Marburg, Germany

University of Marburg
Marburg, Germany

The Philipp University of Marburg , was founded in 1527 by Landgrave Philip I of Hesse as one of Germany's oldest universities, dating back to a Protestant foundation. As a state university it has no religious affiliation anymore.It was the main university of the principality of Hesse and remains a public university of that German state. It now has about 25,000 students and 7,500 employees, making Marburg, a town of 72,000 inhabitants, the proverbial "university town" . Though most subjects are grouped, the University of Marburg is not a campus university in the broader sense. About 12% of the students are international, the highest percentage in Hesse. It offers an International summer university programme every summer and has an awarded ERASMUS programme.Marburg is home to one of Germany's most traditional medical faculties. The German physicians' union is called "Marburger Bund". Wikipedia.

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Rovira i Virgili University, Consejo Superior De Investigaciones Cientificas, University of Vigo, University of Marburg and Medcomtech S.A. | Date: 2017-03-29

A silicon particle comprising a silicon body, a functionalized silica surface surrounding the silicon body, and a targeting moiety specifically targeting tumor cells, and, optionally, an enzymatically metabolizable compound,is useful in the treatment of cancer by producing cell death after particle internalization.

RWTH Aachen and University of Marburg | Date: 2015-03-20

The present invention relates to a method of producing itaconic acid. Further the present invention relates to nucleic acids encoding an aconitate-delta-isomerase (ADI) and trans-aconitate decarboxylase (TAD) and uses of such nucleic acids. Provided is additionally a recombinant host cell engineered to overexpress nucleic acids of the present invention. Furthermore an expression cassette and a vector are provided which include the respective nucleic acid.

An important diagnostic criterion for social communication deficits in autism spectrum disorders (ASD) are difficulties in adjusting behavior to suit different social contexts. While the BTBR T+tf/J (BTBR) inbred strain of mice is one of the most commonly used mouse models for ASD, little is known about whether BTBR mice display deficits in detecting changes in social context and their ability to adjust to them. Here, it was tested therefore whether the emission of isolation-induced ultrasonic vocalizations (USV) in BTBR mouse pups is affected by the social odor context, in comparison to the standard control strain with high sociability, C57BL/6J (B6). It is known that the presence of odors from mothers and littermates leads to a calming of the isolated mouse pup, and hence to a reduction in isolation-induced USV emission. In accordance with their behavioral phenotypes with relevance to all diagnostic core symptoms of ASD, it was predicted that BTBR mouse pups would not display a calming response when tested under soiled bedding conditions with home cage bedding material containing maternal odors, and that similar isolation-induced USV emission rates would be seen in BTBR mice tested under clean and soiled bedding conditions. Unexpectedly, however, the present findings show that BTBR mouse pups display such a calming response and emit fewer isolation-induced USV when tested under soiled as compared to clean bedding conditions, similar to B6 mouse pups. Yet, in contrast to B6 mouse pups, which emitted isolation-induced USV with shorter call durations and lower levels of frequency modulation under soiled bedding conditions, social odor context had no effect on acoustic call features in BTBR mouse pups. This indicates that the BTBR mouse model for ASD does not display deficits in detecting changes in social context, but has a limited ability and/or reduced motivation to adjust to them. © 2015 Wöhr.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-04-2016 | Award Amount: 9.71M | Year: 2017

The projects overall aim is to improve the health, development and quality of life of children and adults born very preterm (VPT, < 32 weeks of gestation) or very low birth weight (VLBW, < 1500g) approximately 50 000 births each year in Europe by establishing an ICT platform to integrate, harmonise and exploit the wealth of data from 20 European cohorts of VPT/VLBW children and adults and their families constituted from the early 1980s to the present, together with data from national registries. VPT/VLBW births have higher risks of cerebral palsy, visual and auditory deficits, impaired cognitive ability, psychiatric disorders and social problems than infants born at term and account for more than a third of the health and educational budgets for children. They may also face higher risks of non-communicable disease as they age. There is emerging evidence of reduced mental health, quality of life, partnering, family life and employment chances and wealth in adulthood. The platform will enable stratified sub-group analyses of sociodemographic and clinical characteristics, neonatal complications, and otherwise rare medical conditions that cannot be studied in national population cohorts. The broad temporal, geographic, cultural and health system diversity makes it possible to study the impact of socioeconomic and organisational contexts and determine the generalisability of outcomes for VPT/VLBW populations. The RECAP platform creates a value chain to promote research and innovation using population cohorts, beginning with the integration of VPT/VLBW cohorts to the translation and dissemination of new knowledge. It will be based on a sustainable governance framework, state-of-the art data management and sharing technologies, tools to strengthen research capacity, a hypothesis-driven research agenda and broad stakeholder participation, including researchers, clinicians, educators, policy makers and very preterm children and adults and their families.

