry | Year: 2013
Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms commonly found in depressed patients. Further, the incorporation of newly born neurons and astrocytes into the preexisting hippocampal neurocircuitry is shown to be necessary for the spontaneous recovery from the adverse effects of stress and for long-term benefits of AD treatments.
Peres N.M.R.,University of Minho
Reviews of Modern Physics | Year: 2010
An introduction to the transport properties of graphene combining experimental results and theoretical analysis is presented. In the theoretical description simple intuitive models are used to illustrate important points on the transport properties of graphene. The concept of chirality, stemming from the massless Dirac nature of the low-energy physics of the material, is shown to be instrumental in understanding its transport properties: the conductivity minimum, the electronic mobility, the effect of strain, the weak (anti)localization, and the optical conductivity. © 2010 The American Physical Society.
Costa F.O.,University of Minho
PloS one | Year: 2012
The increasing availability of reference libraries of DNA barcodes (RLDB) offers the opportunity to the screen the level of consistency in DNA barcode data among libraries, in order to detect possible disagreements generated from taxonomic uncertainty or operational shortcomings. We propose a ranking system to attribute a confidence level to species identifications associated with DNA barcode records from a RLDB. Here we apply the proposed ranking system to a newly generated RLDB for marine fish of Portugal. Specimens (n = 659) representing 102 marine fish species were collected along the continental shelf of Portugal, morphologically identified and archived in a museum collection. Samples were sequenced at the barcode region of the cytochrome oxidase subunit I gene (COI-5P). Resultant DNA barcodes had average intra-specific and inter-specific Kimura-2-parameter distances (0.32% and 8.84%, respectively) within the range usually observed for marine fishes. All specimens were ranked in five different levels (A-E), according to the reliability of the match between their species identification and the respective diagnostic DNA barcodes. Grades A to E were attributed upon submission of individual specimen sequences to BOLD-IDS and inspection of the clustering pattern in the NJ tree generated. Overall, our study resulted in 73.5% of unambiguous species IDs (grade A), 7.8% taxonomically congruent barcode clusters within our dataset, but awaiting external confirmation (grade B), and 18.7% of species identifications with lower levels of reliability (grades C/E). We highlight the importance of implementing a system to rank barcode records in RLDB, in order to flag taxa in need of taxonomic revision, or reduce ambiguities of discordant data. With increasing DNA barcode records publicly available, this cross-validation system would provide a metric of relative accuracy of barcodes, while enabling the continuous revision and annotation required in taxonomic work.
Pacheco-Torgal F.,University of Minho
Construction and Building Materials | Year: 2014
With an overall budget of around 70,000 million € for the next seven years (2014-2020) the EU Framework Programme for research and Innovation-Horizon 2020 constitutes the most important financial instrument for research and innovation in the world. Sustainable development is of paramount significance for Horizon 2020 through climate action and resource efficiency, which will represent at least 60% of the overall budget. This sustainability focus could have a strong impact on the future of the European construction industry and also being an opportunity for the development and commercialization of eco-efficient construction and building materials. This article addresses the case of materials for energy efficiency and materials capable of reusing a high waste content. Nanotech energy efficiency related building materials has the potential to become a hot research area being promoted and funded as a Key Enabling Technology-KET. © 2013 Elsevier Ltd. All rights reserved.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: BIOTEC-2-2015 | Award Amount: 7.09M | Year: 2016
Omics data is not leveraged effectively in the biotechnology industry due to lack of tools to rapidly access public and private data and to design cellular manipulations or interventions based on the data. With this project we aim to make a broad spectrum of omics data useful to the biotechnology industry covering application areas ranging from industrial biotechnology to human health. We will develop novel approaches for integrative model-based omics data analysis to enable 1) Identification of novel enzymes and pathways by mining metagenomic data, 2) Data-driven design of cell factories for the production of chemicals and proteins, and 3) Analysis and design of microbial communities relevant to human health, industrial biotechnology and agriculture. All research efforts will be integrated in an interactive web-based platform that will be available for the industrial and academic research and development communities, in particular enhancing the competitiveness of biotech SMEs by economizing resources and reducing time-to-market within their respective focus areas. The platform will be composed of standardized and interoperable components that service-oriented bioinformatics SMEs involved in the project can reuse in their own products. An important aspect of the platform will be implementation of different access levels to data and software tools allowing controlling access to proprietary data and analysis tools. Two end-user companies will be involved in practical testing of the platform built within the project using proprietary omics data generated at the companies.