The University of Lucknow is a university in the city of Lucknow, Uttar Pradesh, India. It is affiliated to University Grants Commission; Association of Commonwealth Universities ; Association of Indian Universities ; Distance Education Council . Other accreditations include National Assessment and Accreditation Council ; National Council of Teacher Education ; Bar Council of India . It was affiliated to UGC in the year 1921. Most of the courses have an 'Yearly' system, although some of the new courses, like BBA and MBA have opted for a Semester system.The University has a new campus located in Jankipuram, Lucknow where Faculties of Law, Business Tourism have been established. Wikipedia.
Garg M.,University of Lucknow
Expert Reviews in Molecular Medicine | Year: 2017
Cancer metastasis occurs through local invasion of circulating tumour cells (CTCs), intravasation, transportation to distant sites, and their extravasation followed by colonisation at secondary sites. Epithelial–mesenchymal transition (EMT) is a normal developmental phenomenon, but its aberrant activation confers tumour cells with enhanced cell motility, metastatic properties, resistant to therapies and cancer stem cell (CSC) phenotype in epithelium-derived carcinoma. Experimental studies from various research papers have been reviewed to determine the factors, which interlink cancer stemness and cellular plasticity with EMT. Although existence of CSCs has been linked with EMT, nevertheless, there are controversies with the involvement of type of tumour cells, including cells with E (epithelial) and M (mesenchymal) phenotype alone or hybrid E/M phenotype in different types of cancers. Studies on CTCs with hybrid E/M phenotypes during different stages of cancer metastasis reveal strong association with tumour -initiation potential, cellular plasticity and types of cancer cells. Cells with the hybrid E/M state are strictly controlled by phenotypic stability factors coupled to core EMT decision-making circuits, miR200/ZEB and miR-34/Snail. Understanding the regulatory functions of EMT program in cancer metastasis can help us to characterise the biomarkers of prognostic and therapeutic potential. These biomarkers when targeted may act as metastatic suppressors, inhibit cellular plasticity and stemness ability of tumour cells and can block metastatic growth. Copyright © Cambridge University Press 2017
Anand R.,Christian Medical College |
Gill K.D.,Jawaharlal Institute of Postgraduate Medical Education & Research |
Mahdi A.A.,University of Lucknow
Neuropharmacology | Year: 2014
Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential rise in the number of cases of AD, emphasizing the need for developing an effective treatment. AD also imposes tremendous emotional and financial burden to the patient's family and community. The disease has been studied over a century, but acetylcholinesterase inhibitors and memantine are the only drugs currently approved for its management. These drugs provide symptomatic improvement alone but do less to modify the disease process. The extensive insight into the molecular and cellular pathomechanism in AD over the past few decades has provided us significant progress in the understanding of the disease. A number of novel strategies that seek to modify the disease process have been developed. The major developments in this direction are the amyloid and tau based therapeutics, which could hold the key to treatment of AD in the near future. Several putative drugs have been thoroughly investigated in preclinical studies, but many of them have failed to produce results in the clinical scenario; therefore it is only prudent that lessons be learnt from the past mistakes. The current rationales and targets evaluated for therapeutic benefit in AD are reviewed in this article. This article is part of the Special Issue entitled 'The Synaptic Basis of Neurodegenerative Disorders'. © 2013 Elsevier Ltd. All rights reserved.
Tandon V.K.,University of Lucknow |
Kumar S.,University of Lucknow
Expert Opinion on Therapeutic Patents | Year: 2013
Introduction: A large number of natural products including several synthetic drugs possess naphthoquinone chromophore. Various methods have been devised for their synthesis. Several naphthoquinone derivatives have been found to possess diverse biological properties especially anticancer activity which has stimulated keen interest and research in this field. Areas covered: The present review provides recent therapeutic patent literature (2000-2012) describing the applications of naphthoquinones and their derivatives on anticancer activities. Information from articles published in international peer-reviewed journals has been included to comprise a more exhaustive review. Expert opinion: With the advent of stem cell research and molecular mechanism associated with cure of cancer, the use of classical and novel naphthoquinone structures have been more frequently noted in recent (2000-2012) patented agents for treatment of cancer. © 2013 Informa UK, Ltd.
