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Macau, China

The University of Macau is the only public comprehensive university located in Macau, being the leading tertiary institution of the city which has excellence in teaching, research and service to the community. Founded in 1981, it is the oldest higher educational institution in Macau, as well as the largest university in the city in terms of faculty size and programmes offered.It was established as the University of East Asia, which was a private university followed British university structure and most students came from British Hong Kong. As the preparation of Macau's handover, it was renamed to University of Macau, acquired as a public university and reformed to Portuguese university structure by the government of Portuguese Macau.The university's campus is located in Taipa. It is organised into eight residential colleges and seven academic faculties. The main medium of instruction is English, while certain courses are taught in Chinese, Portuguese and Japanese.The university has been relocated to the new campus in August 2014 at Hengqin Island, Zhuhai, Guangdong but continues to operate under Macau SAR jurisdiction. Wikipedia.

Zaroff C.M.,University of Macau
Social Psychiatry and Psychiatric Epidemiology | Year: 2012

Background: The prevalence of autism spectrum disorders (ASD) is generally somewhat lower in countries outside of North America and Europe. While there are culture-specific patterns of social cognitive processing, the influence of such patterns upon ASD prevalence has yet to be fully explored. Methods: A comprehensive literature search for original articles reporting ASD prevalence was undertaken. Data across studies were compared with a particular focus on variables of geographic residence and ethnicity. Results: ASD prevalence varies across countries in a manner that appears to suggest that the greatest influence is due to methodological variables. The nature of a potential influence of culture-specific patterns of cognitive processing upon prevalence remains unknown. The available little data concerning the association between ethnicity and prevalence are limited to studies within the United States (US) showing differences in children of Hispanic descent relative to Whites, a finding for which a definitive explanation is lacking. Conclusions: Available evidence suggests that methodological factors are largely responsible for differences in ASD prevalence across studies. The much discussed increase in prevalence inASDhas been observed worldwide, suggesting that the refinement of diagnostic methodology and/or broadening diagnostic concept is not limited to Western countries. Within individual countries, only in the US has the influence of ethnicity upon ASD prevalence been examined in depth. In the US, children of Hispanic descent have the lowest prevalence of ASD, while Whites tend to have the highest prevalence of ASD. Hypothesized etiological factors for such prevalence differences include methodological factors, socioeconomic variables, and bias. © Springer-Verlag 2011. Source

Xu Q.,University of Macau
Structural Health Monitoring | Year: 2014

Impact force magnitude detection and site location for clamped plates have direct relevance to the maintenance of aircraft and spacecraft structures. This article presents the impact identification of an aluminum plate structure based on least squares support vector machines. The structure is equipped with an array of surface-bounded piezoelectric sensors, which receive strain response signals excited by hammer impacts on different sites with varying magnitudes. To identify the magnitude and location of the impact, two features are extracted from each sensor signal by Hilbert transform, and intelligent models are established using least squares support vector machines. The regression models are then validated through experimental studies, which reveal that the least squares support vector machine-based approach achieves more reliable identification result and better detection accuracy than conventional artificial neural networks. In addition, an empirical index is presented to compare the system efficiency in terms of detection accuracy as well as the numbers of sensors and data sets. Results show that the proposed least squares support vector machine-based impact identification system affords a higher efficiency than the existing ones because it accomplishes a moderate detection accuracy along with greatly reduced hardware cost and workload. © The Author(s) 2013. Source

Ma D.-L.,Hong Kong Baptist University | Chan D.S.-H.,Hong Kong Baptist University | Leung C.-H.,University of Macau
Accounts of Chemical Research | Year: 2014

