University of Maryland, Baltimore | Date: 2017-01-06
The present invention provides dental bonding agents and dental bonding systems comprising the dental bonding agents. The dental bonding agents of the invention are characterized by having antibacterial properties, and in some aspects of the invention, remineralizing properties.
University of Maryland, Baltimore | Date: 2017-01-04
The present invention is directed to therapeutic compounds, treatment methods, and kits affecting the NC_(Ca-ATP )channel of neural tissue, including neurons, glia and blood vessels within the nervous system, and methods of using same. The NC_(Ca-ATP )channel is newly expressed in neural tissue following injury such as ischemia, and is regulated by the sulfonylurea receptor SUR1, being inhibited by sulfonylurea compounds, e.g., glibenclamide and tolbutamide, and opened by diazoxide. Antagonists of the NC_(Ca-ATP )channel, including SUR1 antagonists, are useful in the prevention, diminution, and treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury. Agonists of the NC_(Ca-ATP )channel may be are useful in the treatment neural tissue where damage or destruction of the tissue, such as a gliotic capsule, is desired.
University of Maryland, Baltimore and Tel Aviv University | Date: 2017-03-29
The beta 2 subunit of mouse hemoglobin (HBB2) has been identified as soluble factor from mouse lungs that exhibits cytostatic/cytotoxic activity against neuroblastoma lung micrometastases. The beta subunit of human hemoglobin (HBB) has been found to have similar activity. Methods of using these proteins and fragments thereof in the treatment of cancer and inhibition of metastasis are provided, along with methods of screening a subject for micrometastases by detecting HBB in a biological sample.
University of Maryland, Baltimore | Date: 2017-02-15
The present invention provides a method for imaging microtentacles on isolated, living, non-adherent primary tumor cells from a cancer subject comprising: i) obtaining one or more living, non-adherent primary tumor cells that has been isolated from a solid tumor from the subject; and ii) imaging the one or more living, non-adherent primary tumor cells and detecting the microtentacles.
University of Maryland, Baltimore | Date: 2017-02-08
Embodiments of the disclosure include methods and compositions related to treatment of one or more medical conditions with one or more negative modulators of GABAA receptors. In specific embodiments, depression and/or suicidality is treated or ameliorated or prevented with one or more negative modulators of GABAA receptors, such as a partial inverse agonist of a GABAA receptor comprising an alpha5 subunit.
University of Maryland, Baltimore | Date: 2016-12-28
Improved methods for extracting lipid-containing molecules from microbes are disclosed. The methods utilize selected surfactants for extraction of lipids and lipopolysaccharides from microbes, such as bacteria and fungi. The extracted lipids and lipopolysaccharides may be used, for example, to identify the source microbe via mass spectroscopy.
University of Maryland, Baltimore | Date: 2017-06-14
Disclosed is a hybrid surgical mesh that is partially absorbable or biodegradable. The hybrid surgical mesh described herein generally comprises a central absorbable or biodegradable portion surrounded on at least its sides by a non-absorbable portion which forms a support structure for supporting a prolapsed region. While the absorbable or biodegradable portion provides support to the prolapsed region immediately following the surgical procedure to correct such prolapse, over time the central absorbable or biodegradable portion dissolves so as to leave only the non-absorbable interrupted hammock-like support structure. Such configuration provides the initial structural support required after the surgical procedure necessary to ensure healing and strengthening of the prolapsed region, while significantly reducing the risk of healing abnormalities or complications resulting in the central portion of the graft.
Gpb Scientific, Llc, Princeton University and University of Maryland, Baltimore | Date: 2017-06-07
Described herein are improved microfluidic devices and methods for processing cells that can improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.
University of Maryland, Baltimore | Date: 2017-01-17
Disclosed are systems and methods using ultrasound to predict if a patients cardiac stroke volume will increase with a fluid bolus. Ultrasound measures are taken before administering a fluid bolus, including measurement of the left ventricular outflow tract velocity time integral (LVOT VTI), and venous measurements of the internal jugular vein. Data collected from such ultrasound scan is then used to predict the patients cardiac volume response in the event that a fluid bolus is administered to that patient.
University of Maryland, Baltimore and Gliknik Inc. | Date: 2017-04-10
IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacement compounds efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases