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Cozma A.,University of Oradea | Zaharia V.,University of Medicine and Pharmacy Iuliu Haieganu | Ignat A.,University of Medicine and Pharmacy Iuliu Haieganu | Gocan S.,Babes - Bolyai University | Grinberg N.,Boerhringer Ingelheim Pharmaceutical Inc.
Journal of Chromatographic Science | Year: 2012

Using reversed-phase high-performance thin-layer chromatography and a methanolwater mixture as the mobile phase, the lipophilicity of 12 new synthesized derivatives is studied. The first eight compounds have as a basic chemical structure arylidenhydrazino-selenazoles, and the second group of the three compounds belongs to aroylhydrazinoselenazoles. The linear correlation between RMw and the methanolwater ratios showed high values for the correlation coefficient. The chromatographic hydrophobic index is determined by using the ratio RMw/S, and the obtained values ranged between 99 and 73. A good linear correlation is obtained between RMw and the slope. The log P values are calculated using ACD/Labs Software. The matrices are formed with RMw and log P and are subjected to a principal component analysis (PCA). The best way to extract information from PCA is graphically, by plotting the obtained matrices. By analyzing the scores, the compounds can be grouped as follows: a group containing nine compounds, and a second one containing three compounds. Each group of compounds has the same basic chemical structure. © 2012 The Author. Source


Cozma A.,University of Oradea | Vlase L.,University of Medicine and Pharmacy Iuliu Haieganu | Ignat A.,University of Medicine and Pharmacy Iuliu Haieganu | Zaharia V.,University of Medicine and Pharmacy Iuliu Haieganu | And 2 more authors.
Journal of Liquid Chromatography and Related Technologies | Year: 2012

Using RP-HPTLC and RP-HPLC and a methanol-water mixture as the mobile phase, eight new p-toluenesulfonyl-hydrazinothiazole and hydrazine-bis-thiazole derivatives were studied. The linear correlation between R Mw, k W and methanol/water ratios showed high values, for the correlation coefficient R 2. The chromatographic hydrophobic index φ 0 was determined by using intercept and slope, the obtained values ranging between 60 and 98. A good linear correlation was obtained between R Mw, logk w, and slope. The log P values were calculated using database (Toronto, Canada). The matrices were formed with R Mw, logk w and logP and were subjected to principal component analysis (PCA). The best way to extract information from PCA was graphically, by plotting the obtained matrices. By analyzing the scores, the compounds can be grouped in two: the first group contains three compounds that have a phenyl moiety while the second group comprises other five compounds that contain: methyl, chlor-methyl, acetyl, and ethylic ester. Copyright © Taylor & Francis Group, LLC. Source

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