Amherst, MA, United States
Amherst, MA, United States

The University of Massachusetts Amherst is a public research and land-grant university in Amherst, Massachusetts, United States, and the flagship of the University of Massachusetts system. With 1,174 faculty members and more than 27,000 students, UMass Amherst is the largest public university in New England and is ranked among top 30 public universities in the nation.The university offers bachelor's degrees, master's degrees, and doctoral degrees in 90 undergraduate and 72 graduate areas of study, through eight schools and colleges. The main campus is situated north of downtown Amherst. In a 2009 article for MSN.com, Amherst was ranked first in Best College Towns in the United States. In 2012, U.S. News and World Report ranked Amherst amongst the Top 10 Great College Towns in America.The University of Massachusetts Amherst is categorized as a Research University with Very High research activity by the Carnegie Foundation for the Advancement of Teaching. In 2011, UMass Amherst had research expenditures of $181.3 million. It is also a member of the Five College Consortium.UMass Amherst sports teams are called the Minutemen and Minutewomen, the colors being maroon and white; the school mascot is Sam the Minuteman. All teams participate in NCAA Division I. The university is a member of the Atlantic 10 Conference, while playing ice hockey in Hockey East. In football, UMass upgraded to the FBS level and transition to the Mid-American Conference . Wikipedia.


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Patent
University of Massachusetts Amherst | Date: 2015-04-08

A method of these teachings for designing foods in order to improve the bioavailability of orally administered bioactive agents, the method including designing a food matrix, the food matrix not having bioactivity above its normal nutritional function, that increases bioavailability of a predetermined pharmaceutical or nutraceutical by at least one of facilitating the release and solubilization of bioactive agents in the predetermined pharmaceutical or nutraceutical, altering the absorption of lipophilic bioactive agents in the predetermined pharmaceutical or nutraceutical when co-ingested, or interfering with chemical transformations that occur within gastrointestinal tract (GIT) or after absorption; the food matrix being co-ingested with the predetermined pharmaceutical or nutraceutical or ingested at a specified time soon before or after the pharmaceutical or nutraceutical.


Patent
University of Massachusetts Amherst | Date: 2014-03-14

The invention in some aspects provides compounds useful for targeting bacterial infections. In some embodiments, the compounds comprise a transferrin receptor ligand covalently linked to a bactericidal agent. In some embodiments, the bactericidal agent is a bactericidal peptide, such as a glycoside hydrolase (e.g., lysozyme).


We report the synthesis and characterization of novel bistetracenes, an unconventional, linearly extended conjugated core with eight fused rings. Also described are bisoligoacenes. In general, the properties and stability of large polycyclic aromatic hydrocarbons (PAHs) strongly depend on the mode of ring annellation and the topology of their it-electron systems, which are usually associated with the resonance stabilization energy in large PAHs.


Patent
University of Massachusetts Amherst | Date: 2016-08-02

The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntingtons disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.


Patent
University of Massachusetts Amherst | Date: 2016-09-16

Described herein are methods of identifying host factors that modulate Hepatitis B virus (HBV) replication in mammalian, e.g., human cells, as well as factors identified by those methods, and methods of treating HBV infections by targeting those factors. Zinc finger, CCHC domain containing 14 (ZCCHC14) is an exemplary host factor.


An object has a durable superhydrophic, self-cleaning, and icephobic coating includes a substrate and a layer disposed on the substrate, the layer resulting from coating with a formulation having an effective amount of hierarchical structuring micro/nanoparticles, liquid silane having one or more groups configured to graft to a hierarchical structuring micro/nanoparticle and at least another group that results in hydrophobicity. The hierarchical structuring micro/nanoparticles are dispersed in the liquid silane. Another effective amount of synthetic adhesive, selected from thermosetting binders, moisture curing adhesives or polymers that form a strong interaction with a surface, is in solution with a solvent. Upon curing, the layer has a contact angle greater than 90 and a sliding angle of less than 10 and, less than 5% of an area of the layer is removed in a Tape test.


