The University of Maryland University College is an American public university located in the unincorporated community of Adelphi in Prince George's County, Maryland in the United States. It is known primarily for its distance learning classes and programs, but UMUC also offers classes on campus at its Academic Center in Largo, and at satellite campuses across the Baltimore-Washington Metropolitan Area, throughout Maryland, as well as in Europe, the Middle East, and Asia. UMUC serves over 90,000 students worldwide and is one of the largest distance learning institutions in the world. UMUC is open to all applicants with a 100 percent acceptance rate for undergraduate programs. The university offers 120 academic programs in instructor-led and online classes, including bachelor, masters, and doctoral degrees as well as undergraduate and graduate certificates. UMUC is a member of the University System of Maryland, which includes eleven separate public universities in Maryland. Wikipedia.
University of Maryland University College, United States Of America, George Mason University and George Washington University | Date: 2016-10-19
A nanostructure sensing device comprises a semiconductor nanostructure having an outer surface, and at least one of metal or metal-oxide nanoparticle clusters functionalizing the outer surface of the nanostructure and forming a photoconductive nanostructure/nanocluster hybrid sensor enabling light-assisted sensing of a target analyte.
Toyota Motor Corporation and University of Maryland University College | Date: 2016-11-06
Methods and apparatuses for controlled processing of high temperature bonding systems via devices to control heating and cooling systems of a high temperature heating bonding includes use of a sinter fixture device including a plate surface, that is shaped to contact and conform to a contacting surface of a TLPS substrate assembly, and a plurality of channels below the plate surface within a base body of the sinter fixture device shaped to receive heating and cooling elements. A first set of the one or more channels includes a plurality of cross-channels, a cooling medium inlet, and a cooling medium outlet, which cross-channels, cooling medium inlet, and cooling medium outlet are in fluid communication with one another. A second set of the one or more channels includes a plurality of heating element passageways.
Toyota Motor Corporation and University of Maryland University College | Date: 2016-11-06
Methods and apparatuses for assessing the behavior of high temperature bonding systems such as sinter joint models of virtual interconnect microstructures via simulations that analyze sinter joint model properties include defining a plurality of sinter joint objects in a virtual interconnect microstructure, each sinter joint object having a type and a size, and determining a location of individual sinter joint objects with respect to one another in a virtual joint space to create a sinter joint model. The type is at least one of an intermetallic compound, a void, and a metal particle. The location is determined by, for each object, creating three-dimensional coordinates, and based on a determination that the sinter joint object is spaced from and non-overlapping with previously placed sinter joint objects, locking a position and size of the sinter joint object.
University of Maryland University College and National Security Agency | Date: 2016-07-20
Physical superconducting qubits are controlled according to an encoded qubit scheme, where a pair of physical superconducting qubits constitute an encoded qubit that can be controlled without the use of a microwave signal. For example, a quantum computing system has at least one encoded qubit and a controller. Each encoded qubit has a pair of physical superconducting qubits capable of being selectively coupled together. Each physical qubit has a respective tunable frequency. The controller controls a state of each of the pair of physical qubits to perform a quantum computation without using microwave control signals. Rather, the controller uses DC-based voltage or flux pulses.
University of Maryland University College | Date: 2017-01-27
Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. Also provided are compositions and methods of using them for therapy or prophylaxis of a wide variety of conditions for which therapy or prophylaxis is desirable.
University of Maryland University College and Childrens National Medical Center | Date: 2017-02-22
The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reaction surface comprising one or a plurality of metabolic enzymes or functional fragments thereof, but wherein the reaction surface does not comprise an electrode or electrically conductive support. In some embodiments, the biosensor comprises use of a thermophilic bacterial metabolic enzyme immobilized or attached to the reaction surface.
