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Maldonado, Uruguay

Deneo-Pellegrini H.,Epidemiology Group | De Stefani E.,Epidemiology Group | Boffetta P.,Mount Sinai School of Medicine | Ronco A.L.,University of Maldonado | And 3 more authors.
Head and Neck | Year: 2013

Background In the period 1990 to 2001, a case-control study on oral cancer and maté consumption was conducted at the Cancer Institute of Uruguay. Methods The study included 696 newly diagnosed cases with squamous cell carcinoma and 696 controls afflicted with nonneoplastic conditions not related to tobacco smoking and alcohol drinking. The participants were matched on age and residence and the study was restricted to men. Results In order to control confounding for tobacco and alcohol, we fitted 2 models. According to model 1, the odds ratio (OR) for maté consumption was 1.15 (95% confidence interval [CI], 0.76-1.73), whereas the results for model 2 showed an OR of 3.47 (95% CI, 1.60-7.52). Conclusions The inclusion of a term for the interaction between maté and smoking (or drinking) was rewarding and the ORs were even higher than those observed with the crude estimates. Head Neck, 2013 Copyright © 2012 Wiley Periodicals, Inc.

Deneo-Pellegrini H.,Epidemiology Group | Boffetta P.,Mount Sinai School of Medicine | De Stefani E.,Epidemiology Group | Correa P.,Vanderbilt University | And 5 more authors.
Cancer Causes and Control | Year: 2013

Objective The aim of this study was to investigate the association between nutrient-based dietary patterns and squamous cell cancers of the head and neck. Methods We used a case-control study which included 548 cases and 548 controls. From these participants, we derived 23 nutrients and they were then submitted to a factorability analysis in order to conduct a principal component factor analysis. Results We were able to identify four nutrient-derived patterns. The first pattern (meat-based pattern) was positively associated with squamous cell cancer of the head and neck (OR 2.85, 95 % CI 1.81-4.15), whereas the third pattern (fruit-based) was strongly protective (OR 0.43, 95 % CI 0.27-0.63). The other nutrient patterns were also significantly associated with head and neck squamous cell carcinoma with minor ORs. Conclusion Both patterns suggest that red meat and fruits are major factors in the etiology of head and neck squamous cell cancer, replicating previous studies in the field. © Springer Science+Business Media Dordrecht 2013.

De Stefani E.,Epidemiology Group | Moore M.,UICC Asian Regional Office | Aune D.,Imperial College London | Deneo-Pellegrini H.,Epidemiology Group | And 8 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2011

In the time period 1990-2004 we conducted a multisite case-control study in order to examine the relationship of maté consumption and risk of 13 cancer sites in Montevideo, Uruguay. The study included 13,201 participants (8,875 cases and 4,326 controls) drawn from the four major public hospitals in the city of Montevideo. Newly diagnosed and microscopically confirmed cases of cancers of the mouth, pharynx, esophagus, stomach, colon, rectum, larynx, lung, female breast, cervix uteri, prostate, bladder and kidney were included in the study. Controls were drawn from the same hospitals and in the same time period and were afflicted by non-neoplastic conditions not related with tobacco smoking or alcohol drinking and without recent changes in their diets. Odds ratios for maté consumption was directly associated with cancers of the upper aerodigestive tract (UADT), esophagus, stomach, larynx, lung, cervix uteri, prostate, bladder, and kidney. In conclusion these results suggest that chemicals, like benzo[a]pyrene, could be responsible of the carcinogenic effect of maté in the above mentioned cancer sites.

De Stefani E.,University of the Republic of Uruguay | Boffetta P.,Mount Sinai School of Medicine | Ronco A.L.,University of Maldonado | Deneo-Pellegrini H.,University of the Republic of Uruguay | And 5 more authors.
British Journal of Cancer | Year: 2012

Background: The role of processed meat in the aetiology of several cancers was explored in detail. Methods: In the time period 19962004, a multisite casecontrol study was conducted in Montevideo, Uruguay. The study included 6 060 participants (3 528 cases and 2 532 controls) corresponding to cancers of the oral cavity, pharynx, oesophagus, stomach, colon, rectum, larynx, lung, female breast, prostate, urinary bladder, and kidney (renal cell carcinoma only). Results: The highest odds ratios (ORs) were positively associated with cancers of the colon, rectum, stomach, oesophagus, and lung. With the exception of renal cell carcinoma, the remaining cancer sites were significantly associated with elevated risks for processed meat consumption. Furthermore, mortadella, salami, hot dog, ham, and salted meat were strongly associated with risk of several cancer sites. Conclusion: It could be concluded that processed meat intake could be a powerful multiorgan carcinogen. © 2012 Cancer Research UK All rights reserved.

De Stefani E.,University of the Republic of Uruguay | Boffetta P.,Mount Sinai School of Medicine | Correa P.,Vanderbilt University | Deneo-Pellegrini H.,University of the Republic of Uruguay | And 3 more authors.
Nutrition and Cancer | Year: 2013

In the time period 1996-2004, we conducted a case-control study in Montevideo, Uruguay with the objective of exploring the role of foods and alcoholic beverages in the etiology of cancers of the upper aerodigestive tract (UADT). In brief, 563 male cases and 1099 male controls were frequency matched on age and residence using random sampling. All the participants were drawn from the 4 major public hospitals in Montevideo. We used exploratory factor analysis among controls. Through Scree plot test, the model retained 4 factors, which were labeled as prudent, starchy plants, Western, and drinker. These dietary patterns explained 34.8% of the total variance. Whereas the prudent pattern was inversely associated with UADT cancer [odds ratios (OR) for the upper tertile vs. the lowest one 0.52, 95% confidence intervals 0.32-0.76, P value for trend = 0.0005), the remaining patterns were significantly and positively associated with UADT cancers. We conclude that these patterns were similar among the oral and laryngeal cancers, both in the direction of the ORs and in the magnitude of the associations, suggesting that these cancer sites share the effect of dietary patterns in the etiology of cancer of the upper aerodigestive tract. © 2013 Copyright Taylor and Francis Group, LLC.

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