Marburg, Germany
Marburg, Germany

The Philipp University of Marburg , was founded in 1527 by Landgrave Philip I of Hesse as one of Germany's oldest universities, dating back to a Protestant foundation. As a state university it has no religious affiliation anymore.It was the main university of the principality of Hesse and remains a public university of that German state. It now has about 25,000 students and 7,500 employees, making Marburg, a town of 72,000 inhabitants, the proverbial "university town" . Though most subjects are grouped, the University of Marburg is not a campus university in the broader sense. About 12% of the students are international, the highest percentage in Hesse. It offers an International summer university programme every summer and has an awarded ERASMUS programme.Marburg is home to one of Germany's most traditional medical faculties. The German physicians' union is called "Marburger Bund". Wikipedia.

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Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SFS-07b-2015 | Award Amount: 7.99M | Year: 2016

The goal of GenTree is to provide the European forestry sector with better knowledge, methods and tools for optimising the management and sustainable use of forest genetic resources (FGR) in Europe in the context of climate change and continuously evolving demands for forest products and services. To reach its goal, GenTree will make scientific, technological and implementation breakthroughs in: (i) designing innovative strategies for dynamic conservation of FGR in European forests, (ii) broadening the range of FGR used by European breeding programmes, and (iii) preparing new forest management scenarios and policy frameworks fully integrating genetic conservation and breeding aspects, to adapt forests and forestry to changing environmental conditions and societal demands. GenTree focuses on economically and ecologically important tree species in Europe, growing in a wide range of habitats and covering different societal uses and values. The major outputs of GenTree will include: (i) much needed new scientific knowledge on phenotypic and genotypic diversity across environmental gradients in Europe, (ii) improved genotyping and phenotyping monitoring tools for practitioners, (iii) updated and refined data for information systems of in-situ and ex-situ FGR collections, (iv) innovative strategies for conservation, breeding and exchanging and using diversified forest reproductive material, (v) novel outreach and science-policy support tools to better integrate FGR concerns into forest management and better implement relevant international commitments in Europe. GenTree will improve the status and use of European in-situ and ex-situ FGR collections, support acquisition, conservation, characterisation, evaluation and use of relevant FGR in breeding and forestry practice and policy, will seek to harmonise, rationalise and improve management of existing collections and databases, and will strengthen the EU strategy for cooperation on FGR research and innovation.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SC1-PM-04-2016 | Award Amount: 9.71M | Year: 2017

The projects overall aim is to improve the health, development and quality of life of children and adults born very preterm (VPT, < 32 weeks of gestation) or very low birth weight (VLBW, < 1500g) approximately 50 000 births each year in Europe by establishing an ICT platform to integrate, harmonise and exploit the wealth of data from 20 European cohorts of VPT/VLBW children and adults and their families constituted from the early 1980s to the present, together with data from national registries. VPT/VLBW births have higher risks of cerebral palsy, visual and auditory deficits, impaired cognitive ability, psychiatric disorders and social problems than infants born at term and account for more than a third of the health and educational budgets for children. They may also face higher risks of non-communicable disease as they age. There is emerging evidence of reduced mental health, quality of life, partnering, family life and employment chances and wealth in adulthood. The platform will enable stratified sub-group analyses of sociodemographic and clinical characteristics, neonatal complications, and otherwise rare medical conditions that cannot be studied in national population cohorts. The broad temporal, geographic, cultural and health system diversity makes it possible to study the impact of socioeconomic and organisational contexts and determine the generalisability of outcomes for VPT/VLBW populations. The RECAP platform creates a value chain to promote research and innovation using population cohorts, beginning with the integration of VPT/VLBW cohorts to the translation and dissemination of new knowledge. It will be based on a sustainable governance framework, state-of-the art data management and sharing technologies, tools to strengthen research capacity, a hypothesis-driven research agenda and broad stakeholder participation, including researchers, clinicians, educators, policy makers and very preterm children and adults and their families.

Rensing S.A.,University of Marburg
Current Opinion in Plant Biology | Year: 2014

Most duplicated genes (paralogs) are quickly erased during evolution, and only some are retained. Yet, gene and genome duplications are connected to the evolution of genetic and, in turn, morphological complexity. Plants are especially prone to experience polyploidizations and to enhance their gene repertoire after such events. Genes encoding proteins involved in transcriptional regulation are of especial interest since they are correlated with the occurrence of genome duplication events and with the rise of plant morphological complexity. Here, I review what we know about paralog retention as a driver for morphogenetic evolution of plants. The main focus is on the evolution of plant genes controlling development (morphogenetic transcription factors). © 2013 Elsevier Ltd.