Patent
University of Massachusetts Amherst | Date: 2015-05-05

The invention provides novel compositions and methods of surface mineralization for metallic or ceramic implants and devices and the resulting enhancement of properties and performance in skeletal tissue engineering, orthopedic applications and dental care. The novel approach utilizes zwitterionic brushes (e.g., of poly(sulfobetaine methacrylate) or pSBMA) covalently grafted on the surface of titanium or its alloy substrates (e.g., Ti6Al4V) to promote surface-mineralization of hydroxyapatite with enhanced surface mineral coverage and mineral-substrate interfacial adhesion. The zwitterionic surface brushes, capable of attracting both cationic and anionic precursor ions during hydroxyapatite-mineralization, significantly increase the surface mineral coverage and significantly reinforce the attachment of the surface apatite crystals on the titanium alloy substrate which withstood supersonication treatment.


Patent
University of Massachusetts Amherst | Date: 2016-08-12

Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.


Patent
University of Massachusetts Amherst | Date: 2014-12-11

The invention provides compositions and methods for reducing one or more symptoms of disease by administering compositions comprising SipA. The inventions compositions and methods are particularly advantageous in reducing symptoms of diseases that are associated with overexpression of P-gp and/or p53. The inventions compositions and methods are useful in reducing cancer symptom and/or cancer multidrug resistance (MDR). The invention provides a method for reducing one or more symptoms of cancer in a mammalian subject in need thereof, comprising administering to said subject a composition comprising purified SipA. In one embodiment, said SipA is operably conjugated to a nanoparticle. In another embodiment, said cancer comprises cancer cells resistant to at least one cytotoxin.


Patent
University of Massachusetts Amherst | Date: 2016-11-21

A single-shot terahertz imaging system including an interferometer and a terahertz spectrometer. The interferometer includes a beam splitter configured to receive input terahertz radiation and output first terahertz radiation and second terahertz radiation, a sample configured to reflect the first terahertz radiation, and a mirror configured to reflect the second terahertz radiation. The beam splitter is further configured to receive the reflected first terahertz radiation and the reflected second terahertz radiation, and output interfered terahertz radiation. The terahertz spectrometer is configured to measure the interfered terahertz radiation and includes a frequency dispersive element configured to receive the interfered terahertz radiation and output spatially dispersed terahertz radiation, and a terahertz radiation detector configured to determine the intensity of the spatially dispersed terahertz radiation.


Patent
University of Massachusetts Amherst | Date: 2016-11-18

A user provides a query that includes at least two of a subject, a predicate, and an object. A computer system identifies synonyms of one or more of the subject, predicate, and object, and forms new queries from the identified synonyms. The system searches a dataset using the new queries, and possibly also using the user-provided query, to produce search results. The system may process the search results, such as by filtering and/or sorting them. The system provides output representing the search results to the user. The user may use the search result output to identify answers that are analogous to answers to the query originally provided by the user.


Patent
University of Massachusetts Amherst | Date: 2016-06-30

Provided herein are plants and methods to increase plant biomass, for example, a transgenic plant, plant cell, plant part or seed, wherein the transgenic plant, plant cell, plant part or seed comprises a heterologous promoter which increases expression of SWAM1, other genes related to SWAM1, or GNRF, as compared to a non-transgenic plant.


The invention relates to quantum dot and photodetector technology, and more particularly, to quantum dot infrared photodetectors (QDIPs) and focal plane array. The invention further relates to devices and methods for the enhancement of the photocurrent of quantum dot infrared photodetectors in focal plane arrays.


Patent
University of Massachusetts Amherst | Date: 2015-05-01

A clinical scoring system and methods that effectively and efficiently utilizes a number of different data sources to determine a diagnosis of patient conditions. The score is compared to a spectrum of scores in order to identify between disorders, such as Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBSd) or gastroesophageal reflux disease (GERD) and functional dyspepsia.


