University of Medicine and Pharmacy

Ho Chi Minh City, Vietnam

University of Medicine and Pharmacy

Ho Chi Minh City, Vietnam
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Tran T.T.-D.,Vietnam National University, Ho Chi Minh City | Tran P.H.-L.,Deakin University | Nguyen K.T.,Vietnam National University, Ho Chi Minh City | Tran V.-T.,University of Medicine and Pharmacy
Current Pharmaceutical Design | Year: 2016

Over the last 30 years, nanoparticle-based medicine has received tremendous attention due to its advances with smart therapeutics and less toxicity. Few nanomedicine products have been approved for commercial use in the clinic (such as Doxil®, Ambraxane®…). Nanomedicine research is still at its early stage and the preparation of nanoparticles must be carefully considered. Systems involving further increased supersaturation, either via solvent evaporation, temperature reduction or anti-solvent mixture, were suggested to be capable of inducing nanoprecipitation (NPT). Since this technique is straight-forward, fast and easy to duplicate in practice, it is highly preferred and recommended. In this review, the process of NTP was described and discussed in detail. Factors that affect the encapsulation efficiency, the nanoparticle size, the morphology and the stability of nanoparticles prepared by NTP were described. This process is one of the most preferable processes for preparing solid nano-protein due to their elegant techniques that preserve the bioactivity of proteins. Although the production of nanoparticles by this process has not been applied in the pharmaceutical industry due to the organic solvent issue, the production equipment for large-scale has been marketed. © 2016 Bentham Science Publishers.

Trinh K.X.,The National Poison Control Center Bach Mai Hospital | Khac Q.L.,Choray hospital | Trinh L.X.,University of Medicine and Pharmacy | Warrell D.A.,University of Oxford
Toxicon | Year: 2010

Between 1998 and 2007, 42 patients admitted to Choray hospital, Ho Chi Minh City, and to two hospitals in adjacent regions in southern Viet Nam brought the Malayan kraits (Bungarus candidus) that had been responsible for biting them. Half of the patients had been bitten while they were asleep. Fang marks and numbness were the only local features of the bites. Common signs of neurotoxic envenoming included bilateral ptosis, persistently dilated pupils, limb weakness, breathlessness, hypersalivation, dysphonia and dysphagia. Thirty patients (71.4%) required endotracheal intubation of whom all but one were mechanically ventilated. Fourteen patients (33.3%) developed hypertension, 13 (31.0%) shock, 31 (73.8%) hyponatraemia (plasma sodium concentration < 130 mEq/l) and 30 (71.4%) showed evidence of mild rhabdomyolysis (peak plasma creatine kinase concentration 1375 ± 140 u/l). None developed acute kidney injury. All the patients were treated with a new monospecific B. candidus antivenom. There were no fatalities.Hyponatraemia has been reported previously in victims of Chinese kraits (Bungarus multicinctus) in northern Viet Nam and rhabdomyolysis in patients envenomed by B. niger in Bangladesh. These features of envenoming pose new problems for the management of krait bite cases in South east Asia and should stimulate a search for the causative venom toxins. © 2010 Elsevier Ltd.