Klebe G.,University of Marburg
Nature Reviews Drug Discovery | Year: 2015

Small-molecule drug discovery involves the optimization of various physicochemical properties of a ligand, particularly its binding affinity for its target receptor (or receptors). In recent years, there has been growing interest in using thermodynamic profiling of ligand-receptor interactions in order to select and optimize those ligands that might be most likely to become drug candidates with desirable physicochemical properties. The thermodynamics of binding is influenced by multiple factors, including hydrogen bonding and hydrophobic interactions, desolvation, residual mobility, dynamics and the local water structure. This article discusses key issues in understanding the effects of these factors and applying this knowledge in drug discovery. © 2015 Macmillan Publishers Limited. All rights reserved.

Frenking G.,University of Marburg
Angewandte Chemie - International Edition | Year: 2014

Semantics, definitions? The description of the electronic structure of main-group compounds with dative bonds significantly enriched the chemistry of sp block elements. The new viewpoint has proved to be a useful guideline for the synthesis of unusual donor-acceptor complexes and for explaining novel molecular structures. New compound classes such as carbones CL2 and borylene complexes (BH)L2 have been found. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Nanotoxicology is still a new discipline. In this Perspective, both its origins and its future trends are discussed. In particular, we note several issues we consider important for publications in this field.

Meggers E.,University of Marburg
Angewandte Chemie - International Edition | Year: 2011

The tremendous challenge presented by the specific molecular recognition of single biomacromolecular targets within complex biological systems demands novel and creative design strategies. This Minireview discusses some conventional and unusual approaches for the design of target-selective enzyme inhibitors with a focus on the underlying chemical scaffolds. These include complicated natural-product-like organic molecules, stable octahedral metal complexes, fullerenes, carboranes, polymetallic clusters, and even polymers. Thus the whole repertoire of organic, inorganic, and macromolecular chemistry can be applied to tackle the problem of target-specific enzyme inhibition. Creativity in demand: Enzyme inhibitor scaffolds ranging from typical small organic molecules to inorganic clusters and even to polymers demonstrate that the whole repertoire of organic, inorganic, and macromolecular chemistry can be used to meet the challenge of specific molecular recognition in complex biological systems. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Hoffmann R.W.,University of Marburg
Angewandte Chemie - International Edition | Year: 2013

For almost 200 years, the synthesis of natural products has been practiced. In this time span, not only the target structures have become increasingly more complex (see two examples from the 1970s), the objectives of natural product synthesis have also changed. Likewise, the standards and criteria for the conduction of natural product synthesis have changed. It is these changes that form the subject of this Essay. © 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Jonas K.,University of Marburg
Current Opinion in Microbiology | Year: 2014

Whether to divide or not is an important decision that nearly all cells have to make, especially bacteria that are exposed to drastic environmental changes. Under adverse conditions proliferation and growth could compromise cellular integrity and hence must be downregulated. To this end, bacteria have evolved sophisticated mechanisms to transduce environmental information into the cell cycle engine. Recent studies in Escherichia coli, Bacillus subtilis and Caulobacter crescentus indicate that these mechanisms often involve small molecule-based signaling, regulated proteolysis, as well as protein-protein interactions. Most of them delay replication initiation or septum formation by targeting the key regulators DnaA or FtsZ, respectively. Remarkably, while the targets are conserved, the precise mechanisms show a considerable degree of diversity among different species. © 2014 Elsevier Ltd.

Agency: Cordis | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 1.07M | Year: 2017

Space is the foundational characteristic of visual perception and we generally perceive it as continuous and uniform. Behavioural measurements and the properties of our sensory systems however, demonstrate that this is an illusory situation and our percept is constructed by the brain. One example is our lack of awareness of the blind spot that exists in each eye. Space is non-uniformly represented in the visual brain and this representation is dynamically influenced by motor behaviour, in particular by eye movements. The PLATYPUS consortium will investigate the dynamic nature of spatial sensation and perception, focussing on the continuous mutual interaction of motor behaviour and perception. Our research objectives integrate human behavioural and cutting edge non-human primate electrophysiological research techniques and focus on translation of basic into applied research. Focussing on the adaptive nature of vision and action, strategies to perturb and probe perceptual space and geometry will allow measurement of spatial and geometrical perception in humans and the representation of such in non-human primates. This research will extend to applications for people wearing progressive lenses which distort action and space perception, patients with a blind area in their visual field and for virtual reality technology development. PLATYPUS researchers will grow existing and establish new collaborative teams, sharing research techniques, knowledge and mentoring between established and with upcoming researchers in academia and industry. Individuals will benefit from intense scientific and career development training while institutions will benefit from the exchange of state-of-the-art techniques. The ultimate outcome will be increased understanding of the continuously updating neural construction of space and the production of assistive technologies for people needing corrective lenses, with ocular or visual discontinuity and for the growing virtual reality industry.

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