The University of Massachusetts Amherst is a public research and land-grant university in Amherst, Massachusetts, United States, and the flagship of the University of Massachusetts system. With 1,174 faculty members and more than 27,000 students, UMass Amherst is the largest public university in New England and is ranked among top 30 public universities in the nation.The university offers bachelor's degrees, master's degrees, and doctoral degrees in 90 undergraduate and 72 graduate areas of study, through eight schools and colleges. The main campus is situated north of downtown Amherst. In a 2009 article for MSN.com, Amherst was ranked first in Best College Towns in the United States. In 2012, U.S. News and World Report ranked Amherst amongst the Top 10 Great College Towns in America.The University of Massachusetts Amherst is categorized as a Research University with Very High research activity by the Carnegie Foundation for the Advancement of Teaching. In 2011, UMass Amherst had research expenditures of $181.3 million. It is also a member of the Five College Consortium.UMass Amherst sports teams are called the Minutemen and Minutewomen, the colors being maroon and white; the school mascot is Sam the Minuteman. All teams participate in NCAA Division I. The university is a member of the Atlantic 10 Conference, while playing ice hockey in Hockey East. In football, UMass upgraded to the FBS level and transition to the Mid-American Conference . Wikipedia.
University of Massachusetts Amherst | Date: 2016-08-02
The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntingtons disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.
University of Massachusetts Amherst | Date: 2016-09-16
Described herein are methods of identifying host factors that modulate Hepatitis B virus (HBV) replication in mammalian, e.g., human cells, as well as factors identified by those methods, and methods of treating HBV infections by targeting those factors. Zinc finger, CCHC domain containing 14 (ZCCHC14) is an exemplary host factor.
University of Massachusetts Amherst | Date: 2016-08-12
Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
University of Massachusetts Amherst | Date: 2016-11-21
A single-shot terahertz imaging system including an interferometer and a terahertz spectrometer. The interferometer includes a beam splitter configured to receive input terahertz radiation and output first terahertz radiation and second terahertz radiation, a sample configured to reflect the first terahertz radiation, and a mirror configured to reflect the second terahertz radiation. The beam splitter is further configured to receive the reflected first terahertz radiation and the reflected second terahertz radiation, and output interfered terahertz radiation. The terahertz spectrometer is configured to measure the interfered terahertz radiation and includes a frequency dispersive element configured to receive the interfered terahertz radiation and output spatially dispersed terahertz radiation, and a terahertz radiation detector configured to determine the intensity of the spatially dispersed terahertz radiation.
University of Massachusetts Amherst | Date: 2016-11-18
A user provides a query that includes at least two of a subject, a predicate, and an object. A computer system identifies synonyms of one or more of the subject, predicate, and object, and forms new queries from the identified synonyms. The system searches a dataset using the new queries, and possibly also using the user-provided query, to produce search results. The system may process the search results, such as by filtering and/or sorting them. The system provides output representing the search results to the user. The user may use the search result output to identify answers that are analogous to answers to the query originally provided by the user.
University of Massachusetts Amherst | Date: 2016-06-30
Provided herein are plants and methods to increase plant biomass, for example, a transgenic plant, plant cell, plant part or seed, wherein the transgenic plant, plant cell, plant part or seed comprises a heterologous promoter which increases expression of SWAM1, other genes related to SWAM1, or GNRF, as compared to a non-transgenic plant.
University of Massachusetts Amherst | Date: 2016-10-06
The invention relates to quantum dot and photodetector technology, and more particularly, to quantum dot infrared photodetectors (QDIPs) and focal plane array. The invention further relates to devices and methods for the enhancement of the photocurrent of quantum dot infrared photodetectors in focal plane arrays.
Forbes N.S.,University of Massachusetts Amherst
Nature Reviews Cancer | Year: 2010
Bacterial therapies possess many unique mechanisms for treating cancer that are unachievable with standard methods. Bacteria can specifically target tumours, actively penetrate tissue, are easily detected and can controllably induce cytotoxicity. Over the past decade, Salmonella, Clostridium and other genera have been shown to control tumour growth and promote survival in animal models. In this Innovation article I propose that synthetic biology techniques can be used to solve many of the key challenges that are associated with bacterial therapies, such as toxicity, stability and efficiency, and can be used to tune their beneficial features, allowing the engineering of 'perfect' cancer therapies. © 2010 Macmillan Publishers Limited. All rights reserved.
Rothstein J.P.,University of Massachusetts Amherst
Annual Review of Fluid Mechanics | Year: 2010
This review discusses the use of the combination of surface roughness and hydrophobicity for engineering large slip at the fluid-solid interface. These superhydrophobic surfaces were initially inspired by the unique water-repellent properties of the lotus leaf and can be employed to produce drag reduction in both laminar and turbulent flows, enhance mixing in laminar flows, and amplify diffusion-osmotic flows. We review the current state of experiments, simulations, and theory of flow past superhydrophobic surfaces. In addition, the designs and limitations of these surfaces are discussed, with an eye toward implementing these surfaces in a wide range of applications. Copyright © 2010 by Annual Reviews. All rights reserved.
Chao W.,University of Massachusetts Amherst
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2016
The ATLAS Collaboration has reported excesses in diboson invariant mass searches of new resonances around 2 TeV, which might be a prediction of new physics around that mass range. We interpret these results in the context of a modified stealth doublet model where the extra Higgs doublet has a Yukawa interaction with the first generation quarks, and show that the heavy CP-even Higgs boson can naturally explain the excesses in the WW and ZZ channels with a small Yukawa coupling, ξ ~ 0.15, and a tiny mixing angle with the SM Higgs boson, α ~ 0.05. Furthermore, the model satisfies constraints from colliders and electroweak precision measurements. © 2015 The Author.