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Petkova-Marinova T.,University of Medicine Pleven | Nedkova V.,University of Medicine Pleven | Angelova M.,University of Medicine Pleven
Pediatriya | Year: 2013

Introduction: Iron deficiency is the most common nutritional deficiency in the world. Interesting issue is the status of essential trace elements including copper in iron deficiency anemia states. Objective: To make a brief review of copper metabolism, physiological impact and micronutrient status in the human organism and iron deficiency anemia states. To investigate serum iron, copper and related to copper metabolism zinc in children with iron deficiency anemia. Methods: Serum copper, zinc and iron are measured spectrophotometrically, using AUDIT diagnostics (Ireland) and GIESSE diagnostics tests, and ferozine method of COBAS INTEGRA 400 (Roche) respectively. Results and discussion: \Ne discovered low levels of serum iron 4,3112,27 umol/l in comparison with reference values in investigated children (n=25;3 to 12 years). The levels of copper 12,8±2,1 umol/l were also lower than the reference values, and serum zinc 18,59±3,1 umol/l was within reference values. The proposed mechanism explaining low values of serum copper level in investigated children with anemia is associated with forming a stable copper-metallothionein complex, followed by reduction in copper absorption, sequestration of metal in intestinal mucosal cells and increased copper excretion. Conclusion: Investigation of micronutrient status in patients with iron deficiency anemia represents an interest in the diagnosis and treatment of anemia states. Our study highlights the need to know the synergistic interactions between trace elements that would facilitate adjunctive therapy with a complex of micronutrients. Source


Angelova M.,University of Medicine Pleven | Hristova P.,University of Medicine Pleven | Nedkova V.,University of Medicine Pleven
Pediatriya | Year: 2013

Thiocyanates in urine - a marker of smoking were quantified in 86 students aged 15 to 18 years of voluntary principle. However, that study did not provide the results of a nationally representative sample, received data show that smoking has major sizes among the students surveyed. 44.49% of them were smokers and 47.4% of smokers smoke more than 10 cigarettes daily. Values for concentrations of thiocyanates in urine in non-smokers (n = 48) were 3.00 ± 1.41 mg/l (51.60 ± 24.25 nmol/l); in smokers to 10 cigarettes (n = 20) daily - 4.99 ± 2.24 mg/l (85.83 ± 38.53 umol/l) and to smokers more than 10 cigarettes per day (n = 18) - 6.95 ± 2.36 mg/l (119 + 40.59 umol/l). Differences between groups were statistically significant with a confidence between smoking and smoking up to 10 cigarettes a day - p <0.01, between smokers 10 cigarettes per day and smoking more than 10 cigarettes per day p <0.05. Through an objective quantitative marker to distinguish smokers from non-smokers and to establish the intensity of smoking, confirmed the seriousness of the health and social problem smoking. This requires an informed health education for smoking cessation in school age by applying adequate, coherent, effective controlled European legislation. It is implementation of programs to prevent smoking and to provide help and support to those who want to quit smoking. Source


Angelova M.G.,University of Medicine Pleven | Petkova-Marinova T.V.,University of Medicine Pleven | Pogorielov M.V.,Sumy State University | Loboda A.N.,Sumy State University | And 2 more authors.
Anemia | Year: 2014

Aim. To determine trace element status and aetiologic factors for development of trace elements deficiencies in children with iron-deficiency anaemia (IDA) aged 0 to 3 years. Contingent and Methods. 30 patients of the University Hospital, Pleven, Bulgaria - I group; 48 patients of the Sumy Regional Child's Clinical Hospital, Sumy, Ukraine - II group; 25 healthy controls were investigated. Serum concentrations of iron, zinc, copper, chromium, cobalt, and nickel were determined spectrophotometrically and by atomic absorption spectrophotometry. Results. Because the obtained serum levels of zinc, copper, and chromium were near the lower reference limits, I group was divided into IA and IB. In IA group, serum concentrations were lower than the reference values for 47%, 57%, and 73% of patients, respectively. In IB group, these were within the reference values. In II group, results for zinc, cobalt, and nickel were significantly lower (P < 0.05), and results for copper were significantly higher in comparison to controls. Conclusion. Low serum concentrations of zinc, copper, cobalt, and nickel were mainly due to inadequate dietary intake, malabsorption, and micronutrient interactions in both studied groups. Increased serum copper in II group was probably due to metabolic changes resulting from adaptations in IDA. Data can be used for developing a diagnostic algorithm for IDA. © 2014 Maria Georgieva Angelova et al. Source

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