Manchester, United Kingdom
Manchester, United Kingdom

The University of Manchester is a large research university situated in the city of Manchester, England. Manchester University, as it is commonly known, is a public university formed in 2004 by the merger of the University of Manchester Institute of Science and Technology and the Victoria University of Manchester . Manchester is a member of the worldwide Universities Research Association group, the Russell Group of British research universities and the N8 Group. The University of Manchester is regarded as a "red brick university", and was a product of the civic university movement of the late 19th century. It formed a constituent part of the federal Victoria University between 1880, when it received its royal charter, and 1903-1904, when it was dissolved.The main campus is south of Manchester city centre on Oxford Road. In 2012, the university had around 39,000 students and 10,400 staff, making it the largest single-site university in the United Kingdom. The University of Manchester had an income of £827 million in 2012–13, of which £200 million was from research grants and contracts.In the 2008 Research Assessment Exercise, Manchester came third in terms of research power and eighth for grade point average quality when including specialist institutions. More students try to gain entry to the University of Manchester than to any other university in the country, with more than 60,000 applications for undergraduate courses. According to the 2012 Highfliers Report, Manchester is the most targeted university by the Top 100 Graduate Employers.The University of Manchester is ranked 30th in the world by QS World University Rankings. In the 2014 Academic Ranking of World Universities, Manchester is ranked 38th in the world and 5th in the UK. It is ranked 52nd in the world and 12th in Europe in the 2014 Times Higher Education World University Rankings.The university owns and operates major cultural assets such as the Manchester Museum, Whitworth Art Gallery, John Rylands Library and Jodrell Bank Observatory which includes the Grade I listed Lovell Telescope.The University of Manchester has 25 Nobel laureates among its past and present students and staff, the fourth-highest number of any single university in the United Kingdom. Four Nobel laureates are currently among its staff – more than any other British university. Wikipedia.


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Patent
University of Manchester | Date: 2015-02-16

The invention provides new devices for implantation in a patient having irregular textured surfaces, which devices show significantly improved cellular response compared to conventional smooth and textured implants, indicating that significantly improved biocompatibility would be achieved in vivo. Methods for making such new devices and surface textures are also disclosed.


Patent
University of Manchester | Date: 2015-05-11

Graphene is chemically modified by a process resulting in the introduction of functional groups located only at an edge of the graphene plane. The functionalised graphene finds uses in numerous applications and further chemical synthesis, including a process for coupling an organic or inorganic moiety to the graphene plane via the edge-located functional group. The disclosed products and processes provide highly flexible platforms for the integration of graphene into a variety of applications.


Patent
University of Manchester | Date: 2014-11-12

Described herein are certain steroid derivative compounds, for example of formula (I): wherein X^(1), X^(2), X^(3 )L, and Ar are as defined herein, pharmaceutical compositions comprising such compounds, the use of such compounds and compositions to specifically target glucocorticoid action, and the use of such compounds and compositions in the treatment of acute and chronic inflammatory conditions, in particular rheumatoid arthritis, haematological and other malignancies, and for causing immunosuppression in the prevention or treatment of transplant rejection, as well as methods of preparing such compounds.


Patent
University of Manchester | Date: 2015-05-14

A plasmonic structure (10) comprising a layer of metal (14) in which the metal is selected from: a Group 8 to Group 11 transition metal, aluminium, germanium, antimony or bismuth, and a barrier layer (16) formed from a 2-D material disposed on a surface of the layer of metal (14). The metal layer has a roughness that permits the propagation of running plasmons along the interface of the metal layer and the barrier layer.


Patent
University of Manchester and Salford Royal Nhs Foundation Trust | Date: 2016-09-23

A method of selecting data, the method comprising, receiving data indicating a first requirement and identifying first records stored in a first database. The first records relate to first data subjects and the identification is based upon the first requirement. The first data subjects cannot be identified from the records of the first database. Second records are identified, the second records being stored in a second database and relating to the first data subjects. The first data subjects can be identified from the identified records of the second database. Each of the second records corresponds to a respective one of the first records, and the identification of the second records is based upon the first requirement.


Patent
University of Manchester | Date: 2017-03-08

A seat locking mechanism for a vehicle comprises a plurality of locking elements (9-13) arranged to engage and lock with a mounting (4) provided on the floor of the vehicle. The locking elements (9-13) are each arranged to rotate between locked and unlocked positions and are engaged with one another, for example via partial gears, so that rotation of one locking element causes simultaneous rotation of all locking elements. Each locking element comprises a locking portion (21) that is arranged to engage the mounting (4) in the locked position thereby securing the seat to the vehicle.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: FoF.NMP.2012-4 | Award Amount: 18.22M | Year: 2013

The overarching goal of AMAZE is to rapidly produce large defect-free additively-manufactured (AM) metallic components up to 2 metres in size, ideally with close to zero waste, for use in the following high-tech sectors namely: aeronautics, space, automotive, nuclear fusion and tooling. Four pilot-scale industrial AM factories will be established and enhanced, thereby giving EU manufacturers and end-users a world-dominant position with respect to AM production of high-value metallic parts, by 2016. A further aim is to achieve 50% cost reduction for finished parts, compared to traditional processing. The project will design, demonstrate and deliver a modular streamlined work-flow at factory level, offering maximum processing flexibility during AM, a major reduction in non-added-value delays, as well as a 50% reduction in shop-floor space compared with conventional factories. AMAZE will dramatically increase the commercial use of adaptronics, in-situ sensing, process feedback, novel post-processing and clean-rooms in AM, so that (i) overall quality levels are improved, (ii) dimensional accuracy is increased by 25% (iii) build rates are increased by a factor of 10, and (iv) industrial scrap rates are slashed to <5%. Scientifically, the critical links between alloy composition, powder/wire production, additive processing, microstructural evolution, defect formation and the final properties of metallic AM parts will be examined and understood. This knowledge will be used to validate multi-level process models that can predict AM processes, part quality and performance. In order to turn additive manufacturing into a mainstream industrial process, a sharp focus will also be drawn on pre-normative work, standardisation and certification, in collaboration with ISO, ASTM and ECSS. The team comprises 31 partners: 21 from industry, 8 from academia and 2 from intergovernmental agencies. This represent the largest and most ambitious team ever assembled on this topic.


Grant
Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: ICT-2013.9.9 | Award Amount: 74.61M | Year: 2013

This Flagship aims to take graphene and related layered materials from a state of raw potential to a point where they can revolutionize multiple industries from flexible, wearable and transparent electronics, to new energy applications and novel functional composites.\nOur main scientific and technological objectives in the different tiers of the value chain are to develop material technologies for ICT and beyond, identify new device concepts enabled by graphene and other layered materials, and integrate them to systems that provide new functionalities and open new application areas.\nThese objectives are supported by operative targets to bring together a large core consortium of European academic and industrial partners and to create a highly effective technology transfer highway, allowing industry to rapidly absorb and exploit new discoveries.\nThe Flagship will be aligned with European and national priorities to guarantee its successful long term operation and maximal impact on the national industrial and research communities.\nTogether, the scientific and technological objectives and operative targets will allow us to reach our societal goals: the Flagship will contribute to sustainable development by introducing new energy efficient and environmentally friendly products based on carbon and other abundant, safe and recyclable natural resources, and boost economic growth in Europe by creating new jobs and investment opportunities.


Grant
Agency: Cordis | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CSA) under the 7th framework program (2013-2016), while this and the following parts are implemented as Core Projects under the Horizon 2020 framework. The mission of the Graphene Flagship is to take graphene and related layered materials from a state of raw potential to a point where they can revolutionise multiple industries. This will bring a new dimension to future technology a faster, thinner, stronger, flexible, and broadband revolution. Our program will put Europe firmly at the heart of the process, with a manifold return on the EU investment, both in terms of technological innovation and economic growth. To realise this vision, we have brought together a larger European consortium with about 150 partners in 23 countries. The partners represent academia, research institutes and industries, which work closely together in 15 technical work packages and five supporting work packages covering the entire value chain from materials to components and systems. As time progresses, the centre of gravity of the Flagship moves towards applications, which is reflected in the increasing importance of the higher - system - levels of the value chain. In this first core project the main focus is on components and initial system level tasks. The first core project is divided into 4 divisions, which in turn comprise 3 to 5 work packages on related topics. A fifth, external division acts as a link to the parts of the Flagship that are funded by the member states and associated countries, or by other funding sources. This creates a collaborative framework for the entire Flagship.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.46M | Year: 2015

BigDataFinance, a Marie Skodowska-Curie Innovative Training Network Training for Big Data in Financial Research and Risk Management, provides doctoral training in sophisticated data-driven risk management and research at the crossroads of Finance and Big Data for 13 researchers. The main objectives are i) to meet an increasing commercial demand for well-trained researchers experienced in both Big Data techniques and Finance and ii) to develop and implement new quantitative and econometric methods for empirical finance and risk management with large and complex datasets. To achieve the objectives, the emphasis is put on exploiting big data techniques to manage and use datasets that are too large and complex to process with conventional methods. Banks and other financial institutions must be able to manage, process, and use massive heterogeneous data sets in a fast and robust manner for successful risk management; nonetheless, financial research and training has been slow to address the data revolution. Compared to the USA, Europe is still at an early stage of adopting Big Data technologies and services. Immediate action is required to seize opportunities to exploit the huge potential of Big Data within the European financial world. This world-class network consists of eight academic participants and six companies, representing banks, asset management companies, and data and solution providers. The proposed research is relevant both academically and practically, because the program is built around real challenges faced both by the academic and private sector partners. To bridge research and practice, all researchers contribute to the private sector via secondments. BigDataFinance provides the European financial community with specialists with state-of-the-art skills in finance and data-analysis to facilitate the adoption of reliable and realistic methods in the industry. This increases the financial strength of banks and other financial institutions in Europe.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.81M | Year: 2015

IMMUNOSHAPE aims at training a new generation of scientists that will be capable of combining state of the art synthesis and screening technology to develop new lead structures for highly selective glycan based multivalent immunotherapeutics for the treatment of cancer, autoimmune diseases and allergy. To this end, we have set up a training program in a unique academic-industrial environment that will educate young researchers in scientific and practical biomedical glycoscience with the final aim to produce new talent and innovation in the field and improve their career perspectives in both academic and non-academic sectors. The unique combination of 10 academic groups with expertise in automated solid-phase carbohydrate synthesis, microarray based highthroughput screening technology, tumour immunology, structural glycobiology, multivalent systems and medicinal chemistry along with 4 industrial partners active in nanomedicine, immunotherapy, medicinal device development and the fabrication of scientific instrumentation will provide a multidisciplinary and multisectorial training to 15 ESRs in biomedical glycoscience and its industrial applications.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: HEALTH.2013.4.1-4 | Award Amount: 553.89K | Year: 2013

The landscape of genetic testing is rapidly changing. Soon, whole genome sequence analysis (3Gb-testing) will be an effective and financially viable alternative to targeted gene analysis. New technologies that allow efficient sequencing of a whole human genome in a diagnostic setting will have an enormous impact on diagnostic centres replacing many existing molecular and cytogenetic tests. Patients deserve to benefit from our vastly growing knowledge on functional genomics. 3Gb-testing is the ideal method to bring these benefits to the public. However, it is critical to avoid mistakes with respect to ethics, quality, over or mis-interpretation of data. It is essential that our society is prepared for the change once it is implemented. Hence, current gaps in our knowledge have to be identified and research has to be initiated to bridge these gaps. The 3Gb-TEST project will bring stakeholders together and ensure they are informed with respect to the desirable and undesirable developments. The clinical utility and cost effectiveness of whole genome sequencing needs to be determined as part of a robust health technology assessment process (HTA). Interpretation of sequence data in terms of clinical relevance will pose a challenge to both laboratory and clinical geneticists. Substantial investments may be required and the logistic restructuring of genetic services will need to be addressed. This project aims to prepare Europe for innovations in molecular testing. Quality assessment schemes, HTA and guidelines have to be in place. Healthcare professionals must be aware of the impending change and potential impact on practice. The Consortium will inform the healthcare community and make recommendations to the European Commission, the European Society of Human Genetics, and national organizations relevant to this field. A key output will be a validated roadmap for the implementation of diagnostic genome sequencing in Europe.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.87M | Year: 2016

Cancer is a major social problem, and it is the main cause of death between the ages 45-65 years. In the treatment of cancer, radio therapy (RT) plays an essential role. RT with hadrons (protons and light ions), due to their unique physical and radiobiological properties, offers several advantages over photons for specific cancer types. In particular, they penetrate the patient with minimal diffusion, they deposit maximum energy at the end of their range, and they can be shaped as narrow focused and scanned pencil beams of variable penetration depth. Although significant progress has been made in the use of particle beams for cancer treatment, an extensive research and development program is still needed to maximize the healthcare benefits from these therapies. The Optimization of Medical Accelerators (OMA) is the aim of the here-proposed European Training Network, in line with the requirements of the ECs Medical Exposure Directive. OMA joins universities, research centers and clinical facilities with industry partners to address the challenges in treatment facility design and optimization, numerical simulations for the development of advanced treatment schemes, and in beam imaging and treatment monitoring. The proposed R&D program ranges from life sciences (oncology, cell and micro biology and medical imaging.), physics and accelerator sciences, mathematics and IT, to engineering. It is hence ideally suited for an innovative training of early stage researchers. By closely linking all above research areas, OMA will provide an interdisciplinary education to its Fellows. This will equip them with solid knowledge also in research areas adjacent to their core research field, as well as with business competences and hence give them a perfect basis for a career in research.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: AAT.2012.6.3-1. | Award Amount: 792.52K | Year: 2013

The PEL-SKIN project aims to deliver a novel airfoil coating to improve the global aerodynamic performance and manoeuvrability of future air transport. We propose to investigate drag reduction from a prefabricated coating composed of a densely packed arrangement of flexible fibres that can be attached directly onto a wing or aerodynamic surface, in the region of separated flow. Inspired by the pop up of birds feathers in certain flight modes, the amelioration of aerodynamic performance via a Porous and ELastic (PEL) is based on the concept of reconfiguring/adapting to the separated flow, thereby directly changing the near-wall flow and the subsequent vortex shedding; which can lead to reduced form drag by decreasing the intensity and the size of the recirculation region. This concept of flow control is novel, more efficient than classical actuators, and can lead to significant increase in the aerodynamic performances. The objective of the project is to investigate the performance benefit this technology can deliver for flow at high Reynolds number, relevant for the next generation of aircrafts. The research will endeavour to deliver a clear physical understanding of the principle flow control mechanism and an accompanying numerical model of the phenomena, which shall be implemented and tested into industrial aerodynamics software tools; ready for more detailed downstream design work. Although this research is motivated from low to moderate Reynolds number flows, it is expected that the understanding of the physical mechanisms will pave the way to the development of breakthrough control strategies for separated flows at higher Reynolds-numbers for larger aircraft. The success of this project can thus be expected to deliver direct impact on the environment in long-term; where in the EU, it is currently estimated that 25% of CO2 emissions come from the aeronautical sector.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: NFRP-01-2014 | Award Amount: 13.89M | Year: 2015

The overall aim of the SOTERIA project is to improve the understanding of the ageing phenomena occurring in reactor pressure vessel (RPV) steels and in the internal steels (internals) in order to provide crucial information to regulators and operators to ensure safe long-term operation (LTO) of existing European nuclear power plants (NPPs). SOTERIA has set up a collaborative research consortium which gathers the main European research centres and industrial partners who will combine advanced modelling tools with the exploitation of experimental data to focus on four technical objectives: i) to carry out experiments aiming to explore flux and fluence effects on RPV and internals in pressurised water reactors, ii) to assess the residual lifetime of RPV taking into account metallurgical heterogeneities, iii) to assess the effect of the chemical and radiation environment on cracking in internals and iv) to develop modelling tools and provide a single platform integrating developed modelling tools and experimental data for reassessment of structural components during NPPs lifetime. Building on industry-specific key questions and material, SOTERIA will fill current gaps in safety assessment related to ageing phenomena, by providing a set of modelling tools directly applicable in an industrial environment. Guidelines for better use of modelling, material testing reactors and surveillance data will also be an output of paramount importance. Another important parallel objective is the education of the nuclear engineering and research community of SOTERIA results to improve and harmonise knowledge about NPPs ageing and thereby ensure a high impact of project results. The knowledge and tools generated in SOTERIA will contribute to improving EU nuclear safety policy, to increasing the leadership of the EU in safety related equipment and information and to contribute to improved NPP safety world-wide. The SOTERIA proposal received the NUGENIA label on 10 August 2014.


Grant
Agency: GTR | Branch: AHRC | Program: | Phase: Research Grant | Award Amount: 36.32K | Year: 2016

This project will put in place a new network of scholars and policy-makers who will explore innovations in theory and practice that recover the research methods of the Arts and Humanities and encourage their use by Political Scientists, Area Studies scholars and policy-makers in the UK and beyond. The network will investigate examples of blurring genres, or crossing boundaries, between the disciplines in pursuit of insight into making and remaking theory, policy and practice in modern government. It will consider the practicalities of government policy-making in the United Kingdom, and beyond, seeking to apply the insights in, for example, narrative policy analysis. The network will bring together international scholars working on interpretive approaches to Political Science, with experts on Area Studies, to investigate what added value interdisciplinary research teams can bring to traditional research approaches when exploring modern governance. Particularly significant will be the study of the use of narratives and meta-narratives (narratives about narratives) for Historians, Political Scientists, Sociologists, Anthropologists and Philosophers, as well as for policy-makers. The network together will contemplate the kind of stories created, evolved and recounted in the implementation of everyday policy-making in the practice of modern government. The aim of the project will be to recover methodologies from the Arts and Humanities for the use of Political Scientists and interdisciplinary Area (or country) Studies specialists. Furthermore, the Blurring Genres Network will encourage sharing of best practice necessary to inform future policy-making and innovative scholarly work; for example, by developing narrative policy analysis. The new network will encourage interdisciplinary research between scholars in the United States, the UK, China, Australia, Canada, Brazil and elsewhere with an international and comparative approach involving policy-makers. The Blurring Genres Network will organize a research field that, to date, has been unstructured, lacking regional conferences, publications or directly relevant professional associations. It will assist scholars in the United Kingdom to lead the world in this emerging field of international and interdisciplinary research. It will bring together a number of learned societies (UK Council of Area Studies Associations, Political Studies Association UK and the Western Political Science Association USA) internationally with senior UK policy-makers which have not worked together before so creating a new, unique and practical network.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETHPC-1-2014 | Award Amount: 8.63M | Year: 2015

ExaNoDe will investigate, develop and pilot (technology readiness level 7) a highly efficient, highly integrated, multi-way, high-performance, heterogeneous compute element aimed towards exascale computing and demonstrated using hardware-emulated interconnect. It will build on multiple European initiatives for scalable computing, utilizing low-power processors and advanced nanotechnologies. ExaNoDe will draw heavily on the Unimem memory and system design paradigm defined within the EUROSERVER FP7 project, providing low-latency, high-bandwidth and resilient memory access, scalable to Exabyte levels. The ExaNoDe compute element aims towards exascale compute goals through: Integration of the most advanced low-power processors and accelerators across scalar, SIMD, GPGPU and FPGA processing elements supported by research and innovation in the deployment of associated nanotechnologies and in the mechanical requirements to enable the development of a high-density, high-performance integrated compute element with advanced thermal characteristics and connectivity to the next generation of system interconnect and storage; Undertaking essential research to ensure the ExaNoDe compute element provides necessary support of HPC applications including I/O and storage virtualization techniques, operating system and semantically aware runtime capabilities and PGAS, OpenMP and MPI paradigms; The development of an instantiation of a hardware emulation of interconnect to enable the evaluation of Unimem for the deployment of multiple compute elements and the evaluation, tuning and analysis of HPC mini-apps. Each aspect of ExaNoDE is aligned with the goals of the ETP4HPC. The work will be steered by first-hand experience and analysis of high-performance applications, their requirements and the tuning of their kernels.


Grant
Agency: GTR | Branch: AHRC | Program: | Phase: Research Grant | Award Amount: 4.16M | Year: 2012

Over the last decade, the creative industries have been revolutionised by the Internet and the digital economy. The UK, already punching above its weight in the global cultural market, stands at a pivotal moment where it is well placed to build a cultural, business and regulatory infrastructure in which first movers as significant as Google, Facebook, Amazon or iTunes may emerge and flourish, driving new jobs and industry. However, for some creators and rightsholders the transition from analogue to digital has been as problematic as it has been promising. Cultural heritage institutions are also struggling to capitalise upon new revenue streams that digitisation appears to offer, while maintaining their traditional roles. Policymakers are hampered by a lack of consensus across stakeholders and confused by partisan evidence lacking robust foundations. Research in conjunction with industry is needed to address these problems and provide support for legislators. CREATe will tackle this regulatory and business crisis, helping the UK creative industry and arts sectors survive, grow and become global innovation pioneers, with an ambitious programme of research delivered by an interdisciplinary team (law, business, economics, technology, psychology and cultural analysis) across 7 universities. CREATe aims to act as an honest broker, using open and transparent methods throughout to provide robust evidence for policymakers and legislators which can benefit all stakeholders. CREATe will do this by: - focussing on studying and collaborating with SMEs and individual creators as the incubators of innovation; - identifying good, bad and emergent business models: which business models can survive the transition to the digital?, which cannot?, and which new models can succeed and scale to drive growth and jobs in the creative economy, as well as supporting the public sector in times of recession?; - examining empirically how far copyright in its current form really does incentivise or reward creative work, especially at the SME/micro level, as well as how far innovation may come from open business models and the informal economy; - monitoring copyright reform initiatives in Europe, at WIPO and other international fora to assess how they impact on the UK and on our work; - using technology as a solution not a problem: by creating pioneering platforms and tools to aid creators and users, using open standards and released under open licences; - examining how to increase and derive revenues from the user contribution to the creative economy in an era of social media, mash-up, data mining and prosumers; - assessing the role of online intermediaries such as ISPs, social networks and mobile operators to see if they encourage or discourage the production and distribution of cultural goods, and what role they should play in enforcing copyright. Given the important governing role of these bodies should they be subject to regulation like public bodies, and if so, how?; - consider throughout this work how the public interest and human rights, such as freedom of expression, privacy, and access to knowledge for the socially or physically excluded, may be affected either positively or negatively by new business models and new ways to enforce copyright. To investigate these issues our work will be arranged into seven themes: SMEs and good, bad and emergent business models; Open business models; Regulation and enforcement; Creators and creative practice; Online intermediaries and physical and virtual platforms; User creation, behaviour and norms; and, Human rights and the public interest. Our deliverables across these themes will be drawn together to inform a Research Blueprint for the UK Creative Economy to be launched in October 2016.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.4.4 | Award Amount: 3.75M | Year: 2012

AXLE focuses on automatic scaling of complex analytics, while addressing the full requirements of real data sets.Real data sources have many difficult characteristics. Sources often start small and can grow extremely large as business/initiatives succeed, so the ability to grow seamlessly and automatically is at least as important as managing large data volumes once you know you have them. Extremely large data stores have added concerns such as data quality, privacy, security and auditability.Aspects of the project will include* Scalability Engineering - Autopartitioning, Compression* Security, Privacy and Audit Techniques* Visual Analytics* Advanced Architectures for Hardware and SoftwareValidation will be carried out by industrial consortium partners with access to large volumes of private medical data, as well as other wide ranging data from other interested parties.Software features will be released as commercially-usable open source code, and submitted for wide use as core parts of the PostgreSQL database or Orange visualisation project, or pluggable extensions for those tools.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 212.92K | Year: 2015

A SME-led collaboration between EA Technology, Nortech and the University of Manchester to develop a common, low cost, robust monitoring and management system for the low voltage (LV) network. For retrofit, the solution will help DNOs to optimise asset replacement, reduce emissions and improve security of supply. As well as provide a low cost route to LV network management, the system will make data available to network planners and operation and control. This will focus asset management and support planners in understanding the load, generation and smart control at LV. The development will reduce the costs of connecting and managing low carbon technologies connected to the electricity distribution system.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-15-2015 | Award Amount: 6.83M | Year: 2016

CLINICAL PROBLEM AND UNMET NEED There are 11,827 patients with severe structural airway disease in Europe. Even with the current standard of care, when hospitalised this group of patients has a 22% risk of dying. Patients are currently subjected to repeated surgical interventions (stent insertion) which have a high failure rate. Other therapeutic strategies under development include synthetic tracheal scaffolds seeded with patients own stem cells. Preliminary data show that these scaffolds are poorly integrated and are susceptible to infection. TETRA PROJECT Our SME-led project will address the limitations of standard clinical care and competitor products under development and will: - Build on our successful compassionate use experience using autologous stem cell seeded scaffold-tracheal transplants in 48 patients - Follow on from our Phase I 4 patient INSPIRE clinical trial which will improve on the clinical prototype used in compassionate use cases - Conduct a 48 patient Phase II pivotal clinical trial to provide robust, quality data with validated GMP manufacturing processes to support an accelerated route to market for commercial exploitation in this orphan indication - Prepare a dossier for MAA submission BENEFITS Our product, an ATMP, aims to eliminate the need for repeated surgical interventions of high risk and limited efficacy, reduce deaths and improve the quality of life for surviving patients. If treating 20% of the patients with severe structural airway disease, we estimate that in Europe our technology will improve the quality and length of patient lives and result in savings of 517 million per year. We plan to further develop our platform technology to generate other complex tissues/organs such as bowel and liver replacements for clinical applications which will impact the lives of tens of thousands of patient in the EU with bowel and liver diseases.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.1.4-1 | Award Amount: 7.82M | Year: 2013

This project will tackle the huge complexity of taking stem cell therapies to clinical application for neurodegenerative disease by focusing on selective differentiation of a single neuronal phenotype (medium spiny striatal neuron: MSN) for a single well-defined disease (Huntingtons: HD). Our consortium contains expertise in all elements required to drive this technology to the point of clinical delivery, including expertise in stem cell differentiation and control of proliferation; in vitro genetic, molecular, cellular and functional characterisation; preclinical assessment in both rodents and primates models of HD; GMP knowledge, development and production; and clinical translation. Our clinical team includes world leaders in HD clinical trials, including fetal neural transplants and is well placed to design the translation process. We focus on human embryonic stem (hES) cells as our primary target for first-in-man proof-of-concept studies, as they are closest to clinical readiness. HD is the target disease as it provides both an excellent model relevant to a wide range of neurodegenerative conditions, and is a stringent test of the capacity of selectively differentiated stem cells to repair neural circuits. The starting point for the work is the existence within the consortium of three of the most advanced protocols to date for MSN differentiation, and a feature of our consortium is that the specificity of stem cell differentiation will be tested against primary fetal MSNs (current gold standard) at all stages of both in vitro and in vivo assessment. In order to maintain flexibility in an emerging ethical environment, we will develop induced pluripotent (hiPS) cells to the point of GMP validation as a second generation target to hESCs. This will build European infrastructure and capacity to deliver emergent stem cell therapies through the highest quality clinical trials into clinical practice in a broad range of human neurodegenerative diseases.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRADEV-3-2015 | Award Amount: 19.05M | Year: 2015