Pratap R.,University of Delhi |
Ram V.J.,University of Lucknow
Chemical Reviews | Year: 2014
A study focuses on providing information about the natural products of chromene, furochromenes, pyranochromenes, and benzochromene ring systems, along with the synthesis of various aromatized and partially reduced chromenes, benzo-, and naphtho-fused chromenes, thiochromenopyrans, and their applications in synthetic organic chemistry for the construction of numerous diverse compounds. It is demonstrated that the presence of nitro group at C-5 in XVIIa,b affects the chemical shifts of H-4 and H-6 protons, and they resonate downfield as compared to respective protons of XVIIc due to the presence of electron-withdrawing substituents. It has also been observed that various substituted 2H-chromenes isolated from the leaves of Orthosiphom aristatus have been used as traditional medicine for the treatment of hypertension and diabetes.
Yadav R.R.,University of Lucknow
Journal of Geophysical Research: Atmospheres | Year: 2011
The present study is the first attempt to develop an annual (August-July) precipitation series back to AD 1330 using a tree ring data network of Himalayan cedar (Cedrus deodara (Roxb.) G. Don) from the Lahaul-Spiti region in the western Himalaya, India. The rainfall reconstruction reveals high magnitude multidecadal droughts during the 14th and 15th centuries and thenceforth a gradual increase in precipitation. Increasingly wet conditions during the 20th century are consistent with other long-term precipitation reconstructions from high Asia and reflect a large-scale intensification of the hydrological cycle, coincident with what is anticipated due to global warming. Significant relationships between reconstructed precipitation and precipitation records from central southwest Asia, east of the Caspian Sea, ENSO (NINO4-SST) variability and summer monsoon rainfall over central northeast India underscore the utility of our data in synoptic climatology. Copyright 2011 by the American Geophysical Union.
Yadav R.R.,University of Lucknow
Climate Dynamics | Year: 2011
Tree-ring-width data of Himalayan cedar [Cedrus deodara (Roxb.) G. Don] from 11 homogeneous moisture stressed sites in the monsoon shadow zone of the western Himalaya were used to develop a mean chronology extending back to ad 1353. The chronology developed using Regional Curve Standardization method is the first from the Himalayan region of India showing centennial-scale variations. The calibration of ring-width chronology with instrumental precipitation data available from stations close to the tree ring sampling sites showed strong, direct relationship with March-April-May-June (MAMJ) precipitation. This strong relationship was used to supplement the instrumental precipitation data back to ad 1410. The precipitation reconstruction showed extended period of drought in fifteenth and sixteenth centuries. Increasingly pluvial conditions were recorded since eighteenth century, with the highest precipitation in the early part of the nineteenth century. The decreasing trend in reconstructed precipitation in the last decade of the twentieth century, consistent with the instrumental records, is associated with the decreasing trend in frequency of western disturbances. MAMJ precipitation over the monsoon shadow zone in the western Himalaya is directly associated with the North Atlantic Oscillation (NAO) and NINO3-SST index of El Nino-Southern Oscillation (ENSO), the leading modes of climate variability influencing climate over large parts of the Northern Hemisphere. However, the relationship between ENSO and MAMJ precipitation collapsed completely during 1930-1960. The breakdown in this relationship is associated with the warm phase of Atlantic Multidecadal Oscillation (AMO). A spectral analysis of reconstructed MAMJ precipitation indicates frequencies in the range of the variability associated with modes of NAO, ENSO and AMO. © 2010 Springer-Verlag.
Yadav R.R.,University of Lucknow
Journal of Geophysical Research: Atmospheres | Year: 2013
The paucity of available instrumental climate records in cold and arid regions of the western Himalaya, India, hampers our understanding of the long-term variability of regional droughts, which seriously affect the agrarian economy of the region. Using ring width chronologies of Cedrus deodara and Pinus gerardiana together from a network of moisture-stressed sites, Palmer Drought Severity Index values for October-May back to 1310 A.D. were developed. The twentieth century features dominant decadal-scale pluvial phases (1981-1995, 1952-1968, and 1918-1934) as compared to the severe droughts in the early seventeenth century (1617-1640) as well as late fifteenth to early sixteenth (1491-1526) centuries. The drought anomalies are positively (negatively) associated with central Pacific (Indo-Pacific Warm Pool) sea surface temperature anomalies. However, non-stationarity in such relationships appears to be the major riddle in the predictability of long-term droughts much needed for the sustainable development of the ecologically sensitive region of the Himalayas. Key PointsFirst drought records for the western HimalayaRecords show strong regional scale featuresDroughts associated with large-scale Pacific Sea surface temperature anomalies ©2013. American Geophysical Union. All Rights Reserved.