The International Association of HealthCare Professionals is pleased to welcome Alina M. Grigore, MD, MS, FAHA, FASE, Anesthesiologist, to their prestigious organization with her upcoming publication in The Leading Physicians of the World. She is a highly trained and qualified cardiac anesthesiologist with a vast expertise in all facets of her work. Dr. Grigore has been in practice for over 20 years and is currently serving patients in Las Vegas, Nevada. Dr. Grigore has extensive experience with intraoperative transesophageal echocardiographic, open heart surgery, aortic surgery, heart and lung transplant and ventricular assist devices. Dr. Grigore graduated with her Medical Degree from The Carol Davila University of Medicine and Pharmacy in Bucharest, Romania. Upon relocating to the United States, she completed her residency in Anesthesiology at St. Luke’s-Roosevelt Hospital Center, Columbia University, and underwent a two-year fellowship in Cardiothoracic and Vascular Anesthesia at Duke University, where she obtained a Master’s Degree in Health Sciences and Clinical Research in her second year. Dr. Grigore was honored with the American Patient’s Choice Award in 2010-2011, and the Consumers’ Research Council Award as America’s Top Anesthesiologist. Additionally, Dr. Grigore has received numerous awards attesting to her reputation of comprehensive, personalized, and compassionate care of cardiac patients. Dr. Grigore is certified by the American Board of Anesthesiology, National Board of Echocardiography, and has earned the coveted title of Fellow of American Heart Association, and Fellow American Society of Echocardiography. Dr. Grigore maintains professional memberships with the American Society of Anesthesiology, the Association of University Anesthesiologists, the Society of Cardiovascular Anesthesiology, the American Society of Echocardiography, the American Heart Association, and the American College of Physicians Executives. One of the highlights of her career is working for seven years at the Texas Heart Institute where she founded and lead the Cardiovascular Anesthesia Echocardiography Program. After Texas Heart Institute, she worked at the Mayo Clinic in Arizona where she served as Curriculum Director for residents on the cardiac anesthesia rotation. She provided perioperative care to the first total artificial heart patient at Mayo Clinic Arizona. Her success is attributed to her love and commitment to the field she has dedicated her life to, as well as loving what she does, and providing compassionate care to all patients. In her spare time, she enjoys reading and hiking. Learn more about Dr. Grigore here and be sure to read her upcoming publication in The Leading Physicians of the World. is a hub for all things medicine, featuring detailed descriptions of medical professionals across all areas of expertise, and information on thousands of healthcare topics.  Each month, millions of patients use FindaTopDoc to find a doctor nearby and instantly book an appointment online or create a review. features each doctor’s full professional biography highlighting their achievements, experience, patient reviews, and areas of expertise.  A leading provider of valuable health information that helps empower patient and doctor alike, FindaTopDoc enables readers to live a happier and healthier life.  For more information about FindaTopDoc, visit:

Pham D.-D.,University Paris - Sud | Pham D.-D.,University of Medicine and Pharmacy | Fattal E.,University Paris - Sud | Tsapis N.,University Paris - Sud
International Journal of Pharmaceutics | Year: 2015

Tuberculosis (TB) remains a major global health problem as it is the second leading cause of death from an infectious disease worldwide, after the human immunodeficiency virus (HIV). Conventional treatments fail either because of poor patient compliance to the drug regimen or due to the emergence of multidrug-resistant tuberculosis. The aim of this review is to give an update on the information available on tuberculosis, its pathogenesis and current antitubercular chemotherapies. Direct lung delivery of anti-TB drugs using pulmonary delivery systems is then reviewed since it appears as an interesting strategy to improve first and second line drugs. A particular focus is place on research performed on inhalable dry powder formulations of antitubercular drugs to target alveolar macrophages where the bacteria develop. Numerous studies show that anti-TB drugs can be incorporated into liposomes, microparticles or nanoparticles which can be delivered as dry powders to the deep lungs for instantaneous, targeted and/or controlled release. Treatments of infected animals show a significant reduction of the number of viable bacteria as well as a decrease in tissue damage. These new formulations appear as interesting alternatives to deliver directly drugs to the lungs and favor efficient TB treatment. © 2014 Elsevier B.V. All rights reserved.

Nguyen V.N.,University of Medicine and Pharmacy | Chavannes N.,Leiden University | Le L.T.T.,University of Medicine and Pharmacy | Price D.,University of Aberdeen
Primary Care Respiratory Journal | Year: 2012