The life sciences are undergoing a transformation. Modern experimental tools study the molecules, reactions, and organisation of life in unprecedented detail. The precipitous drop in costs for high-throughput biology has enabled European research laboratories to produce an ever-increasing amount of data. Life scientists are rapidly generating the most complex and heterogeneous datasets that science can currently imagine, with unprecedented volumes of biological data to manage. Data will only generate long-term value if it is Findable, Accessible, Interoperable and Re-usable (FAIR). This requires a scalable infrastructure that connects local, national and European efforts and provides standards, tools and training for data stewardship. Formally established as a legal entity in January 2014, ELIXIR - the European life science Infrastructure for Biological Information - is a distributed organisation comprising national bioinformatics research infrastructures and the European Bioinformatics Institute (EMBL-EBI). This coordinated infrastructure includes data standards, exchange, interoperability, storage, security and training. Recognising the importance of a data foundation for European life sciences, the ESFRI and European Council named ELIXIR as one of Europes priority Research Infrastructures. In response ELIXIR have developed ELIXIR-EXCELERATE. The project will fast-track ELIXIRs early implementation phase by i) coordinate and enhance existing resources into a world-leading data service for academia and industry, ii) grow bioinformatics capacity and competence across Europe, and iii) complete the management processes needed for a large distributed infrastructure. ELIXIR-EXCELERATE will deliver a step-change in the life sciences. It will enable cost-effective and sustainable management and re-use of data for millions of users across the globe and improve the competitiveness of European life science industries through accessible data and robust standards and tools.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: NFRP-10-2014 | Award Amount: 3.18M | Year: 2016

The present situation of nuclear energy in Europe asks for a continuing effort in the field of Education and Training aimed to assure a qualified workforce in the next decades. In this scenario, the present proposal is aimed at enhancing and networking the Europe-wide efforts initiated in the past decades by different organisations belonging to academia, research centres and industry to maintain and develop Education and Training in the nuclear fields. This will allow consolidating, developing and better exploiting the achievements already reached in the past and to tackle the present challenges in preparing the European workforce in the nuclear fields. The main objectives of the proposal are: 1. SURVEY AND COORDINATION OF NETWORKING IN E&T AND VET IN THE NUCLEAR AREAS 2. DESIGN AND IMPLEMENTATION OF COORDINATED E&T AND VET EFFORTS (Master and Summer Courses for continuous professional development) 3. GENERATIONAL TRANSFER OF EXPERTISE (Sustainable production of educational material) 4. CROSS BORDER TRANSFER OF EXPERTISE (Implementation of ECVET based exchanges among industrial bodies) 5. REINFORCING ETI ACTIONS FOR SHARING AND ENHANCING NUCLEAR SAFETY CULTURE COMPETENCE 6. FACILITATING THE NUCLEAR TRANSITION IN FUSION: COORDINATING THE E&T ACTIONS The European Nuclear Education Network (ENEN), as coordinator of the proposed action, together with the other Participants, is committed to pursue the above objectives, being fully coherent with the ones suggested in the call (NFRP10) and proposed by the SET Plan Roadmap for Education and Training for the nuclear sector, tightening at the same time the links among the different nuclear areas and better coordinating their contributions in the E&T fields. Strict links with the SNE-TP; IGD-TP and MELODI platforms and other relevant associations and bodies (EHRO-N, NUGENIA, EUTERP, IAEA, HERCA, etc.) will be implemented to assure coherence of this effort with similar other efforts going on in Europe.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: LCE-06-2015 | Award Amount: 17.86M | Year: 2016

By 2020, several areas of the HVAC pan-European transmission system will be operated with extremely high penetrations of Power Electronics(PE)-interfaced generators, thus becoming the only generating units for some periods of the day or of the year due to renewable (wind, solar) electricity. This will result in i) growing dynamic stability issues for the power system (possibly a new major barrier against future renewable penetration), ii) the necessity to upgrade existing protection schemes and iii) measures to mitigate the resulting degradation of power quality due to harmonics propagation. European TSOs from Estonia, Finland, France, Germany, Iceland, Ireland, Italy, Netherlands, Slovenia, Spain and UK have joined to address such challenges with manufacturers (Alstom, Enercon, Schneider Electric) and universities/research centres. They propose innovative solutions to progressively adjust the HVAC system operations. Firstly, a replicable methodology is developed for appraising the distance of any EU 28 control zone to instability due to PE proliferation and for monitoring it in real time, along with a portfolio of incremental improvements of existing technologies (the tuning of controllers, a pilot test of wide-area control techniques and the upgrading of protection devices with impacts on the present grid codes). Next, innovative power system control laws are designed to cope with the lack of synchronous machines. Numerical simulations and laboratory tests deliver promising control solutions together with recommendations for new PE grid connection rules and the development of a novel protection technology and mitigation of the foreseen power quality disturbances. Technology and economic impacts of such innovations are quantified together with barriers to be overcome in order to recommend future deployment scenarios. Dissemination activities support the deployment schemes of the project outputs based on knowledge sharing among targeted stakeholders at EC level.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: LCE-16-2014 | Award Amount: 3.40M | Year: 2015

Securing abundant, affordable, and clean energy remains a critical scientific challenge. Fortuitously, large shale formations occur within Europe. As the conventional gas production in Europe peaked in 2004, European shale gas could become a practical necessity for the next 50 years. However, the exploitation of shale gas remains challenging. Further, its environmental footprint is at present poorly quantified. Great care is needed to assess and pursue this energy resource in the safest possible way for the long-term future of Europe whilst protecting the European diverse natural environment. With this in mind, ShaleXenvironmenT assembled a multi-disciplinary academic team, with strong industrial connections. A comprehensive approach is proposed towards ensuring that the future development of shale gas in Europe will safeguard the public with the best environmental data suitable for governmental appraisal, and ultimately for encouraging industrial best practice. The primary objective is to assess the environmental footprint of shale gas exploitation in Europe in terms of water usage and contamination, induced seismicity, and fugitive emissions. Using synergistically experiments and modeling activities, ShaleXenvironmenT will achieve its objective via a fundamental understanding of rock-fluid interactions, fluid transport, and fracture initiation and propagation, via technological innovations obtained in collaboration with industry, and via improvements on characterization tools. ShaleXenvironmenT will maintain a transparent discussion with all stakeholders, including the public, and will suggest ideas for approaches on managing shale gas exploitation, impacts and risks in Europe, and eventually worldwide. The proposed research will bring economical benefits for consultancy companies, service industry, and oil and gas conglomerates. The realization of shale gas potential in Europe is expected to contribute clean energy for, e.g., the renaissance of the manufacturing industry.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.1. | Award Amount: 6.45M | Year: 2013

Referring to the increasingly challenging EU2020-ambition of Inclusive Growth, the objectives of the InGRID project are to integrate and to innovate existing, but distributed European social sciences research infrastructures on poverty and living conditions and working conditions and vulnerability by improving the transnational data access, organising mutual knowledge exchange and improving methods and tools for comparative research. This integration will provide the related European scientific community with new and better opportunities to fulfil its key role in the development of evidence-based European policies for Inclusive Growth. In this regard specific attention is paid to a better measurement of related state policies, to high-performance statistical quality management, and to dissemination/outreach activities with the broader stakeholder community-of-interest, including European politics, civil society and statistical system. For this purpose key actors of the related European Research Area are coupled in the InGRID consortium, representing specific data infrastructures and cumulated know-how. Pan-European optimisation of the infrastructure is created by organising an open, harmonised high-performance on-site access with an extensive visiting grant system. Joint research activities are conducted for the innovation and optimisation of the infrastructure. Key issues tackled in this respect include: the multidimensionality as a standard for poverty research; the problem of hard-to-identify and hard-to-reach vulnerable groups in data collection; the improvement of longitudinal and regional poverty mapping; the survey technology for linking vulnerability in working conditions with economic change and employers behaviour; the harmonisation of classifying jobs and skills; improving tools to generate comparative policy indicators; optimising the micro-simulation of policy impacts; and statistical quality management.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.3.4-02 | Award Amount: 9.94M | Year: 2012

SYNPOL aims to propel the sustainable production of new biopolymers from feedstock. SYNPOL will thereto establish a platform that integrates biopolymer production through modern processing technologies, with bacterial fermentation of syngas, and the pyrolysis of highly complex biowaste (e.g., municipal, commercial, sludge, agricultural). The R&D activities will focus on the integration of innovative physico-chemical, biochemical, downstream and synthetic technologies to produce a wide range of new biopolymers. The integration will engage novel and mutually synergistic production methods as well as the assessment of the environmental benefits and drawbacks. This integrative platform will be revolutionary in its implementation of novel microwave pyrolytic treatments together with systems-biology defined highly efficient and physiologically balanced recombinant bacteria. The latter will produce biopolymer building-blocks and polyhydroxyalkanoates that will serve to synthesize novel bio-based plastic prototypes by chemical and enzymatic catalysis. Thus, the SYNPOL platform will empower the treatment and recycling of complex biological and chemical wastes and raw materials in a single integrated process. The knowledge generated through this innovative biotechnological approach will not only benefit the environmental management of terrestrial wastes, but also reduce the harmful environmental impact of petrochemical plastics. This project offers a timely strategic action that will enable the EU to lead worldwide the syngas fermentation technology for waste revalorisation and sustainable biopolymer production.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: SCC-01-2014 | Award Amount: 29.50M | Year: 2015

The Triangulum project will demonstrate how a systems innovation approach based around the European Commissions SCC Strategic Implementation Plan can drive dynamic smart city development. We will test the SIP across three lighthouse cities: Manchester, Eindhoven and Stavanger, which represent the main typologies of European cities. They will be complemented by our follower cities Prague, Leipzig and Sabadell. This powerful combination reflects an urban population of between 100k and 1,2m inhabitants across six different countries, allowing us to demonstrate successful replication across a wide range of typical urban areas in Europe. Each city has already made significant progress towards the transition of becoming a smart city; developing their own individual approach reflecting specific local circumstances. These inherent strengths will now serve to accelerate the smart city development across proposed demonstration sites within Triangulum. The suite of projects developed will be based around zero/low energy districts, integrated infrastructures and sustainable urban mobility designed to deliver a range of cross-cutting outcomes across different sectors and stakeholders. This will provide the basis to road test the SIP and provide recommendations to the Commission on how it could be improved to facilitate wider replication. The Triangulum goals target a series of direct impacts around; reduced energy consumption of buildings, increased use of renewable energies, increased utilisation of electric vehicles, deployment of intelligent energy management technologies and the deployment of an adaptive and dynamic ICT data hub. The design and implementation of innovative Business Models and the activation of citizens as co-creators are core cross-cutting elements to base the technologies in real-world city environments and facilitate replication.


Grant
Agency: Cordis | Branch: H2020 | Program: FCH2-IA | Phase: FCH-03.1-2015 | Award Amount: 106.22M | Year: 2016

Hydrogen Mobility Europe 2 (H2ME 2) brings together action in 8 European countries to address the innovations required to make the hydrogen mobility sector truly ready for market. The project will perform a large-scale market test of hydrogen refuelling infrastructure, passenger and commercial fuel cell electric vehicles operated in real-world customer applications and demonstrate the system benefits generated by using electrolytic hydrogen solutions in grid operations. H2ME 2 will increase the participation of European manufacturers into the hydrogen sector, and demonstrate new vehicles across a range of platforms, with increased choice: new cars (Honda, and Daimler), new vans (range extended vehicles from Renault/Symbio and Renault/Nissan/Intelligent Energy) and a new medium sized urban delivery truck (Renault Trucks/Symbio). H2ME 2 develops an attractive proposition around range extended vehicles and supports a major roll-out of 1,000 of these vehicles to customers in France, Germany, Scandinavia and the UK. 1,230 new hydrogen fuelled vehicles will be deployed in total, trebling the existing fuel cell fleet in Europe. H2ME 2 will establish the conditions under which electrolytic refuelling stations can play a beneficial role in the energy system, and demonstrate the acquisition of real revenues from provision of energy services for aggregated electrolyser-HRS systems at a MW scale in both the UK and France. This has the further implication of demonstrating viable opportunities for reducing the cost of hydrogen at the nozzle by providing valuable energy services without disrupting refuelling operations. H2ME 2 will test 20 new HRS rigorously at high level of utilisation using the large vehicle deployment. The loading of stations by the end of the project is expected to average 20% of their daily fuelling capacity, with some stations exceeding 50% or more. This will test the HRS to a much greater extent than has been the case in previous projects.


Grant
Agency: Cordis | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around the world, to develop a unified multi-level understanding of the brain and diseases, and ultimately to emulate its computational capabilities. The goal is to catalyze a global collaborative effort. During the HBPs first Specific Grant Agreement (SGA1), the HBP Core Project will outline the basis for building and operating a tightly integrated Research Infrastructure, providing HBP researchers and the scientific Community with unique resources and capabilities. Partnering Projects will enable independent research groups to expand the capabilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitious Flagship Objectives.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.93M | Year: 2017

We propose a European Training Network that will provide a total of 540 ESR-months of training in Monte Carlo event generator physics and techniques, and related applications in experimental particle physics. Monte Carlo event generators are central to high energy particle physics. They are used by almost all experimental collaborations to plan their experiments and analyze their data, and by theorists to simulate the complex final states of the fundamental interactions that may signal new physics. We will build on the success of our current MCnetITN, by creating a European Training Network incorporating all the authors of current general purpose event generators, with the main purposes of: (a) training a large section of our user base, using annual schools on the physics and techniques of event generators and short-term studentships of Early Stage Researchers as a conduit for transfer of knowledge to the wider community; (b) training the next generation of event generator authors through dedicated PhD studentships; (c) providing broader training in transferable skills through our research, through dedicated training in entrepreneurship and employability and through secondments to non-academic partners. We will achieve these training objectives both through dedicated activities and through our research activities: (d) developing the next generation of higher precision event generators and supporting them for use throughout the LHC era and beyond; (e) playing a central role in the analysis of LHC data and the discovery of new physics there; and (f) extracting the maximum potential from existing data to constrain the modeling of the higher-energy data from the LHC and future experiments.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.85M | Year: 2017

Antiprotons, stored and cooled at low energies in a storage ring or at rest in traps, are highly desirable for the investigation of basic questions on fundamental interactions, the static structure of antiprotonic atoms, CPT tests by high-resolution spectroscopy on antihydrogen, as well as gravity experiments. Antimatter experiments are at the cutting edge of science. They are, however, very difficult to realize and have been limited by the performance of the only existing facility in the world, the Antiproton Decelerator (AD) at CERN. The Extra Low Energy Antiproton ring (ELENA) will be a critical upgrade to this unique facility and commissioned from summer 2016. This will significantly enhance the beam quality and enable new experiments. To fully exploit the discovery potential of this facility and to pave the way for a vibrant long-term physics program with low energy antiprotons, advances are urgently required in numerical tools that can adequately model beam transport, life time and interaction, beam diagnostics tools and detectors that can fully characterize the beams properties, as well as in into advanced experimental techniques for improved precision and novel experiments that exploit the enhanced beam quality that ELENA will provide. AVA is a new European training network between universities, research centers and industry that will carry out an interdisciplinary and cross-sector antimatter research and training program for a cohort of 15 Fellows. It targets new scientific and technical developments and aims at boosting the career prospects of all trainees.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.93M | Year: 2016

Industries are in need of highly skilled academically trained experts and powerful sets of tools enabling the design, control & prediction of optimized & efficient production process of future high-value products such as chiral pharmaceuticals. The CORE Network will in parallel train 15 ESRs and develop tools, approaches and methods within the area of Continuous Resolution (CORE), the process to obtain enantiopure molecules of chiral compounds. The training objective of the CORE network is to deliver a CORE skills toolbox of knowledge, personal, organizational and impact skills to a core of multi-disciplinary scientists and engineers in the interdisciplinary and cross-sectional field of Continuous Resolution. Each ESR obtains dedicated training through their research project, network events, a webinar course, management involvement and an academic & industrial secondment. The research objective of the CORE Network is to jointly construct a CORE Industrial Toolbox on Continuous Resolution that provides next generation tools, approaches and methods to industry for the development continuous resolution processes. The strongly involved industrial partners will ensure that the CORE Industrial Toolbox fulfils their requirements in the skills gap areas Towards Continuous, Hybrid Resolution and Enabling Resolution. CORE brings together 8 academic and 7 industrial partners resulting in an unparalleled combination of chirality, synthesis and crystallization training and research covering the areas of Chemical Engineering, Chemistry and Applied Physics.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA | Phase: ICT-2013.4.2 | Award Amount: 2.60M | Year: 2014

The objective of the RETHINK big project is to bring together the key European hardware, networking, and system architects with the key producers and consumers of Big Data to identify the industry coordination points that will maximize European competitiveness in the processing and analysis of Big Data over the next 10 years. Specifically, RETHINK big will deliver a strategic roadmap for how technology advancements in hardware and networking can be exploited for the purpose of data analytics while also taking into consideration advancements in applications, algorithms and systems.\n\nIn this project, we will not carry out actual research on Hardware optimizations for Big Data, but rather survey the landscape of opportunities and propose a strategic roadmap from that landscape. The outcome of the project will be a series of detailed (mentioning specific technologies), realistic (considering our 10-year timeline), verifiable (including target metrics) and coordinated technology development recommendations that would be in the best interest of European Big Data companies to undertake in concert as a matter of competitive advantage.\n\nPractically speaking, the roadmap will be produced as a result of area specific and cross-functional working groups meetings and congresses. We will initially identify and evaluate the existing competencies across European Big Data application domains and technology providers in Europe and then identify the key European stakeholders, or the established and up-and-coming institutions that possess or are developing the technologies, processes or services that map to these competencies. From these stakeholder institutions, we will select technology and business experts that will chart the technological advancements, their respective challenges and the potential business opportunities that they present. These experts will not only share an interest in defining a credible roadmap, but also hold the decision-making power within their respective institutions (and collectively) to implement that roadmap.\n\nAt the highest level, this project will identify and evaluate the existing competencies across European Big Data Hardware and Networking technology sectors and application domains and prioritize the complementary interests and the shared opportunities that allow all key industrial stakeholder companies to unlock the highest return on their respective investments; it will result in a roadmap that would be irrational not to follow.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INSO-4-2015 | Award Amount: 3.47M | Year: 2016

MOVING is an innovative training platform that enables users from all societal sectors to fundamentally improve their information literacy by training how to use, choose, reflect and evaluate data mining methods in connection with their daily research tasks and to become data-savvy information professionals. The platform provides users with technical support as well as social advice and learning input to organise, filter and exploit information in a more efficient and sustainable way. Thus, we tackle the core challenge of knowledge society to manage large amounts of information in a professional way. The ability for understanding, using and developing data mining strategies will become a basic cultural technique. In fact, information management is one of the basic competences today. The open innovation training platform MOVING is both: a working environment for the quality analysis of large data collections with data mining methods and a training environment with information, learning and exchange offers for digital information management. This connection of technical application and curriculum does overcome any artificial distinction in training and practice. The MOVING platform provides beyond state-of-the-art semantic search and analysis of large data sets. It makes its own functioning understandable to the users and offers individually configurable training programmes and guidance based on a proved qualification concept. The MOVING platform will be implemented in two use cases: (i) EY provides the use case of compliance officers with worldwide 60.000 public administrators. (ii) TUD provides a use case on educating young researchers on how to apply and interpret data-intensive research tasks. Here, we address 100.000 students. The exploitation is two-fold, a business-plan strategy for EY and a public-financed and tailoring of services-based strategy for the researcher use case. This will have decisive impact on the innovative capacity of the European society.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-03-2016 | Award Amount: 4.57M | Year: 2017

The objective of INSPEX is to make obstacle detection capabilities that are currently only feasible on autonomous vehicles available as a personal portable/wearable multi-sensor, miniaturised, low power spatial exploration system. The INSPEX System will be used for real-time 3D detection, location and warning of obstacles under all environmental conditions in indoor and outdoor environments with static and mobile obstacles. Applications include navigation for the visually/mobility impaired, safer human navigation in reduced visibility conditions and small robot/drone obstacle avoidance. The partners bring state-of-the-art range sensors (LiDAR, UWB radar and MEMS ultrasound) to the project. INSPEX will miniaturise and reduce the power consumption of these sensors to facilitate systems integration. These will then be integrated with an IMU, environmental sensing, signal and data processing, wireless communications, power efficient data fusion and user interface, all in a miniature, low power system designed to operate within wider smart/IoT environments. The main INSPEX Demonstrator will embed the INSPEX System in a white cane for the visually impaired and provide 3D spatial audio feedback on obstacle location. INSPEX directly addresses: - ICT-3 Challenge to develop and manufacture smart objects and systems that closely integrate sensors, actuators, innovative MEMS, processing power, embedded memory and communication capabilities, all optimising the use of supply power that can easily be made interoperable within systems of systems - RIA aims to make technological breakthroughs and their validation in laboratory environments of the next generations of miniaturised smart integrated systems and industrial-relevant technological developments, modelling and validation that will enable solutions in particular for health and well-being safety and security manufacturing. INSPEX is taking reliability and ethical issues strongly into consideration.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: INFRADEV-03-2016-2017 | Award Amount: 3.31M | Year: 2016

Joining up Users for Maximising the Profile, the Innovation and the Necessary Globalisation of JIVE (JUMPING JIVE) aims to prepare and position European Very Long Baseline Interferometry (VLBI) for the SKA era, and to secure the role of JIV-ERIC in the European and global landscape of Research Infrastructures. On a European scale, the proposed activities will raise the profile of JIVE among scientists and operators of radio-astronomical facilities, by widely advocating its science capabilities and its role as research infrastructure provider within the international radio astronomy community. These activities will focus on outreach and on reinforcing science cases for the next decade. New partnerships will be pursued, and in addition JIVE will expand its potential user base by offering geodetic and enhanced astrometric processing. Finally, the possibility of the International LOFAR Telescope using the same ERIC governance structure in the future will be investigated. With respect to global VLBI, the aim is to place JIV-ERIC in a leading role in the definition of scientific and technical standards in the SKA era. JIVE will take charge of a number of operational interfaces that will be essential for truly global VLBI, and establish close connections with the African VLBI Network and the SKA as the main strategic partners for the next decade.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRAIA-01-2016-2017 | Award Amount: 10.51M | Year: 2017

RadioNet is a consortium of 28 institutions in Europe, Republic of Korea and South Africa, integrating at European level world-class infrastructures for research in radio astronomy. These include radio telescopes, telescope arrays, data archives and the globally operating European Network for Very Long Baseline Interferometry (EVN). RadioNet is de facto widely regarded to represent the interests of radio astronomy in Europe. A comprehensive, innovative and ambitious suite of actions is proposed that fosters a sustainable research environment. Building on national investments and commitments to operate these facilities, this specific EC program leverages the capabilities on a European scale. The proposed actions include: - Merit-based trans-national access to the RadioNet facilities for European and for the first time also for third country users; and integrated and professional user support that fosters continued widening of the community of users. - Innovative R&D, substantially enhancing the RadioNet facilities and taking leaps forward towards harmonization, efficiency and quality of exploitation at lower overall cost; development and delivery of prototypes of specialized hardware, ready for production in SME industries. - Comprehensive networking measures for training, scientific exchange, industry cooperation, dissemination of scientific and technical results; and policy development to ensure long-term sustainability of excellence for European radio astronomy. RadioNet is relevant now, it enables cutting-edge science, top-level R&D and excellent training for its European facilities; with the Atacama Large Millimetre Array (ALMA) and the ESFRI-listed Square Kilometre Array (SKA) defined as global radio telescopes, RadioNet assures that European radio astronomy maintains its leading role into the era of these next-generation facilities by involving scientists and engineers in the scientific use and innovation of the outstanding European facilities.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INT-05-2015 | Award Amount: 2.50M | Year: 2016

The EUNPACK project unpacks EU crisis response mechanisms, with the aim to increase their conflict sensitivity and efficiency. By combining bottomup perspectives with an institutional approach, EUNPACK will increase our understanding of how EU crisis responses function and are received on the ground in crisis areas. This entails exploring local agencies and perceptions in target countries without losing sight of the EUs institutions and their expectations and ambitions. It also entails examining the whole cycle of crisis, from pre-crisis, through crisis, and into post-crisis phase. EUNPACK analyses two gaps in EU crisis response. First, the intentionsimplementation gap, which relates to 1) the capacity to make decisions and respond with one voice and to deploy the necessary resources, 2) how these responses are implemented on the ground by various EU institutions and member states, and 3) how other actors local and international enhance or undermine the EUs activities. Second, the project addresses the gap between the implementation of EU policies and approaches, and how these policies and approaches are received and perceived in target countries, what we refer to as the implementationlocal reception/perceptions gap. Our main hypothesis is that the severity of the two gaps is a decisive factor for the EUs impacts on crisis management and thereby its ability to contribute more effectively to problem-solving on the ground. We analyse these gaps through cases that reflect the variation of EU crisis responses in three concentric areas surrounding the EU: the enlargement area (Kosovo, Serbia), the neighbourhood area (Ukraine, Libya), and the extended neighbourhood (Mali, Iraq, Afghanistan). The results of our research will enable us to present policy recommendations fine-tuned to making the EUs crisis response mechanisms more conflict and context sensitive, and thereby more efficient and sustainable.