(Chemical Equation Presented) Compared with organic small molecules, metal complexes offer several distinct advantages as therapeutic agents or biomolecular probes. Carbon atoms are typically limited to linear, trigonal planar, or tetrahedral geometries, with a maximum of two enantiomers being formed if four different substituents are attached to a single carbon. In contrast, an octahedral metal center with six different substituents can display up to 30 di fferent stereoisomers. While platinum- and ruthenium-based anticancer agents have attracted significant attention in the realm of inorganic medicinal chemistry over the past few decades, group 9 complexes (i.e., iridium and rhodium) have garnered increased attention in therapeutic and bioanalytical applications due to their adjustable reactivity (from kinetically liable to substitutionally inert), high water solubility, stability to air and moisture, and relative ease of synthesis. In this Account, we describe our efforts in the development of group 9 organometallic compounds of general form [M(C∧N)2(N∧N)] (where M = Ir, Rh) as therapeutic agents against distinct biomolecular targets and as luminescent probes for the construction of oligonucleotide-based assays for a diverse range of analytes. Earlier studies by researchers had focused on organometallic iridium(III) and rhodium(III) half-sandwich complexes that show promising anticancer activity, although their precise mechanisms of action still remain unknown. More recently, kinetically-inert group 9 complexes have arisen as fascinating alternatives to organic small molecules for the specific targeting of enzyme activity. Research in our laboratory has shown that cyclometalated octahedral rhodium(III) complexes were active against Janus kinase 2 (JAK2) or NEDD8-activating enzyme (NAE) activity, or against NO production leading to antivasculogenic activity in cellulo. At the same time, recent interest in the development of small molecules as modulators of protein-protein interactions has stimulated our research group to investigate whether kinetically-inert metal complexes could also be used to target protein-protein interfaces relevant to the pathogenesis of certain diseases. We have recently discovered that cyclometalated octahedral iridium(III) and rhodium(III) complexes bearing C∧N ligands based on 2-phenylpyridine could function as modulators of protein-protein interactions, such as TNF-α, STAT3, and mTOR. One rhodium(III) complex antagonized STAT3 activity in vitro and in vivo and displayed potent antitumor activity in a mouse xenograft model of melanoma. Notably, these studies were among the first to demonstrate the direct inhibition of protein-protein interfaces by kinetically-inert group 9 metal complexes. Additionally, we have discovered that group 9 solvato complexes carrying 2-phenylpyridine coligands could function as inhibitors and probes of β-amyloid fibrillogenesis. Meanwhile, the rich photophysical properties of iridium complexes have made them popular tools for the design of luminescent labels and probes. Luminescent iridium(III) complexes benefit from a high quantum yield, responsive emissive properties, long-lived phosphorescence lifetimes, and large Stokes shift values. Over the past few years, our group has developed a number of kinetically-inert, organometallic iridium(III) complexes bearing various C∧N and N∧N ligands that are selective for G-quadruplex DNA, which is a DNA secondary structure formed from planar stacks of guanine tetrads stabilized by Hoogsteen hydrogen bonding. These complexes were then employed to develop G-quadruplex-based, label-free luminescence switch-on assays for nucleic acids, enzyme activity, small molecules, and metal ions. © 2014 American Chemical Society. Source

Pan H.,University of Macau
Journal of Physical Chemistry C | Year: 2014

First-principles calculations based on density-functional theory are carried out to systematically investigate the effects of hydrogenation on the electronic and magnetic properties of vanadium dichalcogenides (VX2, X = S, Se, and Te) monolayers. We find that semimetallic and ferromagnetic VX2 monolayers can be tuned to be nonmagnetic/antiferromagnetic and intrinsically semiconducting by functionalizing with hydrogen atoms on one of their surfaces, and ferromagnetic/antiferromagnetic and n-type semiconducting when both of their two surfaces are fully covered by hydrogen atoms. The ferromagnetism and antiferromagnetism are contributed to carrier-mediated double-exchange and superexchange, respectively. Ferromagnetism is obtained in semimetallic or lightly doped semiconducting monolayers due to double-exchange of localized spins with static localized states, while antiferromagnetism can be achieved in intrinsic or heavily doped semiconducting monolayer duo to the superexchange interaction. These vanadium dichalcogenides monolayers with hydrogenation may apply to nanodevices, sensors, and spintronics. © 2014 American Chemical Society. Source

Tan W.,University of Macau
International journal of nanomedicine | Year: 2011

Berberine hydrochloride is a conventional component in Chinese medicine, and is characterized by a diversity of pharmacological effects. However, due to its hydrophobic properties, along with poor stability and bioavailability, the application of berberine hydrochloride was hampered for a long time. In recent years, the pharmaceutical preparation of berberine hydrochloride has improved to achieve good prospects for clinical application, especially for novel nanoparticulate delivery systems. Moreover, anticancer activity and novel mechanisms have been explored, the chance of regulating glucose and lipid metabolism in cancer cells showing more potential than ever. Therefore, it is expected that appropriate pharmaceutical procedures could be applied to the enormous potential for anticancer efficacy, to give some new insights into anticancer drug preparation in Chinese medicine. We accessed conventional databases, such as PubMed, Scope, and Web of Science, using "berberine hydrochloride", "anti-cancer mechanism", and "nanoparticulate delivery system" as search words, then summarized the progress in research, illustrating the need to explore reprogramming of cancer cell metabolism using nanoparticulate drug delivery systems. With increasing research on regulation of cancer cell metabolism by berberine hydrochloride and troubleshooting of issues concerning nanoparticulate delivery preparation, berberine hydrochloride is likely to become a natural component of the nanoparticulate delivery systems used for cancer therapy. Meanwhile, the known mechanisms of berberine hydrochloride, such as decreased multidrug resistance and enhanced sensitivity of chemotherapeutic drugs, along with improvement in patient quality of life, could also provide new insights into cancer cell metabolism and nanoparticulate delivery preparation. Source

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