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Mocan T.,University of Medicine and Pharmacy, Cluj-Napoca
International journal of nanomedicine | Year: 2011

In recent years, a new concept of an anticancer vaccine has been proposed to prevent and control the proliferation and expansion of cancer cells by eliciting an immune boost in biological systems. The recent literature supports the role of embryonic stem cells (ESC) as cellular agents that stimulate the biological systems to destroy cancer cells. However, at present, a true anticancer vaccine remains elusive. There are several lines of evidence showing that carbon nanotubes may be used to initiate and maintain immune responses. The authors proposed to test the therapeutic potential of multiwalled carbon nanotubes (MWCNTs) combined with ESC as agents to induce an immune boost and provide subsequent anticancer protection in mice. C57 BL/6 mice were immunized with ESC and MWCNTs. The proposed vaccine led to significant antitumor responses and enhanced tumor rejection in mice with subcutaneous inoculation of MC38 colon malign cells compared with groups only administered ESC, only MWCNTs, and controls. The application and potential of ESC combined with MWCNTs as anticancer immunization agents may represent the beginning of a new chapter in the treatment of colon cancer. Source


Iancu C.,University of Medicine and Pharmacy, Cluj-Napoca
International journal of nanomedicine | Year: 2011

Carbon nanotubes (CNTs) are emerging versatile tools in nanomedicine applications, particularly in the field of cancer targeting. Due to diverse surface chemistry and unique thermal properties, CNTs can act as strong optical absorbers in near infrared light where biological systems prove to be highly transparent. The process of laser-mediated ablation of cancer cells marked with biofunctionalized CNTs is frequently termed "nanophotothermolysis." This paper illustrates the potential of engineered CNTs as laser-activated photothermal agents for the selective nanophotothermolysis of cancer cells. Source


Albu S.,University of Medicine and Pharmacy, Cluj-Napoca
International Journal of Oral and Maxillofacial Surgery | Year: 2013

Abstract The purpose of this article is to present a new surgical technique - the double-barrel approach - employed for the extraction of dental implants from the maxillary sinus, and to compare it with the classic canine fossa puncture (CFP). The surgical steps in the performance of the double-barrel approach (DBA) are systematically described. In order to compare the two techniques (CFP versus DBA), a prospective, randomized study was carried out between 2004 and 2011, comparing the length of duration of the procedure and the incidence of adverse effects. The average duration was 6.3 ± 5.2 min for the DBA group and 14.8 ± 8.4 min for the CFP group (P = 0.0001, Mann-Whitney test). Nevertheless, the incidence of adverse effects within the first postoperative week did not differ between the two groups. We have demonstrated that the double-barrel approach is faster, has the same incidence of adverse effects, provides excellent visualization, and permits a more accurate withdrawal of implants in comparison with the classic CFP. It is minimally invasive, requires no sutures, and minimizes the risks to local vascular and neural structures. © 2013 International Association of Oral and Maxillofacial Surgeons. Source


Mihu D.,University of Medicine and Pharmacy, Cluj-Napoca
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology | Year: 2013

The adipose cell has been considered an inert cell from a secretory point of view. Studies over the past years have confirmed the capacity of the adipocyte to synthesize many substances including: adiponectin, leptin, which integrate multiple metabolic and endocrine signals. In the context of endometrial cancer, abdominal obesity as a risk factor is associated with a chronic inflammatory process, confirmed by the increase of inflammatory markers. The study aimed to identify a correlation between abdominal obesity, plasma adipokine levels and endometrial cancer. Two groups of patients were included in the study: group I - 44 patients diagnosed with endometrial cancer, group II - 44 patients without gynecological pathology or inflammatory disorders. After the performance of clinical examination and anthropometric measurements, abdominal fat was determined by dual X-ray absorptiometry and plasma adiponectin and leptin levels were measured. A significantly higher abdominal fat and leptin value was found in the group of patients in with endometrial cancer (p < 0.0001), while the plasma adiponectin level was significantly lower, compared to the control group (p < 0.0001). Abdominal fat was in a negative linear correlation with the plasma adiponectin level and in a positive linear correlation with the plasma leptin level. The measurement of adiponectin and leptin levels associated with the determination of abdominal adipose tissue can be a useful predictor factor for endometrial cancer. Source


Seicean A.,University of Medicine and Pharmacy, Cluj-Napoca
World Journal of Gastroenterology | Year: 2014

Pain in pancreatic cancer is often a major problem of treatment. Administration of opioids is frequently limited by side effects or insufficient analgesia. Endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN) represents an alternative for the palliative treatment of visceral pain in patients with pancreatic cancer. This review focuses on the indications, technique, outcomes of EUS-CPN and predictors of pain relief. EUS-CPN should be considered as the adjunct method to standard pain management. It moderately reduces pain in pancreatic cancer, without eliminating it. Nearly all patients need to continue opioid use, often at a constant dose. The effect on quality of life is controversial and survival is not influenced. The approach could be done in the central position of the celiac axis, which is easy to perform, or in the bilateral position of the celiac axis, with similar results in terms of pain alleviation. The EUS-CPN with multiple intraganglia injection approach seems to have better results, although extended studies are still needed. Further trials are required to enable more confident conclusions regarding timing, quantity of alcohol injected and the method of choice. Severe complications have rarely been reported, and great care should be taken in choosing the site of alcohol injection. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved. Source

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