Patent
University of Massachusetts Amherst | Date: 2015-05-06

The invention provides novel materials, methods and designs to enable improved power conversion efficiencies of organic photovoltaics (OPVs). In particular, the invention provides novel materials and interlayers for polymer-based solar cells. Novel functional fullerene-based interlayers are disclosed that enable high efficiency devices in conjunction with numerous active layer and electrode materials.


Lee D.-H.,Kyungpook National University | Porta M.,Autonomous University of Barcelona | Jacobs Jr. D.R.,University of Minnesota | Jacobs Jr. D.R.,University of Oslo | Vandenberg L.N.,University of Massachusetts Amherst
Endocrine Reviews | Year: 2014

Persistent organic pollutants (POPs) are lipophilic compounds that travel with lipids and accumulate mainly in adipose tissue. Recenthumanevidence links low-dose POPs to an increased risk of type 2 diabetes (T2D). Because humans are contaminated by POP mixtures and POPs possibly have nonmonotonic dose-response relations with T2D, critical methodological issues arise in evaluating human findings. This review summarizes epidemiological results on chlorinated POPs and T2D, and relevant experimental evidence. It also discusses how features of POPs can affect inferences in humans. The evidence as a whole suggests that, rather than a few individual POPs, background exposure to POP mixtures-including organochlorine pesticides and polychlorinated biphenyls- can increase T2D risk in humans. Inconsistent statistical significance for individual POPs may arise due to distributional differences in POP mixtures among populations. Differences in the observed shape of the doseresponse curvesamonghumanstudies may reflect an inverted U-shaped association secondary to mitochondrial dysfunction or endocrine disruption. Finally, we examine the relationship between POPs and obesity. There is evidence in animal studies that low-dose POP mixtures are obesogenic. However, relationships between POPs and obesity in humans have been inconsistent. Adipose tissue plays a dual role of promoting T2D and providing a relatively safe place to store POPs. Large prospective studies with serial measurements of a broad range of POPs, adiposity, and clinically relevant biomarkers are needed to disentangle the interrelationships among POPs, obesity, and the development of T2D. Also needed are laboratory experiments that more closely mimic real-world POP doses, mixtures, and exposure duration in humans. © 2014 by the Endocrine Society.


The present invention is directed to a recombinant immunogenic polypeptide. The polypeptide includes a loop peptide inserted into an immunogenic scaffold protein. The loop polypeptide has an amino acid sequence which presents the 3074 mAb- or the 2219/2557 mAb-targeted epitope of the HIV gp120 protein and not other known epitopes of the HIV gp120 protein. When used as an immunogen, the polypeptide induces an antibody response which neutralizes heterologous HIV-1 viruses in a pattern similar to that observed for the 3074 mAb- or the 2219/2557 mAb-targeted epitope, respectively. Pharmaceutical compositions containing the immunogenic polypeptide as well as methods of making and using it are also disclosed.


Wagner D.L.,University of Connecticut | Van Driesche R.G.,University of Massachusetts Amherst
Annual Review of Entomology | Year: 2010

Endangerment factors are reviewed for 57 U.S. federally listed insects and 116 rare eastern North American lepidopterans to determine the importance of invasive species relative to 15 other recognized endangerment factors. Invasive plants, social insects (especially ants), and vertebrate grazers and predators repeatedly were identified as groups directly or indirectly threatening native insect biodiversity. Among rare eastern North American lepidopterans, the (mostly indirect) consequences of the establishment of the gypsy moth (Lymantria dispar) surfaced as a general threat. Remote islands, especially those with high human visitation, stand out as being highly threatened by invasives. In the worst cases, impacts from invasive species cascade through a community and destabilize existing trophic interconnections and alter basic ecosystem properties, changing hydrology, nutrient cycles, soil chemistry, fire susceptibility, and light availability, and precipitate myriad other changes in biotic and abiotic parameters. Invasive ants and herbivorous insects provide some of the most dramatic examples of such insect-induced invasional cascades. © 2010 by Annual Reviews All rights reserved.