Troxel M.A.,University of Texas at Dallas | Troxel M.A.,University of Manchester | Ishak M.,University of Texas at Dallas
Physics Reports | Year: 2015

The wealth of incoming and future cosmological observations will allow us to map out the structure and evolution of the observable universe to an unprecedented level of precision. Among these observations is the weak gravitational lensing of galaxies, e.g.,cosmic shear that measures the minute distortions of background galaxy images by intervening cosmic structure. Weak lensing and cosmic shear promise to be a powerful probe of astrophysics and cosmology, constraining models of dark energy, measuring the evolution of structure in the universe, and testing theories of gravity on cosmic scales. However, the intrinsic alignment of galaxies-their shape and orientation before being lensed-may pose a great challenge to the use of weak gravitational lensing as an accurate cosmological probe, and has been identified as one of the primary physical systematic biases in cosmic shear studies. Correlations between this intrinsic alignment and the lensing signal can persist even for large physical separations, and isolating the effect of intrinsic alignment from weak lensing is not trivial. A great deal of work in the last two decades has been devoted to understanding and characterizing this intrinsic alignment, which is also a direct and complementary probe of structure formation and evolution in its own right. In this review, we report in a systematic way the state of our understanding of the intrinsic alignment of galaxies, with a particular emphasis on its large-scale impact on weak lensing measurements and methods for its isolation or mitigation. We begin with an introduction to the use of cosmic shear as a probe for cosmology and describe the various physical contributions by intrinsic alignment to the shear or convergence 2- and 3-point correlations. We then review developments in the modeling of the intrinsic alignment signal, including a trend toward attempting to incorporate more accurate nonlinear and single halo effects. The impact on cosmological constraints by the intrinsic alignment of galaxies is also outlined based on these models. We then summarize direct measurements of the large-scale intrinsic alignment signal in various surveys and discuss their constraints on models of intrinsic alignment, as well as progress in utilizing numerical simulations of structure formation to further our understanding of intrinsic alignment. Finally, we outline the development of a variety of mitigation techniques for reducing the impact of the intrinsic alignment contamination on weak lensing signals both within a galaxy data set and between complementary probes of gravitational lensing. The methodology and projected impact of these techniques are discussed for both 2- and 3-point correlations. We conclude by presenting a summary and outlook on the state of intrinsic alignment study and its impact on ongoing and planned weak lensing surveys. © 2014 Elsevier B.V.


Black A.J.,University of Adelaide | McKane A.J.,University of Manchester
Trends in Ecology and Evolution | Year: 2012

The increasing use of computer simulation by theoretical ecologists started a move away from models formulated at the population level towards individual-based models. However, many of the models studied at the individual level are not analysed mathematically and remain defined in terms of a computer algorithm. This is not surprising, given that they are intrinsically stochastic and require tools and techniques for their study that may be unfamiliar to ecologists. Here, we argue that the construction of ecological models at the individual level and their subsequent analysis is, in many cases, straightforward and leads to important insights. We discuss recent work that highlights the importance of stochastic effects for parameter ranges and systems where it was previously thought that such effects would be negligible. © 2012 Elsevier Ltd.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH-2011.2.2.1-2 | Award Amount: 24.91M | Year: 2012

The goal of this proposal (INMiND) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into the clinic. The general objectives of INMiND are: (i) to identify novel mechanisms of regulation and function of microglia under various conditions (inflammatory stimuli; neurodegenerative and -regenerative model systems); (ii) to identify and implement new targets for activated microglia, which may serve for diagnostic (imaging) and therapeutic purposes; (iii) to design new molecular probes (tracers) for these novel targets and to implement and validate them in in vivo model systems and patients; (iv) to image and quantify modulated microglia activity in patients undergoing immune therapy for cognitive impairment and relate findings to clinical outcome. Within INMiND we bring together a group of excellent scientists with a proven background in efficiently accomplishing common scientific goals (FP6 project DiMI, www.dimi.eu), who belong to highly complementary fields of research (from genome-oriented to imaging scientists and clinicians), and who are dedicated to formulate novel image-guided therapeutic strategies for neuroinflammation related neurodegenerative diseases. The strength of this proposal is that, across Europe, it will coordinate research and training activities related to neuroinflammation, neurodegeneration/-regeneration and imaging with special emphasis on translating basic mechanisms into clinical applications that will provide health benefits for our aging population. With its intellectual excellence and its crucial mass the INMiND consortium will play a major role in the European Research Area and will gain European leadership in the creation of new image-guided therapy paradigms in patients with neurodegenerative diseases.


Grant
Agency: Cordis | Branch: FP7 | Program: BSG-SME-AG | Phase: SME-2011-2 | Award Amount: 3.88M | Year: 2012

Restaurants, hotels, markets, fisheries and other small to medium size agro-food industries have to manage 239 million tonnes of organic waste in Europe per year. The specific management of such waste, with respect to the legislative regulations of EU, involves costly treatment for SMEs and potential hygiene issues on site. ORION aims at allowing a vast majority of SMEs to manage their organic waste by themselves in order to decrease their treatment costs (storage, transport, landfill or incineration) and increase on-site hygiene conditions. Wastes will be also valorised as biomass to produce energy and increase SME autonomy and profitability. ORION main objectives consist of: Developing for the first time anaerobic digestion machine at the SME scale (1 m3 to 50 m3) that will combine effectiveness for a large range of organic wastes and reduced capital and operating costs. Developing advanced control tools and sensors to reach an optimum reliability Increasing know-how on the impact of nanostructured surfaces on bacterial growth and increase waste throughput in the digestor Developing a dissemination and training strategy in order to address a vast community of SMEs and offer them a personalized service Contributing to the implementation of EU policies on waste management and renewable energies production. A maximum autonomy, adaptability and reliability are targeted. The digester is expected to be very cost-effective for users. ORION partnership is composed of European and National IAG representing the targeted sectors: fishery/aquaculture, hotel-restaurants, small agro-food industries and a Core Group of representative SME partners involved in the pilot design ND testing with various waste qualities and quantities. They will rely on a interdisciplinary group of research centers in order to achieve the technical goals of the project.


Grant
Agency: Cordis | Branch: FP7 | Program: CPCSA | Phase: ICT-2013.9.9 | Award Amount: 72.73M | Year: 2013

Understanding the human brain is one of the greatest challenges facing 21st century science. If we can rise to the challenge, we can gain profound insights into what makes us human, develop new treatments for brain diseases and build revolutionary new computing technologies. Today, for the first time, modern ICT has brought these goals within sight. The goal of the Human Brain Project, part of the FET Flagship Programme, is to translate this vision into reality, using ICT as a catalyst for a global collaborative effort to understand the human brain and its diseases and ultimately to emulate its computational capabilities. The Human Brain Project will last ten years and will consist of a ramp-up phase (from month 1 to month 36) and subsequent operational phases.\nThis Grant Agreement covers the ramp-up phase. During this phase the strategic goals of the project will be to design, develop and deploy the first versions of six ICT platforms dedicated to Neuroinformatics, Brain Simulation, High Performance Computing, Medical Informatics, Neuromorphic Computing and Neurorobotics, and create a user community of research groups from within and outside the HBP, set up a European Institute for Theoretical Neuroscience, complete a set of pilot projects providing a first demonstration of the scientific value of the platforms and the Institute, develop the scientific and technological capabilities required by future versions of the platforms, implement a policy of Responsible Innovation, and a programme of transdisciplinary education, and develop a framework for collaboration that links the partners under strong scientific leadership and professional project management, providing a coherent European approach and ensuring effective alignment of regional, national and European research and programmes. The project work plan is organized in the form of thirteen subprojects, each dedicated to a specific area of activity.\nA significant part of the budget will be used for competitive calls to complement the collective skills of the Consortium with additional expertise.


Grant
Agency: Cordis | Branch: FP7 | Program: JTI-CP-ARTEMIS | Phase: SP1-JTI-ARTEMIS-2013-AIPP5 | Award Amount: 93.92M | Year: 2014

Embedded systems are the key innovation driver to improve almost all mechatronic products with cheaper and even new functionalities. Furthermore, they strongly support todays information society as inter-system communication enabler. Consequently boundaries of application domains are alleviated and ad-hoc connections and interoperability play an increasing role. At the same time, multi-core and many-core computing platforms are becoming available on the market and provide a breakthrough for system (and application) integration. A major industrial challenge arises facing (cost) efficient integration of different applications with different levels of safety and security on a single computing platform in an open context. The objective of the EMC project (Embedded multi-core systems for mixed criticality applications in dynamic and changeable real-time environments) is to foster these changes through an innovative and sustainable service-oriented architecture approach for mixed criticality applications in dynamic and changeable real-time environments. The EMC2 project focuses on the industrialization of European research outcomes and builds on the results of previous ARTEMIS, European and National projects. It provides the paradigm shift to a new and sustainable system architecture which is suitable to handle open dynamic systems. EMC is part of the European Embedded Systems industry strategy to maintain its leading edge position by providing solutions for: . Dynamic Adaptability in Open Systems . Utilization of expensive system features only as Service-on-Demand in order to reduce the overall system cost. . Handling of mixed criticality applications under real-time conditions . Scalability and utmost flexibility . Full scale deployment and management of integrated tool chains, through the entire lifecycle Approved by ARTEMIS-JU on 12/12/2013 for EoN. Minor mistakes and typos corrected by the Coordinator, finally approved by ARTEMIS-JU on 24/01/2014. Amendment 1 changes approved by ECSEL-JU on 31/03/2015.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: SiS.2013.1.2-1 | Award Amount: 4.38M | Year: 2014

The proposal responds to the Horizon 2020 challenge called Climate action, resource efficiency and raw materials. In addition, it addresses the second specific challenge of the Mobilising and Mutual Learning Action Plans (MMLAP) topics, listed in the Science in Society call for proposals of the Capacities Work Programme 2013, namely Assessment of sustainable innovation. The projects main objective will be to develop a methodological framework for assessing sustainable innovation and managing multi-disciplinary solutions through public engagement in the RTDI system by ensuring the commitment of a broad spectrum of societal stakeholders into its implementation, including industry, policy-makers, research organisations and academia, civil society organisations and the general public. In achievement to the overall objective of the proposed action, the specific objectives include the development of: - a working definition of sustainable innovation, building on common definitions, academic literature as well as expert advice internal and external to the project consortium; - ways to include general public concerns in assessing the social impact of these innovations on society in consultation workshops. Issues such as participation in the development of innovation, inclusiveness, ethics, gender and open access will be considered in these sessions; - a common understanding of best practices in sustainable innovation management; - a framework for assessment and management of sustainable innovations; - specific policy recommendations on how to improve innovation management and how sustainability considerations can be incorporated into it based on the findings of the assessment framework and public consultations. CASI mobilises 19 partners from 12 EU Member States. Through a network of country correspondents CASI will cover the whole of Europe. The work is structured in 11 work packages, and the mandatory work packages as outlined in the call are included.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: AAT.2013.1-4. | Award Amount: 37.06M | Year: 2013

AFLoNext is a four year EC L2 project with the objective of proving and maturing highly promising flow control technologies for novel aircraft configurations to achieve a quantum leap in improving aircrafts performance and thus reducing the environmental footprint. The project consortium is composed by forty European partners from fifteen countries. The work has been broken down into seven work packages. The AFLoNext concept is based on six Technology Streams: (1) Hybrid Laminar Flow technology applied on fin and wing for friction drag reduction. (2) Flow control technologies applied on outer wing for performance increase. (3) Technologies for local flow separation control applied in wing/pylon junction to improve the performance and loads situation mainly during take-off and landing. (4) Technologies to control the flow conditions on wing trailing edges thereby improving the performance and loads situation in the whole operational domain. (5) Technologies to mitigate airframe noise during landing generated on flap and undercarriage and through mutual interaction. (6) Technologies to mitigate/control vibrations in the undercarriage area during take-off and landing. AFLoNext aims to prove the engineering feasibility of the HLFC technology for drag reduction on fin in flight test and on wing by means of large scale testing as well as for vibrations mitigation technologies for reduced aircraft weight and for noise mitigation technologies. The peculiarity of the AFLoNext proposal in terms of holistic technical approach and efficient use of resources becomes obvious through the joint use of a flight test aircraft as common test platform for the above mentioned technologies. To improve aircraft performance locally applied active flow control technologies on wing and wing/pylon junction are qualified in wind tunnels or by means of lab-type demonstrators.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-2.2.4. | Award Amount: 6.56M | Year: 2012

The Infrastructure for Systems Biology in Europe (ISBE) programme comprises an infrastructure that is designed to meet the needs of European systems biology, in terms of development, applications and training. In order to address this requirement, we are proposing a distributed, interconnected infrastructure which primarily comprises three types of centres: Data Integration Centres (DICs), and systems biology dedicated Data Generation Centres (DGCs), and Data Stewardship Centres (DSCs). DICs are research centres that apply and develop expertise in model-driven data integration and make this expertise available to the community. DGCs are technology-based centres that make available a wide range of high, medium and low throughput technologies that are essential for the acquisition of quantitative datasets under standardised conditions. DSCs are centres that are responsible for data processing, curation and analysis they store data, models and simulations. Each type of centre will be functionally different, but organisationally similar. Within participating universities and other organisations across Europe there will be foci of expertise and facilities which fit the requirements for a DIC, DGC or DSC. Such foci will be evaluated and then designated as local centres of a particular type. Each focus will then form a component of a particular type of DIC, DGC or DSC centre. ISBE centres may be single institutions or can be distributed. Large institutions, such as leading universities, may well contribute facilities and expertise across different types of centres. A particular distributed centre may focus on an area of Systems Biology; for example, a model organism, a disease, or, alternatively an area such as biotechnology, ecology or green biology. Importantly, the ISBE will include technological expertise; for example, stochastic computation, algorithmic modelling, multi-scale modelling integration of diverse high-and low-throughput datasets.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2011.4.0-1 | Award Amount: 17.87M | Year: 2012

The ExoMet proposal revolves around innovative liquid metal engineering and the application of external physical fields, in order to significantly influence the microstructures and properties of light alloys, such as aluminium and magnesium. Three types of external fields will be explored, namely: electromagnetic, ultrasonic and intensive mechanical shearing. To meet the future EU challenges of lightweighting and pollution reduction, especially relevant in transportation, it is necessary to improve the castability of light alloys, to enhance grain and eutectic refinement in monolithic alloys, and to develop new high-strength nanocomposites using nano-reinforcers which have only recently become available. Significant mechanical property improvements are foreseen in ExoMet - including 50% increases in tensile strength and ductility, as well as creep resistance up to 300-350 degC (currently limited to about 200 degC in Al and Mg alloys). This applies to both shape castings and wrought products like extruded profiles, bar, cable, sheet and plate. Manufacturing scale-up will be tackled in ExoMet, using a variety of techniques such as low and high-pressure die casting, sand casting, investment casting, differential-presssure casting, twin-roll casting, ultrasound-assisted casting and twin-shear casting. The application of external fields to these industrial techniques is novel and would bring about major savings in energy, scrap and processing cost. Having developed the field-enabled processes and produced high-quality light alloys and nanocomposites, the next stage of ExoMet will be prototypying and the assessment of industrial applications in four selected commercial sectors: (i) automotive powertrain and chassis, (ii) aircraft and aero-engine structures, (iii) space satellite and rockets, and (iv) high-strength high-conductivity Al electrical cabling. Computer modelling, rig-testing, standardisation, life-cycle analysis and patenting will also be undertaken.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 4.17M | Year: 2012

The objective of the P4FIFTY project is to deliver a trans-European network of industrially oriented white biotechnologists fully trained in the application of cytochrome P450 monooxygenases (P450s) for application in the chemical manufacturing and pharmaceutical industries. This will involve academic groups investigating P450 diversity exploration from the wild type enzymes and their genes, genome mining for novel P450s, the expression of these in suitable hosts, the enzymology and molecular biological manipulation of these (including directed evolution and high throughput screening [HTS] methods), the chemical application and finally the chemical and biochemical engineering aspects of application. These inputs are supported by two industrial partners one from the pharmaceutical industries (drug metabolism and synthesis) and one from the large scale chemical manufacturing industry.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 3.65M | Year: 2012

ENTITLE will train 17 researchers in the emerging supra-disciplinary field of Political Ecology, giving them the theoretical, analytical and complementary skills that will make them employable in jobs related to environmental policy analysis and advocacy. Research and training are framed around five key cluster sub-programmes concerned with the analysis of: environmental conflicts; environmental movements; natural disasters; changes in the commons; and environmental justice and democracy. Research is based on a series of empirical-based investigations of a geographically and thematically diverse set of case-studies. The researchers of the network will collaborate to offer a theoretical and methodological framework for the empirical research and will synthesise the results of the individual cases in a series of publishable outputs. Research will be action and policy-oriented culminating in a series of Action and Policy Briefs targeting civil society organizations and policy-makers. Training includes an integrated curriculum of local and intensive network courses, summer schools, secondments and training through work. Researchers will be seconded to and recruited by one SME and two NGO partners of the project, building bridges between academia and practice. ENTITLE builds on an on-going collaboration in training between the participating institutions, manifested in a series of successful summer schools. It brings together some of the worlds top scholars in the field, and overcomes the fragmentation of existing political ecological research in Europe, offering a critical mass of research and training. It is integrated with a number of related FP7 research projects, and builds on a network of reliable and capable partners with considerable experience in EU project management. The researchers trained in the network will be employable in academia, public administration, NGOs and the consultancy sector


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2012.2.1.1-1-B | Award Amount: 15.82M | Year: 2012

EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts assembled to date (collectively >10,000 patients) with detailed phenotypic information and comprehensive biorepositories containing DNA, blood, urine, amniotic fluid and kidney tissue. The project aims to (1) identify the genetic and epigenetic causes and modifiers of disease and their molecular pathways; (2) define a novel mechanistic disease ontology beyond phenotypical or morphological description; (3) develop innovative technologies allowing rapid diagnostic testing; (4) discover and validate biomarkers of disease activity, prognosis and treatment responses; and (5) develop in vitro and in vivo disease models and apply high-throughput compound library screening. For these purposes we will integrate comprehensive data sets from next generation exome and whole-genome sequencing, ChiP-sequencing, tissue transcriptome and antigen/epitope profiling, and miRNome, proteome/peptidome, and metabolome screening in different body fluids within and across conventional diagnostic categories. These data will be combined in a systems biology approach with high-resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models (functiomics) to identify disease-associated genetic variants involved in monogenic or complex genetic transmission, disease-defining molecular signatures, and potential targets for therapeutic intervention. These efforts will converge in the development of innovative diagnostic tools and biomarkers and efficient screening strategies for novel therapeutic agents.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2012.1.4-1 | Award Amount: 13.40M | Year: 2013

In this proposed integrating project we will develop innovative in-line high throughput manufacturing technologies which are all based on atmospheric pressure (AP) vapour phase surface and on AP plasma processing technologies. Both approaches have significant potential for the precise synthesis of nano-structures with tailored properties, but their effective simultaneous combination is particularly promising. We propose to merge the unique potential of atmospheric pressure atomic layer deposition (AP-ALD), with nucleation and growth chemical vapour deposition (AP-CVD) with atmospheric pressure based plasma technologies e.g. for surface nano-structuring by growth control or chemical etching and, sub-nanoscale nucleation (seed) layers. The potential for cost advantages of such an approach, combined with the targeted innovation, make the technology capable of step changes in nano-manufacturing. Compatible with high volume and flexible multi-functionalisation, scale-up to pilot-lines will be a major objective. Pilot lines will establish equipment platforms which will be targeted for identified, and substantial potential applications, in three strategically significant industrial areas: (i) energy storage by high capacity batteries and hybridcapacitors with enhanced energy density, (ii) solar energy production and, (iii) energy efficient (lightweight) airplanes. A further aim is to develop process control concepts based on in-situ monitoring methods allowing direct correlation of synthesis parameters with nanomaterial structure and composition. Demonstration of the developed on-line monitoring tools in pilot lines is targeted. The integrating project targets a strategic contribution to establishing a European high value added nano-manufacturing industry. New, cost efficient production methods will improve quality of products in high market value segments in industries such as renewable energy production, energy storage, aeronautics, and space. DoW adaptations being made responding on requests from Phase-2 Evaluation Report In Phase-2 of the evaluation process, a number of points were noted by the evaluators where the project had insufficient information or could benefit from upgrading or justification. Our response and actions against each point raised has been summarized and send to the project officer, Dr. Rene Martins, in a separate document.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2012.1.2-1 | Award Amount: 7.24M | Year: 2012

While early detection of breast cancer by screening appears effective, many women derive little or no benefit from screening, due to the way it is currently organized: as a one-size-fits all approach irrespective of personalised risk factors. It is known, however, that some women are at a much higher risk of getting the disease than others, and that mammography is unsuitable for cancer detection in women with dense breasts. The aim of this project is to develop personalised methods to tailor breast cancer screening to the individual needs of the woman. We will propose methods to stratify women at the highest risk to MRI; those with intermediate risk and/or dense breasts to follow-on ultrasound. A risk model will be developed that includes both breast cancer risk and the risk of missing cancers in mammograms. In this model, breast density plays a key role, as one of the largest known risk factors and the factor making mammograms ineffective. Two SMEs focusing on breast density are involved, where academic partners bring unique databases with over 80,000 screening mammograms and associated risk profiles. These are essential for model development, and subsequently for the development of products that benefit all women. Personalised screening is only economically feasible if it is based upon cost-effective strategies. While current methods in breast MRI imaging and breast ultrasound are promising, more efficient protocols must be developed to use these modalities routinely in screening. With leading SMEs and clinical partners, screening procedures will be optimized by developing automated image analysis tools to guide workflow and quality assurance. More efficient MRI protocols will be investigated to reduce time and cost, while the use of novel MRI imaging sequences without intravenous contrast will be explored. Cost-effectiveness of the stratification models will be assessed by combining the risk model with cost and effectiveness of alternative screening strategies.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.15. | Award Amount: 11.18M | Year: 2013

IS-ENES2 is the second phase project of the distributed e-infrastructure of models, model data and metadata of the European Network for Earth System Modelling (ENES). This network gathers together the European modelling community working on understanding and predicting climate variability and change. ENES organizes and supports European contributions to international experiments used in assessments of the Intergovernmental Panel on Climate Change. This activity provides the predictions on which EU mitigation and adaptation policies are built. IS-ENES2 further integrates the European climate modelling community, stimulates common developments of software for models and their environments, fosters the execution and exploitation of high-end simulations and supports the dissemination of model results to the climate research and impact communities. IS-ENES2 implements the ENES strategy published in 2012 by: extending its services on data from global to regional climate models, supporting metadata developments based on the FP7 METAFOR project, easing access to climate projections for studies on climate impact and preparing common high-resolution modeling experiments for the large European computing facilities. IS-ENES2 also underpins the communitys efforts to prepare for the challenge of future exascale architectures. IS-ENES2 combines expertise in climate modelling, computational science, data management and climate impacts. The central point of entry to IS-ENES2 services, the ENES Portal, integrates information on the European climate models and provides access to models and software environments needed to run and exploit model simulations, as well as to simulation data, metadata and processing utilities. Joint research activities improve the efficient use of high-performance computers and enhance services on models and data. Networking activities increase the cohesion of the European ESM community and advance a coordinated European Network for Earth System modelling.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.66M | Year: 2016

The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimers disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer, which account for >25% of the global disease burden. The CaSR is a unique GPCR whose principal physiological ligand is the Ca2\ ion; it is expressed almost ubiquitously; interacts with multiple G subtypes regulating highly divergent downstream signalling pathways, depending on the cellular context. The CaSR Biomedicine is a fully translational project that utilises the concept of a single molecule, the CaSR, influencing a range of physiological and disease processes, to develop a unique, strong multidisciplinary and intersectoral scientific training programme preparing 14 young scientists to become specialists in GPCR biology and signalling. The objectives of CaSR Biomedicine are: 1. Educate and train Early Stage Researchers to become highly innovative scientists to enhance their career perspective. 2. Elucidate ligand- and tissue-dependent differences in CaSR physiology by examining its functions at cellular level and thus to contribute to the understanding of GPCR signalling in general. 3. Assess how CaSR function is altered in AD, CVD, DM, sarcopenia, and cancer, and to find innovative CaSR-based therapeutic approaches for these major, age-related disorders. 4. Establish long-lasting interdisciplinary and intersectoral cooperation among researchers and between researchers and industry, to strengthen the European Research Area. Therefore the CaSR Biomedicine will investigate the complexity of CaSR signalling and function to identify CaSR-based therapeutic approaches to diseases linked to changes in CaSR expression or function (AD, CVD, DM, sarcopenia, and cancer).


