University of Milan Bicocca | Date: 2015-07-31
The present invention relates to an extracorporeal circuit for CO_(2 )removal from blood comprising a line for taking blood from the patient, a decarboxylation assembly and a line for returning the blood to the patient; said decarboxylation assembly comprising a first filtering unit, an oxygenator, an electrodialyzer adapted to generate an acid solution and a basic solution and means for the infusion of said acid solution upstream of said oxygenator, wherein said electrodialyzer comprises a first electrodialysis chamber and a second electrodialysis chamber, said first and second electrodialysis chambers being separated by an ionic membrane, and in that wherein said first chamber and said second chamber are respectively separated from the positive electrode, or anode, and from the negative electrode, or cathode, by means of a bipolar membrane.
Los Alamos National Security LLC and University of Milan Bicocca | Date: 2014-10-13
Disclosed herein are embodiments of a composition comprising a polymer or sol-gel matrix and one or more nanocrystals. The composition is useful for making various products, including a luminescent solar concentrator. The nanocrystals are dispersed in the polymer or sol-gel matrix to reduce or substantially prevent nanocrystal-to-nanocrystal energy transfer and a subsequent reduction in the emission efficiency of the composition. The nanocrystals may comprise an antenna portion and an emitter portion, and in some embodiments the materials for the antenna and emitter portions are selected to produce a large Stokes shift between the absorption and emission wavelengths. In some embodiments, the polymer matrix comprises an acrylate polymer. Also disclosed herein is a method for making the composition, which may comprise a pre-polymerization step before the nanocrystals are introduced. Devices comprising the composition and a photovoltaic cell also are disclosed. In some examples, the device is a window.
Agency: European Commission | Branch: H2020 | Program: IA | Phase: PILOTS-02-2016 | Award Amount: 9.44M | Year: 2017
PROTECT aims to introduce to the market One step antimicrobial finish processes for polymeric materials used in i) specialty textiles for public areas and hospitals, ii) water treatment membranes, and iii) implantable medical devices. Compared to main existing manufacturing routes, the proposed one-step coating technologies are simple, fast, and reproducible. For this, PROTECT uses as a starting point four existing pilot lines emanated from high successful FP7 projects SONO, NOVO and BioElectricSurface. PROTECT will upgrade the nanocoating One step process platform comprising: two roll to roll (R2R) pilots (sonochemical and spray coating) for functional textiles production, a R2R thermo-embedding pilot for antibacterial/biofilm preventing water treatment membranes, and a batch sonochemical pilot for antibacterial/antibiofilm/biocompatible medical devices. This platform will cover a wide range of applications due to their specific characteristics by the following objectives: a) Incorporating antibacterial antibiofilm biocompatible novel nanoparticles(NPs) of the following categories: inorganic (CuxZn1-xO ,5 Ga@C-dots, Si/TiO2 composite) polymer (polypyrrole, PPy)) and biologicals (antibacterial enzymes, functionalized lipids (FSLs), hybrid antibacterials) to obtain biocompatible nanostructured surfaces with antimicrobial and anti-adhesive properties. b) Implementing real time characterization methods for monitoring at the nanoscale to characterise relevant materials, process properties and product features for real-time nanoscale characterization to ensure reproducibility and quality of the nano-coated products c) Improving coating efficiency, production capacity, reproducibility, robustness, cost-effectiveness, safety and sustainability of the processes in relation to the targeted applications. d) Introducing a Labs Network (PLN) that will include also lab scale processes of the proposed technologies for training and knowledge dissemination.