Grant
Agency: Department of Defense | Branch: Air Force | Program: STTR | Phase: Phase I | Award Amount: 99.99K | Year: 2011

ABSTRACT: The ability to oxidize organic functional groups in a selective manner is of major importance in preparing compounds of interest to the Air Force and DoD. This is particularly critical in the preparation of high energy density compounds and fuels. Heterocyclic ring systems that contain both nitro and amino groups have been found to be an important class of compounds that are useful in these applications. Their synthesis by oxidation of the corresponding polyamino systems would be particularly advantageous in terms of cost, ease of preparation and handling, and safety. The USAF is primarily interested in conversion of 4,4"-azobis(3-aminofurazan) to 4-[(4-nitro-furazan-3-yl)azo]-furazan-3-amine. Unfortunately, the only practical large scale synthesis of this compound makes it necessary to produce 3,3"-azobis(4-nitrofurazan) first, which is friction sensitive. The safety of this process could be greatly improved by avoiding this intermediate. Infoscitex Corporation and University of Massachusetts at Lowell developed a concept and laid out biocatalytic route to selectively oxidize only one amino-group of the insensitive diamine, 4,4"-azobis(3-aminofurazan). Thus, 4,4"-azobis(3-aminofurazan) will be converted directly into to 4-[(4-nitro-furazan-3-yl)azo]-furazan-3-amine. This oxidation will open new molecular design space for the synthesis of asymmetric amino-nitro-heterocycles and will create low-cost access to new energetic and/or pharmaceutical ingredients. BENEFIT: The proposed biocatalytic oxidation reaction is anticipated to be a viable production process to manufacture 4,4"-azobis(3-aminofurazan) safely and affordably. In addition to production of energetic materials the oxidation process may be useful in the field of pharmaceuticals.


Patent
President And Fellows Of Harvard College, The General Hospital Corporation and University of Massachusetts Amherst | Date: 2012-08-30

Systems and methods are disclosed to monitor physiological for the occurrence of life threatening events and to apply stimulation to prevent the occurrence of said life-threatening events. Systems and methods for applying the stimulation are also disclosed. These systems include applying the stimulation through via a mattress having a passive section and an active section, a plurality of focal stimulators, and/or an array to apply the stimulation are also disclosed. These devices include a mattress with an active region and a passive region, a stimulating array do deliver targeted stimulation, and a plurality of stimulators to apply focused stimulation.


Patent
University of Massachusetts Amherst, Massachusetts Institute of Technology, President And Fellows Of Harvard College and Whitehead Institute For Biomedical Research | Date: 2016-04-25

The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be used to identify long-range interactions between distant genomic loci.


Patent
University of Massachusetts Amherst and President And Fellows Of Harvard College | Date: 2014-05-05

The invention, in some aspects, relates to compounds and compositions useful for inhibiting Type III secretion systems in pathogenic bacteria, such as Yersinia Pestis. In some aspects, the invention relates to methods for discovering inhibitors of the Type III secretion system and uses of such inhibitors in the treatment and prevention of disease.


Grant
Agency: Department of Defense | Branch: Army | Program: STTR | Phase: Phase I | Award Amount: 99.89K | Year: 2011

The low cost chloroperoxidase can be potentially applicable to the inactivation of chemical agents due to its exceptional stability, broad substrate profile, and high catalytic efficiency. However, the high cost of producing large amounts of CPO is a major obstacle precluding the formulation and field deployment of this enzyme for chemical agent decontamination. Infoscitex Corporation (IST) and University of Massachusetts at Lowell (UML) propose a technology for high yield commercial production of CPO by an improved strain of filamentous fungus Caldariomyces fumago. The high yields of the enzyme production by C. fumago will be achieved via an advanced method of strain improvement by its directed evolution for target resistance established at Infoscitex. The high activity and stability of the resultant product will be assured by use of the most advanced technology for CPO isolation and purification. The new CPO producing strain will be coupled with state of the art protein production and purification capacity to achieve the required kilogram-scale manufacturing capabilities.