Aims: To determine the reliability and validity of the Asthma Control Test (ACT) to detect Global Initiative for Asthma (GINA)-defined uncontrolled or partly controlled asthma, and to determine the agreement between ACT and GINA in classifying asthma control among Vietnamese patients. Methods: A cross-sectional study was performed in 323 of 360 invited outpatients with asthma in Ho Chi Minh City to compare the ACT and GINA classification for asthma control. Results: Internal consistency of the ACT (Cronbach's alpha) was 0.83. The kappa coefficient of 0.55, based on the ternary split, represents moderate agreement between the two rating systems with a correctly classified rate of 75%. The area under the receiver operating characteristics curve for the ACT score predicting GINA control was 0.85. To detect GINA-defined 'not controlled asthma', the ACT had a sensitivity of 70%, specificity of 93%, and a positive predictive value of 89%, with a cut-off point of 19. The validity of the ACT with regard to agreement with the GINA classification was consistent across both sexes, but less so in adolescents or younger adults. The ACT score was significantly correlated with the percentage predicted forced expiratory volume in 1 second (r=0.35, p<0.001) and percentage predicted peak expiratory flow (r=0.26, p<0.001). Conclusions: The Vietnamese ACT is useful for identifying outpatients with GINA-defined uncontrolled or partly controlled asthma. © 2012 Primary Care Respiratory Society UK.

Tomai X.H.,University of Medicine and Pharmacy
The journal of obstetrics and gynaecology research | Year: 2011

Epstein-Barr virus (EBV) infection in pregnancy and consequent fetal outcomes are rarely reported. The majority of cases described strongly support the possibility of transmission of this virus in utero and during delivery, resulting in stillbirth and/or congenital defects. We present a case of EBV reactivation in pregnancy that caused a severe symmetrical fetal growth restriction (FGR) and ultimately spontaneous fetal death. A 36-year-old woman, whose infection status was undetermined, was diagnosed with severe FGR at 24 weeks' gestation. The fetal karyotype was normal. EBV DNA was detected in the amniotic fluid and maternal immunoglobulin G antibodies were positive. At 30 weeks' gestation, the fetus died spontaneously. Placental examination found evidence of deciduitis and villitis. Reactivation of EBV infection appears to be related to FGR and warrants further research to determine the optimal management strategy in pregnancy. © 2011 The Authors. Journal of Obstetrics and Gynaecology Research © 2011 Japan Society of Obstetrics and Gynecology.

Khue N.T.,University of Medicine and Pharmacy
Annals of Global Health | Year: 2015

Background The prevalence for diabetes, prediabetes, and gestational diabetes in Vietnam are low relative to other parts of the world, but they are increasing at alarming rates. These changes have occurred in the setting of economic and cultural transitions. Objectives The aim of this study was to provide relevant information depicting the diabetes burden in Vietnam. Methods Literature was reviewed using PubMed and local Vietnamese sources, including papers published in the Vietnamese language. Findings In 2012, the prevalence of diabetes was 5.4% and prediabetes 13.7%. In 2005, the prevalence of obesity was 1.7%. There is a dual burden of over- and undernutrition observed in Vietnam. Diabetes is associated with an increased waist-to-hip ratio despite normal body mass index. Nutritional transitions occurred with increased protein, fat, and fast foods, and with decreased fresh fruits and vegetables. Tobacco use is very high in Vietnam with 66% of adult men currently smoking. Challenges include endocrinology training, health care coverage, patient education, and lack of coordination among government and specialist agencies. Conclusion Diabetes is a growing problem in Vietnam and is associated with obesity, changes in dietary patterns, and other cultural transitions. More research is needed to better understand this health care problem and to devise targeted interventions. © 2015 The Author. Published by Elsevier Inc.

Nguien Hieu T.,University of Medicine and Pharmacy
Oral health and dental management | Year: 2012

Several studies have shown a large diversity in the prevalence, extent and severity of gingival recession as well as controversial conclusions of its associated factors. Therefore, the aim of this pilot study was to evaluate gingival recession with predisposing factors in young Vietnamese. A cross-sectional study using clinical examination was performed in 120 dental students. Oral hygiene status, tooth malposition and fraenal attachment were recorded. The width of keratinised gingiva was measured after mucosa staining with Lugol's iodine solution. Measurements of gingival recession were performed on labial tooth surfaces. Chisquare test, t-test and Pearsonâs correlation were used for data analysis. The prevalence of gingival recession was 72.5% of the studied population. The extent of affected teeth was 11.1% of the examined teeth. The proportion of root-surface exposure was statistically higher (P<0.05) in the maxilla (12.5%) than in the mandible (9.6%). Premolars and right canines were the teeth most frequently and most seriously associated with gingival recession, respectively. There was a strong negative correlation between narrow width of keratinised gingiva and gingival recession (P<0.001). The recession was statistically associated with tooth malposition (P<0.001) but it was not related to high fraenal attachment and gender. A high prevalence of gingival recession was found in Vietnamese dental students. Gingival recession was associated with narrow width of keratinised gingiva, tooth malposition and maxillary teeth. Further studies performed in larger populations with more extended age groups are needed to confirm these findings.