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: FoF-ICT-2011.7.1 | Award Amount: 11.74M | Year: 2012

The production and ramp-up of complex and highly customized products are exceptionally challenging for planning and control, especially in small lot sizes. Daily challenges like late requests for change, immature high technology products and processes create significant risks. The occurring risks are bigger than production of big series such as automotive. Thus, new ICT-based approaches are required. The aim is to develop mitigation strategies to respond faster to unexpected events. Therefore the knowledge base has to be enriched for real-time decision support, to detect early warning and to accelerate learning. Our approach is based on a new generation of service orientated enterprise information platforms, a service orientated bus integrating service-based architecture and knowledge-based multi-agent systems (MAS). A holonic MAS combined with a service architecture will improve performance and scalability beyond the state of the art. The solution integrates multiple layers of sensors, legacy systems and agent-based tools for beneficial services like learning, quality, risk and cost management. Additionally the ecological footprints will be reduced. The ARUM solution will run in two modes: predictive and real time simulation. The predictive mode supports the planning phase whereas the real-time operations mode supports dynamic, time-, cost- and risk-oriented re-planning of operations. The provision of information for engineering to alter in case of immaturity or late requests for changes is supported equally. ARUM is strongly end-user driven and the results will be tested on three industrial use cases with a focus on aircraft, aircraft interiors and ship manufacturing. The solution will be validated in a real industrial environment by industrial partners and benchmarked against todays ICT solutions. In collaboration with universities a test-bed will be established for design and testing of ARUM systems and tools and will be opened for dissemination and demonstration.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 13.00M | Year: 2015

Particle physics is at the forefront of the ERA, attracting a global community of more than 10,000 scientists. With the upgrade of the LHC and the preparation of new experiments, the community will have to overcome unprecedented challenges in order to answer fundamental questions concerning the Higgs boson, neutrinos, and physics beyond the Standard Model. Major developments in detector technology are required to ensure the success of these endeavours. The AIDA-2020 project brings together the leading European infrastructures in detector development and a number of academic institutes, thus assembling the necessary expertise for the ambitious programme of work. In total, 19 countries and CERN are involved in this programme, which follows closely the priorities of the European Strategy for Particle Physics. AIDA-2020 aims to advance detector technologies beyond current limits by offering well-equipped test beam and irradiation facilities for testing detector systems under its Transnational Access programme. Common software tools, micro-electronics and data acquisition systems are also provided. This shared high-quality infrastructure will ensure optimal use and coherent development, thus increasing knowledge exchange between European groups and maximising scientific progress. The project also exploits the innovation potential of detector research by engaging with European industry for large-scale production of detector systems and by developing applications outside of particle physics, e.g. for medical imaging. AIDA-2020 will lead to enhanced coordination within the European detector community, leveraging EU and national resources. The project will explore novel detector technologies and will provide the ERA with world-class infrastructure for detector development, benefiting thousands of researchers participating in future particle physics projects, and contributing to maintaining Europes leadership of the field.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EINFRA-1-2014 | Award Amount: 6.07M | Year: 2015

Recent years witness an upsurge in the quantities of digital research data, offering new insights and opportunities for improved understanding. Text and data mining is emerging as a powerful tool for harnessing the power of structured and unstructured content and data, by analysing them at multiple levels and in several dimensions to discover hidden and new knowledge. However, text mining solutions are not easy to discover and use, nor are they easily combinable by end users. OpenMinTeD aspires to enable the creation of an infrastructure that fosters and facilitates the use of text mining technologies in the scientific publications world, builds on existing text mining tools and platforms, and renders them discoverable and interoperablethrough appropriate registriesand a standards-based interoperability layer, respectively. It supports training of text mining users and developers alike and demonstrates the merits of the approach through several use cases identified by scholars and experts from different scientific areas, ranging from generic scholarly communication to literaturerelated tolife sciences, food and agriculture, and social sciences and humanities. Through its infrastructural activities, OpenMinTeDs vision is tomake operational a virtuous cycle in which a) primary content is accessed through standardised interfaces and access rules b) by well-documented and easily discoverable text mining services that process, analyse, and annotate text c) to identify patterns and extract new meaningful actionable knowledge, which will be used d) for structuring, indexing, and searching content and, in tandem, e) acting as new knowledge useful to draw new relations between content items and firing a new mining cycle. To achieve its goals, OpenMinTeD brings together different stakeholders, content providers and scientific communities, text mining and infrastructure builders, legal experts, data and computing centres, industrial players, and SMEs.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: BES-09-2014 | Award Amount: 11.83M | Year: 2015

Efficient NII (non-intrusive inspection) of containerised freight is critical to trade and society. Freight containers are potential means for smuggling (e.g. tobacco), illegal immigration, trafficking of drugs, mis-declared goods and dangerous illicit substances, including explosives, nuclear material, chemical and biological warfare agents and radioactively contaminated goods. One inspection NII technology cannot cope with all these targets. The C-BORD Toolbox and Framework will address all these targets and enable customs to deploy comprehensive cost-effective container NII solutions to potentially protect all EU sea- and land-borders, satisfying a large range of container NII needs. The C-BORD Toolbox will include 5 complementary innovative detection technologies: delivering improved X-rays, Target Neutron Interrogation, Photofission, Sniffing and Passive Detection. User interfaces and data will be integrated to optimise effectiveness and efficiency of end-users and systems. The C-BORD Framework will help customs analyse their needs, design integrated solutions, and optimise the container inspection chain; it will address detection levels, false alarm levels, throughput, health & safety, logistics and cost & benefits. C-BORD will increase the probability of finding illicit or dangerous content with at least equal throughput of containers per time unit, reduce the need for costly, time-consuming and dangerous manual container inspections by customs officials, and in case a container is opened, increase the probability of finding illicit materials. C-BORD involves stakeholders from 8 EU countries, as partners (5) and advisory group members (3). On 3 custom sites integrated solutions will be trialled, respectively addressing the needs of big seaports, small seaports and mobile land-borders. To optimise sustainable impact, C-BORD will actively engage with a large community, will support policy implementation, evolution and start early exploitation planning.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: INSO-7-2014 | Award Amount: 3.20M | Year: 2015

Building on the ERA-LEARN, NETWATCH & JPIs To Co Work predecessor projects ERA-LEARN 2020 will provide an integrated framework to make P2P more efficient and effective and support national and regional funding organisations in the preparation, implementation and monitoring of joint actions. ERA-LEARN 2020 will increase mutual learning within the P2P community and will thereby support the implementation of streamlined mechanisms. Useful input will be provided towards the analysis and possible future development of P2P formats. ERA-LEARN 2020 will highlight synergies between different forms of national/regional programme coordination and facilitate high-level analysis of P2P policy-related issues. It will provide tools for analysis and communication formats for supporting future developments of transnational programme coordination. The ERA-LEARN 2020 team is highly qualified & complementary with national authorities and experts for analysis with many years experience of P2P at both the operational and policy levels. ERA-LEARN 2020 will: 1. provide a web-based information, learning and support platform for P2P to avoid duplication of efforts; 2. support the ongoing optimisation of P2P networks by providing a toolbox for the wider activities of joint programming, particularly the JPIs, Art.185 and ERA-NET Cofund instrument, as well as their associated impacts; 3. implement a systematic process for monitoring & impact assessment of P2P networks, including their impacts at both the policy, programme and co-funded RTD project-level; 4. assess and benchmark current approaches to alignment and explore options for new modalities to better align national and/or regional activities under common research agendas; 5. implement an annual cycle of knowledge exchange aimed at increasing the impact of investment in P2P activities and exploring options to support less research intensive countries.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETOPEN-01-2016-2017 | Award Amount: 5.73M | Year: 2017

We envision a radical redesign of Earth observation platforms for sustained operation at significantly lower altitudes than the current state of the art, using a combination of new aerodynamic materials, aerodynamic control and air-breathing electric propulsion for drag-compensation, for a variety of observation methods with the aim of creating a new platform paradigm. This vision requires foundational research in spacecraft aerodynamic characterization, in material aerodynamics and atomic oxygen resistance, in electric propulsion, and control methods. These activities are by their nature multidisciplinary covering atmospheric science, surface chemistry and material characterization, control engineering, spacecraft design, payload engineering, etc.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-22-2015 | Award Amount: 6.87M | Year: 2016

Mental, cognitive, vision and hearing health problems in elderly people are amongst the top 10 public health challenges in Europe. They frequently occur co-concurrently and have an additive negative effect on quality of life and mental well-being. To address this negative impact, and promote mental well-being, particularly from a gender and minority community perspective, SENSE-Cogs aim is to: (1) understand the inter-relationship of sensory impairments and cognitive and mental health functioning; (2) identify novel means of screening/detection for diagnostic and therapeutic purposes; and (3) translate this knowledge into clinical applications for the mental well-being of EU citizens. Methods: SENSE-Cog will use a mixed methods approach with a trans-EU, UK-led, multidisciplinary collaboration of 7 EU countries with academics, SMEs, city government and patient-public voice members. We will deliver linked Work Packages (WPs) reflecting 7 themes: (1) exploration: an epidemiological analysis of 5 large EU longitudinal databases to detect risk profiles for good and poor mental health outcomes; (2) assessment: the adaptation/validation of assessment tools for cognition and sensory impairment for vulnerable populations, including the development of a composite e-screen for sensory, cognitive and mental functioning; (3) intervention: a clinical trial of a newly developed sensory support intervention; (4) participation: an EU patient and public voice and innovative public engagement network to inform the WPs and communicate findings; (5) valuation: health economic and cost effectiveness analyses; & (6) management, governance/ethics. Impact: SENSE-Cog will promote earlier detection of sensory, cognitive and mental impairments to enable swift interventions, prevent deterioration and limit negative impacts.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: BIOTEC-03-2016 | Award Amount: 5.06M | Year: 2017

TOPCAPI will exploit the natural fabrication power of actinomycetes as microbial cell factories to produce three high value compounds: GE2270, a starter compound for the semi-synthesis of NAI-Acne, a new topical anti-acne drug in Phase II clinical trials; 6-desmethyl-tetracycline (6DM-TC) and 6-desmethyl 6-deshydro tetracycline (6DM6DH-TC), intermediates for semi-synthetic conversion to medically important type II polyketide tetracyclines (TC), e.g. minocycline, tigecycline, and the novel omadacycline, which is in Phase III clinical trials, to be used against Methicillin-resistant Staphylococcus aureus infections. Our work will focus on two bacterial host species: Streptomyces coelicolor and Streptomyces rimosus. These host species will be characterised using systems biology approaches, applying integrated data analysis to transcriptomics and metabolomics experiments, combined with predictive mathematical modelling to drive the rapid improvement of these microbial cell factories for industrial drug production using advanced metabolic and biosynthetic engineering approaches. At the same time, we will establish an expanded toolbox for the engineering of actinomycete bacteria as cell factories for other high added-value compounds. In the proposed 4-year project, we will: 1. Host engineer two new actinomycete strains for industry-level improved heterologous compound production through integrating systems biology-driven strain design and state-of-the-art genome editing. 2. Engineer the biosynthesis pathways to obtain high-efficiency synthesis of GE2270 and new pathway variants for 6DM-TC and 6DM6DH-TC as well as improve its production purity. 3. Optimise the expression of the engineered target pathways in pre-engineered strains to achieve industrially viable production levels of 1 g/L for GE2270 and 24 g/L for 6DM-TC, while creating a complete novel production strain for 6DM6DH-TC.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA | Phase: Fission-2013-2.1.1 | Award Amount: 10.28M | Year: 2013

Preparing NUGENIA for HORIZON 2020 The objective of the NUGENIA\ project is to support the NUGENIA Association in its role to coordinate and integrate European research on safety of the Gen II and III nuclear installations in order to better ensure their safe long term operation, integrating private and public efforts, and initiating international collaboration that will create added value in its activity fields. The project consists of two parts, the first part being a Coordination and Support Action and the second part a Collaborative Project. The aim of the first part, the Coordination and Support Action, is to establish an efficient, transparent and high quality management structure to carry out the planning and management of R&D including project calls, proposal evaluation, project follow-up dissemination and valorisation of R&D results in the area of safety of existing Gen II and future Gen III nuclear installations. The preparatory work will encompass governance, organizational, legal and financial work, as well as the establishment of annual work plans, with the aim to structure public-public and/or private-public joint programming enabling NUGENIA to develop into the integrator of the research in the respective field in Europe. The management structure will build on the existing organisation of the NUGENIA Association, currently grouping over 70 nuclear organisations from research and industry (utilities, vendors and small and medium enterprises) active in R&D. In the second part, the Collaborative project, one thematic call for research proposals will be organized among the technical areas of plant safety and risk assessment, severe accident prevention and management, core and reactor performance, integrity assessment of systems, structures and components, innovative Generation III design and harmonisation of procedures and methods. The call will take place one year after the start of the project. The call will implement the priorities recognised in the NUGENIA Roadmap, in line with the Sustainable Nuclear Energy Technology Platform (SNETP) and International Atomic Energy Agency (IAEA) strategies. The research call which is going to be organised within the project is open to all eligible organisations. The NUGENIA\ project will benefit from the experience of the NUGENIA Association member organisations on managing national research programmes and from the track record of the NUGENIA project portfolio.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2013.6.4-1 | Award Amount: 14.89M | Year: 2013

Assessing individual exposure to environmental stressors and predicting health outcomes implies that both environmental exposures and epi/genetic variations are reliably measured simultaneously. HEALS (Health and Environment-wide Associations based on Large population Surveys) brings together in an innovative approach a comprehensive array of novel technologies, data analysis and modeling tools that support efficiently exposome studies. The general objective of HEALS is the refinement of an integrated methodology and the application of the corresponding analytical and computational tools for performing environment-wide association studies in support of EU-wide environment and health assessments. The exposome represents the totality of exposures from conception onwards, simultaneously identifying, characterizing and quantifying the exogenous and endogenous exposures and modifiable risk factors that predispose to and predict diseases throughout a persons life span. The HEALS approach brings together and organizes environmental, socio-economic, exposure, biomarker and health effect data; in addition, it includes all the procedures and computational sequences necessary for applying advanced bioinformatics coupling thus effective data mining, biological and exposure modeling so as to ensure that environmental exposure-health associations are studied comprehensively. The overall approach will be verified and refined in a series of population studies across Europe including twin cohorts, tackling different levels of environmental exposure, age windows of exposure, and socio-economic and genetic variability. The HEALS approach will be applied in a pilot environment and health examination survey of children including singletons and sets of twins with matched singletons (each twins pair having also a matched singleton) covering ten EU Member States (the EXHES Study). The lessons learned will be translated into scientific advice towards the development of protocols and guidelines for the setting up of a larger European environment and health examination survey.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.78M | Year: 2013

The Spintronics in Graphene Training project (SPINOGRAPH) will create a European network of experts providing state-of-the-art training for early stage researchers (ESR) and Experienced Researchers (ER) in the blooming field of Spintronics in Graphene. The huge success of spintronics in metals which, starting from the pioneering discovery of Giant Magnetoresistance (GMR), has revolutionized the magnetoelectronics industry, and the remarkable progress in the fabrication of graphene devices, have naturally led to the exploration of spintronic devices based on graphene. The primary objective of this network is to significantly enhance the employment prospects of E(S)Rs by: (a) choosing a scientific subject that has both a solid ground and an enormous scientific and industrial potential, (b) engaging E(S)R in research projects in world-leading laboratories, including those of 2 Nobel laureates and in collaboration with small and medium enterprises in the emerging industry of graphene (c) ensuring that all researchers receive scientific and complementary skills training that is critical both to academia and industry.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: KBBE.2013.2.2-03 | Award Amount: 7.95M | Year: 2013

Vitamin D deficiency has significant implications for human health and impacts on healthy growth and development and successful aging. Fundamental knowledge gaps are barriers to implementing a safe and effective public health strategy to prevent vitamin D deficiency and optimize status. ODIN will provide the evidence to prevent vitamin D deficiency in Europe and improve nutrition and public health through food. By establishing an internationally standardized analytical platform for 25OHD, ODIN will measure the distribution of circulating 25OHD and describe the prevalence of vitamin D deficiency in Europe. Using available biobanks and databases from National nutrition surveys ODIN will delineate the relative contributions of sun and dietary sources of vitamin D to circulating 25OHD. In support of planned EFSA revisions of vitamin D recommendations, ODIN will carry out three RCT in pregnant women, children and teenagers and a fourth RCT in ethnic immigrant groups to provide experimental data to specify vitamin D intake requirements. Using dietary modeling, innovative food-based solutions to increase vitamin D in the food supply through a combination of bio-fortification of meats, fish, eggs, mushrooms and yeast will be developed and ODIN will test the efficacy and safety of these products in food-based RCT varying in scale from small product-specific trials to a large total diet study in vulnerable indigenous and immigrant sub-groups. ODIN has assembled the largest critical mass of prospective adult, pregnancy and birth cohort studies to date and will conduct meta-analyses and individual subject-level meta-regression analyses to integrate standardized data on vitamin D status, a priori defined clinical endpoints and genotype to examine relationships between vitamin D and human health, including beneficial and adverse effects, on perinatal outcomes, bone growth and body composition and allergic disease in children and cardiovascular disease and mortality in adults.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.2.4-04 | Award Amount: 12.16M | Year: 2013

Up to 20 million European citizens suffer from food allergy. However management of both food allergy (by patients and health practitioners) and allergens (by industry) is thwarted by lack of evidence to either prevent food allergy developing or protect adequately those who are already allergic. iFAAM will develop evidence-based approaches and tools for MANAGEMENT of ALLERGENS in FOOD and integrate knowledge derived from their application and new knowledge from intervention studies into FOOD ALLERGY MANAGEMENT plans and dietary advice. The resulting holistic strategies will reduce the burden of food allergies in Europe and beyond, whilst enabling the European food industry to compete in the global market place. Our approach will build on e-Health concepts to allow full exploitation of complex data obtained from the work in this proposal and previous and ongoing studies, maximising sharing and linkage of data, by developing an informatics platform Allerg-e-lab. This will enable us to (1) Extend and integrate existing cohorts from observation and intervention studies to provide evidence as to how maternal diet and infant feeding practices (including weaning) modulate the patterns and prevalence of allergies across Europe (2) Establish risk factors for the development of severe reactions to food and identify associated biomarkers (3) Develop a clinically-validated tiered risk assessment and evidence-based risk management approach for food allergens for allergens in the food chain (4) Develop clinically-relevant multi-analyte methods of analysis suited to allergen management across the food chain Stakeholders will be integrated into iFAAM to deliver harmonised integrated approaches, including RISK ASSESSORS AND MANAGERS managing population risk, the FOOD INDUSTRY who manage allergens to ensure consumer safety, HEALTH CARE PRACTITIONERS to provide food allergy management plans and dietary advice and ALLERGIC CONSUMERS to manage individual risk.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2013.6.1-2 | Award Amount: 11.46M | Year: 2013

Clouds are a very important, yet not well understood feedback factor in climate change and they contribute to the effective radiative forcing (ERF) from aerosol-cloud interactions (ACI). The uncertainty in ERFaci is larger than for any other forcing agent. Also, feedbacks between the terrestrial and marine biosphere and the atmosphere involving ACI are thought to play an important role in regulating climate change but their relevance remains poorly quantified. BACCHUS proposes to quantify key processes and feedbacks controlling ACI, by combining advanced measurements of cloud and aerosol properties with state-of-the-art numerical modelling. The analysis of contrasting environments will be the guiding strategy for BACCHUS. We will investigate the importance of biogenic versus anthropogenic emissions for ACI in regions that are key regulators of Earths climate (Amazonian rain forest) or are regarded as tipping elements in the climate system (Arctic). BACCHUS will generate a unique database linking long-term observations and field campaign data of aerosol, cloud condensation and ice nuclei and cloud microphysical properties; this will enable a better quantification of the natural aerosol concentrations and the anthropogenic aerosol effect. BACCHUS will advance the understanding of biosphere aerosol-cloud-climate feedbacks that occur via emission and transformation of biogenic volatile organic compounds, primary biological aerosols, secondary organic aerosols and dust. Integration of new fundamental understanding gained in BACCHUS in Earth Systems Models allows to reduce the uncertainty in future climate projections. This will have a direct impact on decision-making addressing climate change adaptation and mitigation. BACCHUS brings together a critical mass of experimentalists and modellers with the required scientific expertise to address these complex topics and a high commitment to communicate their findings in many ways in order to ensure a high-impact project.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.3.6-02 | Award Amount: 11.33M | Year: 2013

STREPSYNTH aims to set-up a Streptomyces-based new industrial production platform (SNIP) for high value added biomolecules. Streptomyces lividans was chosen as a bacterial host cell because it has been already shown to be highly efficient for the extracellular production of a number of heterologous molecules that vary chemically, has a robust tradition of industrial fermentation and is fully accessible to genetic intervention. To develop SNIP our strategy has two components: first, we will construct a collection of reduced-genome S. lividans strains. This will metabolically streamline the cell and rid it of agents (e.g. proteases) of potential harm to the heterologous polypeptides. Second, we will engineer synthetic parts and cassettes, i.e. reshuffled, rewired and repurposed genetic elements either indigenous to S. lividans or heterologous genes organized in artificial operon clusters. These elements will serve three aims: transcriptional and translational optimization, sophisticated on-demand transcriptional regulation that will provide unique fermentation control and metabolic engineering of complete cellular pathways channeling biomolecules to profuse extracellular secretion. Synthetic parts and cassettes will be either directly incorporated into the genome or be hosted in the form of plasmids. Systems biology tools will guide fine-tuning rounds of cell factory engineering and fermentation optimization. To set up SNIP we chose two classes of biomolecules with obvious immediate industrial value and application: heterologous proteins (industrial enzymes, biopharmaceuticals, biofuel enzymes, diagnostics) and small molecules (lantipeptides and indolocarbozoles) useful for multiple industrial purposes (biopharmaceuticals, additives, food technology, bioenergy). These biomolecules are of immediate interest to SMEs that participate and guide the industrial relevance of STREPSYNTH. SNIP is a modular platform that can be repurposed for diverse future applications.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.45M | Year: 2013

In vivo Magnetic Resonance Spectroscopy and Spectroscopic Imaging (MRS(I)) are unique, indispensable techniques for non-invasive metabolic imaging. Important areas where MRS(I) can make a difference are oncology and neurology, where metabolic changes due to, e.g., tumour formation, can be detected earlier and more sensitively than with morphological imaging modalities alone. Despite its huge proven potential, MRS(I) is not yet a routine clinical tool operated solely by clinicians. This requires reliable automation of complex procedures, strengthening standardisation and quality control. This in turn requires significant research progress and training of a new generation of scientists. Specifically, TRANSACT aims at: - Training 13 young scientists as future leaders in the field of MRS(I), capable of contributing with essential new developments such as spectral quality assurance criteria and standards, and optimal exploitation of complementarities between multi-modal magnetic resonance imaging modalities. - Pursuing research advances in theoretical and practical aspects of MRS, in particular experimental design by quantum mechanical simulation, data acquisition, data processing, data fusion and biomedical applications in oncology and neurology. - Establishing Europe as leader in the field within three sectors: academia, industry, clinic. TRANSACT links 10 academic and 4 industrial partners with complementary expertise in basic science, clinical research and information technology. Through a detailed training programme consisting of individual research projects, well-targeted secondments, scientific network-wide workshops, transferable skills courses, and individualized progress follow-up, TRANSACT will ensure a successful outcome in terms of career perspectives for the recruited researchers, continued collaboration between the partners and a more structured doctoral training in this field.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.3.3-2 | Award Amount: 3.74M | Year: 2012

The overall aim of this project is to offer a deeper understanding of the different mechanisms involved in the management of chronic conditions with a specific focus on how initiatives are translated and embedded into the illness management practices in peoples everyday life. It is in work, domestic and community settings where these practices are shaped by the emotional, symbolic, ethical, economic, and institutional inter-dependencies that people have with intimate and distant others, and where personal health is constantly negotiated in relation to ones own well-being and the health and well-being of others. Framed this way, questions related to self-care practices and changes in health behaviours can be stated as a shift in emphasis to a broader agenda for the provision of healthcare. Such an agenda brings into view ideas dominant in academic and policy debates and discussions of self-management which has drawn attention to the limitations of deploying a one size fits all approach and the need to devise and implement workable, personally sensitive strategies for self-management and behaviour change that make full use of available technologies (e.g. eHealth, telehealth, virtual networks), personal, community and institutional resources, and which more adequately addresses the needs of socially disadvantaged people. Thus, the current focus on individuals (e.g. understanding and improving their knowledge and capabilities) requires a complementary focus on understanding capabilities, resources, and change in health related practices as an integral part of peoples social networks and as being co-shaped by wider determinants of health). There is also a need to focus on the translation of efforts within health services to explore how professionally defined priorities of chronic illness management are translated acted upon and resourced outside of the consultation.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA | Phase: Fission-2013-2.3.1 | Award Amount: 8.65M | Year: 2013

The European Energy Research Alliance, set-up under the European Strategic Energy Technology Plan, has launched an initiative for a Joint Programme on Nuclear Materials (JPNM). The JPNM aims at establishing key priorities in the area of advanced nuclear materials, identifying funding opportunities and harmonizing this scientific & technical domain at the European level by maximizing complementarities and synergies with the major actors of the field. The JPNM partners propose, through MatISSE, a combination of Collaborative Projects and Coordination and Support Actions to face the challenge of implementing a pan-European integrated research programme with common research activities establishing, at the same time, appropriate strategy and governance structure. Focusing on cross-cutting activities related to materials used in fuel and structural elements of safe and sustainable advanced nuclear systems, the project aims at covering the key priorities identified in the JPNM: pre-normative research in support of ESNII systems, Oxide Dispersed Strengthened steels, refractory composites for the high temperature applications, development of predictive capacities. MatISSE will foster the link between the respective national research programmes through networking and integrating activities on material innovations for advanced nuclear systems, sharing partners best practices and setting-up efficient communication tools. It is expected that, through MatISSE, a real boost toward Joint Programming among the Member States, the European Commission and the main European research actors, will be achieved.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: BIOTEC-3-2014 | Award Amount: 11.39M | Year: 2015

Oxygen functionalities are key functional groups in many of todays chemicals and materials. The efficient introduction of oxygen-functionalities into raw materials are key chemical transformations in bulk and fine chemicals. Innovative bio-catalytic oxidation routes using molecular oxygen (from air) under benign and mild (pH) conditions such as ambient temperature and pressure can greatly improve the sustainability and economics of processes, but were so far mainly been applied in the pharma segments. In this segment, the enzyme-catalyzed step often represents the highest added value and the high price of the end-product (> 1000/kg) justifies less than optimal enzyme production and limitations in its catalytic efficiency. In order to achieve the widening of industrial application of enzymatic bio-oxidation processes to also larger volume but lower price chemical markets, ROBOX will demonstrate the techno-economic viability of bio-transformations of four types of robust oxidative enzymes: P450 monooxygenases (P450s), Baeyer-Villiger MonoOxygenase (BVMOs), Alcohol DeHydrogenase (ADH) and Alcohol OXidase (AOX) for which target reactions have already been validated on lab-scale in pharma, nutrition, fine & specialty chemicals and materials applications. ROBOX will demonstrate 11 target reactions on large scale for these markets in order to prepare them for scale up to commercial-scale plants. ROBOX is industry-driven with 2 major industrial players and 6 SMEs. It will assess the potential of technologies applied to become platform technologies technologies (multi-parameter screening systems, computational methodologies, plug bug expression systems) for broad replication throughout the chemical industry. The markets addressed within ROBOX represent a joint volume of over 6.000 ktons/year. The introduction of bio-oxidation processes is expected to bring substantial reductions in cost (up to -50%), energy use (-60%), chemicals (-16%) and GHG-emissions (-50%).


