Amherst, MA, United States

University of Massachusetts Amherst

www.umass.edu
Amherst, MA, United States

The University of Massachusetts Amherst is a public research and land-grant university in Amherst, Massachusetts, United States, and the flagship of the University of Massachusetts system. With 1,174 faculty members and more than 27,000 students, UMass Amherst is the largest public university in New England and is ranked among top 30 public universities in the nation.The university offers bachelor's degrees, master's degrees, and doctoral degrees in 90 undergraduate and 72 graduate areas of study, through eight schools and colleges. The main campus is situated north of downtown Amherst. In a 2009 article for MSN.com, Amherst was ranked first in Best College Towns in the United States. In 2012, U.S. News and World Report ranked Amherst amongst the Top 10 Great College Towns in America.The University of Massachusetts Amherst is categorized as a Research University with Very High research activity by the Carnegie Foundation for the Advancement of Teaching. In 2011, UMass Amherst had research expenditures of $181.3 million. It is also a member of the Five College Consortium.UMass Amherst sports teams are called the Minutemen and Minutewomen, the colors being maroon and white; the school mascot is Sam the Minuteman. All teams participate in NCAA Division I. The university is a member of the Atlantic 10 Conference, while playing ice hockey in Hockey East. In football, UMass upgraded to the FBS level and transition to the Mid-American Conference . Wikipedia.

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Patent
University of Massachusetts Amherst | Date: 2017-01-25

The invention relates to inhibitory nucleic acids and rAAV-based compositions, methods and kits useful for treating Amyotrophic Lateral Sclerosis.


Patent
University of Massachusetts Amherst | Date: 2017-02-03

A terahertz endoscopic system including a flexible waveguide and system optics. The waveguide is configured to transmit terahertz radiation from a first end of the waveguide to a second end of the waveguide proximate to a sample, and transmit reflected terahertz radiation from the second end of the waveguide to the first end of the waveguide, wherein the reflected terahertz radiation is a portion of the terahertz radiation reflected by the sample towards the second end of the waveguide. The system optics are configured to direct the terahertz radiation from a radiation source into the first end of the waveguide, isolate the reflected terahertz radiation from other radiation, and direct the reflected terahertz radiation from the first end of the waveguide to a terahertz radiation detector.


Patent
University of Massachusetts Amherst | Date: 2017-03-22

Methods for treating chronic myeloid leukemia (CML), e.g., BCR-ABL inhibitor imatinib mesylate (IM)-resistant CML, using combination treatments, e.g., combined treatment with a BCR-ABL inhibitor, e.g., IM, and a MEK inhibitor, e.g., trametinib.


Patent
University of Massachusetts Amherst | Date: 2017-02-15

A method of these teachings for designing foods in order to improve the bioavailability of orally administered bioactive agents, the method including designing a food matrix, the food matrix not having bioactivity above its normal nutritional function, that increases bioavailability of a predetermined pharmaceutical or nutraceutical by at least one of facilitating the release and solubilization of bioactive agents in the predetermined pharmaceutical or nutraceutical, altering the absorption of lipophilic bioactive agents in the predetermined pharmaceutical or nutraceutical when co-ingested, or interfering with chemical transformations that occur within gastrointestinal tract (GIT) or after absorption; the food matrix being co-ingested with the predetermined pharmaceutical or nutraceutical or ingested at a specified time soon before or after the pharmaceutical or nutraceutical.


Patent
University of Massachusetts Amherst | Date: 2017-02-22

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.


An object has a durable superhydrophic, self-cleaning, and icephobic coating includes a substrate and a layer disposed on the substrate, the layer resulting from coating with a formulation having an effective amount of hierarchical structuring microanoparticles, liquid silane having one or more groups configured to graft to a hierarchical structuring microanoparticle and at least another group that results in hydrophobicity. The hierarchical structuring microanoparticles are dispersed in the liquid silane. Another effective amount of synthetic adhesive, selected from thermosetting binders, moisture curing adhesives or polymers that form a strong interaction with a surface, is in solution with a solvent. Upon curing, the layer has a contact angle greater than 90 and a sliding angle of less than 10 and, less than 5% of an area of the layer is removed in a Tape test.


Patent
University of Massachusetts Amherst | Date: 2017-03-01

The disclosure in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products.


Patent
University of Massachusetts Amherst | Date: 2017-06-21

The invention provides anti-OspA antibodies and methods of using the same.


Patent
University of Massachusetts Amherst | Date: 2017-02-03

The invention in some aspects relates to isolated nucleic acids, compositions, and kits useful for identifying adeno-associated viruses in cells. In some aspects, the invention provides kits and methods for producing somatic transgenic animal models using recombinant AAV (rAAV) to an animal having at least one transgene that expresses a small interfering nucleic acid or at least one binding site for a miRNA.


Patent
University of Massachusetts Amherst | Date: 2017-02-03

The invention in some aspects relates to isolated nucleic acids, compositions, and kits useful for identifying adeno-associated viruses in cells. In some aspects, the invention provides kits and methods for producing somatic transgenic animal models using recombinant AAV (rAAV) to an animal having at least one transgene that expresses a small interfering nucleic acid or at least one binding site for a miRNA.

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