Agency: European Commission | Branch: H2020 | Program: IA | Phase: ICT-14-2016-2017 | Award Amount: 3.60M | Year: 2017
Corporate information, including basic company firmographics (e.g., name(s), incorporation data, registered addresses, ownership and related entities), financials (e.g., balance sheets, ratings) as well as contextual data (e.g., cadastral data on corporate properties, geo data, data about directors and shareholders, public tenders data, press mentions) are the foundation that many data value chains are built on. Furthermore, this type of information contributes to the transparency and accountability of enterprises, is instrumental input to the process of marketing and sales, and plays a key role in many business interactions. Existing initiatives to increase the interoperability and access of corporate data are mostly fragmented (across borders), limited in scope and size, and silo-ed within specific business communities with limited accessibility from outside their originating sectors and countries. As a result, collecting and aggregating data about a business entity from several public sources (be it private/public, official or non-official ones), and especially across country borders and languages is a tedious, time consuming, error prone, and very expensive operation which renders many potential business models non-feasible. euBusinessGraph represents a key initiative to simplify and disrupt the cross-border and cross-lingual collection, reconciliation, aggregation, and provisioning and analytics of company-related data from authoritative and non-authoritative public or private sector sources, with the aim of enabling cross-sectorial innovation. By a combination of large companies, SMEs, public organizations, and technology transfer providers euBusinessGraph sets the foundations of a European cross-border and cross-lingual business graph, aggregating, linking, and provisioning (open and non-open) high-quality company-related data, demonstrating innovation across sectors where company-related data value chains are relevant.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: REV-INEQUAL-06-2016 | Award Amount: 5.00M | Year: 2017
ISOTIS addresses the nature, causes and impact of early emerging social and educational inequalities in the context of socioeconomic, cultural and institutional processes. The aim is to contribute to effective policy and practice development to combat inequalities. Quasi-panels and pooled longitudinal datasets will be used to examine the variation in early educational gaps and developmental trajectories across countries, systems and time. To disentangle the complex interactions between characteristics of systems and target groups, ISOTIS will study significant immigrant, indigenous ethnic-cultural and low-income native groups, associated with persistent educational disadvantages. ISOTIS will examine current resources, experiences, aspirations, needs and well-being of children and parents in these groups in the context of acculturation and integration, and in relation to local and national policies. ISOTIS aims to contribute to effective policy and practice development by generating recommendations and concrete tools for (1) supporting disadvantaged families and communities in using their own cultural and linguistic resources to create safe and stimulating home environments for their children; for (2) creating effective and inclusive pedagogies in early childhood education and care centres and primary schools; for (3) professionalization of staff, centres and schools to improve quality and inclusiveness; for (4) establishing inter-agency coordination of support services to children and families; and for (5) developing policies to combat educational inequalities. ISOTIS will develop inter-linked programmes for parents, classrooms and professionals using Virtual Learning Environments for working in linguistically diverse contexts. All this work together is expected to support the education practice and policy field in Europe in meeting the challenges of reducing social and educational inequalities.
Agency: European Commission | Branch: H2020 | Program: IA | Phase: ICT-14-2016-2017 | Award Amount: 3.57M | Year: 2017
In this project we aim at supporting companies operating in the fragmented European ecosystem of the eCommerce, Retail and Marketing industries to increase their efficiency and competitiveness by leveraging deep customer insights that are too challenging for them to obtain today. Improved insights will result from the analysis of large amount of data, acquired from different sources and sectors, and in multiple languages. The integration of consumer and market data collected by different business partners will ensure to cover customer interactions and activities across different channels, providing insights on rich customer journeys. These integrated data will be further enriched with information about weather and events, two crucial factors impacting on consumer choices. By disruptively increasing the analytical power coming from the integration of cross-sectorial and cross-language data sources and new data sources companies will deploy real-time responsive services for digital marketing, reporting-style services for market research, and advanced data and resource management services for Retail & eCommerce and their technology providers. As of today, developing these services is too costly or nearly impossible for a large number of European companies. Even when these companies have developed excellent skills in analyzing data in their sector, they lack knowledge, technology and resources that are needed to integrate and analyze large and divers data in a timely manner. Enriching business data with weather data is difficult and costly. Using event data to obtain precise customer and market insights is even more challenging because of the difficulty of collecting and accessing data about events at a large scale. Language barriers, lack of agreed models and shared systems of identifiers to interlink data make these data integration tasks even only more challenging.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMBP-02-2016 | Award Amount: 8.05M | Year: 2017
Silicon carbide presents a high breakdown field (2-4 MV/cm) and a high energy band gap (2.33.2 eV), largely higher than for silicon. Within this frame, the cubic polytype of SiC (3C-SiC) is the only one that can be grown on a host substrate with the huge opportunity to grow only the silicon carbide thickness required for the targeted application. The possible growth on silicon substrate has remained for long period a real advantage in terms of scalability regarding the reduced diameter of hexagonal SiC wafer commercially available. Even the relatively narrow band-gap of 3C-SiC (2.3eV), which is often regarded as detrimental in comparison with other polytypes, can in fact be an advantage. The lowering of the conduction band minimum brings about a reduced density of states at the SiO2/3C-SiC interface and MOSFET on 3C-SiC has demonstrated the highest channel mobility of above 300 cm2/(Vxs) ever achieved on SiC crystals, prompting a remarkable reduction in the power consumption of these power switching devices. The electrical activity of extended defects in 3C SiC is a major concern for electronic device functioning. To achieve viable commercial yields the mechanisms of defects must be understood and methods for their reduction developed.. In this project new approaches for the reduction of defects will be used, working on new compliance substrates that can help to reduce the stress and the defect density at the same time. This growth process will be driven by numerical simulations of the growth and simulations of the stress reduction. The structure of the final devices will be simulated using the appropriated numerical tools where new numerical model will be introduced to take into account the properties of the new material. Thanks to these simulations tools and the new material with low defect density, several devices that can work at high power and with low power consumption will be realized inside the project.