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.3.3-03 | Award Amount: 7.40M | Year: 2012

BIOINTENSE is directed at addressing the challenges of low productivity and process intensity frequently hampering the implementation of bioprocesses in industry. For the future of the next generation of chemical processes in Europe it provides the opportunity not only to address intensification but also to enable this in a rapid manner. BIOINTENSE will make use of -technology to develop economically feasible intensified processes by integration of separation and process control, and to create tools to speed up the characterization and assessment of different process options and technologies and biocatalysts for increased process intensity. A strong focus lies in increasing the scale of biocatalytic and cascade reactions and to improve the fundamental factors that affect the economic feasibility. Both numbering up and scale-up methodologies will be tested. The BIOINTENSE consortium is ideally suited to address the challenges in KBBE.2012.3.3-03 and to meet the objectives, as it spans across disciplines, academia and industry: SMEs with a strong technology base in the areas of integrating separation in bioprocessing, biocatalyst development, immobilization, -reactor fabrication, and on-line monitoring will ensure top of the line industry focused research with a strong focus on scale-up and implementation. There is an urgent need for these challenges to be overcome to move towards a European Knowledge Based BioEconomy to exploit the environmental savings and economic potential if such bioprocesses were in place. Building on the recent advances in molecular biology, the time is now right to develop the necessary process engineering methodologies and implementation strategies to unlock the full potential of bioprocesses.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.90M | Year: 2013

The goal of the Multi-Partner ITN-RAPID (Reactive Atmospheric Plasma processIng - eDucation network) is the realization of an interdisciplinary training involving the disciplines physics, chemistry and engineering. As a result, RAPID will create the platform for a truly European PhD in plasma technology. The scientific goal is the development of non-equilibrium reactive processes in atmospheric pressure plasmas. Thereby, the great success of low pressure plasmas enabling a multitude of applications ranging from material synthesis, automotive and microelectronics can be repeated. In addition, even more applications become possible due to the easy integration of atmospheric pressure plasmas in current industrial processes. Hot topics such as large area solar cells, barrier coatings to improve the permeation properties of polymers and plasma chemical gas conversion are selected. The research success requires a specific training covering diverse aspects such as modeling and simulation of plasmas and surfaces, diagnostic to validate these models and the implications for industrial scale-up. This will be trained in a coordinated effort involving 10 academic and 10 industrial partners from 8 European countries.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.54M | Year: 2013

SPRITE is a multi-disciplinary European training network which brings together Europes premier research institutes in technology and applications of ion beams. Those involved are already actively collaborating, for example in the recently very favourably reviewed EC Infrastructure project SPIRIT. SPRITE addresses the urgent European need - identified in a recent Foresight Review - to train the next generation of researchers in this multi- and supra- disciplinary emerging field. Through its Internship Mobility Partnerships (IMPs) SPRITE offers an innovative training package, providing the researchers with the opportunity to gain real world experience and business facing skills in the private and public sectors. In addition, ELVEs (European Laboratory Visit Exchanges) are an integral part of the training program. In combination with the IMPs, every ER and ESR will thus spend up to 30% of its time outside its host laboratory, part of this time in another EC country. Collaboration with the IAEA opens up a further dimension to SPRITE, enabling the researchers to put their research into a global context and to interact with scientists from all over the world. Despite the numerous participants SPRITE is able to offer a personalized training program. For this purpose the Action Planner, a web-based training needs analysis tool, developed at the University of Surrey will be used. This maps on to the Researcher Development Framework, currently being trialled by the European Science Foundation. Action Planner allows the training for each researcher to be tailored to their individual needs and aspirations. In addition to individualized training, SPRITE organizes network wide training events, encompassing amongst others technical training and business facing skills. In this way SPRITE researchers will leave not only as a brilliant and experienced researcher but also as a skilled manager, able to lead their own group.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.24. | Award Amount: 23.40M | Year: 2013

Research accelerators are facing important challenges that must be addressed in the years to come: existing infrastructures are stretched to all performance frontiers, new world-class facilities on the ESFRI roadmap are starting or nearing completion, and strategic decisions are needed for future accelerators and major upgrades in Europe. While current projects concentrate on their specific objectives, EuCARD-2 brings a global view to accelerator research, coordinating a consortium of 40 accelerator laboratories, technology institutes, universities and industry to jointly address common challenges. By promoting complementary expertise, cross-disciplinary fertilisation and a wider sharing of knowledge and technologies throughout academia and with industry, EuCARD-2 significantly enhances multidisciplinary R&D for European accelerators. This new project will actively contribute to the development of a European Research Area in accelerator science by effectively implementing a distributed accelerator laboratory in Europe. Transnational access will be granted to state-of-the-art test facilities, and joint R&D effort will build upon and exceed that of the ongoing EuCARD project. Researchers will concentrate on a few well-focused themes with very ambitious deliverables: 20 T accelerator magnets, innovative materials for collimation of extreme beams, new high-gradient high-efficiency accelerating systems, and emerging acceleration technologies based on lasers and plasmas. EuCARD-2 will include six networks on strategic topics to reinforce synergies between communities active at all frontiers, extending the scope towards innovation and societal applications. The networks concentrate on extreme beam performance, novel accelerator concepts with outstanding potential, energy efficiency and accelerator applications in the fields of medicine, industry, environment and energy. One network will oversee the whole project to proactively catalyze links to industry and the innovation potential.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: EEB-ICT-2011.6.5 | Award Amount: 5.84M | Year: 2012

Buildings are responsible for 40% of energy consumption and 36% of EU CO2 emissions, whilst the transportation sector is responsible for about 30% of the EU CO2 emissions. Achieving energy performance of neighbourhoods, including buildings, transportation systems and other supporting systems, is key to achieving the EU Climate & Energy objectives, namely a reduction of 20% of greenhouse gas emissions compared to 1990 levels by 2020 and a 20% energy savings in primary energy use by 2020. These challenging environmental targets can be met only by a mix of energy-saving and energy-efficiency measures, together with other relevant actions achieved through research and innovation. Improving the energy consumption and holistic performance of buildings and neighbourhood systems is a cost-effective way of fighting against climate change and improving energy security, while also creating new markets and new job opportunities, particularly in the building sector. COOPERATE will develop an open, scalable neighbourhood service and management platform that integrates local monitoring and control functions with a cloud based service platform for the delivery of innovative energy management, security and other services in order to progress towards energy positive neighbourhoods and achieving 2020 targets. COOPERATE will carry out a substantial validation of the concepts in two validation sites, the Bouygues Challenger campus and the CIT Bishopstown campus. In doing so, COOPERATE addresses the challenges of the call by developing management and control systems, and decision-support systems addressing the dynamics of energy supply and demand in neighbourhoods. COOPERATE will optimise the use of energy beyond the buildings, includes the integration of renewable energy sources and the connection to the electricity distribution grid, and will consider appropriate business models.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA | Phase: Fission-2013-4.1.2 | Award Amount: 9.33M | Year: 2013

The CHANDA project main objective is to address the challenges in the field of nuclear data for nuclear applications and its acronym stands for solving CHAllenges in Nuclear DAta The project will prepare a proposal for an organization that will coordinate the nuclear data research program, and the infrastructures and capabilities of the EU Member States in a stable structure, well integrated with R&D coordination tools (EERA, HORIZON 2020) , and with priorities aligned with the SET Plan and the SRAs of the EURATOM Technological Platforms, including the following general objectives: - to provide the nuclear data required for the safe and sustainable operation, and development, of existing and new reactors and nuclear fuel cycle facilities, - to prepare solutions for the challenges risen by the nuclear data measurements needed by nuclear systems, like the data for highly radioactive, short lived or rare materials, - to prepare tools that solve the challenges of quantifying and certifying the accuracy of the results of simulations based on available nuclear data and models (uncertainties), - to identify and promote synergies with other nuclear data applications. Using these tools will allow EU to upgrade the nuclear data up to the level needed by simulation codes to fulfill present requirements. In particular, the simulations should be able to: reduce the number of expensive experimental validations, to support the new tendencies in safety assessments to use best estimate codes to understand the limits of the plat safety towards extreme operational conditions, to optimize safety and performance of present and future reactors and other radioactive facilities. Other applications will benefit from this accuracy in nuclear data, notably in medical applications to optimize performance and minimize dose of radiation for diagnose and treatment.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRADEV-4-2014-2015 | Award Amount: 14.84M | Year: 2015

The social and economic challenges of ageing populations and chronic disease can only be met by translation of biomedical discoveries to new, innovative and cost effective treatments. The ESFRI Biological and Medical Research Infrastructures (BMS RI) underpin every step in this process; effectively joining scientific capabilities and shared services will transform the understanding of biological mechanisms and accelerate its translation into medical care. Biological and medical research that addresses the grand challenges of health and ageing span a broad range of scientific disciplines and user communities. The BMS RIs play a central, facilitating role in this groundbreaking research: inter-disciplinary biomedical and translational research requires resources from multiple research infrastructures such as biobank samples, and resources from multiple research infrastructures such as biobank samples, imaging facilities, molecular screening centres or animal models. Through a user-led approach CORBEL will develop the tools, services and data management required by cutting-edge European research projects: collectively the BMS RIs will establish a sustained foundation of collaborative scientific services for biomedical research in Europe and embed the combined infrastructure capabilities into the scientific workflow of advanced users. Furthermore CORBEL will enable the BMS RIs to support users throughout the execution of a scientific project: from planning and grant applications through to the long-term sustainable management and exploitation of research data. By harmonising user access, unifying data management, creating common ethical and legal services, and offering joint innovation support CORBEL will establish and support a new model for biological and medical research in Europe. The BMS RI joint platform will visibly reduce redundancy and simplify project management and transform the ability of users to deliver advanced, cross-disciplinary research.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: Health | Award Amount: 2.25M | Year: 2015

The European Consortium for Communicating Stem Cell Research (EuroStemCell) unites 33 partner institutions, that collectively represent >400 stem cell research groupings across Europe. Our common goal is to provide trusted high quality information on stem cells accessible to citizens and stakeholders across Europe, through support and further development of the multi-lingual European Stem Cell Information Portal www.eurostemcell.org. To achieve our aims, EuroStemCell will adopt the highly structured system for coordinated information management established by the FP7 Coordination and Support Action (CSA) also called EuroStemCell. From this, we will implement an ambitious programme of online and direct stakeholder engagement with stem cell research and regenerative medicine, aimed at European citizens at all educational levels. This will include provision of resources tailored specifically for decision-making on stem cell-related questions and an extensive programme of dissemination and capacity building in science communications and public engagement. The proposed work centres on an information hub team, which will link to all project partners and to stakeholders in the stem cell and regenerative medicine arenas and wider society, working with these groupings to implement the project. All outputs will be delivered in 6 European languages, to ensure broad accessibility, and will be rigorously evaluated against measurable objectives throughout the project duration. The proposed consortium comprises leading stem cell labs across Europe, including new member states, together with experts in ethical and societal concerns and evaluating clinical outcomes. It thus provides unparalleled European expertise across the fields of stem cell biology and regenerative medicine and is uniquely placed to maintain and further develop www.eurostemcell.org as a world-leading stem cell information resource, thus meeting the challenge outlined in Topic HOA-6-2014.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRADEV-04-2016 | Award Amount: 9.95M | Year: 2017

The EOSCpilot project will support the first phase in the development of the European Open Science Cloud (EOSC) as described in the EC Communication on European Cloud Initiatives [2016]. It will establish the governance framework for the EOSC and contribute to the development of European open science policy and best practice; It will develop a number of pilots that integrate services and infrastructures to demonstrate interoperability in a number of scientific domains; and It will engage with a broad range of stakeholders, crossing borders and communities, to build the trust and skills required for adoption of an open approach to scientific research . These actions will build on and leverage already available resources and capabilities from research infrastructure and e-infrastructure organisations to maximise their use across the research community. The EOSCpilot project will address some of the key reasons why European research is not yet fully tapping into the potential of data. In particular, it will: reduce fragmentation between data infrastructures by working across scientific and economic domains, countries and governance models, and improve interoperability between data infrastructures by demonstrating how data and resources can be shared even when they are large and complex and in varied formats, In this way, the EOSC pilot project will improve the ability to reuse data resources and provide an important step towards building a dependable open-data research environment where data from publicly funded research is always open and there are clear incentives and rewards for the sharing of data and resources.


Klingenberg C.P.,University of Manchester | Marugan-Lobon J.,Autonomous University of Madrid
Systematic Biology | Year: 2013

Quantifying integration and modularity of evolutionary changes in morphometric traits is crucial for understanding how organismal shapes evolve. For this purpose, comparative studies are necessary, which need to take into account the phylogenetic structure of interspecific data. This study applies several of the standard tools of geometric morphometrics, which mostly have been used in intraspecific studies, in the new context of analyzing integration and modularity based on comparative data. Morphometric methods such as principal component analysis, multivariate regression, partial least squares, and modularity tests can be applied to phylogenetically independent contrasts of shape data.We illustrate this approach in an analysis of cranial evolution in 160 species from all orders of birds. Mapping the shape information onto the phylogeny indicates that there is a significant phylogenetic signal in skull shape. Multivariate regression of independent contrasts of shape on independent contrasts of size reveals clear evolutionary allometry. Regardless of whether or not a correction for allometry is used, evolutionary integration between the face and braincase is strong, and tests reject the hypothesis that the face and braincase are separate evolutionarymodules. These analyses can easily be applied to other taxa and can be combined with other morphometric tools to address a wide range of questions about evolutionary patterns and processes. [Aves;comparativemethods; independent contrasts;morphological integration; partial least squares; Procrustes superimposition; shape; skull.] © The Author(s) 2013.


Travis M.A.,University of Manchester | Sheppard D.,University of California at San Francisco
Annual Review of Immunology | Year: 2014

The cytokine TGF-β plays an integral role in regulating immune responses. TGF-β has pleiotropic effects on adaptive immunity, especially in the regulation of effector and regulatory CD4+ T cell responses. Many immune and nonimmune cells can produce TGF-β, but it is always produced as an inactive complex that must be activated to exert functional effects. Thus, activation of latent TGF-β provides a crucial layer of regulation that controls TGF-β function. In this review, we highlight some of the important functional roles for TGF-β in immunity, focusing on its context-specific roles in either dampening or promoting T cell responses. We also describe how activation of TGF-β controls its function in the immune system, with a focus on the key roles for members of the integrin family in this process. © 2014 by Annual Reviews. All rights reserved.


Bray A.J.,University of Manchester | Majumdar S.N.,University Paris - Sud | Schehr G.,University of Manchester
Advances in Physics | Year: 2013

In this review, we discuss the persistence and the related first-passage properties in extended many-body nonequilibrium systems. Starting with simple systems with one or few degrees of freedom, such as random walk and random acceleration problems, we progressively discuss the persistence properties in systems with many degrees of freedom. These systems include spin models undergoing phase-ordering dynamics, diffusion equation, fluctuating interfaces, etc. Persistence properties are nontrivial in these systems as the effective underlying stochastic process is non-Markovian. Several exact and approximate methods have been developed to compute the persistence of such non-Markov processes over the last two decades, as reviewed in this article. We also discuss various generalizations of the local site persistence probability. Persistence in systems with quenched disorder is discussed briefly. Although the main emphasis of this review is on the theoretical developments on persistence, we briefly touch upon various experimental systems as well. © 2013 Copyright Taylor and Francis Group, LLC.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.59M | Year: 2013

The production of the next generation of functional soft systems and materials capable of meeting the current and future demands of society in a sustainable manner will require both new technologies and highly trained scientists. Supramolecular chemistry provides a powerful approach to develop new self-assembled materials with emerging properties, such as healability, recyclability and facile processability. The SASSYPOL ITN will train the next generation of European scientists with the skills necessary to overcome such future demands and simultaneously develop new strategies for the preparation of hierarchically self-assembled polymeric soft systems, which greatly impact important fields such as biomedicine, energy, composite materials and sensing. The ITN unites many leading experts in the areas of supramolecular and polymer chemistry with partners from the industrial sector. Expertise of all partners encompasses the general areas of non-covalent chemistry, with individual research competencies focusing on a number of specific themes including liquid crystalline materials, hydrogen-bonded supramolecules, molecular systems based on host-guest interactions, and advanced modeling and characterisation techniques of complex polymeric and self-assembled materials. The complementarity and diversity realised in synthesis, analysis, and applications is crucial for successful research and training in this area. A number of partners from the private sector will extend the fellows training beyond that of traditional academic settings they will have the critical role of bridging fundamental science with application and commercialisation of the results. Indeed, SupraPolix (a SME), one of SASSYPOLs industrial full partners is a perfect example of the commercialisation of cutting-edge science initially developed at an academic laboratory. Our activities will thus possess both breadth and quality that can only be achieved through an interdisciplinary pan-European effort.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2013.2.1.1-1 | Award Amount: 15.78M | Year: 2013

The aim of SYBIL is to carry out extensive functional validation of the genetic determinants of rare and common skeletal diseases and the age related factors contributing to these painful conditions. To achieve this goal SYBIL will gather complementary translational and transnational scientists, systems biologists, disease modellers, leading SMEs and industrialists that will perform in-depth characterisation (complete molecular phenotyping) of pre-clinical models (cellular and animal) for a variety of common and rare skeletal diseases. SYBIL will establish a systematic pipeline of in vitro, ex vivo and in vivo models of increasing complexity and will also make use of novel technologies such as iPS cells and exclusive Virtual Patient software to identify potential therapeutic targets for further validation through simultaneous modelling of fundamental and complex physiological pathways. SYBIL will rely on i) an Omics Knowledge Factory for systematically generating new knowledge on skeletal disease pathophysiology and to generate the relevant Omics profiles necessary to detect and validate new disease determinants, biomarkers and therapeutic targets for future clinical developments, and ii) a Systems Biology Hub to integrate the high-throughput and data-dense information, to gain a global understanding of pathophysiological commonalities between different skeletal diseases and recognize predominant shared pathways and mechanisms that may represent new targeted routes to treatment. SYBIL will also identify potential modifier genes and study the epigenome that will ultimately influence the timing and efficacy of new personalised treatments. Overall SYBIL achievements will tremendously boost the efficient pre-clinical assessment and development of therapeutics against skeletal diseases and thus indirectly reduce their social and healthcare burden.


Grant
Agency: GTR | Branch: STFC | Program: | Phase: Research Grant | Award Amount: 96.77K | Year: 2015

With this grant we will develop the first system for accurately validating organ dose estimates for patients receiving cancer therapy using radioactive materials which target their tumours, known as Molecular Radiotherapy (MRT). Currently simple water filled cylinders or spheres of varying sizes are used to represent patient organs when testing the accuracy of measurements of radiation dose delivered to tumours and critical organs in a patients body. These cylinders are used as a calibration to convert the number of gamma rays detected in a SPECT gamma-camera system to an activity inside a patients organ. Our current research has shown that this calibration method can actually result in organ dose estimates with systematic errors of up to 40%, preventing individualised patient treatments from being optimised. Consequently a significant number of patients do not currently receive the optimal therapy. By using realistic 3D printed models based on CT scans of patient organs we can accurately determine how well current commercial systems measure the dose to individual patient organs. This provides the first rigorous validation of these systems, a necessary requirement if the systems are to be used for all patient therapies. Our 3D printed models will also provide a much more accurate activity calibration, based on real organ geometries, for the SPECT scanner systems used to measure dose for MRT. Accurate MRT dose information is now considered very important in countries across Europe. Legislation now recommends accurate dosimetry for every patient receiving Molecular radiotherapy treatment. Our research will provide a new gold standard for assessing dosimetry systems used in clinical departments. This will highlight any weaknesses in current systems and in combination with our new realistic calibration factor measurements will allow the accuracy of dose measurements to be improved for all SPECT camera systems and MRT therapies. By establishing the accuracy of current dosimetry systems we will be able to provide a pathway to improve current commercial systems based on techniques from our recent research and future developments based on our 3D printed models. We are currently working with a leading provider of nuclear medicine workstation software who are supporting our work to validate their system. A rigorously validated commercial system has the potential to provide a significant improvement in the outcome of an estimated 201,00 MRT therapies performed annually in Europe.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.6.3 | Award Amount: 3.61M | Year: 2014

Urban water use is highly dynamic, variable over time and space, and is expected to constantly increase in the coming years both in Europe and worldwide. Expanding existing infrastructures to access farther or deeper water resources might be one option, but the economic and energy costs could be unsustainably high. There is a need for water demand management strategies (incentives, water pricing, awareness campaigns) to be efficient and sustainable technically, economically, and socially. Yet, individual and collective behavioural response to specific water conservation policies might significantly vary with economic drivers as well as socio-psychological determinants within the same urban context.The SmartH2O project aims at providing water utilities, the municipalities, and citizens, with an ICT enabled platform to design, develop and implement better water demand management policies, which are based on a shared understanding and motivation by the water users, thus leading to a reduction in water consumption, while not compromising the quality of life.SmartH2O builds a bi-directional communication stream between citizens and the water utility: in one direction, user behavioural data are collected through smart meters and an online social participation application (social game); in the other, awareness campaigns and price signals are delivered through the same app to inform the users on how to save water and money.SmartH2O will be tested in two real world cases: in the United Kingdom (in the London area), and in Switzerland (in Canton Ticino). In these two exemplary cases, the SmartH2O project will enable a constructive and continuous interaction between citizens and water utilities in the management of our most precious resource: water.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: NMP.2012.2.1-3 | Award Amount: 4.28M | Year: 2013

This project deals with the creation of a new, unique self-healing thermal barrier coating (TBC) for turbines and other thermally loaded structures in order to realize a significant extension of the lifetime of critical high-temperature components. The concept is based on novel Al2O3 coated Mo-Si particles embedded in the TBC layer, typically consisting of yttria-stabilised zirconia. As the current TBCs do not exhibit any self-repair, the new self-healing TBC will offer a reduction of the number of TBC replacements during an engine lifetime and enhance the reliability of the critical components. Ceramic thermal barrier coatings are applied on the most critical parts of engines, because it enhances the engine efficiency by allowing higher operation temperatures, which saves fuel and thus reduces CO2 emissions. Furthermore, it protects the high-tech structural components against severe high-temperature corrosion and consequently extends the lifetime of these components. The primary goal of this project is to realize and optimize the self-healing capacity of thermal barrier coatings with Mo-Si based dispersed particles for application in aero engines and industrial gas turbine engines to prolong the lifetime of their components. This will be achieved through a combined theoretical, experimental and modelling approach of a new, innovative self-healing concept. Upon local fracture of the TBC, these particles fill the crack initially with a glassy phase that subsequently reacts with the matrix to form a load bearing crystalline ceramic phase. This prospective self-healing concept can be exploited to other high temperature structural ceramics as well. The approach as formulated in this proposal has the potential to initiate a new school to design durable high temperature ceramic systems. The project is structured around interrelated work packages, each with clearly defined tasks and deliverables. The project as a whole will span the technology readiness levels (TRLs) 1-5.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2012.2.1.1-2 | Award Amount: 17.67M | Year: 2013

As more people survive into old age, the prevalence of heart failure (HF), one of the most common and debilitating diseases in older people, will rise still further. Delaying or preventing HF will have great benefit to those at personal risk, their families, society and the economy. HOMAGE aims to provide a biomarker (BM) approach that will a) help identify i. patients at high risk of developing HF before the onset of symptoms and ii. subsets of patients who are more likely to respond to specifically targeted therapies (personalized medicine). In available cohorts, we will identify the most promising omics-based BM profiles for the pre-symptomatic diagnosis and future prediction of HF in patients at risk. The predictive value of the BMs for other co-morbidities commonly associated with HF and ageing will also be investigated. Furthermore, in a prospective trial, we will investigate the potential for targeting preventive therapy at patients with the greatest likelihood of response and the lowest risk of adverse effects. Our selection of innovative omics-based BMs is based on knowledge of biological pathways of the disease, which may facilitate identification of Biotargets for future therapies. On the economic side, HOMAGE will act as an economic catalyst for European SMEs in the field of cardiovascular and ageing BMs, estimated to peak annual turnovers of up to 800 M.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: KBBE.2012.2.3-03 | Award Amount: 11.98M | Year: 2012

The PickNPack concept offers the food industry the benefits of automation cost reduction, greater hygiene and more efficient use of resources combined with the unique ability to adapt to the product and batch size at hand. PickNPack will give the European food industry a vital competitive advantage in the rapidly changing marketplace of the future, where customers demand more quality, more choice and more safety for lower prices. The project will develop three types of modules that can cope with the typical variability of food products and the requirements of the sector regarding hygiene, economics and adaptability. Three modules are working closely together. A sensing module that assesses quality of the individual or small batch products before or after packaging (i), a vision controlled robotic handling module that picks up and separates the product from a harvest bin or transport system and places it in the right position in a package (ii) and an adaptive packaging module that can accommodate various types of packaging with flexibility in terms of package shape, size, product environment, sealing and printing (iii). These modules connect to a multipoint framework for flexible integration into a production line that optimally makes use of the capabilities of the modules. The communication is based on a shared, vendor-independent vocabulary. The combination of modules will be with a user-friendly interface and all modules are equipped with automated cleaning systems to ensure hygiene. All available information in the production chain and the information produced by the sensors in the system is combined, stored and made available to the different modules and both upstream and downstream in the chain. With added intelligence this will lead to maximum performance in quality, reducing change over time, reducing time for reprogramming, adaption to operators, reducing waste of food and packaging material and stock. Human intervention will be reduced to a minimum.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: NMP.2010.2.3-1 | Award Amount: 14.80M | Year: 2012

The development of functional materials for tissue regeneration is today mostly based on perceived and limited design criteria often using a single point approach with lengthy animal trials. The outcome after in-vitro and in-vivo evaluation is often disappointing resulting in a tedious iteration process. The main objective of this project is to achieve radical innovations in state-of-the-art biomaterials and to design highly performing bioinspired materials learning from natural processes. By this outcome driven project comprising first class academic and industrial participants the project will create scientific and technical excellence and through links with these SMEs will strengthen the technological capacity and their ability to operate competitively on an international market. BIODESIGN will (i) perform a careful retrospective-analysis of previous outcomes from clinical studies performed with humans through animal modelling in a reverse engineering approach applied to an in-vitro to the molecular design level, (ii) develop new strategies for a more rational design of ECM mimetic materials serving both as gels and load carrying scaffolds, (iii) link novel designs to adequate and more predictive in-vitro methods allowing significant reduction in development time and use of animals and (iv) evaluate these concepts for musculoskeletal and cardiac regeneration. By the development of safe, ethically and regulatory acceptable, and clinically applicable materials this project will promote harmonization while at the same time creating awareness in society of the benefits of these innovations as one of the key points is to improve health and quality of life of the patients. BIODESIGN will stimulate technological innovation, utilization of research results, transfer of knowledge and technologies and creation of technology based business in Europe. It will also support the development of world-class human resources, making Europe a more attractive to top researchers.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 3.85M | Year: 2012

The consortium RADDEL (RADioactivity DELivery) has a research-based approach for the training of the new generation of scientists in the development of novel functional nanomaterials . A well structured training program will be provided with a balanced combination of local and network-wide training through secondments, joint network meetings, workshops, schools, industrial training and the final network conference. The research program focuses on the design, synthesis, characterisation, pharmacological studies and dosimetry calculations of nanocapsules that seal in their interior radioactive materials for biomedical applications in the areas of cancer diagnosis and therapy. After sealing the chosen radionuclides, the external walls of the nanocapsules will be decorated with biomolecules to render them biocompatible and for targeting purposes. In a recent study we have recently observed that these nanocapsules allow the delivery of unprecedented radiodosage and remain stable for extended periods thus guaranteeing essentially zero leakage of the radionuclides. Surface functionalisation of these nanocapsules offers versatility towards modulation of tissue biodistribution of the radioemitting crystals in a manner determined by the nanocapsule that delivers them. The delivery of radioactivity takes place through the walls of nanocapsules (carbon) and release of the encapsulated radionuclides is therefore not needed and certainly not desired. The present research objectives go beyond the-state-of-the art in the field and innovative products and solutions are expected.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: CO-CREATION-09-2016 | Award Amount: 2.00M | Year: 2017