Patent
University of Massachusetts Amherst and University of Notre Dame | Date: 2014-05-16

High-affinity variants of the DMF5 TCR, and methods of use thereof for the treatment and imaging of cancer in a patient.


Stoffolano Jr. J.G.,University of Massachusetts Amherst | Haselton A.T.,State University of New York at New Paltz
Annual Review of Entomology | Year: 2013

The diverticulated crop is a unique and overlooked foregut organ in the Diptera that affects many physiological and behavioral functions. Historically, the crop was viewed simply as a reservoir for excess nutrients. The crop lobes and crop duct form an elaborate sphincter and pump system that moves stored nutrients to the crop lobes, oral cavity, and the midgut. The storage capacity of the crop lobes is significant when filled maximally and supplies sufficient carbohydrates to sustain prolonged activity and flight, and adequate protein and lipids to facilitate reproductive events. Crop emptying is under complex neuroendocrine and neural control and may be influenced by multiple neuromessengers, such as serotonin and dromyosuppressin. The crop lobes also serve as a site for the initial mixing of enzymes from the salivary glands and antimicrobials from the labellar glands with ingested food. These food-processing functions are associated with behaviors unique to dipterans, such as regurgitation (or bubbling), nuptial gift giving, and substrate droplet deposition or trap-lining. © 2013 by Annual Reviews. All rights reserved.


Chandra D.,University of Pennsylvania | Chandra D.,University of Massachusetts Amherst | Yang S.,University of Pennsylvania
Accounts of Chemical Research | Year: 2010

High aspect-ratio (HAR) micropillar arrays have many interesting and technologically important applications. Their properties, such as large mechanical compliance, large surface area, and a topography that is well-separated from the underlying substrate, have allowed researchers to design and explore biomimetic dry adhesives, superhydrophobic, superoleophobic, and tunable wetting surfaces, mechanical sensors and actuators, and substrates for cell mechanics studies. However, the mechanical compliance and large surface area of the micropillars also make these structures susceptible to deformation by adhesive and capillary surface forces. As a result such micropillars, particularly those made from soft polymers, can prove challenging to fabricate and to use in various applications. Systematic understanding of these forces is thus critical both to assemble stable micropillar arrays and to harness these surface forces toward controlled actuation for various applications. In this Account, we review our recent studies on the stability of HAR polymeric micropillar arrays against adhesive and capillary forces. Using the replica molding method, we have successfully fabricated HAR epoxy micropillar arrays with aspect ratios up to 18. The stability of these arrays against adhesive forces is in agreement with theoretical predictions. We have also developed a new two-step replica molding method to fabricate HAR (up to 12) hydrogel micropillar arrays using monomers or monomer mixtures. By varying the monomer composition in the fabrication process, we have fabricated a series of hydrogel micropillar arrays whose elastic moduli in wet state range from less than a megapascal to more than a gigapascal, and we have used these micropillar arrays to study capillary force induced clustering behavior as a function of the modulus. As a result, we have shown that as liquid evaporates off the micropillar arrays, the pillars bend and cluster together because of a much smaller capillary meniscus interaction force while the micropillar structures are surrounded by a continuous liquid body. Previously, researchers had often attributed this clustering effect to a Laplace pressure difference because of isolated capillary bridges. Our theoretical analysis of stability against capillary force and micropillar cluster size as a function of pillar elastic modulus agrees well with our experimental observations. The fabrication approaches presented here are quite general and will enable the fabrication of tall, stable micropillar arrays in a variety of soft, responsive materials. Therefore, researchers can use these materials for various applications: sensors, responsive wetting, and biological studies. The new insights into the capillary force induced clustering of micropillar arrays could improve rational design and fabrication of micropillar arrays that are stable against capillary force. In addition, these results could help researchers better manipulate capillary force to control the assembly of micropillar arrays and actuate these structures within novel devices. © 2010 American Chemical Society.


Patent
University of Pennsylvania and University of Massachusetts Amherst | Date: 2012-03-28

The present invention discloses compositions of facially amphiphilic polymers and oligomers and their use in methods for treating or reducing cancers in humans or animals.


