Amherst, MA, United States

University of Massachusetts Amherst

www.umass.edu
Amherst, MA, United States

The University of Massachusetts Amherst is a public research and land-grant university in Amherst, Massachusetts, United States, and the flagship of the University of Massachusetts system. With 1,174 faculty members and more than 27,000 students, UMass Amherst is the largest public university in New England and is ranked among top 30 public universities in the nation.The university offers bachelor's degrees, master's degrees, and doctoral degrees in 90 undergraduate and 72 graduate areas of study, through eight schools and colleges. The main campus is situated north of downtown Amherst. In a 2009 article for MSN.com, Amherst was ranked first in Best College Towns in the United States. In 2012, U.S. News and World Report ranked Amherst amongst the Top 10 Great College Towns in America.The University of Massachusetts Amherst is categorized as a Research University with Very High research activity by the Carnegie Foundation for the Advancement of Teaching. In 2011, UMass Amherst had research expenditures of $181.3 million. It is also a member of the Five College Consortium.UMass Amherst sports teams are called the Minutemen and Minutewomen, the colors being maroon and white; the school mascot is Sam the Minuteman. All teams participate in NCAA Division I. The university is a member of the Atlantic 10 Conference, while playing ice hockey in Hockey East. In football, UMass upgraded to the FBS level and transition to the Mid-American Conference . Wikipedia.


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Patent
University of Massachusetts Amherst | Date: 2017-02-03

A terahertz endoscopic system including a flexible waveguide and system optics. The waveguide is configured to transmit terahertz radiation from a first end of the waveguide to a second end of the waveguide proximate to a sample, and transmit reflected terahertz radiation from the second end of the waveguide to the first end of the waveguide, wherein the reflected terahertz radiation is a portion of the terahertz radiation reflected by the sample towards the second end of the waveguide. The system optics are configured to direct the terahertz radiation from a radiation source into the first end of the waveguide, isolate the reflected terahertz radiation from other radiation, and direct the reflected terahertz radiation from the first end of the waveguide to a terahertz radiation detector.


Patent
University of Massachusetts Amherst | Date: 2017-03-01

The disclosure in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products.


Patent
University of Massachusetts Amherst | Date: 2017-01-25

The invention relates to inhibitory nucleic acids and rAAV-based compositions, methods and kits useful for treating Amyotrophic Lateral Sclerosis.


Patent
University of Massachusetts Amherst | Date: 2017-02-03

The invention in some aspects relates to isolated nucleic acids, compositions, and kits useful for identifying adeno-associated viruses in cells. In some aspects, the invention provides kits and methods for producing somatic transgenic animal models using recombinant AAV (rAAV) to an animal having at least one transgene that expresses a small interfering nucleic acid or at least one binding site for a miRNA.


Patent
University of Massachusetts Amherst | Date: 2017-02-03

The invention in some aspects relates to isolated nucleic acids, compositions, and kits useful for identifying adeno-associated viruses in cells. In some aspects, the invention provides kits and methods for producing somatic transgenic animal models using recombinant AAV (rAAV) to an animal having at least one transgene that expresses a small interfering nucleic acid or at least one binding site for a miRNA.


Patent
University of Massachusetts Amherst | Date: 2017-06-21

The invention provides anti-OspA antibodies and methods of using the same.


Patent
University of Massachusetts Amherst and Aurora Flight Sciences Corporation | Date: 2017-01-11

Various embodiments disclosed relate to methods and apparatuses for forming composites. In various embodiments, the present invention provides a method of making a composite. The method can include placing a resin-impregnated fiber on a tooling surface. The method can include at least partially curing the resin-impregnated fiber. The method can also include placing a material in contact with the resin-impregnated fiber, to provide a composite.


The invention provides pH- or redox-responsive and charge-neutral polymeric nanogels that stably encapsulate a biomolecule at one pH or redox condition and then release it at a different pH or redox condition, and compositions and methods of preparation and use thereof


Patent
University of Massachusetts Amherst and Worcester Polytechnic Institute | Date: 2017-04-07

Antimicrobial agents, compositions that include the agent(s) and use(s) thereof are provided. Also disclosed are screening assays for identifying antimicrobial agents.


Patent
University of Massachusetts Amherst | Date: 2017-02-07

The invention provides a novel system of nano-assemblies and related method for delivery of therapeutic, diagnostic or imaging agent to biological sites. The compositions and methods of the invention enable the syntheses of novel polymeric nano-assemblies (nanoparticles) under non-emulsion conditions with the incorporation of hydrophobic guest molecules. The versatilities and advantages of the polymer nanoparticles of the invention include: (i) the guest molecules (e.g., drug molecules) can be readily incorporated non-covalently within the nanoparticles; (ii) the surface of the nanoparticles are functionalizable; (iii) the non-covalently encapsulated guest molecule (payload) can be released in response to a biologically relevant stimulus at the target site; (iv) the payload is held by the polymeric nanoparticle before being internalized in cells and can be released within the cellular interiors; (v) encapsulating lipophilic small molecules within its crosslinked interiors and binding proteins on its surface through electrostatic interactions; (vi) facile synthetic methods for ligand functionalization that can be utilized to decorate nanogels with cell targeting ligands that facilitate receptor-dependent cellular uptake, and (vii) the payload release kinetics is tunable and controllable.

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