KNOWMAK project aims at developing a web-based tool, which provides interactive visualisations and state-of-the-art indicators on knowledge co-creation in the European Research Area (ERA). It is structured around three integrative elements: Research topics, by developing ontologies around Societal Grand Challenges and Key Enabling Technologies. Actors, with a focus on the quadruple helix and the involvement of societal actors in knowledge co-creation. Geographical spaces, with a focus on multiple level metropolitan, regional, national and European spaces and their interconnectedness. The tool combines three main data sources: established indicators of scientific and technological knowledge production based on scientific publications and patents; information on knowledge in the making derived from research projects descriptions; information on social innovation projects and user attention to knowledge production derived from the Internet and from social media. The integrative elements (topics, actors, space) allow for the interlinking of data items, to produce a characterisation of different dimensions of knowledge in the making. KNOWMAK will be tailored to the needs of specific user groups with a focus on four groups: policy-makers, regional actors and representatives of the civil society, business sector, and managers of public research organisations and universities. User groups will be involved in the design of the system, the specification of the indicators and of the visualisations to be provided. This user-centred approach will ensure responsiveness of the tool to (changing) needs of relevant stakeholders in the ERA. Moving beyond the existing approaches to S&T indicators, the project will design and implement a consistent infrastructure where different types of data sources are interlinked and mobilized to produce a rich set of indicators and visualisations responding to the needs of specific user groups, thanks to experienced consortium.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.4.1-1 | Award Amount: 7.56M | Year: 2013

Ewing Sarcomas (ES) are fatal, rare bone cancers particularly affecting young people. About 60% of patients achieve long term survival with current treatment but there has been no improvement in this proportion for 25 years. Treatment is unsuccessful because chemotherapy fails to prevent the development of, or to effectively treat established, metastases. In addition, of the 600 new cases of ES occurring in the EU each year, less than half will receive treatment appropriate to deliver the most favourable outcome. The EUROEWING Consortium (EEC) is a coalition of clinical study groups bringing together the most active clinicians and scientists in Europe dedicated to improving survival from ES. This initiative can achieve this through an integrated programme of investigator-driven, inclusive clinical trials that are rigorously designed, conducted, analysed and reported, and underpinned by complementary embedded translational research. These include i) a first line randomised study in patients of all ages with ES which defines standards of care to prevent development of metastases and serves as a backbone for implementation of new agents, and ii) a randomised study of current second line chemotherapy in patients of all ages with ES which will serve as a platform for testing of new agents. Companion studies in association with these trials will be performed investigating tumour biology, underlying causes of differential response and toxicity, and other biomarkers. The programme will be supported by new initiatives for the involvement of patients in research planning and operation. Through collaborative working, the EEC will provide ES patients with greater access to clinical trials, allow efficient acquisition of knowledge and deliver clinically meaningful results within the lifetime of the grant, thereby contributing to improved survival from ES.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRASUPP-03-2016 | Award Amount: 3.00M | Year: 2017

The objective of the AENEAS project is to develop a concept and design for a distributed, federated European Science Data Centre (ESDC) to support the astronomical community in achieving the scientific goals of the Square Kilometre Array (SKA). The scientific potential of the SKA radio telescope is unprecedented and represents one of the highest priorities for the international scientific community. By the same token, the large scale, rate, and complexity of data the SKA will generate, present challenges in data management, computing, and networking that are similarly world-leading. SKA Regional Centres (SRC) like the ESDC will be a vital resource to enable the community to take advantage of the scientific potential of the SKA. Within the tiered SKA operational model, the SRCs will provide essential functionality which is not currently provisioned within the directly operated SKA facilities. AENEAS brings together all the European member states currently part of the SKA project as well as potential future EU SKA national partners, the SKA Organisation itself, and a larger group of international partners including the two host countries Australia and South Africa.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: Fission-2011-2.3.1 | Award Amount: 9.69M | Year: 2012

Nuclear power issues have been attracting research interest for decades even since the actual use of power reactors using oxide fuels was considered a mature science. It has mainly been due to one of the great drawbacks of nuclear power, the waste handling. Presently, there is a renaissance in nuclear power research focused on a new generation of reactor concepts utilising more of the inherent energy of the fuels. Additionally, these new concepts will also produce less radioactive waste, which is radiotoxic for a shorter time frame. If such concept succeeds, nuclear power can be considered almost sustainable bearing in mind that the waste we already have generated may be used for next generations. In order to reach these goals, there are several issues to be considered and the future nuclear fuel is one of the most important ones. ASGARD project will conduct crosscutting studies in synergy with the current nuclear fuel and waste research projects in Europe (e.g. ACSEPT and FAIRFUELS projects), but will also extend further into the research on new innovative nuclear concepts (SFR-Prototype, MYRRHA). ASGARD will provide a structured R&D framework for developing compatible techniques for dissolution, reprocessing and manufacturing of new nuclear fuels. The fuels to be considered will mainly consist of the next generation of fuels, e.g. oxides, nitrides and carbides, since the current oxide fuels and their reprocessing is dealt within already existing projects. An educational programme will be implemented to share the knowledge between students, researchers in the fuel manufacturing and the fuel reprocessing communities. The challenging objectives of ASGARD will be addressed by a multi-disciplinary consortium composed of European universities, nuclear research bodies and major industrial stakeholders. ASGARD will be an essential contribution to the development of new sustainable nuclear fuel cycle concepts and thus pave the road to more sustainable nuclear future.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.95M | Year: 2013

We propose a multi-site ITN consisting of 8 Full and 3 Associated Partners that will deliver a total of 500 ESR-months of training in the physics and techniques of Monte Carlo event generators to a total of at least 15 long-term and 40 short-term appointed researchers. Monte Carlo event generators are central to high energy particle physics. They are used by almost all experimental collaborations to plan their experiments and analyze their data, and by theorists to simulate the complex final states of the fundamental interactions that may signal new physics. We intend to build on the success of our RTN MCnet, by creating an ITN incorporating all the authors of current general purpose event generators, with the main purposes of: (a) training a large section of our user base, using annual schools on the physics and techniques of event generators and short-term residencies of Early Stage Researchers as a conduit for transfer of knowledge to the wider community; (b) training the next generation of event generator authors through a significant number of dedicated studentships in our research groups; (c) providing broader training in transferable skills through our research, through dedicated training in entrepreneurship and employability and through secondments to private sector partners. We will achieve these training objectives both through dedicated activities and through our outreach and research activities: (d) enhancing the visibility of particle physics in the wider community by specific outreach projects using event generators to visualize current particle physics research; (e) developing and supporting the new generation of event generators intended for use throughout the LHC data analysis era and beyond; (f) playing a central role in the analysis of LHC data and the discovery of new particles and interactions there; and (g) extracting the maximum potential from existing data to constrain the modeling of the data from the LHC and future experiments.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2012.2.1.2-2 | Award Amount: 15.73M | Year: 2012

Inflammatory bowel disease (IBD) is a major health problem with severe co-morbidities, requiring life-long treatment. Oscillating processes, like biological clocks are well studied and modeled in a number of systems. Circadian rhythms are extremely important for optimal treatments of patients. Recently, the NfkB pathway has been shown to be oscillating. In this project, we will model NfkB oscillation in chronic inflammatory bowel diseases in animal models and patient cohorts with immunosuppressive treatments and controls. The aim is to build an experimentally validated model the NfkB oscillation in 4D within the gut tissue. Dynamic, experimental validation will be done for various types of cells in the gut by a combination of methods, including single-cell based transcriptomics, multi-photon microscopy and time-dependent, multi-component profiling. The validated model framework will enable searching for critical components of the NfB oscillation and to assess their relevance for the disease in patients. Interfering with the oscillation of biological pathways may provide new possibilities to influence biological processes like inflammation. Hence, we will search (assisted by the models and databases developed) for small molecules interfering with the NfkB oscillation in chemical databases and validate selected candidates in experimental systems. To this end, we will use cell lines with the correct indicator constructs using high content microscopy. To better translate the findings in animal models to patients, we will use a mouse model with transplanted human tissue so that we can verify the mathematical model in human tissue and verify functionality of small molecules in vivo. Owing to its systems, highly focused approach, the project will generate substantial insights into key mechanisms underlying IBD and will provide ways to modulate the oscillatory behavior of the NfB in IBD and IBD-dependent co-morbidities.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2011-1.1.21. | Award Amount: 11.58M | Year: 2012

RadioNet is an I3 that coordinates all of Europes leading radio astronomy facilities in an integrated cooperation to achieve transformational improvement in the quality and quantity of the scientific research of European astronomers. RadioNet3 includes 27 partners operating world-class radio telescopes and/or performing cutting-edge R&D in a wide range of technology fields important for radio astronomy. RadioNet3 proposes a work plan that is structured into 6 NAs, 7 TNAs and 4 JRAs with the aim to integrate and optimise the use and development of European radio astronomy infrastructures. The general goals of RadioNet3 are to: - facilitate, for a growing community of European researchers, access to the complete range of Europes world-leading radio-astronomical facilities, including the ALMA telescope; - secure a long-term perspective on scientific and technical developments in radio astronomy, pooling resources and expertise that exist among the partners; - stimulate new R&D activities for the existing radio infrastructures in synergy with ALMA and the SKA; - contribute to the implementation of the vision of the ASTRONET Strategic Plan for European Astronomy by building a sustainable and world leading radio astronomical research community. RadioNet3 builds on the success of two preceeding I3s under FP6 and FP7, but it also takes a leap forward as it includes facilitation of research with ALMA via a dedicated NA, and 4 pathfinders for the SKA in its TNA Program. It has a transparent and efficient management structure designed to optimally support the implementation of the project. RadioNet is now recognized by funding agencies and international project consortia as the European entity representing radio astronomy and facilitating the access to and exploitation of excellent facilities in this field. This is of paramount importance, as a dedicated, formal European radio astronomy organisation to coordinate and serve the needs of this community does not yet exist.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 2.83M | Year: 2015

Pure accelerated radioisotope beams have been used for 50 years in fundamental physics R&D, e.g. for nuclear structure studies (pear shaped exotic nuclei, Nature 2013); CERN-ISOLDE plays a central role in developing accelerator technologies and fostering collaborative approaches to advance this field of isotope mass separation online. Our most recent contribution was the use of nanomaterial targets for more intense and reliable beam production, and laser ion sources for their purification (discovery of yet unknown 233Francium). Radioisotopes are widely used for functional imaging in medicine, based on 99mTechnetium or on 18Fluorine. This field is expected to rapidly expand, when coupling imaging with new cancer treatments, with isotopes emitting different type of radioactivity, e.g. alpha particles. This is shown with the recently introduced 223Radium chloride (Xofigo) used as a treatment drug in advanced bone cancers. However, either shortage in the supply of 99mTechnetium or lack of access to new radioisotope with adequate properties is a severe treat to develop personalized treatment that combine functional imaging and therapy. Ovarian cancers have poor prognosis, are the second most frequent cancer for women and one of the deadliest. They are difficult to treat, because of possible presence of metastasis, and because this region is difficult to irradiate without collateral damages. MEDICIS-PROMED will train a new generation of scientists to develop systems for personalized Medicine combining functional imaging and treatments based on radioactive ion beam mass-separation. This will be done across a coherent intersectorial multidisciplinary network with world-leading scientists in their field. Subsystems for the development of new radiopharmaceuticals, of isotope mass separators at medical cyclotrons, and of mass separated 11Carbon for PET-aided hadron therapy will be specifically developed to treat the ovarian cancer.


Grant
Agency: Cordis | Branch: FP7 | Program: ERC-AG | Phase: ERC-AG-SH6 | Award Amount: 2.49M | Year: 2014

This project explores the concept of agricultural spread as analogous to enforced climate change and asks how cereals adapted to new environments when agriculture was introduced into Europe. Archaeologists have long recognized that the ecological pressures placed on crops would have had an impact on the spread and subsequent development of agriculture, but previously there has been no means of directly assessing the scale and nature of this impact. Recent work that I have directed has shown how such a study could be carried out, and the purpose of this project is to exploit these breakthroughs with the goal of assessing the influence of environmental adaptation on the spread of agriculture, its adoption as the primary subsistence strategy, and the subsequent establishment of farming in different parts of Europe. This will correct the current imbalance between our understanding of the human and environmental dimensions to the domestication of Europe. I will use methods from population genomics to identify loci within the barley and wheat genomes that have undergone selection since the beginning of cereal cultivation in Europe. I will then use ecological modelling to identify those loci whose patterns of selection are associated with ecogeographical variables and hence represent adaptations to local environmental conditions. I will assign dates to the periods when adaptations occurred by sequencing ancient DNA from archaeobotanical assemblages and by computer methods that enable the temporal order of adaptations to be deduced. I will then synthesise the information on environmental adaptations with dating evidence for the spread of agriculture in Europe, which reveals pauses that might be linked to environmental adaptation, with demographic data that indicate regions where Neolithic populations declined, possibly due to inadequate crop productivity, and with an archaeobotanical database showing changes in the prevalence of individual cereals in different regions.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SPA.2012.1.3-01 | Award Amount: 2.65M | Year: 2013

IAGOS (In-service Aircraft for a Global Observing System), one of the European Research Infrastructures (ERI) on the ESFRI roadmap and currently in its preparatory phase, is establishing a distributed infrastructure for long-term observations of atmospheric composition on a global scale from a fleet of initially 10-20 long-range in-service aircraft of internationally operating airlines. IAGOS will provide accurate, spatially highly resolved in-situ observations of greenhouse gases (GHGs) and reactive gases, as well as aerosol and cloud particles, in fact covering the essential climate variables (ECVs) for atmospheric composition as designated by the GCOS programme (Implementation Plan for the Global Observing System for Climate in Support of the UNFCCC, 2010). With the CARIBIC container, operated aboard an in-service aircraft on a four flights per month basis as part of IAGOS, a much larger number of parameters are routinely available. This project aims to make these valuable in-situ measurements available to the GMES Atmospheric Service in both near-real-time (for the IAGOS measurements) and delayed mode (for CARIBIC measurements). The interface between GMES and the IAGOS and CARIBIC communities is established in work package two, which also includes work on the development of database and graphical tools to make the data availalbe for the broader scientific community as well. The near-real-time provision of data requires the installation of Real Time Transmissin Units (RTTUs) on the in-service aircraft, which is carried out in work package three. Work package four focuses on the harmonization and systematic evaluation of the data quality collected on board the aircraft, and work package five supports the development of four new instruments designed to measure atmospheric quantities on board in-service aircraft, as well as a study to investigate the possible modular redesign of the IAGOS system to improve its flexibility in the future.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2011.5.4 | Award Amount: 4.59M | Year: 2012

Healthy independent living is a major challenge for the ageing European population. Promotion of stimulating physical activity and prevention of falls are two key factors. Smart ICT offers unique proactive opportunities to support older people in their own homes. The FARSEEING project aims to provide groundbreaking results for health promotion, fall prevention and technical development. Falls in older persons are common, often leading to institutionalisation and loss of independence. FARSEEING aims to promote better prediction, prevention and support of older persons, by long-term analysis of behavioural and physiological data collected using Smartphones, wearable and environmental sensors: leading to self-adaptive responses. FARSEEING aims to build the worlds largest fall repository. This will include samples of both high functioning community-dwelling elders and high-risk groups of fallers. The architecture of the database will facilitate collection, analysis and processing of data related to falls, daily activity and physiological factors. The inclusion of a longstanding cohort study ensures a representative population sample, which is urgently needed to translate technological advance into real world service provision. Telemedicine service models using open technological platforms, independent of sensor systems, will be developed for detection of falls and exchange of information between the older person, family, caregivers and health-care personnel. Novel exercise regimens will be developed that increase adaptability and stimulate motor learning, and cognitive and emotional well being. The exercise model will focus on capacity to manage a complex challenging environment. User acceptability is central to FARSEEING. Psychological and gerontological expertise is a core activity, including ethical, privacy and e-inclusion dimensions. Data protection will be paramount to build and validate realistic business models and service provision.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.65M | Year: 2014

SNAL is a multidisciplinary programme specially designed to provide scientific and transferable skill training and career development for early stage researchers and experienced researchers in membrane research. Working in a multidisciplinary network will give the researchers a broad perspective on their research field as well as the basic ability of pursuing a research project from basic sciences to industrial applications. The broad aim is to train a new cohort of researchers with systemic thinking equipped with generic skills in combining experimental studies and computer simulations to prepare them for fruitful careers in academia and industry. One challenge for the project is the design and synthesis of novel biomaterials able to modify membrane properties. This requires deep understanding of the interactions of lipid membranes with nano-objects including functional biomimetic polymers, polymeric micelles, carbon nanotubes and polymer therapeutic complexes/conjugates to enable the intelligent design of novel materials with improved bilayer modifying properties. To achieve this goal we have assembled a highly interdisciplinary team of leading groups all having synergies in their established research interests in the field of lipid bilayer nano-objects interactions. The project combines computer simulations, chemical synthesis, clinical and industrial expertise, physical and biological experiments. The industry involvement in the project is very high with full participation of Unilever and Biopharma, the companies from different sectors. Complementarity of partner skills provides a logical basis for a collective training programme. The full cycle of the design process, from theoretical models to synthesis and experimental and clinical validation, is of particular importance for training of ESRs and their future career development.


Grant
Agency: GTR | Branch: EPSRC | Program: | Phase: Training Grant | Award Amount: 4.34M | Year: 2014

This world-leading Centre for Doctoral Training in Bioenergy will focus on delivering the people to realise the potential of biomass to provide secure, affordable and sustainable low carbon energy in the UK and internationally. Sustainably-sourced bioenergy has the potential to make a major contribution to low carbon pathways in the UK and globally, contributing to the UKs goal of reducing its greenhouse gas emissions by 80% by 2050 and the international mitigation target of a maximum 2 degrees Celsius temperature rise. Bioenergy can make a significant contribution to all three energy sectors: electricity, heat and transport, but faces challenges concerning technical performance, cost effectiveness, ensuring that it is sustainably produced and does not adversely impact food security and biodiversity. Bioenergy can also contribute to social and economic development in developing countries, by providing access to modern energy services and creating job opportunities both directly and in the broader economy. Many of the challenges associated with realising the potential of bioenergy have engineering and physical sciences at their core, but transcend traditional discipline boundaries within and beyond engineering. This requires an effective whole systems research training response and given the depth and breadth of the bioenergy challenge, only a CDT will deliver the necessary level of integration. Thus, the graduates from the CDT in Bioenergy will be equipped with the tools and skills to make intelligent and informed, responsible choices about the implementation of bioenergy, and the growing range of social and economic concerns. There is projected to be a large absorptive capacity for trained individuals in bioenergy, far exceeding current supply. A recent report concerning UK job creation in bioenergy sectors concluded that there may be somewhere in the region of 35-50,000 UK jobs in bioenergy by 2020 (NNFCC report for DECC, 2012). This concerned job creation in electricity production, heat, and anaerobic digestion (AD) applications of biomass. The majority of jobs are expected to be technical, primarily in the engineering and construction sectors during the building and operation of new bioenergy facilities. To help develop and realise the potential of this sector, the CDT will build strategically on our research foundation to deliver world-class doctoral training, based around key areas: [1] Feedstocks, pre-processing and safety; [2] Conversion; [3] Utilisation, emissions and impact; [4] Sustainability and Whole systems. Theme 1 will link feedstocks to conversion options, and Themes 2 and 3 include the core underpinning science and engineering research, together with innovation and application. Theme 4 will underpin this with a thorough understanding of the whole energy system including sustainability, social, economic public and political issues, drawing on world-leading research centres at Leeds. The unique training provision proposed, together with the multidisciplinary supervisory team will ensure that students are equipped to become future leaders, and responsible innovators in the bioenergy sector.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 706.71K | Year: 2015

The proposed work aims to improve the understanding of graphite fracture and irradiation creep behaviour by studying large specimens extracted from a reactor at end-of-service. This uniquely will enable valid fracture and creep data to be determined on material that had seen reactor conditions to high dose and weight loss conditions. Current data are determined on small specimens that are either unirradiated or irradiated in materials test reactors. In particular, the likely life-limiting failure mode is through a process known as keyway root cracking. Here a crack initiates at a sharp re-entrant corner; to study this failure mode in particular requires specimens of sufficient size to give a valid range of notch geometries. In addition, the relaxation of stress by irradiation creep is a key process to mitigate processes at sharp corners. No work on irradiation creep has been performed on corner geometries or at high tensile strain; both of these will be addressed in the current proposal. The results will allow the continued safe operation of reactors, enabling low carbon energy to be produced in the UK.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SSH.2012.1.1-2 | Award Amount: 3.22M | Year: 2013

Creativity is a fundamental transformative mechanism of the European economy. To study this mechanism, this project brings together 11 of Europes leading innovation research centres, and is structured around six themes: 1. Mapping and measuring the creative-cultural industries and their impacts; 2. Understanding and modelling creativity and design; 3. Entrepreneurship and industrial dynamics in the creative-cultural industries; 4. Digital ecosystems, user participation and the blurring of production and consumption; 5. Intellectual property, IP rights and innovation in creative-cultural activities, and, 6. Policy issues and recommendations. Together, and through nearly 25 person years of research, we will make substantial progress in methodologies and provide fresh and integrated approaches in the study of creativity and innovation, as well as in the dynamics of these industries. This will result in new data sets, policy briefs and tools, as well as academic articles and books. Above all, the project will substantially enhance the state of knowledge and understanding of the nature and characteristics of creativity and innovation, the cultural-creative industries, and their role in shaping the future European economy and society. It will also provide important and reliable evidence regarding the emergence, promotion and stimulation of creativity in relation to innovation in Europe, and how creativity-based entrepreneurship contributes to economic growth and wellbeing. The project will also be a highly valuable and original source of knowledge and understanding for the research, business and policymaking communities at both the EU and national / regional levels. The project will also help build a European research community focused on creativity and innovation, and will contribute to building research capacity by providing opportunities for early career researchers. It will also seek to advance the role of women researchers and research managers in Europe.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2012.2.1.1-3 | Award Amount: 4.68M | Year: 2012

High-throughput sequencing (HTS) is a powerful and rapidly evolving family of technologies with a multitude of applications. They include genetics of rare and common diseases, understanding of disease mechanism and progression through transcriptome and epigenome profiling, cancer stratification, personalised medicine and molecular systems biology of gene regulation. The genome, epigenome, transcriptome and interactome are all intricately connected, and modern HTS technology can probe all of these -omic levels. Statistical analysis is a crucial component of many experiments and studies, and the quality and efficiency of the analysis often determines the success of a project. In this collaborative project we will develop a range of new statistical analysis tools to solve open problems in HTS data analysis, ranging from low-level processing of sequence reads up to systems-level modelling of disease associated and cellular processes. We will provide to a wide audience an integrated computational framework for HTS data analysis and interpretation that is robust, efficient and user-friendly. We will establish improved procedures for the publishing of statistical software as an integral part of the scientific publication process, within the framework of the Bioconductor project. We will provide tools to benchmark experimental protocols and statistical methods, and we will provide training materials and a extensive training programme to rapidly disseminate these new tools to the broader biomedical community. SME partners will integrate these new tools within their analysis pipelines with associated user-friendly commercial software providing access to their additional proprietary tools. SMEs will benefit from basic methodology development done in a public, pre-competitive arena and will be able to use these technologies to enhance their products and services.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA-Infra | Phase: INFRA-2012-1.1.2. | Award Amount: 7.12M | Year: 2014

The RISIS project aims at creating a distributed research infrastructure to support and advance science and innovation studies. This will give the field a strong scientific push forward, and at the same time, provide a radically improved evidence base for research and innovation policies, for research evaluation, and for the quality of policy relevant indicators. The field of science and innovation studies is interdisciplinary, and is related to political sciences, sociology, management and economics. It has a strong quantitative core - with specialties such as scientometrics, technometrics and more widely indicators design - but for many important questions data were lacking or small scale only. This has made the field too much dependent on a few pre-existing datasets. However, during the last decade important efforts have been undertaken to develop new datasets on burning issues such as industrial R&D globalisation, patenting activities of firms, university performance, Europeanisation through joint programming, or the dynamics of nano S&T. Another new characteristic of the field is the development together with computer scientists of software platforms for collecting, integrating and analysing ever more data. Data and platforms are currently owned and/or located at many different organizations, such as individual research groups, companies, and public organizations with very restricted access to others. Through deploying various networking and access strategies, and through joint research, RISIS will decisively open, harmonize, integrate, improve, and extend their availability, quality and use.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: Fission-2012-2.3.1 | Award Amount: 10.27M | Year: 2013

Nuclear power plays a key role in limiting EUs greenhouse gases emissions, and makes an important contribution to improve European Unions independence, security and diversity of energy supply. However, its social acceptance is closely linked to an enhanced safety in the management of long-lived radioactive waste contributing to resource efficiency and cost-effectiveness of this energy and ensuring a robust and socially acceptable system of protection of man and environment. Among the different strategies, partitioning and transmutation (P&T) allows a reduction of the amount, the radiotoxicity and the thermal power of these wastes, leading to an optimal use of geological repository sites. In line with the Strategic Research Agenda of SNE-TP, the SACSESS collaborative project will provide a structured framework to enhance the fuel cycle safety associated to P&T. In addition, safety studies will be performed for each selected process to identify weak points to be studied further. These data will be integrated to optimise flowsheets and process operation conditions. A training and education programme will be implemented in close collaboration with other European initiatives, addressing safety issues of nuclear energy industry. The multidisciplinary consortium composed of European universities, nuclear research bodies, TSOs and industrial stakeholders will generate fundamental safety improvements on the future design of an Advanced Processing Unit. SACSESS will thus be an essential contribution to the demonstration of the potential benefits of actinide partitioning to the global safety of the long-lived waste management.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2013.6.2-3 | Award Amount: 3.88M | Year: 2013

The ambitious EU policy goals to move to sustainable, resource efficient, low-carbon and climate-resilient and biodiversity rich societies requires substantial transitions in the energy system and land-use and food systems. Different scientific approaches offer different perspectives on transitions, each with strengths and weaknesses. The PATHWAYS project takes a step in coupling three scientific disciplines, i.e. integrated assessment analysis, transitions studies and participative action research, to generate a chain of analysis. This chain links the goal-oriented, quantitative, 1) systems-wide analysis from IAM models to 2) the thick analysis of transitions as dynamic, multi-scale processes from transitions studies to 3) finally real-world insights from participative action research. By doing so, the PATHWAYS project will be able to develop a more integrated methodological approach for analyzing on-going transitions pathways in key transitions domains relevant for EU policy (energy and land-use & food). Taken together, we can go beyond existing research as we account for long-term economic or technological consequences, but also the opportunities and barriers for innovation, and the role, attitudes, resources and strategies of key actors. The chain will also be able to link the macro level of European goals to the micro level of implementation. For the latter, the project will particularly focus on bottom-up level of transitions-in-the-making (specific projects) in a set of selected European cities and regions, and analyse case studies related to the power system, transport, household energy use, food production and consumption and bio-energy. Information from these studies will be used to also update the transition pathways at the macro-level. The main outputs will be concepts (transition pathways) and methods to assess progress towards desired sustainability transitions, based on a well-founded knowledge base.