Patent
University of Pennsylvania and University of Massachusetts Amherst | Date: 2011-03-23

The present invention discloses compositions of facially amphiphilic polymers and oligomers and their use in methods for treating or reducing cancers in humans or animals.


Grant
Agency: Department of Defense | Branch: Navy | Program: STTR | Phase: Phase II | Award Amount: 499.99K | Year: 2012

There is a need to find more efficient methods for producing high-density, liquid, tactical fuels for use in missile propulsion or as components to improve key performance characteristics of currently available jet and diesel fuels. Generation of such fuels from renewable sources including waste cellulose, grasses, waste agricultural material and forestry products will provide important national security benefits as compared with the use of raw petroleum products--a large fraction of which are imported. During Phase I research PSI, in collaboration with Dr. Michael Henson"s laboratory at the University of Massachusetts, Amherst, explored development of a consolidated bioprocess for bioconversion of cellulosic biomass to high purity alpha- or beta-pinene precursors for high-density, liquid tactical fuel. That work will be extended during Phase II efforts. During the base effort PSI will pursue several genetic approaches to significantly increase beta-pinene production and export from the fungal mycelia, and will also pursue development of other key feedstocks including linalool and isopropanol for high-density, liquid hydrocarbon fuel production. In parallel UMass will develop efficient methods for solid-state fermentation. During the option period production of beta-pinene or isopropanol will be scaled up to produce several gallons of solvent.


Grant
Agency: Department of Defense | Branch: Navy | Program: STTR | Phase: Phase I | Award Amount: 99.96K | Year: 2011

There is a need to find more efficient methods for producing high-density, liquid, tactical fuels for use in missile propulsion or as components to improve key performance characteristics of currently available jet and diesel fuels. Generation of such fuels from renewable sources such as waste cellulose, grasses, waste agricultural material and forestry products will provide important national security benefits as compared with the use of raw petroleum products a large fraction of which are imported. In addition renewable feedstocks yield important environmental and potential cost benefits. PSI, in collaboration with Dr. Michael Henson's laboratory at the University of Massachusetts, Amherst, proposes to develop an efficient process for bioconversion of cellulosic biomass to high purity alpha- or beta-pinene precursors for high-density, liquid tactical fuel. Our approach will yield high-purity alpha- or beta-pinene isomers in a scalable process. Phase I research will demonstrate proof-of-concept for development of bioengineered strains and fermentation processes for efficient production of beta-pinene from cellulosic materials without pretreatment. Phase II research will continue with additional genetic modification of the beta-pinene producing microbe with a goal of increasing efficiency of beta-pinene production and eliminating undesired products and will include scale-up for pilot production.


Patent
University of Pennsylvania and University of Massachusetts Amherst | Date: 2012-03-28

The present invention discloses compositions of facially amphiphilic polymers and oligomers and their use in methods for treating or reducing cancers in humans or animals.


Patent
Qteros and University of Massachusetts Amherst | Date: 2011-04-14

Methods and compositions are provided for improving the production of products, such as fuel products like ethanol, in microorganisms. In particular, methods and compositions are described for improving ethanol production utilizing genes identified in Clostridium phytofermentans.


Patent
University of Pennsylvania and University of Massachusetts Amherst | Date: 2011-03-30

The present invention discloses compositions of facially amphiphilic polymers and oligomers and their use in methods for treating or reducing cancers in humans or animals.


Farr R.H.,University of Massachusetts Amherst | Patterson C.J.,University of Virginia
Child Development | Year: 2013

Coparenting is associated with child behavior in families with heterosexual parents, but less is known about coparenting among lesbian- and gay-parent families. Associations were studied among self-reported divisions of labor, coparenting observations, and child adjustment (Mage = 3 years) among 104 adoptive families headed by lesbian, gay, or heterosexual couples. Lesbian and gay couples reported sharing child care, whereas heterosexual couples reported specialization (i.e., mothers did more child care than fathers). Observations confirmed this pattern-lesbian and gay parents participated more equally than heterosexual parents during family interaction. Lesbian couples showed the most supportive and least undermining behavior, whereas gay couples showed the least supportive behavior, and heterosexual couples the most undermining behavior. Overall, supportive coparenting was associated with better child adjustment. © 2013 Society for Research in Child Development, Inc.