Garg M.,University of Lucknow
Expert Opinion on Therapeutic Targets | Year: 2015
Introduction: Epithelial-to-mesenchymal transition (EMT) is a pathological phenomenon of cancer that confers tumor cells with increased cell motility, invasive and metastatic abilities with the acquisition of 'cancer stem-like cell' (CSC) phenotype. EMT endows tumor cells with intrinsic/acquired resistant phenotype at achievable doses of anticancer drugs and leads to tumor recurrence and progression. Besides the complex network of signaling pathways, microRNAs (miRNAs) are being evolved as a new player in the induction and regulation of EMT. Areas covered: In this review article, the author has searched the PubMed and Google Scholar electronic databases for original research and review articles to gather current information on the association of EMT-induced CSCs with therapeutic resistance, tumor growth and metastasis, which are believed to be regulated by certain miRNAs. Expert opinion: This review outlines not only the perspective on selective targeting of EMT-induced CSCs through altered expression of novel miRNAs and/or the use of conventional drugs that affect the levels of critical miRNAs but also the strategies on overcoming the drug resistance by interfering with EMT and modulating its associated pathways in CSCs that can be considered as potential therapeutic approaches toward eradicating the tumor recurrence and metastasis. © 2015 Informa UK, Ltd.
Awasthi A.,University of Lucknow
Thermochimica Acta | Year: 2012
The viscosity (η) of formamide (FA) with 2-methoxyethanol (2-ME) and 2-ethoxyethanol (2-EE) has been measured at 303.15, 308.15, 313.15, 318.15 and 323.15 K over the entire composition range. From the experimental viscosity data, viscosity deviations (Δη) of binary mixtures were evaluated and fitted to the Redlich-Kister equation. The Δη values are positive over the entire range of composition for (formamide + 2-methoxyethanol) and (formamide + 2-ethoxyethanol) systems. The Grunberg-Nissan (d 12), Tamura-Kurata (T 12) and Hind (H 12) interaction parameters have been calculated. Furthermore, Gibbs free energy of activation (ΔG*), enthalpy of activation (ΔH*), entropy of activation (ΔS*) and excess Gibbs free energy of activation (ΔG* E) of viscous flow have also been evaluated by using Eyring viscosity equation. The results are discussed in terms of molecular interactions due to physical, chemical and structural effects between the unlike molecules. It is observed that the strength of intermolecular interaction between FA and 2-alkoxyethanol molecules is in order: FA + 2-EE > FA + 2-ME. © 2012 Elsevier B.V. All rights reserved.
Awasthi A.,University of Lucknow
Journal of Chemical Thermodynamics | Year: 2012
The ultrasonic velocity (u) and density (ρ) of binary mixtures of formamide (FA) with 2-methoxyethanol (2-ME) and 2-ethoxyethanol (2-EE) have been measured over the entire composition range at temperatures (303.15, 313.15, and 323.15) K. The experimental values of ultrasonic velocities and densities have been used to determine the adiabatic compressibility (β S), intermolecular free length (L f), molar sound velocity (R), molar compressibility (B), and specific acoustic impedance (Z). The excess values of ultrasonic velocity (u E), adiabatic compressibility (β S E), acoustic impedance (Z E), and molar volume (V m E) were also calculated. The observed variations of these parameters, with composition and temperature, are discussed in terms of the molecular interactions due to physical, chemical, and structural effects between the unlike molecules of the binary mixtures. Further, the infrared spectra of both the systems, (FA + 2-ME) and (FA + 2-EE), have also been recorded at room temperature and found to be useful for understanding the presence of extensive hydrogen bonding between oxygen atom of C=O group of formamide and hydrogen atoms of the H-O group of 2-alkoxyethanol molecules in these binary liquid mixtures. © 2012 Elsevier Ltd. All rights reserved.