Grant
Agency: GTR | Branch: EPSRC | Program: | Phase: Research Grant | Award Amount: 294.01K | Year: 2015

Computational Discrete Mathematics applied computers to a number of areas within pure mathematics, including abstract algebra, combinatorics and number theory and their applications in, for instance, cryptography, network routing, experimental design and others. Although less visible than the use of numerical methods in solving continuous problems such as differential equations, computation in discrete mathematics has an equally long history. The project is aimed at the community-building activities centred around the two main open-source software systems, GAP and Sage. GAP (www.gap-system.org) is a 25 year old software package widely used for computations in important areas of pure mathematics, especially in abstract algebra, the mathematics of structure and symmetry. The Sage project is a free open-source general mathematics software system, started in 2005 with the ambitious aim of providing an open-source alternative to such well-established closed systems. Sage builds on the Python and incorporates dozens of open-source mathematical packages, in particular GAP, Singular, PARI/GP and others. GAP and Sage both have quite well established user communities in the UK and internationally. However these communities are limited in a two ways, which the CCP is designed to address. Firstly they are limited by discipline -- while finite group theorists are well aware of GAP, for instance, few physicists or computer scientists are; while Sage is well known in number theory research, it is still not much used in the UK for mixed symbolic-numeric work; etc. Secondly the level of involvement of users is limited. Users need support to become programmers; programmers to become package authors and package authors to become contributors to the core system and all need support to best use parallel programming. The proposed software management and user support activity underpins the whole project. The CCP will provide baseline support in these areas which will have a direct impact on GAPs sustainability. It will support the rollout of its next mainstream version, GAP 5, which supports shared memory parallelism, and will facilitate the transition to GAP 5 in the user and developer communities. For the Sage system, of which GAP is an essential component, the CCP funding will facilitate tighter Sage-GAP integration, in particular regarding memory management and parallelisation, and incorporating into Sage as many GAP packages as possible; the latter currently is done on an ad hoc basis, is hard to maintain and error-prone. Last but not the least, closer GAP-Sage collaboration will allow GAP to learn from the newer Sage project which has been very successful in using modern tools and software development workflows and in being exceptionally welcoming to new developers.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2011.3.1.9-1 | Award Amount: 4.77M | Year: 2012

Within the FP7 PEOPLE project (Blue4Glue), Fraunhofer Institute (IFAM) and Procter and Gamble discovered a (PPO based) enzymatic process used by marine-organisms, which produce polymers in a much simpler way (less process steps) than industry does in classical chemistry. BIO-MIMETIC aims to transfer this new scientific knowledge into a blueprint for a novel (pre-)industrial enzymatic-based bio-polymerization process. It involves research partners (IFAM and UNITOV) with experience in enzymatic transformation and bio-based synthetic polymers, as well as expert SMEs such as Dyadic (enzymes), CIMV (biomass transformation into bio-chemistry) and CULGI (computational modeling of bio-chemical processes) to develop the process that firstly transforms biomass (lignin) into new bio-based polymers (pseudo peptides). These will used to create respectively: 1) Bioconjugated copolymers, that will be tested in detergents (by P&G) 2) Bio-cross-linked adhesive gels, to be experimented in antiageing cosmetics and in bio-textiles preparation (by an SME cosmetic producer MAVI). Potential environmental benefits are over 124 kton/yr less toxic solvents to produce chemicals, over 1 Billion kWh of energy savings (room temperature process) and a drastically reduced CO2 footprint i.e. replace 8000 Mtons of petrochemical based deposition aides and in the future substitute a large amount of phenol and phenolic derivatives, which are used to produce chemical intermediates for a myriad of applications. BIO-MIMETIC will carry out LCA and LCC (cost) assessments over the value chain as input to business plan and will use a new SME LCA tool (cCALC) to develop an LCA showcase, which will come available for SMEs. The cCALC tool and showcase will be freely downloadable as part of the exploitation plan targeted at the market uptake of project results in the emerging European market of bio-based products, projected to grow towards 250 billion Euro by 2020.


Grant
Agency: Cordis | Branch: FP7 | Program: ERC-CG | Phase: ERC-CG-2013-PE10 | Award Amount: 1.96M | Year: 2014

With an average toll of 80.000 deaths per year over the last decade, earthquakes remain one of the most dreadful geohazards. The advancement of earthquake risk assessment and forecasting methods (probability estimates that a mainshock may occur in terms of hypocentre location, magnitude and time) calls for a sound physical basis. The nucleation, propagation and arrest of an earthquake rupture results from the interplay of stress perturbations, micro- to macro-scale friction- and rupture-related processes and fault zone geometrical complexity. Most of the information about these parameters is out of reach of seismic waves and geophysical analysis. Here we aim at enhancing our knowledge of earthquake physics (from nucleation to arrest) by means of a multidisciplinary approach that includes: 1) experiments to investigate earthquake nucleation by reproducing crustal (pressure, temperature, presence of fluids, stress perturbations, etc.) deformation conditions with the most powerful earthquake simulator installed worldwide (SHIVA); 2) experiments to investigate rupture propagation on simulated faults using natural rocks and small-scale analogue models; 3) field studies of exhumed seismogenic sources to quantify the geometrical complexity of natural fault zones; 4) advanced numerical simulation techniques that will integrate the above information and allow up-scaling to natural faults. The numerical models will produce physically-based earthquake simulations that will be compared with high-resolution seismic data. By reproducing crustal deformation conditions (stress, temperature, fluid pressures, etc.) in the laboratory and by monitoring acoustic emissions, gases, electromagnetic waves, etc., produced by the rock samples during deformation, a by-product of our research will be the systematic investigation of precursory phenomena (seismic, chemical, and electromagnetic) associated to earthquake nucleation processes.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-CSA | Phase: Fission-2012-4.2.1 | Award Amount: 5.40M | Year: 2013

Safety issues are of fundamental importance for the acceptance and sustainable application of nuclear energy. Actinides play a central role in the nuclear fuel cycle from mining, fuel fabrication, energy production, up to treatment of used fuel by reprocessing, partitioning and transmutation and/or finally management and disposal of radioactive waste. A fundamental understanding of actinide properties and behaviour in fuel materials, during the separation processes and once in geological repository is an imperative prerequisite to tackle all the related safety issues. Unravelling the complexity of the principal actinide components of used nuclear fuel certainly represents one of the grand challenges in nuclear science. In order to meet the needs of the safe and sustainable management of nuclear energy, it is therefore essential to maintain highest level of expertise in actinide sciences in Europe and to prepare the next generation of scientists and engineers who will contribute to develop safe actinide management strategies. Because actinides are radioactive elements, their study requires specific tools and facilities that are only available to a limited extent in Europe. Only a few academic and research organisations have the capabilities and licenses to work on these elements under safe conditions. It is therefore strategic to coordinate the existing actinide infrastructures in Europe, and to strengthen the community of European scientists working on actinides. In the continuation of ACTINET-6 and ACTINET-I3, TALISMAN will foster the networking between existing European infrastructures in actinide sciences open them widely to any European scientists by offering and supporting transnational access to unique facilities. To meet its objectives, TALISMAN will animate and organize a network of actinide facilities across the EU that will increase our knowledge for a safer management of actinides fostering training and education.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2012.3.2-1 | Award Amount: 3.76M | Year: 2012

The proposed research responds to the call for research into the Quality, Efficiency and Solidarity of Health Systems. European countries are reforming their health systems to improve health care delivery. One of the ways they are doing this is by changing skill mix within teams delivering health services: extending the roles of existing health professions and introducing new ones. This project will undertake a systematic evaluation of the impact of these new professional roles on practice, outcomes and costs in a range of different health care settings within European Union and Associate Countries. It will detail the nature, scope and contribution of the new professional roles, evaluate their impact on clinical practice and outcomes, and identify their scope to improve the integration of care. It will conduct economic evaluation to identify the cost effectiveness of the new professional roles, identify optimal models for delivery of health care and the consequences of these for management of human resources and workforce planning. Study design is cross-sectional and multi-level. A mixed methods approach will combine analysis of routinely collected data and primary data generated through interviews and questionnaires to health professionals, managers and patients. Data analysis will employ multi-level modelling techniques.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.04M | Year: 2013

Nanomedicine offers capability to significantly change the course of treatment for life-threatening diseases. Many of the most significant current therapeutic targets, to be viable in practice, require the efficient crossing of at least one biological barrier. However, the efficient and controlled crossing of the undamaged barrier is difficult. The range of small molecules that can successfully do so (via diffusive or other non-specific processes) is limited in size and physiochemical properties, greatly restricting the therapeutic strategies that may be applied. In practice, after several decades of limited success, there is a broad consensus that new multi-disciplinary, multi-sectoral strategies are required. Key needs include detailed design and understanding of the bionano-interafce, re-assessment of in vitro models used to assess transport across barriers, and building regulatory considerations into the design phase of nanocarriers. The overarching premises of the PathChooser ITN are that (i) significant advances can only be made by a more detailed mechanistic understanding of key fundamental endocytotic, transcytotic, and other cellular processes, especially biological barrier crossing; (ii) elucidating the Mode of Action / mechanism of successful delivery systems (beyond current level) will ensure more rapid regulatory and general acceptance of such medicines. Paramount in this is the design and characterization of the in situ interface between the carrier system and the uptake and signalling machinery. (iii) inter-disciplinary knowledge from a range of scientific disciplines is required to launch a genuine attack on the therapeutic challenge. The PathChooser ITN program of research and training will equip the next generation of translational scientists with the tools to develop therapies for a range of currently intractable (e.g. hidden in the brain) and economically unviable diseases (e.g. orphan diseases affecting a limited population).


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-SA | Phase: AAT.2013.7-7. | Award Amount: 534.35K | Year: 2013

As mentioned in the Executive Summary of the Strategic Research & Innovation Agenda, Aviation has an important role to play in reducing greenhouse gas emissions as well as noise and local air quality issues. The continuous increase of air passenger transport generates an increasing use of hydrocarbon fuel with excessive emission of CO2 and NOX (greenhouse gases, pollutants and noise). It is well known that commercial aircraft operations impact the atmosphere by the emissions of greenhouse gases and greenhouse gas precursors, and also through the formation of contrails and cirrus clouds. In 2011, during the Aerodays in Madrid, the EC launched the future of Aeronautics in the ACARE Flight Path 2050 Vision for the Aircraft report containing the ambitious goals on the environmental impact with 90% reduction in NOx emissions, 75% reduction in CO2 emissions per passenger kilometer, and the reduction of the noise in by 65%, all relative to year 2000. To achieve the ACARE Strategic Research & Innovation Agenda green aeronautics technologies will play a more and more dominant role in mastering the challenge on Protecting the environment and the energy supply. GRAIN2 Supported Action, based on the same collaborative and win-win spirit introduced in former EU-China GRAIN project, will provide inputs and roadmaps for the development of large scale simulation strategies for greener technologies to meet the above future requirements on emissions, fuel consumption and noise. To reach these targets, green technologies efforts will have to be collected and prospected in three major lines: Air vehicle, Air Transport System and Sustainable Energies. Three folds to be investigated as future greening technologies: 1) Greening the aircraft and the aero engine 2) Greening the operational environment 3) Reducing the carbon foot print of aviation via sustainable alternative fuels


Grant
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.3.3-04 | Award Amount: 7.41M | Year: 2013

Currently the aerobic bio-catalytic oxidation reaction is the one that would have the biggest impact on the future uptake of industrial biotechnology in Europe. Chemical oxidation is both hazardous and has high environment impacts. Many oxidative bio-catalytic reactions and transformations have been identified in academic laboratories but only a very small number have been applied by industry to oxidize non-natural substrates. Hence biocatalysis for oxidative chemical manufacture processes can deliver a major advantage to the European chemical-using industries and the environment. In this project we intend to develop the tools for implementation of bio-oxidation to synthesize and oxidize alcohols. Cytochrome P450 enzymes will be investigated for hydroxylation of fatty acid derivatives and terpenes which have potential to be used in biopolymers and fragrance chemicals respectively form one line of investigation. The second is the selective oxidation of primary alcohols to give products with added value in their own right and as intermediates towards other valuable products. To support the implementation culture collections and literature reported DNA sequences will be used to identify diverse enzymes with predicted oxidase activities, which will be used as starting point for an enzyme improvement program. Then fermentation and enzyme formulation techniques will improve reaction performance to a level where useful quantities of target products can be produced for evaluation by industrial partners, and engineering techniques will analyse and implement reactor configurations that will further improve this technology platform to enable this technology to be introduced as a routine technology in the IB industry and support the European KBBE. Further a dynamic public engagement and dissemination program will be used to promote the project, IB and the FP7 program within the science community and the public, especially schoolchildren, to create extra value for the funders.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: LCE-07-2014 | Award Amount: 14.03M | Year: 2015

NOBEL GRID will develop, deploy and evaluate advanced tools and ICT services for energy DSOs cooperatives and medium-size retailers, enabling active consumers involvement i.e. new demand response schemas and flexibility of the market i.e. new business models for aggregators and ESCOs. Through the dual-use of telecommunication networks, and validating the integration of renewable generation presence and demand response systems, NOBEL GRID will offer advanced services to all actors in the retail markets of the electricity system in order to ensure that all consumers will benefit from cheaper prices, more secure and stable grids and low carbon electricity supply. The project results will be demonstrated and validated in real world environments with active involvement of all the actors, and based on the new business models defined during the project.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.42M | Year: 2013

Even in the simplest cells, the integration of proteins into a biological membrane is a complex process that is frequently coupled to ribosomal protein synthesis, and requires the coordinated actions of several additional cellular machines. The de novo recapitulation of such a complex process is well beyond the scope of our current technical abilities. Indeed, the techniques that are used to create novel proteoliposomes, for drug delivery, and artificial membranes, for synthetic biology, are extremely crude. A common approach is to mix detergent solubilised proteins with lipids, and then remove the detergent to form proteoliposomes, a process that is inefficient and difficult to control. Another major limitation of this approach is our inability to alter the protein complement of the resulting phospholipid-bilayers once they are formed. It is precisely this issue that our consortium will address, by creating a flexible and ubiquitous platform that is ideally suited to incorporating proteins into preformed liposomes. To achieve this novel and innovative breakthrough in liposome technology, we will harness the unusual ability of tail-anchored proteins to be inserted into pre-existing membranes. This technique will enable the production of customised liposomes that can be tailored to optimise drug delivery, and allow the creation of multifunctional artificial membranes for the newly emerging field of synthetic biology. The overriding ethos of our network is to develop a robust platform for the application and exploitation of tail-anchored membrane proteins based on a framework that develops and enhances fundamental insight and training in this new field of research.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: LCE-02-2015 | Award Amount: 4.56M | Year: 2016

The main objective of the SOLPART project is to develop, at pilot scale, a high temperature (950C) 24h/day solar process suitable for particle treatment in energy intensive industries (e.g. cement or lime industries). The project aims at supplying totally or partially the thermal energy requirement for CaCO3 calcination by high temperature solar heat thus reducing the life cycle environmental impacts of the process and increasing the attractiveness of renewable heating technologies in process industries. This will be achieved by the demonstration of a pilot scale solar reactor suitable for calcium carbonate decomposition (Calcination reaction: CaCO3 = CaO \ CO2) and to simulate at prototype scale a 24h/day industrial process (TRL 4-5) thereby requiring a high-temperature transport and storage system. The system will operate at 950C and will include a 30 kWth solar reactor producing 30 kg/h CaO and a 16h hot CaO storage. Life cycle environmental impacts of the solar-based solution in comparison with standard processes will be developed as well as economic evaluation. The project develops and merges three advanced technologies: high temperature solar reactor, transport of high-temperature solid materials and high temperature thermal storage. The synergy between these technologies lies in using the solar-treated particles as storage medium. The development of a such innovative technology for continuous particle processed by concentrated solar energy at about 950C is unique in the world. Thanks to the solar unit integration in the industrial process (potentially combined with CO2 capture), this should result in the considerable reduction of the carbon footprint of the CO2 emitter industries and open a new market for renewable energies.


Grant
Agency: GTR | Branch: EPSRC | Program: | Phase: Research Grant | Award Amount: 438.49K | Year: 2015

The isolation of single-atomic layer graphene has led to a surge of interest in other layered crystals with strong in-plane bonds and weak, van der Waals-like, interlayer coupling. A variety of two-dimensional (2D) crystals have been investigated, including large band gap insulators and semiconductors with smaller band gaps such as transition metal dichalcogenides. Interest in these systems is motivated partly by the need to combine them with graphene to create field effect transistors with high on-off switching ratios. More importantly, heterostructures made by stacking different 2D crystals on top of each other provide a platform for creating new artificial crystals with potential for discoveries and applications. The possibility of making van der Waals heterostructures has been demonstrated experimentally only for a few 2D crystals. However, some of the currently available 2D layers are unstable under ambient conditions, and those that are stable offer only limited functionalities, i.e. low carrier mobility, weak optical emission/absorption, band gaps that cannot be tuned, etc. In a recent series of pilot experiments, we have demonstrated that nanoflakes of the III-VI layer compound, InSe, with thickness between 5 and 20 nanometers, have a thickness-tuneable direct energy gap and a sufficiently high chemical stability to allow us to combine them with graphene and related layer compounds to make heterostructures with novel electrical and optical properties. The main goal of this project is to develop graphene-hybrid heterostructures based on this novel class of two-dimensional (2D) III-VI van der Waals crystals. This group of semiconductors will enrich the current library of 2D crystals by overcoming limitations of currently available 2D layers and by offering a versatile range of electronic and optical properties. From the growth and fabrication of new systems to the demonstration of prototype devices, including vertical tunnel transistors and optical-enhanced-microcavity LEDs, our project will provide a platform for scientific investigations and will contribute to the technology push required to create new routes to device miniaturization, fast-electronics, sensing and photonics. There is great potential for further growth of all these sectors as the fabrication of 2D systems improves and as new properties are discovered and implemented in functional devices.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.93M | Year: 2015

The aim of the project Euro-Sequences is to establish a multidisciplinary training network on the emerging topic of sequence-controlled polymers. It has been shown during the last 5 years that such polymers open up unprecedented options for the future of manmade materials. Indeed, similarly to biopolymers such as DNA and proteins, synthetic sequence-controlled polymers contain precisely engineered chain-microstructures that allow a fine control over their molecular, nanoscopic and macroscopic properties. For instance, these new types of polymers are relevant for applications in molecular data storage, catalysis, and nanomedicine. However, this field of research is young and therefore, fundamental and applied research is still mandatory. Thus, it seems timely and appropriate to federate top-European researchers working on that topic. The proposed network is composed of 7 academic partners and 2 companies and connects researchers with complementary expertise in areas such as organic chemistry, polymer synthesis, supramolecular chemistry, physico-chemistry and materials science. This multidisciplinary network will focus on different scientific aspects. A first important objective will be the development of facile and rapid chemical methods for writing molecular information on polymers. In addition, analytical techniques that allow characterization and sequencing of polymers will be studied. The folding and self-assembly of sequence-controlled polymers will be also examined in order to understand the correlation between controlled primary structure and higher levels of organization. Eventually, a crucial aim of this project will be the conception of new types of plastics materials. This network will be a unique scientific environment for training PhDs. The students will conduct their research in top-European laboratories and will receive a complete training, including lectures and summer schools, on polymer chemistry, supramolecular chemistry and biomaterials.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EINFRA-5-2015 | Award Amount: 4.78M | Year: 2015

Life Science research has become increasingly digital, and this development is accelerating rapidly. Biomolecular modelling techniques such as homology modelling, docking, and molecular simulation have advanced tremendously due to world-leading European research, resulting in extreme demands for better computational performance and throughput as these tools are used in applied research and industrial development. This research has direct influence on our daily life in areas such as health and medical applications, the development of new drugs, efficient drug delivery, biotechnology, environment, agriculture and food industry. Life Science is one of the largest and fastest growing communities in need of high-end computing, and it is a critically important industrial sector for Europe. However, compared to some other disciplines, the use of e-Infrastructure is still relatively new - many advanced techniques are not applied commercially due to limited experience. It requires significant support to: Make e-Infrastructure useable by researchers who are not computing experts, Improve the performance and applicability of key life science applications, Handle large amounts of data in computational workflows. BioExcel proposes to tackle these challenges by establishing a dedicated CoE for Biomolecular Research, covering structural and functional studies of the building blocks of living organisms - proteins, DNA, saccharides, membranes, solvents and small molecules like drug compounds - all areas where with large academic and industrial users bases in Europe. Specifically, BioExcel will Improve the efficiency and scalability of important software packages for biomolecular research; Improve the usability of ICT technologies for biomolecular researchers in academia and industry; Promote best practices and train end users in making good use of both software and e-Infrastructure; Develop appropriate governance structures and business plans for a sustainable CoE.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2011.8.1-2 | Award Amount: 7.37M | Year: 2012

The overall objective of EFENIS is to facilitate and accelerate a move to low carbon manufacturing processes and site management by deployment and demonstration of innovative energy management systems and enabling efficiency technologies, which extend the scope of energy management outside the boundaries of a single plant to total site and then beyond the total site to district heating/cooling systems. The potential is demonstrated across a selection of the EUs most energy-intensive sectors thereby enabling integration across industries and processes while at the same time ensuring wide-spread deployment post-project. The EFENIS project will significantly advance the state-of-the-art with regards to site optimisation and Energy Management Systems. Currently, no deployed solution with a similar holistic scope exists. The major novelty of the project will be the creation of the foundation required for comprehensive, high-impact industrial deployment of energy systems based on Total Site Integration approach in the target industries and subsequent commercial exploitation. The project is focused on allowing integration of the developed technologies and solutions to both new designs and as retrofits to existing sites to ensure fast, widespread and cost-efficient industrial deployment. Until now, both technical and non-technical barriers have prevented the exploitation of this potential.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: NFRP-06-2014 | Award Amount: 4.71M | Year: 2015

The multidisciplinary project will address key technical issues that must be tackled to support the implementation of planned geological disposal projects for higher-level radioactive wastes across the EU. Our current understanding of the impact of microbial metabolism on the safety of geological repositories remains tenuous, even though microorganisms may have controlling influences on wasteform evolution in situ, multibarrier integrity and ultimately radionuclide migration from the repository. This proposal targets a number of high urgency and high importance topics identified in the most recent IGD-TP Strategic Research Agenda, focusing specifically on the influence of microbial processes on waste forms and their behavior, and the technical feasibility and long-term performance of repository components. The project will bring together, for the first time, 15 European groups working on the impact of microbial processes on safety cases for geological repositories across the EU, focusing on key questions posed by waste management organisations. The emphasis will be on quantifying specific measureable impacts of microbial activity on safety cases under repository-relevant conditions, thus altering the current view of microbes in repositories and leading to significant refinements of safety case models currently being implemented to evaluate the long-term evolution of radwaste repositories. The integration of society and policy oriented studies in the project will also extend the impact of the project outside the scientific and technical domain, while a study of expert conceptualization, public perception and risk communication concerning microbial influences in geological disposal, will improve awareness of microbial issues on a broader level. The programme will help the EU claim international leadership in the understanding of the impact of microbial processes on geodisposal, and indeed other technological areas pertinent to the exploitation of the subsurface.