Rensing S.A.,University of Marburg
Current Opinion in Plant Biology | Year: 2014

Most duplicated genes (paralogs) are quickly erased during evolution, and only some are retained. Yet, gene and genome duplications are connected to the evolution of genetic and, in turn, morphological complexity. Plants are especially prone to experience polyploidizations and to enhance their gene repertoire after such events. Genes encoding proteins involved in transcriptional regulation are of especial interest since they are correlated with the occurrence of genome duplication events and with the rise of plant morphological complexity. Here, I review what we know about paralog retention as a driver for morphogenetic evolution of plants. The main focus is on the evolution of plant genes controlling development (morphogenetic transcription factors). © 2013 Elsevier Ltd.

Klebe G.,University of Marburg
Nature Reviews Drug Discovery | Year: 2015

Small-molecule drug discovery involves the optimization of various physicochemical properties of a ligand, particularly its binding affinity for its target receptor (or receptors). In recent years, there has been growing interest in using thermodynamic profiling of ligand-receptor interactions in order to select and optimize those ligands that might be most likely to become drug candidates with desirable physicochemical properties. The thermodynamics of binding is influenced by multiple factors, including hydrogen bonding and hydrophobic interactions, desolvation, residual mobility, dynamics and the local water structure. This article discusses key issues in understanding the effects of these factors and applying this knowledge in drug discovery. © 2015 Macmillan Publishers Limited. All rights reserved.

Frenking G.,University of Marburg
Angewandte Chemie - International Edition | Year: 2014

Semantics, definitions? The description of the electronic structure of main-group compounds with dative bonds significantly enriched the chemistry of sp block elements. The new viewpoint has proved to be a useful guideline for the synthesis of unusual donor-acceptor complexes and for explaining novel molecular structures. New compound classes such as carbones CL2 and borylene complexes (BH)L2 have been found. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Nanotoxicology is still a new discipline. In this Perspective, both its origins and its future trends are discussed. In particular, we note several issues we consider important for publications in this field.

Meggers E.,University of Marburg
Angewandte Chemie - International Edition | Year: 2011

The tremendous challenge presented by the specific molecular recognition of single biomacromolecular targets within complex biological systems demands novel and creative design strategies. This Minireview discusses some conventional and unusual approaches for the design of target-selective enzyme inhibitors with a focus on the underlying chemical scaffolds. These include complicated natural-product-like organic molecules, stable octahedral metal complexes, fullerenes, carboranes, polymetallic clusters, and even polymers. Thus the whole repertoire of organic, inorganic, and macromolecular chemistry can be applied to tackle the problem of target-specific enzyme inhibition. Creativity in demand: Enzyme inhibitor scaffolds ranging from typical small organic molecules to inorganic clusters and even to polymers demonstrate that the whole repertoire of organic, inorganic, and macromolecular chemistry can be used to meet the challenge of specific molecular recognition in complex biological systems. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Jonas K.,University of Marburg
Current Opinion in Microbiology | Year: 2014

Whether to divide or not is an important decision that nearly all cells have to make, especially bacteria that are exposed to drastic environmental changes. Under adverse conditions proliferation and growth could compromise cellular integrity and hence must be downregulated. To this end, bacteria have evolved sophisticated mechanisms to transduce environmental information into the cell cycle engine. Recent studies in Escherichia coli, Bacillus subtilis and Caulobacter crescentus indicate that these mechanisms often involve small molecule-based signaling, regulated proteolysis, as well as protein-protein interactions. Most of them delay replication initiation or septum formation by targeting the key regulators DnaA or FtsZ, respectively. Remarkably, while the targets are conserved, the precise mechanisms show a considerable degree of diversity among different species. © 2014 Elsevier Ltd.

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