Patent
University of Massachusetts Amherst and Medarex | Date: 2011-01-05

Antibodies that specifically bind to toxins of C.difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.


Patent
Medarex and University of Massachusetts Amherst | Date: 2012-06-07

Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.


Patent
Medarex and University of Massachusetts Amherst | Date: 2013-11-14

Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.


Condron A.,University of Massachusetts Amherst | Renfrew I.A.,University of East Anglia
Nature Geoscience | Year: 2013

Atmospheric processes regulate the formation of deep water in the subpolar North Atlantic Ocean and hence influence the large-scale ocean circulation. Every year thousands of mesoscale storms, termed polar lows, cross this climatically sensitive region of the ocean. These storms are often either too small or too short-lived to be captured in meteorological reanalyses or numerical models. Here we present simulations with a global, eddy-permitting ocean/sea-ice circulation model, run with and without a parameterization of polar lows. The parameterization reproduces the high wind speeds and heat fluxes observed in polar lows as well as their integrated effects, and leads to increases in the simulated depth, frequency and area of deep convection in the Nordic seas, which in turn leads to a larger northward transport of heat into the region, and southward transport of deep water through Denmark Strait. We conclude that polar lows are important for the large-scale ocean circulation and should be accounted for in short-term climate predictions. Recent studies predict a decrease in the number of polar lows over the northeast Atlantic in the twenty-first century that would imply a reduction in deep convection and a potential weakening of the Atlantic meridional overturning circulation. © 2013 Macmillan Publishers Limited. All rights reserved.


Grant
Agency: Department of Defense | Branch: Navy | Program: STTR | Phase: Phase I | Award Amount: 149.71K | Year: 2011

HYPRES, in collaboration University of Massachusetts, proposes an energy-efficient hybrid-temperature-heterogeneous-technology (HTHT) digital data link for interfacing 4K superconductor electronics with room-temperature electronics. Comprising several stages of cryogenic SiGe amplifiers at different temperatures, followed by equalization techniques, this data link will be designed to minimize the energy/bit figure-of-merit while exceeding the solicited specifications of 10^-12 bit-error rate (BER) at 30Gbps. Based on preliminary simulations, we believe that the design will extend to a 10^-15 BER at 50Gbps, and the power consumption per link will be 0.2mW on the 4K stage. Building on HYPRES"hybrid Josephson junction and transistor modeling infrastructure, we propose to complete the first set of IC designs in Phase I itself and release for fabrication. Upon testing these designs in Phase I option, we plan a second design iteration during the option period. This will be followed by a full implementation and demonstration with representative superconductor ICs and one of the ADR prototype systems in Phase II. During Phase I, we will also analyze the need for digital equalization, clock-data recovery and deserialization. We will also explore the design of an optical data link after SiGe amplifiers to get the data out of the cryostat without electromagnetic interference.


Patent
University of Massachusetts Amherst and Saint - Gobain | Date: 2013-12-24

A polyester or polyester copolymer based composition, such as a polylactic acid based composition, is provided herein. The polyester or polyester copolymer based composition may include a plasticizer, such as an ether based, an ester based, and/or an ether-ester based plasticizer.


Patent
U.S. Center for Disease Control, Prevention and University of Massachusetts Amherst | Date: 2012-07-19

Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.


Patent
University of Massachusetts Amherst and E. R. Squibb & Sons L.L.C. | Date: 2015-10-29

Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.


Patent
University of Massachusetts Amherst and Saint - Gobain | Date: 2012-06-29

A composition includes a) a melt processable polymer including at least one chemical moiety having a partial charge; and b) a nucleating agent having a surface charge that is opposite the partial charge of the chemical moiety of the polymer, wherein the nucleating agent accelerates the rate of crystallization of the melt processable polymer; wherein the nucleating agent has a melting point greater than the melting point of the melt processable polymer. In an embodiment, a method of making the composition is also provided.