University of Maryland University College | Date: 2016-11-30
Ceramic ion-conducing structures are disclosed. The structures can be in the form of a single layer or multilayer structures. A ceramic ion-conducting structure can be a layer. In an example, the ceramic ion-conducing material does not have observable dendrites (e.g., lithium dendrites). Methods of fabricating ceramic-ionic conducing structures are also disclosed. The methods are based on particular slurry formulation methods and/or particular sintering methods. The methods can be tape casting methods. Uses of ceramic ion-conducing structures are disclosed. For example, the ceramic ion conducing structures can be used as solid-state electrolyte materials in ion-conducing batteries (e.g., solid-state ion-conducing batteries). An ion-conducting battery can comprise ion-conducting solid state electrolyte comprising one or more ceramic ion conducing material of the present disclosure.
University of Maryland University College | Date: 2017-02-01
A method is provided of targeted genome editing of an animal using site specific homologous integration. A composition comprising a single stranded oligonucleotide or double stranded nucleic acid molecule comprising a nucleic acid molecule of interest and sequences flanking a target locus cleavage site is injected into the zygote of an animal along with a nuclease and a guide nucleic acid molecule that targets the nuclease to a target locus. The composition is injected into the zygote after fertilization and prior to formation of a nucleus. The nucleic acid molecule of interest is recombined into the genome with high efficiency. The process allows for integration of nucleic acid molecules into the genome of animals in which the pronuclei cannot be visually observed during injection.
University of Maryland University College | Date: 2017-04-05
The present disclosure relates to devices and systems for separating motile pathogenic bacterial cells from samples. The disclosure also provides for methods of determining whether a sample is contaminated by pathogenic bacteria. The devices and systems disclosed herein are useful for screening water sources, environmental testing sites, food sources, and bodily fluids for the presence, absence, or quantity of bacterial cells in a sample representative of the screened sources.
Isaacs L.,University of Maryland University College
Accounts of Chemical Research | Year: 2014
ConspectusThis Account focuses on stimuli responsive systems that function in aqueous solution using examples drawn from the work of the Isaacs group using cucurbit[n]uril (CB[n]) molecular containers as key recognition elements. Our entry into the area of stimuli responsive systems began with the preparation of glycoluril derived molecular clips that efficiently distinguish between self and nonself by H-bonds and π-π interactions even within complex mixtures and therefore undergo self-sorting. We concluded that the selectivity of a wide variety of H-bonded supramolecular assemblies was higher than previously appreciated and that self-sorting is not exceptional behavior. This lead us to examine self-sorting within the context of CB[n] host-guest chemistry in water.We discovered that CB[n] homologues (CB and CB) display remarkably high binding affinity (Ka up to 1017 M-1) and selectivity toward their guests, which renders CB[n]s prime components for the construction of stimuli responsive host-guest systems. The CB ·adamantaneammonium ion complex, which is particularly privileged (K a = 4.2 × 1012 M-1), was introduced by us as a stimulus to trigger constitutional changes in multicomponent self-sorting systems. For example, we describe how the free energy associated with the formation of host-guest complexes of CB[n]-type receptors can drive conformational changes of included guests like triazene-arylene foldamers and cationic calixarenes, as well as induced conformational changes (e.g., ammonium guest size dependent homotropic allostery, metal ion triggered folding, and heterochiral dimerization) of the hosts themselves.Many guests display large pKa shifts within their CB[n]-guest complexes, which we used to promote pH controlled guest swapping and thermal trans-to-cis isomerization of azobenzene derivatives. We also used the high affinity and selectivity of CB toward its guests to outcompete an enzyme (bovine carbonic anhydrase) for a two-faced inhibitor, which allowed stimuli responsive regulation of enzymatic activity. These results prompted us to examine the use of CB[n]-type receptors in both in vitro and in vivo biological systems. We demonstrated that adamantaneammonium ion can be used to intracellularly sequester CB from gold nanoparticles passivated with hexanediammonium ion·CB complexes and thereby trigger cytotoxicity. CB derivatives bearing a biotin targeting group enhance the cytotoxicity of encapsulated oxaliplatin toward L1210FR cells. Finally, acyclic CB[n]-type receptors function as solubilizing excipients for insoluble drugs for drug delivery purposes and as a broad spectrum reversal agent for the neuromuscular blocking agents rocuronium, vecuronium, and cis-atracurium in rats. The work highlights the great potential for integration of CB[n]-type receptors with biological systems. © 2014 American Chemical Society.