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Micu M.C.,County Hospital Turda | Bogdan G.D.,County Hospital | Fodor D.,University of Medicine and Pharmacy Iuliu Hatieganu
Rheumatology | Year: 2010

Objective: To determine the efficacy of IA corticosteroid (CS) injection in pain reduction for hip OA under ultrasound (US) guidance. Methods: Forty patients [mean age 62.78 (8.16) years] fulfilling ACR criteria for hip OA, with synovitis detected at US, gave their consent for IA US-guided CS injection because of pain refractory to conventional therapy. At baseline, at 1 and 3 months, patients filled up a visual analogue scale (VAS) pain on walking, performed the Lequesne index and were checked by US for synovitis. Results were compared with age-matched controls. The occurrence of side effects both short and long term was monitored. Results: IA steroid deposition was performed under US guidance. After 1 and 3 months, walking pain VAS was significantly reduced vs baseline (P < 0.001) and had high correlation with Lequesne index. Synovial hypertrophy was reduced in 75% of the hips after 1 and 3 months vs baseline (P < 0.001). In the group of controls, hip walking pain VAS, Lequesne index and synovial hypertrophy were not changed at 3 months vs baseline (P > 0.05). Transient facial rash was present in 16 patients during the first 24-48 h after injection. No side effects were reported. Conclusion: US-guided steroid injections in hip OA is an efficacious and safe therapeutic approach to achieve pain control and reduction of synovial hypertrophy avoiding the use of X-ray-guided procedure. © The Author 2010.

Ivanescu B.,Grigore T. Popa University of Medicine and Pharmacy | Vlase L.,University of Medicine and Pharmacy Iuliu Hatieganu | Corciova A.,Grigore T. Popa University of Medicine and Pharmacy | Lazar M.I.,Grigore T. Popa University of Medicine and Pharmacy
Natural Product Research | Year: 2011

Artemisinin, a sesquiterpene lactone from Artemisia annua L., has received considerable attention in the last few decades as a potent antimalarial drug. Artemisinin has rather low toxicity; it is effective against drug-resistant Plasmodium species and against cerebral malaria. This study reports the development of a rapid and sensitive assay for the quantification of artemisinin in A. annua by reversed phase HPLC/MS. In the selected optimal experimental conditions, artemisinin exhibited a well-defined chromatographic peak with a retention time of 2 ±0.2 min. The chromatographic signal shows a linear dependence with artemisinin concentration, enabling the use of this signal for artemisinin quantification according to the following regression equation: y = 2665.40x-14697.61. The correlation coefficient (R 2) was 0.9989. For every concentration within the range of the standard curve (0.1-2 μg mL -1), accuracy was between 95 and 104%. Artemisinin content in Romanian A. annua wild plants varies between 0.17 and 0.21% (dry weight basis). © 2011 Taylor &Francis.

Wykes T.,Kings College London | Reeder C.,Kings College London | Huddy V.,Kings College London | Taylor R.,Kings College London | And 4 more authors.
Schizophrenia Research | Year: 2012

Background: Cognitive remediation (CRT) affects functioning but the extent and type of cognitive improvements necessary are unknown. Aim: To develop and test models of how cognitive improvement transfers to work behaviour using the data from a current service. Method: Participants (N49) with a support worker and a paid or voluntary job were offered CRT in a Phase 2 single group design with three assessments: baseline, post therapy and follow-up. Working memory, cognitive flexibility, planning and work outcomes were assessed. Results: Three models were tested (mediation - cognitive improvements drive functioning improvement; moderation - post treatment cognitive level affects the impact of CRT on functioning; moderated mediation - cognition drives functioning improvements only after a certain level is achieved). There was evidence of mediation (planning improvement associated with improved work quality). There was no evidence that cognitive flexibility (total Wisconsin Card Sorting Test errors) and working memory (Wechsler Adult Intelligence Scale III digit span) mediated work functioning despite significant effects. There was some evidence of moderated mediation for planning improvement if participants had poorer memory and/or made fewer WCST errors. The total CRT effect on work quality was d = 0.55, but the indirect (planning-mediated CRT effect) was d = 0.082. Conclusion: Planning improvements led to better work quality but only accounted for a small proportion of the total effect on work outcome. Other specific and non-specific effects of CRT and the work programme are likely to account for some of the remaining effect. This is the first time complex models have been tested and future Phase 3 studies need to further test mediation and moderated mediation models. © 2012 Elsevier B.V.

Miclea D.,University of Medicine and Pharmacy Iuliu Hatieganu | Pop I.V.,University of Medicine and Pharmacy Iuliu Hatieganu
Annals of the Romanian Society for Cell Biology | Year: 2012

Turner syndrome is very heterogeneous, short stature often being the only clinical sign. In this pathology, classical karyotype is the gold standard in genetic investigation for the positive diagnosis, and it is recommended to be performed in every girl with unexplained short stature. We investigated by standard and molecular cytogenetics a girl who presented for short stature not explained by common medical reasons. Standard karyotype showed homogeneous monosomy, 45,X, FISH technique revealing a mosaicism undetected before, 45,X/46,XX, the level of mosaicism for the second cell line being of 22%. This difference could be explained by an augmented number of cells analyzed by FISH, thus improving the cytogenetic diagnosis. FISH technique is useful in medical practice, complementary to the classical techniques due to a greater resolution and for the detection of the mosaicism.

Tantau M.,University of Medicine and Pharmacy Iuliu Hatieganu | Tantau M.,Regional Institute of Gastroenterology and Hepatology Octavian Fodor | Procopet B.,University of Medicine and Pharmacy Iuliu Hatieganu | Procopet B.,Regional Institute of Gastroenterology and Hepatology Octavian Fodor | Bureau C.,University Paul Sabatier
Journal of Gastrointestinal and Liver Diseases | Year: 2013

Portal hypertension is a major consequence of any chronic liver disease and it represents the main mechanism of complication occurrence. Therefore, the assessment of portal hypertension presence is one of the most important steps in the management of any chronic liver diseases. The most accurate tool for portal pressure assessment is hepatic venous pressure gradient (HVPG) measurement, which has diagnostic and prognostic relevance. In this paper we review the methodology of HVPG measuring, together with the clinical relevance of this technique. Portal hypertension is denned as a HVPG higher than 5 mmHg, but clinically significant portal hypertension that predisposes to clinical decompensation is defined as HVPG higher than 10 mmHg. HVPG is useful for portal hypertension treatment monitoring. A decrease in HVPG greater than 20% or under the threshold of 12 mmHg is considered to be protective against portal hypertension-related events. Even if HVPG measurement is a safe procedure, it is still considered an invasive technique and not widely available. Therefore, non-invasive markers of portal hypertension were searched for. Until now only liver stiffness measurement by transient elastography has proved to be sufficiently accurate but there is still heterogeneity among the cut-off values for portal hypertension diagnosis.

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