Jayson G.C.,University of Manchester | Kohn E.C.,U.S. National Cancer Institute | Kitchener H.C.,University of Manchester | Ledermann J.A.,University College London
The Lancet | Year: 2014

Epithelial ovarian cancer is the commonest cause of gynaecological cancer-associated death. The disease typically presents in postmenopausal women, with a few months of abdominal pain and distension. Most women have advanced disease (International Federation of Gynecology and Obstetrics [FIGO] stage III), for which the standard of care remains surgery and platinum-based cytotoxic chemotherapy. Although this treatment can be curative for most patients with early stage disease, most women with advanced disease will develop many episodes of recurrent disease with progressively shorter disease-free intervals. These episodes culminate in chemoresistance and ultimately bowel obstruction, the most frequent cause of death. For women whose disease continues to respond to platinum-based drugs, the disease can often be controlled for 5 years or more. Targeted treatments such as antiangiogenic drugs or poly (ADP-ribose) polymerase inhibitors offer potential for improved survival. The efficacy of screening, designed to detect the disease at an earlier and curable stage remains unproven, with key results expected in 2015. © 2014 Elsevier Ltd.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2011.2.2.2-1 | Award Amount: 13.07M | Year: 2012

As the European population is ageing rapidly, the growing number of seniors with age-related chronic diseases poses a challenge on European societies and health care systems. Therapeutic interventions that are effective, affordable and well-tolerated in the prevention of chronic disease are urgently needed and will have an outstanding impact on public health as a whole. Among the most promising interventions that meet these requirements are vitamin D, marine omega-3 fatty acids and physical exercise. However, their individual and combined effects have yet to be confirmed in a clinical trial. The DO-HEALTH will close this knowledge gap in a large 3-year multi-centre clinical trial that will establish long-term efficacy and safety data for the 3 interventions in the prevention of age-related diseases in seniors. The DO-HEALTH trial will enrol 2152 community-dwelling men and women aged 70 and older, when chronic diseases increase substantially. The randomized-controlled trial will test the individual and the combined benefit of 2000 IU vitamin D/day, 1 g of omega-3 fatty acids/day and a simple home exercise program in an efficient factorial trial design. DO-HEALTH will establish evidence in 5 primary endpoints: the risk of incident non-vertebral fractures; the risk of functional decline; the risk of blood pressure increase; the risk of cognitive decline; and the rate of any infection. Key secondary endpoints include risk of hip fracture, rate of falls, pain in symptomatic knee osteoarthritis, glucose tolerance, gastro-intestinal symptoms, mental and oral health, quality of life, and mortality. Follow-up will be in-person, in 3-monthly intervals (4 clinical visits and 9 phone calls). DO-HEALTH will further assess the comparative effectiveness of the interventions by evaluating reasons why or why not seniors adhere to them, and will assess their cost-benefit in a health economic model based on documented health care utilization and observed incidence of chronic disease.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA | Phase: ICT-2013.9.1 | Award Amount: 1.34M | Year: 2013

Young researchers working in future and emerging technologies (FET) are critical to the success of strategically important areas of science and technology in Europe. However, to realise their full potential as individuals and as a collective resource, they need to optimise their capacity and capability to generate and realise breakthrough ideas and research. The aim of the EYE project is to build a lasting European community of high potential young researchers (YRs) that are able to generate radical new ideas and build research collaborations in interdisciplinary areas, EYE will help them to develop their research potential and their ability to develop new curricula for FET. Specifically, EYE focuses on (a) S&T ideas of higher risk nature that can be generated through ideation and brainstorming and (b) collaboration between YRs across various disciplines and from different parts of Europe, and (c) on the YRs themselves, by developing their leadership potential through networking and training in the specific methods used in European collaborative projects.\nEYE will achieve its goal by implementing an integrated programme of complementary regional and European events:\n(a) Lab Surfing workshops in 6 regions of Europe that inform YRs about the most advanced FET research across various disciplines, brainstorm future paradigms and enhance YRs scientific administration skills;\n(b) Europe-wide Blue Sky Conferences for YRs in 38 countries in Europe (EU members states and selected countries associated with FP7) to enable further consolidation of ideas at a European level and wider networking with academia, industry and policy makers;\n(c) Science Incubator Summer Schools to assist selected YRs in bringing their ideas to a position where they might form the basis of future FET project proposals.\nEYE will conduct two rounds of these events over 2 years in order to reach a wider group of YRs in Europe and to ensure the sustainability of the EYE action after the end of the project. The EYE activities are supported with an online platform (NOVA-Networking for Outstanding Visionaries & Academics) which serves as an operational tool to prepare the events and as a professional platform for ideation, networking, collaboration and discussion amongst YRs.\nThe projects thematic scope is broadly defined by 9 multidisciplinary research areas identified in the recent public consultation on future FET, as well as Horizon 2020 societal challenges. In particular, EYE will seek areas where Information and Communication Technologies (ICT) can bring new interdisciplinary research opportunities and will support both curiosity- and agenda-driven research. The project brings together a broad representation of the multidisciplinary research community in Europe with 11 participants from 9 countries including 7 universities, 2 strong research institutions, and 2 SMEs.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENV.2013.6.3-1;ENV.2013.6.2-3 | Award Amount: 4.48M | Year: 2014

Every year, more than 50 million vehicles reach the end of their service life throughout the World. In the EU, the amount of waste generated by the automotive industry raised up to 10 million tonnes in 2010, and it is foreseen that it will increase by 40% until 2015. Thus, the appropriate recycling of this waste has important implications from the environmental point of view. About 8% of the total weight in the automotive shredder corresponds to non-ferrous metals, which is often processed by Heavy Media Separation, and handsorting. Vision systems can be used to separate metals based on their colour. However this requires thermal and chemical etching treatments of the shredder to remove coatings, and to induce surface colour modifications, resulting in substantial operational costs, higher energy and water consumption and associated waste and GHG emissions. Moreover, none of current sorting technologies is still able to successfully sort the light fraction of the metals (Al and Mg) into individual alloys, which consequently must be downgraded to produce cast aluminium. In the next years, unless new technologies enable the recovery of Al in the form of wrought alloys (cradle-to-cradle approach), secondary Al will not be completely absorbed by the market, and the production of primary Al will increase by 25%. This represents a major environmental concern due to the much higher energy and emissions of primary production process. This project aims at developing a new dry sorting technology for non-ferrous automotive shredder. First, shredder will be separated into different metals, based on their conductivity. To this end, a new electromagnetic sensing technique combined with a vision system will be used. In a next step, the light fraction (Al and Mg alloys, with overlapping conductivities), will be alloy-sorted using LIBS. A novel LIBS system design is proposed, enabling upscaling the sorting throughput by one order of magnitude with respect to existing systems.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: AAT.2013.4-2.;AAT.2013.1-1. | Award Amount: 1.31M | Year: 2013

The aeronautical industry lacks confidence in the accuracy of computational fluid dynamics (CFD) in areas of highly non-linear, unsteady flows close to the flight envelope borders, which demands advanced approaches and methods. The family of Hybrid RANS-LES Methods (HRLM) is the best candidate for the next generation of CFD methods for increased fidelity at industrially-feasible expense. While HRLM have been proven to perform considerably better than conventional (U)RANS approaches in situations with strong or massive flow separation, they are hampered by the Grey Area issue once they have to deal with thin separation regions and where shear layer instabilities are weaker. As exactly these areas are of high importance for aircraft performance (lift, loads) the acceptance of HRLM strongly depends on the ability to mitigate the extent of the Grey Area (GA). With the new/advanced Grey Area mitigation approaches, the Go4Hybrid project offers hybrid RANS-LES methods that improve predictive capability with increased flexibility and reduced user decision load. Hence, the incentive for future use of these highly sophisticated methods goes in line with a considerably high impact: Progress beyond the state-of-the-art for non-zonal methods is achieved by the development and demonstration of generally-applicable extensions to mitigate the Grey Area problem, thereby extending their applicability to important industrial flows at the performance frontiers. For embedded methods, a focus will be placed on improving methods so that they are applicable to arbitrary complex geometries, as opposed to many existing techniques that require e.g. canonical boundary layer assumptions or homogeneous flow directions and are hence fundamentally less flexible. In general, development work will pursue a number of key goals contributing to extended applicability, improved accuracy, increased flexibility, reduced user decision load and increased Technology Readiness Level of hybrid approaches.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: GARRI-2-2015 | Award Amount: 1.52M | Year: 2016

The aim of SMART-map is to connect a wide range of industrial players with actors from research and civil society organisations and establish innovative formats of collaboration to jointly discuss, define and implement concrete roadmaps (SMART Maps) for the responsible development of technologies and services in three key time-changing fields. Based on the Societal Challenges of Horizon2020, SMART-map will address the areas of precision medicine, 3D printing in the biomedical field, and synthetic biology. On each of these areas we will pair two regions of Europe, on the north/south and east/west axes, and the unique partnership will enable a comparative assessment of these innovation fields. On each theme, SMART-map will deliver an implementation plan, to be demonstrated, tested and assessed. SMART-map will build on the results of the FP7 ResAGorA project, adapted and integrated with other RRI and social responsibility frameworks (i.e. CSR). The project will reach its ambitious goals by developing a new format for open and collaborative dialogues between industry and societal actors (Industrial Dialogues) which will allow the co-design of concrete roadmaps. We will organise two Dialogues per theme in each of the two regions identified, and pilot the roadmap in one industry per theme. The project has already gathered a vast network of industrial players and stakeholders interested in participating, in giving inputs to the roadmaps implementation and in discussing the outcomes. A uniquely designed Advisory Board, composed of RRI experts (SMART-map RRI Angels) and society representatives (Societal Watchdog), will ensure the dimensions of RRI to be included in all activities, as well as the increase of social value and acceptability of innovation produced with this approach. SMART-map will deliver practical evidence of the benefits for industry in using the SMART Maps, and highlight opportunities for new business models embedding social responsibility.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.3.0-1;HEALTH.2013.1.3-4 | Award Amount: 7.80M | Year: 2013

Although vaccination is the cornerstone of prophylaxis, current vaccines provide only moderate protection. Most employ inactivated or protein-based, including multimeric antigen, vaccines requiring annual updating. Their limited antigen loads provide limited capacity for inducing robust immune defences, without assurance that both humoral and cell mediated (CMI) responses, as well as durable immunity, will be induced. Replicating vaccines may provide several rounds of antigen production, increasing potential for humoral and CMI defence induction. Neither live, attenuated nor vector vaccines can be produced synthetically, being reliant on cell culture or egg production. They cannot be targeted to immune cells; interference from pre-existing immunity is also a risk. Efficacious, synthetic vaccines would be the answer, as seen with self-replicating RNA replicon (RepRNA) technology these replicate and translate without producing infectious progeny. RepRNA produced in vitro is combined with synthetic delivery vehicles targeting dendritic cell (DC) receptors essential for efficient immune defences with glycoconjugate ligands. The UniVax project promotes the first synergising of approaches with synthetic targeted delivery systems for RepRNA. The innovation integrates technologies of (i) RepRNA vaccines, (ii) lipoplexes (biodegradable lipid/adjuvant/RNA for cytosolic delivery), (iii) polyplexes (biodegradable, polysaccharide vehicles), (iv) glycoconjugates targeting DC receptors, (v) adjuvants with well-defined molecular targets and effector functions. This promotes efficacious mucosal and systemic responses, ensuring for the first time both humoral and CMI responses. Components developed in PANFLUVAC and Replixcel projects allow UniVax to create the first Universal Flu vaccine prototypes. This innovative approach creates the first synthetic vaccine of its kind, promoting consortium SMEs to a unique position of world leaders.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ICT-2013.6.4 | Award Amount: 5.79M | Year: 2013

ICT is recognized as being a key player against climate change: pervasive sensors and actuators can efficiently control the whole energy chain (Smart Thermal/Electricity Grid). On the other side, advances on 3D modeling, visualization and interaction technologies enable user profiling and real-time feedback to promote energy efficient behaviors. To unlock the potentiality of these technologies, the DIMMER project\nfocuses on:\n-\tInteroperability of district energy production/consumption, environmental conditions and user feedback data;\n-\tExploitation of effective visual and web-based interfaces to provide pervasive and real-time feedback about energy impact of user behaviors;\n-\tIntegration of Building Information Models (BIM) with real-time data and their extension at the district level (DIM);\n-\tNew business models for energy traders and prosumers exploiting user energy profiling.\nThe DIMMER system integrates BIM and district level 3D models with real-time data from sensors and user feedback to analyze and correlate buildings utilization and provide real-time feedback about energy-related behaviors. It allows open access with personal devices and Augmented Reality (A/R) visualization of energy-related information to client applications for energy and cost-analysis, tariff planning and evaluation, failure identification and maintenance, energy information sharing. All the following technologies are included: Real-time data collection; Advanced middleware technology for data integration; Simulation and virtual visualization; User/social profiling, visualization and feedback; Energy efficiency and cost analysis engine; Web interface and interaction.\nIn order to validate the DIMMER innovative system, both public (university campuses, schools) and private buildings included in mixed-up (mixit) urban districts are considered in two different cities, in the North and South Europe, Turin (IT) and Manchester (UK). As most energy usage of buildings throughout their life cycle is during the operational stage (~80%), the project gives special attention to existing and historical buildings.\nIn conclusion, the expected results are a consistent reduction in both energy consume and CO2 emissions by enabling a more efficient energy distribution policies, according to the real characteristics of district buildings and inhabitants as well as a more efficient utilization and maintenance of the energy distribution network, based on social behavior and users attitudes and demand.


Grant
Agency: Cordis | Branch: FP7 | Program: ERC-SG | Phase: ERC-SG-LS7 | Award Amount: 1.50M | Year: 2014

Direct comparisons of risk factor profiles for different forms of self-destructive, hazardous and violent behaviour in young people have rarely been made in the same study cohort. This maintains a possibly erroneous assumption that these behaviours have distinct aetiologies. These outcomes may represent different aspects of the same complex underlying aetiology, rather than being disjunctive phenomena. I shall collaborate with Professor Preben Mortensen and colleagues at the world renowned National Centre for Register-based Research (NCRR), University of Aarhus, Denmark to identify risk factors that are common across a set of poor outcomes in young people, and also those that are specific to particular outcomes. Among all Danish singleton births during 1980-1996, in a national cohort of over a million young persons, we will assess a comprehensive range of potential individual-level and familial risk factors for attempted and completed suicide, violent offending, and serious accidental injury and death. This cohort has complete ascertainment and follow-up at 15-29 years of age until 31st December 2011. My research team and I will utilise an exceptional array of interlinked registers. As well as conducting nested epidemiological studies based on rigorous and representative population-based sampling procedures, we shall also conduct sibling-comparison studies with the aim of identifying stronger indications of causality. My research topic is of considerable importance to countries across Europe and throughout the world. It is of particular relevance given the prevailing context of enduring macro economic stagnation, and the specific challenges that this milieu presents for young people as they approach maturity facing an uncertain future. I expect to generate novel findings that will inform clinicians and service planners across a wide range of healthcare specialties, as well as the social services, the police and emergency services, and other relevant public agencies.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: MG-1.10-2015 | Award Amount: 1.89M | Year: 2016

Composites are important materials used in aircrafts due to their excellent mechanical properties combined with relatively low weight enabling the reduction of fuel consumption. Expensive carbon fibre reinforced plastics (CFRP) are used in fuselage and wing structures and increasingly replace classic metals. Glass fibre reinforced plastics (GFRP) are mainly used for the interior panels. All these composite materials used in aviation have one thing in common: they are man-made. Renewable materials like bio-fibres and bio-resins are under investigation for a long time for composites but they did not made it into modern aircraft yet. The project ECO-COMPASS aims to bundle the knowledge of research in China and Europe to develop ecological improved composites for the use in aircraft secondary structures and interior. Therefore bio-based reinforcements, resins and sandwich cores will be developed and optimized for their application in aviation. Furthermore the use of recycled man-made fibres to increase the mechanical strength and multifunctional aspects of bio-composites will be evaluated. To withstand the special stress in aviation environment, protection technologies to mitigate the risks of fire, lightning and moisture uptake will be investigated. An adapted modelling and simulation will enable the optimization of the composite design. Electrical conductive composites for electromagnetic interference shielding and lightning strike protection will be investigated as well. A cradle to grave Life Cycle Assessment (LCA) will be carried out to compare the new eco-composites with the state-of-the-art materials. 8 European partners will be involved in ECO-COMPASS. The duration of the project is three years.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: EE-19-2015 | Award Amount: 1.71M | Year: 2016

The main barriers to finance of Sustainable Energy Assets (SEA) projects namely energy efficiency, demand response, distributed renewable energy generation and electricity storage are: 1) project valuation difficulties; 2) difficulties in project optimisation; 3) a communication gap between contractors and investors leading to a lack of trust. Today, protocols and tools exist for project valuation, but they are used separately, in different ways by different investors or contractors. Therefore, SEA projects are valuated on a one-off basis, without any standardisation. The SEAF project will significantly lower the entry barriers to finance for small to medium projects, through combining existing tools and protocols, namely Joule Assets market valuation tool, the risk assessment methodology from insurance company HSB and the Investor Confidence Projects energy performance protocols. These three service tools will be integrated into an all-in-one, easy to use, single source valuation and risk assessment framework, which aims to: 1) Facilitate and support an intensive stakeholder engagement process; 2) Provide independent valuation and optimisation for SEA projects according to up-to-date energy market data; 3) Standardise energy efficiency valuation criteria for easy comparability with other similar projects; 4) Enable initial risk assessment at much lower cost and with less administrative effort; 5) Facilitate the matchmaking between investors and contractors; 6) Lay the foundation for robust exploitation. In addition to its demonstration with a large network of investors and contractors, SEAF seeks to enable investments of 10-15m and primary energy savings of 18-45 GWh/a over the course of its duration. Through its unique combination of services, SEAF will specifically target small projects, which would otherwise not get financed and it will have a disproportionately large impact on job creation, as reduced energy costs have a much stronger effect on SMEs.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EE-12-2014 | Award Amount: 996.55K | Year: 2015

In recent years, research has shown that energy savings resulting from energy efficiency improvements have wider benefits for the economy and society such as increases in employment, GDP, energy security, positive impacts on health, ecosystems and crops or resource consumption. In order to develop more cost-effective energy efficiency policies and optimised long-term strategies in the EU, these multiple benefits have to be accounted for more comprehensively in the future. Although this field of research is growing, the findings are disperse and mostly have important gaps regarding geographic, sectorial or technical measure coverage and findings vary largely. This makes a consideration of multiple benefits in policy making and policy evaluation difficult today. The proposed project addresses these issues and aims at closing the identified gaps by five central research innovations: 1) data gathering on energy savings and technology costs per EU country for the most relevant 20 to 30 energy efficiency measures in the residential, commercial, industrial and transport sectors, 2) developing adequate methodologies for benefit quantification, monetisation and aggregation, 3) quantifying the most important multiple benefits and where adequate, monetising, 4) developing an openly available calculation tool that greatly simplifies the evaluation of co-impacts for specific energy efficiency measures to enable decision-making and 5) developing a simple online visualisation tool for customisable graphical analysis and assessment of multiple benefits and data exportation. Project outcomes can thus directly be used by stakeholders and will help to define cost-effective policies and support policy-makers and evaluators in the development and monitoring of energy efficiency strategies and policies in the future.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 2.42M | Year: 2015

AUT00206 is a new drug that has been characterised in preclinical studies under an Early Stage Innovate UK award (Ref. 101443) due to complete in 2Q15. 206 acts on Kv3 channels that are implicated in brain circuits believed to be dysfunctional in schizophrenia. This pioneering proposal builds on the preclinical work to take ‘206 into the clinic, and conduct a first-in-human trial to explore safety as well as bio-markers of efficacy in patients with schizophrenia. The clinical project will also include an experimental ketamine-challenge, translating Early Stage preclinical work into humans. The programme will provide crucial data to aid progression of ‘206 into Phase II and enable Autifony to secure a high value partnering deal or further funding. Continued academic collaboration the Institute of Psychiatry, and Universities of Manchester and Newcastle will follow on from previous work on the ‘206 mechanism of action, critical to understanding the therapeutic potential of this new medicine.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETHPC-1-2014 | Award Amount: 3.86M | Year: 2015

This project addresses the problem of programming model design and implementation for the Exascale. The first Exascale computers will be very highly parallel systems, consisting of a hierarchy of architectural levels. To program such systems effectively and portably, programming APIs with efficient and robust implementations must be ready in the appropriate timescale. A single, silver bullet API which addresses all the architectural levels does not exist and seems very unlikely to emerge soon enough. We must therefore expect that using combinations of different APIs at different system levels will be the only practical solution in the short to medium term. Although there remains room for improvement in individual programming models and their implementations, the main challenges lie in interoperability between APIs. It is this interoperability, both at the specification level and at the implementation level, which this project seeks to address and to further the state of the art. INTERTWinE brings together the principal European organisations driving the evolution of programming models and their implementations. The project will focus on seven key programming APIs: MPI, GASPI, OpenMP, OmpSs, StarPU, QUARK and PaRSEC, each of which has a project partner with extensive experience in API design and implementation. Interoperability requirements, and evaluation of implementations will be driven by a set of kernels and applications, each of which has a project partner with a major role in their development. The project will implement a co- design cycle, by feeding back advances in API design and implementation into the applications and kernels, thereby driving new requirements and hence further advances.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.14M | Year: 2015

The renal tract (kidneys, the ureters, bladder) is a complex organ system crucial for maintaining the body homeostasis. This organ system arises from different precursor pools through a complex program of patterning, differentiation and morphogenesis in embryonic development. Alteration of this program leads to renal tract malformations (RTM) that are incompatible with a healthy life. While some of these RTM can be surgically corrected, others develop into chronic entities that may lead to renal failure; the burden for the patients and for the socio-economic impact for the health systems is immense. Although congenital RTM are amongst the most frequent human birth defects, the different programs that direct normal and pathological development have remained poorly understood. The RENALTRACT training network aims to address these deficits and provide a better understanding of the programs that underlie RTM and provide solutions to clinical problems. This shall be achieved by using a multidisciplinary team approach with partners working in complementary disciplines (developmental biology, renal physiology, Omics, clinical medicine). RENALTRACT has unique and distinguishing features by uniting studies on components of the urinary tract, by building a bridge between basic and clinician scientists and by combining state of the art methods from a number of complementary fields in a variety of animal models. RENALTRACT aims to establish a first class multidisciplinary training program for outstanding Early-Stage Researchers (ESRs) to provide a group of young scientists with expert knowledge to envision and embark on novel therapies of renal tract malformations in the future. ESRs will benefit from an excellent working environment with state-of-the-art technologies and supervision by international leaders in the field and an inter-disciplinary approach. This will be complemented by intersectoral exposure and exchange between the RENALTRACT public and private participants.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2012-ITN | Award Amount: 3.77M | Year: 2012

The aim of CLOUD-TRAIN is to establish a multi-site network of Early Stage Researchers (here predominantly PhD students) and Experienced Researchers at 10 partner institutions across Europe. The role of aerosol nucleation for atmospheric CCN levels, clouds and climate is investigated. The influence of various vapours and ions for aerosol nucleation, growth and cloud processes is studied to significantly improve our understanding of natural and anthropogenic climate forcing as well as feedback mechanisms. The major focus of the network will be three sets of common experiments on ternary nucleation (ion-induced and neutral) and ion-aerosol-cloud interaction carried out at CERN to which all trainees contribute. These experiments are conducted at the newly established unique aerosol chamber CLOUD that is exposed to a CERN ionizing particle beam where the effects of cosmic rays on aerosol and clouds can be efficiently simulated. At the CLOUD chamber nucleation experiments are performed at an unprecedented level of precision and completeness using highly innovative instrumentation. A comprehensive high quality training programme is set up for the fellows. Additional to the experiments at CERN, they are brought together for network training events such as annual summer schools and workshops for integral data analysis. Courses by world leading experts are taught spanning from general aerosol chemistry and physics to specialized sessions. The summer schools and workshops are specifically tailored to the needs of the trainees and are scheduled in addition to the national PhD programmes of their hosting institutions. Comprehensive transferable skills training is included (e.g. scientific writing, presenting talks, interaction with the media, entrepreneurship, IPR, management). Five network partners are from the private sector (2 full, 3 assoc.). Secondments are planned for each fellow to broaden the experience and to include exposure to another sector.


Grant
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: Fission-2012-5.1.1 | Award Amount: 2.21M | Year: 2013

The GENTLE project is a pan-European effort in the field of education and training (E&T) on Nuclear Energy. It brings together leading European academic and research institutions with the goal to set up a life-long learning programme, strongly supported by stakeholders from industry. GENTLE focuses on two E&T domains: (a) the education of students by means of student research experiences in the nuclear laboratories, and intersemester courses on special topics that are generally not part of the academic curriculum, (b) the high-level training of young professionals by an Executive master course (60 ECTS) on Nuclear Energy, accredited by one of the participating academic institution. These tools will strongly impact on the education and training quality in Europe as they broaden the scope of interest to industry and safety organisations, and give the student better opportunities to obtain hands-on experience in high level nuclear research. This will help the European industry to consolidate its leading position in the international market. In addition, to the inter-consortium collaboration, GENTLE will actively coordinate E&T efforts in the domain and will initiate a dialogue with the associated stakeholders from industry on nuclear E&T in Europe, to steer its own E&T programme but also to advice the European Commission and EU member states. GENTLE is thus a holistic approach to training and education on nuclear energy and is complementary to the ongoing efforts in Europe.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: SSH.2012.5.1-2 | Award Amount: 3.28M | Year: 2013

The presence of Roma migrants from Romania on the streets of major western European cities has been the centre of public debates, and regarded by many as a challenge to social integration, law and order, human rights and EU mobility principles. The project will investigate the experiences, motivations, and ambitions of Roma migrants and popular, media and official reactions to Roma immigration. We intend to carry out interviews in a selection of Romanian towns that are key centres of Roma emigration, and among immigrant Rom originating from these communities in France, Italy, Spain and the UK. We will observe local reactions to the Roma immigrants and processes of friction as well as integration, and assess the factors involved, such images, clashes in customs and expectations, competition over resources and attention of the authorities, and more. Throughout the process, we will involve young members of the immigrant Roma community in documenting their situation and in articulating their needs. The project will produce a comparative ethnography of Romanian Roma migrants in a selection of larger western European cities, as well as a policy paper outlining good practice and positive engagement strategies.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: Fission-2011-1.1.1 | Award Amount: 5.09M | Year: 2012

Recent safety assessments nuclear waste repositories have shown that the formation and stability of colloids may have a direct impact on the overall performance of the repository. The main aim of the BELBaR project is increase the knowledge of the processes that controls clay colloid stability, generation and ability to transport radionuclides. The overall purpose of the project will be to suggest a treatment of the issues in long-term safety assessment. The key areas of research will be: erosion of bentonite buffers, the main objective of these studies will be to understand the main mechanisms of erosion from the bentonite surface and to quantify the extent of the possible erosion under different conditions clay colloid stability studies under different geochemical conditions. The colloids formed at the near/far field interface would be stable only if favourable conditions exist and therefore their relevance for radionuclide transport will be strongly dependent on the local geochemical conditions interaction between colloids and radionuclides and the host rock, how colloid mobility may be affected be the composition of the host rock and the mechanism of sorption and de-sorption of radionuclides on the colloids In these areas substantial laboratory studies will be undertaken. The modelling studies will support the laboratory studies through development of conceptual and mathematical descriptions of the observed phenomena. The final outcome is to consider how colloids and related phenomena can be considered in the long term safety case and to make recommendations on how the safety case could pursue to address this potentially very significant issue. The project will have strong focus on cooperation and integration. This will be achieved by exchange of staff between partners and arrangement of frequent seminars. The BELBaR consortium consists of research institutes, implementers and universities from within and outside the European Union.


Grant
Agency: Cordis | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2011-ITN | Award Amount: 4.10M | Year: 2012

HPCFinance, a 4-year multi-site Marie Curie Initial Training Network in modern quantitative methods and High-Performance Computing for Finance, provides solutions to managing financial risks by high-performance computing. HPCFinance will help improve the financial strength of banks, pension funds, insurance companies, other financial institutions and households in Europe. The main goal of the network is to enhance the career development of 12 early-stage researchers and 2 experienced ones in finance-related sectors. Currently, while recovering from the financial crisis, the European financial world and academic researchers are facing major challenges to create and apply more reliable quantitative models and methods to manage risks. Simultaneously, computationally challenging new hybrid products combining traditional financial investments with insurance policies are gaining popularity. Consequently, demand for experts in finance with superior computing skills is growing rapidly. HPCFinance consists of 7 universities and 8 companies, representing investment and insurance companies, banks, consultants, and high-performance computing solution providers. The networks US partners provide invaluable experience for benchmarking and knowledge transfer into Europe. This world-class network provides training in robust financial models and numerical methods on high-performance computing platforms with emphasis on variable annuities and asset and liability management. The intended research is not only academically but also practically relevant as the program is built around real life challenges identified together by the academic and private sector partners. To bridge research and practice, all researchers contribute to the private sector via secondments. The major societal impacts of HPCFinance are to provide the European finance community with specialists with state-of-the-art skills in computational finance and to ease the adoption of reliable models in the industry.

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