Patent
University of Massachusetts Amherst and E. R. Squibb & Sons L.L.C. | Date: 2015-04-08

Antibodies that specifically bind to toxins of C.difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen binding portions thereof are provided herein.


Patent
University of Massachusetts Amherst, U.S. Center for Disease Control and Prevention | Date: 2014-12-02

Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein.


Patent
University of Massachusetts Amherst and Saint - Gobain | Date: 2011-11-29

A method of forming a polymer film includes dispensing a substrate and coating the substrate with a composition that is curable using actinic radiation. In an example, the method further includes exposing the composition to actinic radiation in presence of an atmosphere including 1 vol % to 37 vol % oxygen, whereby the surface of the composition forms an undulating morphology. In another example, the method further includes applying an oxygen-containing overlay over the composition, exposing the composition to actinic radiation through the oxygen-containing overlay, and removing the oxygen-containing overlay, whereby the surface of the composition forms an undulating morphology.


Patent
University of Massachusetts Amherst and Saint - Gobain | Date: 2012-04-25

A composition includes a blend of (a) a multi-block copolymer including at least one block of an elastomeric polymer and at least one block of a first polymer including a chiral polymer having a stereo isomeric configuration; and (b) a second polymer including an anti-chiral polymer corresponding to the chiral polymer in (a), wherein the second polymer includes an opposite handed stereo isomeric configuration to the chiral polymer in (a); wherein the blend of the chiral polymer and the anti-chiral polymer form stereo complex sites. A flexible tubing material further includes the blend. In an embodiment, a method of making the blend material is also provided.


Grant
Agency: Department of Defense | Branch: Navy | Program: STTR | Phase: Phase II | Award Amount: 1.49M | Year: 2013

HYPRES, in collaboration with University of Massachusetts, proposes an energy-efficient hybrid-temperature-heterogeneous-technology (HTHT) digital data link for interfacing 4K superconductor electronics with room-temperature electronics. Comprising several stages of cryogenic SiGe amplifiers at different temperatures, followed by equalization techniques, this data link will be designed to minimize the energy/bit figure-of-merit while exceeding the solicited specifications of 10^-12 bit-error rate (BER) at 30Gbps. Following simulation of the hybrid superconductor-semiconductor circuitry, a chain of three cryogenic SiGe integrated circuits (ICs) was designed and released for fabrication during Phase I. The estimated power consumption is 0.3 mW on the 4K stage. Upon testing these ICs in Phase I option, we plan to iteratively develop the cryogenic SiGe ICs and design the remaining semiconductor ICs which will operate at room temperature; a representative superconductor IC with differential output driver will also be iteratively developed. A major task in Phase II will be to build the HTHT data link by incorporating these ICs in their respective electronic modules and interconnecting them. The interconnect design uniquely combines electrical and thermal aspects and must be performed together with the IC design. Following the semiconductor and superconductor IC development, we will demonstrate the single channel and multi-channel data links.


Grant
Agency: National Aeronautics and Space Administration | Branch: | Program: STTR | Phase: Phase I | Award Amount: 125.00K | Year: 2012

Aerodyne Research, Inc. and the University of Massachusetts at Amherst will collaborate to develop laser desorption ionization (LDI) mass spectrometric analysis of organic analytes of interest in planetary exploration, based on microchip laser illumination. The key advantage of microchip lasers in this application is their much smaller size and weight than lasers used to date for LDI. These lasers have not been used because they have much smaller pulse energies than currently used LDI lasers. We propose to investigate the use of LDI substrates with special properties that include lowering the laser fluence required for LDI. Our Phase I candidate substrate will be gold nanoparticles coated with functionalized monolayers. Coated nanoparticles have been shown to have significant advantages in LDI applications, including selectivity of analyte adsorption, and enhancement of desorption via surface plasmon resonance (SPR) effects.

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