University of Mediterranea

Marseille, France

University of Mediterranea

Marseille, France

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Moureau-Zabotto L.,Institute Paoli Calmettes | Chetaille B.,Institute Paoli Calmettes | Bladou F.,Jewish General Hospital | Dauvergne P.-Y.,Clinique Rhone Durance | And 6 more authors.
Case Reports in Oncology | Year: 2012

Solitary fibrous tumor (SFT), usually described in the pleura, is exceedingly rare in the prostate. We report a 60-year-old man with prostatic SFT revealed by obstructive urinary symptoms, and detected by ultrasonography. Computed tomography (CT) and magnetic resonance imaging suggested a prostatic origin. CT-guided tumor biopsy diagnosed a SFT. A cystoprostatectomy was performed. Pathologic examination showed a 15-cm tumor arising from the prostate and showing histological criteria suggestive of aggressiveness. The surgical resection margins were tumor-free. The patient was then regularly monitored and is still alive in complete remission, 28 months after surgery. In conclusion, we report a new exceptional case of prostatic SFT. We review the literature and discuss the challenging issues of misdiagnosis, prognosis and treatment. Copyright © 2012 S. Karger AG, Basel.


Sabatier R.,Institute Paoli Calmettes | Bouvier C.,Marseille University Hospital Center | de Pinieux G.,Hopital Trousseau | Sarran A.,Institute Paoli Calmettes | And 9 more authors.
BMC Cancer | Year: 2010

Background: Low-grade extraskeletal osteosarcomas (ESOS) are extremely rare.Case presentation: We present the first case of low-grade ESOS of the chest wall, which occurred in a 30-year-old man. Because of initial misdiagnosis and patient's refusal of surgery, the diagnosis was done after a 4-year history of a slowly growing mass in soft tissues, leading to a huge (30-cm diameter) calcified mass locally extended over the left chest wall. Final diagnosis was helped by molecular analysis of MDM2 and CDK4 oncogenes. Unfortunately, at this time, no surgical treatment was possible due to loco-regional extension, and despite chemotherapy, the patient died one year after diagnosis, five years after the first symptoms.Conclusion: We describe the clinical, radiological and bio-pathological features of this unique case, and review the literature concerning low-grade ESOS. Our case highlights the diagnostic difficulties for such very rare tumours and the interest of molecular analysis in ambiguous cases. © 2010 Sabatier et al; licensee BioMed Central Ltd.


Romeo E.,HIA Sainte Anne | Gisserot O.,HIA Sainte Anne | De Jaureguiberry J.-P.,HIA Sainte Anne | Desse N.,HIA Sainte Anne | And 6 more authors.
Journal of Neuro-Oncology | Year: 2010

Primary meningeal osteosarcomas are exceedingly rare. We report a case of a 51-year-old man with a chondroblastic osteosarcoma treated with pre-operative embolization, surgical removal, followed by adjuvant chemotherapy and radiation therapy. Patient is alive without any recurrence 43 months after diagnosis. © 2010 Springer Science+Business Media, LLC.

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