Vreju F.,University of Medicine and Pharmacy of Craiova
Medical ultrasonography | Year: 2010
Osgood-Schlatter disease is a condition that is caused by traction of the muscle-tendon unit at tibial tuberosity, which affects adolescents who exercise. The predisposing factors include rapid growth and physical activity, particularly running and jumping. Osgood- Schlatter disease causes intermittent pain, which can be aggravated by running, cycling and climbing stairs. We present the case of a young boy, soccer player, which presented for pain at the level of the tibial tuberosity. Ultrasonography showed changes at the distal part of the patellar tendon and at the tibial tuberosity, consistent with Osgood-Schlatter disease.
Popescu F.C.,University of Medicine and Pharmacy of Craiova
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie | Year: 2011
Pericytes and myofibroblasts are two types of connective cells that appear in large quantities in reparative processes. In order to evaluate their response and any relationships between them, we have inflicted third degree skin burns to seven groups of five common Wistar rats each from which we sampled granulation tissue at three days interval for histological and immunohistochemical studies. Alpha-SMA and CD34 antibodies revealed that granulation tissue myofibroblasts do not express CD34 and do not arise from pericytes. The parallel arrangement of myofibroblasts in relation to the burned wound surface suggests that their main function is mechanical traction on granulation tissue and wound edges.
Vere C.C.,University of Medicine and Pharmacy of Craiova
Chirurgia (Bucharest, Romania : 1990) | Year: 2012
Videocapsule endoscopy (VCE) can identify lesions in the small bowel which would otherwise be hard to detect. We have selected 53 patients with digestive symptoms in which upper and lower endoscopy had provided no findings. Patients were classified into three groups, based on their main indication for VCE exploration: group one--obscure gastrointestinal bleeding (OGIB); group two--unspecific abdominal symptoms; group 3--monitoring of a prior known pathology. We found that VCE has high predictive values, sensibility and specificity in the diagnosis of OGIB. VCE was also useful in the detection and extent evaluation of lesions in Crohn's and celiac disease. VCE is also able to detect tumors of the small bowel with sufficient accuracy, and can be used to monitor patients with hereditary pre-malignant diseases such as FAP. There were few light adverse effects and no major complications. We conclude that VCE is a safe and effective procedure for the detection of small bowel lesions.
Gaman A.M.,University of Medicine and Pharmacy of Craiova
Romanian Journal of Morphology and Embryology | Year: 2013
Hairy cell leukemia (HCL) is a chronic B-cell lymphoid leukemia characterized by pancytopenia, splenomegaly, myelofibrosis and the presence in peripheral blood, bone marrow and spleen of atypical lymphoid cells with a hairy aspect. This is a retrospective analysis of 39 patients hospitalized in the Clinic of Hematology, "Filantropia" Municipal Hospital, Craiova, Romania, between 1997-2012, devised by age, sex, and HCL type. Characteristic features of diagnosis (including clinical features, laboratory data: complete blood cell count, differential count, peripheral blood and bone marrow infiltration with atypical lymphoid cells with cytoplasm fine prolongations, immunophenotyping of peripheral blood, bone marrow, spleen or lymph node biopsies with histopathological exams and immunohistochemistry), types of therapy (focused on IFN-α), complications (infections, hemorrhage, autoimmune, second malignancies) and survival rate were monitored. Conclusions of the study revealed the importance of histopathology and immunohistochemistry for diagnosis, of the therapeutic options in the absence of purine nucleoside analogues, the most frequent complications and the decrease of their incidence correlated with therapy and increased count of neutrophils.
Saftoiu A.,University of Medicine and Pharmacy of Craiova
World Journal of Gastroenterology | Year: 2011
Endoscopic ultrasound (EUS) has recently evolved through technological improvement of equipment, with a major clinical impact in digestive and mediastinal diseases. State-of-the-art EUS equipment now includes realtime sono-elastography, which might be useful for a better characterization of lesions and increased accuracy of differential diagnosis (for e.g. lymph nodes or focal pancreatic lesions). Contrast-enhanced EUS imaging is also available, and is already being used for the differential diagnosis of focal pancreatic masses. The recent development of low mechanical index contrast harmonic EUS imaging offers hope for improved diagnosis, staging and monitoring of anti-angiogenic treatment. Tridimensional EUS (3D-EUS) techniques can be applied to enhance the spatial understanding of EUS anatomy, especially for improved staging of tumors, obtained through a better assessment of the relationship with major surrounding vessels. Despite the progress gained through all these imaging techniques, they cannot replace cytological or histological diagnosis. However, real-time optical histological diagnosis can be achieved through the use of single-fiber confocal laser endomicroscopy techniques placed under real-time EUS-guidance through a 22G needle. Last, but not least, EUS-assisted natural orifice transluminal endoscopic surgery (NOTES) procedures offer a whole new area of imaging applications, used either for combination of NOTES peritoneoscopy and intraperitoneal EUS, but also for access of retroperitoneal organs through posterior EUS guidance. © 2011 Baishideng. All rights reserved.