Pham T.A.,University of Medicine and Pharmacy
Journal of investigative and clinical dentistry | Year: 2012

To examine the associations between oral health status, the presence of N-benzoyl-DL-arginine-2-naphthylamide-positive bacteria, and oral malodor in periodontal patients. A total of 137 periodontitis and 80 gingivitis patients were included in the study. Oral malodor was measured by an organoleptic test and the OralChroma. An oral examination was conducted, including the assessment of decayed teeth, periodontal status, and tongue coating. The presence of N-benzoyl-DL-arginine-2-naphthylamide-positive bacteria in the subgingiva, tongue coating, and saliva was evaluated by the N-benzoyl-DL-arginine-2-naphthylamide test. In the periodontitis group, oral malodor was significantly correlated with decayed teeth, periodontal parameters, and tongue coating. Among the N-benzoyl-DL-arginine-2-naphthylamide test parameters, the highest correlation of oral malodor was found with N-benzoyl-DL-arginine-2-naphthylamide subgingiva, followed by N-benzoyl-DL-arginine-2-naphthylamide tongue coating and N-benzoyl-DL-arginine-2-naphthylamide saliva. In the gingivitis group, oral malodor was significantly correlated with the plaque index, bleeding on probing, and tongue coating. Among the N-benzoyl-DL-arginine-2-naphthylamide test parameters, the highest correlation of oral malodor was found with N-benzoyl-DL-arginine-2-naphthylamide tongue coating, followed by N-benzoyl-DL-arginine-2-naphthylamide saliva and N-benzoyl-DL-arginine-2-naphthylamide subgingiva. Dental plaque, bleeding on probing, tongue coating, and N-benzoyl-DL-arginine-2-naphthylamide-positive bacteria contribute to oral malodor, but with different degrees in periodontitis and gingivitis patients. © 2012 Wiley Publishing Asia Pty Ltd.

Petrescu B.C.,University of Medicine and Pharmacy
Revista medico-chirurgicalǎ̌ a Societǎ̌ţii de Medici ş̧i Naturaliş̧ti din Iaş̧i | Year: 2010

MATERIAL AND METHOD: Pretreatment with apelin-13 (AP-13, 2 mg/kg, i.p.), sodium butyrate (BUT, 200 mg/kg, s.c.) and N-acetyl-L-cysteine (NAC, 150 mg/kg, s.c.), all reduced the LPS-induced vascular leak measured as Evans blue extravasation, in rats lung tissue when compared to intranasal LPS (10 mg/100 mL) administered alone. RESULTS: Although there is a significant difference either between AP-13 and BUT on one hand, and NAC and BUT on the other hand pretreatments, there is no significant difference between AP-13 and NAC pretreatments. Firstly, apelin-13 pretreatment might justify its effects through the modulation of endothelial layer functions. We recently demonstrated that AP-13 could diminish the endothelial dysfunction of pulmonary vein from both ovalbumin sensitized rats and rats with pulmonary hypertension. Furthermore, pretreatment with AP-13 + BUT, AP-13+NAC as well as BUT+ NAC reduced the LPS-induced vascular leak when compared to LPS alone. The reduction effects of BUT and NAC association were higher than those of either BUT or NAC alone. These synergistic effects might be associated to different and additive mechanisms of action of BUT and NAC. Thus, BUT might be primarily effective on macrophage migration and secondarily on activation and cytokine secretion by macrophages and NAC might be primarily effective on macrophages activation. Furthermore, since there are no significant effects between AP-13, NAC and AP-13+NAC we can conclude that AP-13 and NAC effects might be mediated through the same mechanisms (with the possible involvement of nuclear transcription factor NF-kB).

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