Melbourne, Australia

University of Melbourne
Melbourne, Australia

The University of Melbourne is an Australian public university located in Melbourne, Victoria. Founded in 1853, it is Australia's second oldest university and the oldest in Victoria. Melbourne was named Australia's best university by Times Higher Education, Academic Ranking of World Universities and National Taiwan University Rankings. Times Higher Education ranks Melbourne as 34th in the world, while the QS World University Rankings places Melbourne 31st in the world. According to QS World University Subject Rankings 2014, the University of Melbourne is ranked 2nd in the world for Education, 8th in Accounting & Finance, and Law, 10th in Psychology, 12th in Medicine, and 15th in Computer Science & IT.Melbourne's main campus is located in Parkville, an inner suburb north of the Melbourne central business district, with several other campuses located across Victoria. Melbourne is a sandstone university and a member of the Group of Eight, Universitas 21 and the Association of Pacific Rim Universities. Since 1872 various residential colleges have become affiliated with the university. There are 12 colleges located on the main campus and in nearby suburbs offering academic, sporting and cultural programs alongside accommodation for Melbourne students and faculty.Melbourne comprises 11 separate academic units and is associated with numerous institutes and research centres, including the Walter and Eliza Hall Institute of Medical Research, Florey Institute of Neuroscience and Mental Health, the Melbourne Institute of Applied Economic and Social Research and the Grattan Institute. Amongst Melbourne's 15 graduate schools the Melbourne Business School, the Melbourne Law School and the Melbourne Medical School are particularly well regarded.Four Australian prime ministers and five governors-general have graduated from Melbourne. Seven Nobel laureates have been students or faculty, the most of any Australian university. Wikipedia.

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University of Queensland, Monash University and University of Melbourne | Date: 2015-04-01

The present invention provides ligands which bind to MR1, some of which induce MR1 to bind to MAIT cells thereby activating or inhibiting MAIT cell activation.

University of Melbourne | Date: 2014-11-14

The present invention relates to a gas separation membrane for separating a target gas species from a mixture of gas species, the membrane comprising:

University of Melbourne | Date: 2017-07-19

The present invention relates to a phosphopeptide-stabilized amorphous calcium phosphate and/or amorphous calcium fluoride phosphate complex, wherein the complex is formed at a pH of below 7.0. Methods of making such complexes are also provided. The complexes are useful in dental applications, in particular in dental remineralisation.

AUCKLAND UNISERVICES Ltd and University of Melbourne | Date: 2017-02-10

The present invention is concerned with methods for reprogramming of mammalian somatic cells and in particular to reprogramming of mature mammalian somatic cells into multi-potent precursor cells.

Monash University and University of Melbourne | Date: 2014-02-05

The invention described herein relates to a method of detecting malaria comprising the steps of: (i) delivering an evanescent IR beam through said ATR substrate in contact with a patient blood sample; (ii) detecting IR radiation transmitted from the ATR substrate to produce a signal characteristic for one or more lipids in the sample, and (iii) processing said signal and a set of reference library spectra of lipids associated with malaria parasites in order to detect matches and quantify said one or more lipids in the sample. In contrast to the prior art, the present invention relies on detecting lipids instead of hemozoin.

Pasricha S.R.,University of Melbourne
Blood | Year: 2013

Despite worldwide economic and scientific development, more than a quarter of the world's population remains anemic, and about half of this burden is a result of iron deficiency anemia (IDA). IDA is most prevalent among preschool children and women. Among women, iron supplementation improves physical and cognitive performance, work productivity, and well-being, and iron during pregnancy improves maternal, neonatal, infant, and even long-term child outcomes. Among children, iron may improve cognitive, psychomotor, and physical development, but the evidence for this is more limited. Strategies to control IDA include daily and intermittent iron supplementation, home fortification with micronutrient powders, fortification of staple foods and condiments, and activities to improve food security and dietary diversity. The safety of routine iron supplementation in settings where infectious diseases, particularly malaria, are endemic remains uncertain. The World Health Organization is revising global guidelines for controlling IDA. Implementation of anemia control programs in developing countries requires careful baseline epidemiologic evaluation, selection of appropriate interventions that suit the population, and ongoing monitoring to ensure safety and effectiveness. This review provides an overview and an approach for the implementation of public health interventions for controlling IDA in low- and middle-income countries, with an emphasis on current evidence-based recommendations.

Bowtell D.D.L.,University of Melbourne
Nature Reviews Cancer | Year: 2010

Germline mutation in either BRCA1 or BRCA2 is associated with an increased risk of ovarian cancer, particularly the most common invasive histotype ĝ€" serous carcinoma. In addition, serous ovarian cancers have an unusually high frequency of other molecular events involving BRCA pathway dysfunction. Recent findings show a high frequency of TP53 mutation, chromosomal instability, distinct molecular subtypes and DNA copy number-driven changes in gene expression. These findings suggest a model in which homologous recombination repair deficiency initiates a cascade of molecular events that sculpt the evolution of high-grade serous ovarian cancer and dictate its response to therapy. © 2010 Macmillan Publishers Limited. All rights reserved.

Nugent K.A.,University of Melbourne
Advances in Physics | Year: 2010

X-ray sources are developing rapidly and their coherent output is growing correspondingly. The increased coherent flux from modern X-ray sources is being matched with an associated development in experimental methods. This article reviews the literature describing the ideas that utilize the increased brilliance from modern X-ray sources. It explores how ideas in coherent X-ray science are leading to developments in other areas, and vice versa. The article describes measurements of coherence properties and uses this discussion as a base from which to describe partially coherent diffraction and X-ray phase-contrast imaging, with applications in materials science, engineering and medicine. Coherent diffraction imaging methods are reviewed along with associated experiments in materials science. Proposals for experiments to be performed with the new X-ray free-electron lasers are briefly discussed. The literature on X-ray photon-correlation spectroscopy is described and the features it has in common with other coherent X-ray methods are identified. Many of the ideas used in the coherent X-ray literature have their origins in the optical and electron communities and these connections are explored. A review of the areas in which ideas from coherent X-ray methods are contributing to methods for the neutron, electron and optical communities is presented.

Emery B.,University of Melbourne
Science | Year: 2010

Despite the importance of myelin for the rapid conduction of action potentials, the molecular bases of oligodendrocyte differentiation and central nervous system (CNS) myelination are still incompletely understood. Recent results have greatly advanced this understanding, identifying new transcriptional regulators of myelin gene expression, elucidating vital roles for microRNAs in controlling myelination, and clarifying the extracellular signaling mechanisms that orchestrate the development of myelin. Studies have also demonstrated an unexpected level of plasticity of myelin in the adult CNS. These recent advances provide new insight into how remyelination may be stimulated in demyelinating disorders such as multiple sclerosis.

Radical cyclizations and multicomponent radical cascades in solution were studied, which are initiated by intermolecular radical addition to C-C triple bond in alkynes as well as to related C?N triple bonds in nitriles and isonitriles. The reactions were arranged according to the atom that carries the unpaired electron in the attacking radical and cover main group IV-VI elements. The initial radical addition is highly regioselective and in reactions with substrates possessing several π systems, the alkyne moiety is usually attacked with high preference. This selectivity can be rationalized by the reversibility with which the initial radicaladdition occurs in many cases, in particular with Sn- and S centered radicals. Due to their high reactivity, vinyl radicals that are formed through radical attack at the alkyne moiety in enynes. Alkyl radicals resulting from radical addition to an alkene are far less reactive so that the competing dissociation and regeneration of the starting materials is often faster than the forward reaction steps.

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