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.90M | Year: 2017
We propose to forge a partnership between the leading European groups working on the next generation of solid state quantum emitters based on novel growth methods such as Droplet Epitaxy. Future, practical Nano-photonics and Quantum Circuits applications demand semiconductor quantum dots that can be grown on substrates with different lattice parameters (Si, Ge, GaAs), different substrate orientations (such as (001) and (111)) and tuneable optical, electrical and spin properties. All these requirements are met by high quality quantum dots grown with Droplet based Epitaxy techniques, circumventing the limitations of currently available systems based on strain-driven dot self-assembly. This vast novel research area at the crossroads of photonics, material science, quantum physics and nano-scale device fabrication will allow delivering top level multidisciplinary training to 15 early stage researcher (ESRs). The successful training of the ESRs by leading academic and 3 full industrial partners will be crucial for achieving the headline goals of this first ever consortium on droplet dot devices: (1) Entangled light emitting diodes with droplet dots grown on (111) substrates (2) Electrically triggered, droplet dot based single photon sources on Si/Ge substrates (3) Strain tuning in droplet dots without wetting layer: photon polarization and single spin control (4) Droplet Dot based single photon sources for non- classical light storage devices based on hybrid quantum systems (dots & laser-cooled atoms). The training and research progress will be discussed and monitored during the 4 project meetings, 3 summer schools and the final international conference on Droplet Dot Devices, all of which are open to the whole scientific community. We expect this network, based on the solid collaboration between growth groups, microscopists, quantum optics experimentalists and theorists to explore the full potential of this emerging technology.
Gambacorti Passerini C.,University of Milan Bicocca
Journal of the National Cancer Institute | Year: 2014
Anaplastic lymphoma kinase (ALK)-positive lymphomas respond to chemotherapy, but relapses, which bear a poor prognosis, occur. Crizotinib inhibits ALK in vitro and in vivo and was administered as monotherapy to 11 ALK+ lymphoma patients who were resistant/refractory to cytotoxic therapy. The overall response rate was 10 of 11 (90.9%; 95% confidence interval [CI] = 58.7% to 99.8%). Disease status at the latest follow-up is as follows: four patients are in complete response (CR) (months >21, >30, >35, >40) under continuous crizotinib administration; 4 patients had progression of disease (months 1, 2, 2, 2); 1 patient obtained CR on crizotinib, received an allogeneic bone marrow transplant, and is in CR; 2 patients (treated before and/or after allogeneic bone marrow transplant) obtained and are still in CR but they have stopped crizotinib. Overall and progression-free survival rates at 2 years are 72.7% (95% CI = 39.1% to 94.0%) and 63.7% (95% CI = 30.8% to 89.1%), respectively. ALK mutations conferring resistance to crizotinib in vitro could be identified in relapsed patients. Crizotinib exerted a potent antitumor activity with durable responses in advanced, heavily pretreated ALK+ lymphoma patients, with a benign safety profile.
Peri F.,University of Milan Bicocca
Chemical Society Reviews | Year: 2013
Are there general rules to obtain efficient immunization against carbohydrate antigens? Thanks to technological advances in glycobiology and glycochemistry we entered a new era in which the rational design of carbohydrate vaccines has become an achievable goal. The aim of this Tutorial Review is to present the most recent accomplishments in the field of semi and fully synthetic carbohydrate vaccines against viruses, bacteria and cancer. It is also pointed out that the understanding of the chemical and biochemical processes related to immunization allows the modern chemist to rationally design carbohydrate vaccines with improved efficiency. © 2013 The Royal Society of Chemistry.