Nancy is a city with a strong university tradition. The University of Lorraine was founded in 1572 by the Dukes of Lorraine. It gained year after year a longstanding renown in Science, Law, Humanities and Medecine. Its current student population is 55,000, the majority being in Nancy. This is almost one student for seven inhabitants. Some 6,000 international students study on various campus in Nancy. The University of Lorraine , often abbreviated in UL, is a grand établissement created on 1 January 2012 by the merger of Henri Poincaré, Nancy 2 and Paul Verlaine Universities, and the National Polytechnic Institute of Lorraine . The merger process started in 2009 with the creation of a "pôles de recherche et d'enseignement supérieur" or PRES.The university is divided into two university centers, one in Nancy and one in Metz . The University of Lorraine has over 52,000 students and offers 101 accredited research centers organized in 9 research areas and 8 doctoral colleges. Wikipedia.
French Institute of Health, Medical Research, University of Lorraine, Nancy University Hospital Center, University Paris Diderot and University of Paris Descartes | Date: 2017-01-31
The present invention relates to methods and pharmaceutical compositions for the treatment of cardiovascular fibrosis. In particular, the present invention relates to an inhibitor of Neutrophil Gelatinase-Associated Lipocalin (NGAL) activity or expression for use in a method for treating or preventing cardiovascular fibrosis in a subject in need thereof.
Leach International Europe SA and University of Lorraine | Date: 2015-02-03
A method and a circuit for detecting an electric arc in an electric circuit supplied with AC current during a supply period includes measuring at least one input signal (S) among a current (I) and an input voltage (U) of the electric circuit, supplying a warning signal (A1) to indicate that an electric arc occurs when the input signal (S) is constant over at least one portion of the supply period, digitally sampling the input signal (S) during the measurement thereof according to predetermined levels and, to identify that the input signal (S) is constant, determining the frequency at which each level is reached by the input signal (S) over a predetermined time window, comparing the frequency of each level with a predetermined warning threshold, and issuing the warning signal if the frequency of at least one of the levels is higher than the warning threshold.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMP-29-2015 | Award Amount: 8.00M | Year: 2016
A definitive conclusion about the dangers associated with human or animal exposure to a particular nanomaterial can currently be made upon complex and costly procedures including complete NM characterisation with consequent careful and well-controlled in vivo experiments. A significant progress in the ability of the robust nanotoxicity prediction can be achieved using modern approaches based on one hand on systems biology, on another hand on statistical and other computational methods of analysis. In this project, using a comprehensive self-consistent study, which includes in-vivo, in-vitro and in-silico research, we address main respiratory toxicity pathways for representative set of nanomaterials, identify the mechanistic key events of the pathways, and relate them to interactions at bionano interface via careful post-uptake nanoparticle characterisation and molecular modelling. This approach will allow us to formulate novel set of toxicological mechanism-aware end-points that can be assessed in by means of economic and straightforward tests. Using the exhaustive list of end-points and pathways for the selected nanomaterials and exposure routs, we will enable clear discrimination between different pathways and relate the toxicity pathway to the properties of the material via intelligent QSARs. If successful, this approach will allow grouping of materials based on their ability to produce the pathway-relevant key events, identification of properties of concern for new materials, and will help to reduce the need for blanket toxicity testing and animal testing in the future.
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2015 | Award Amount: 1.33M | Year: 2016
Increasingly challenging global and environmental requirements have resulted in agricultural systems coming under increasing pressure to enhance their resilience capabilities in order to respond to the abrupt changes in resource quality, quantity and availability, especially during unexpected environmental circumstances, such as uncertain weather, pests and diseases, volatile market conditions and commodity prices. Therefore, integrated solutions are necessary to support the whole food agricultural life-cycle value chain. Solutions necessarily must consider the products cycle, as well as each of the value chain stages. Thus, managing risks and the uncertain availability of information will lead farmers to take advantage of these managerial, technical and social based-solutions. This implies the need for innovative technology-based knowledge management system to capture the agricultural information, at a variety of regional locations, in terms of collecting, storing, processing, and disseminating information about uncertain environmental conditions that affect agricultural decision-making production systems. Hence, from the genetic design of the seed, till their planting and harvest processes, RUCAPS provides knowledge of the full agricultural life-cycle based-decision making process to realise the key impacts of every stage of the agriculture-related processes. Therefore, RUCAPS implies the development of a high impact research project in order to integrate real-life based agriculture requirements, alternative land management scenarios, unexpected weather and environmental conditions as well as supporting innovation in the development of agriculture production systems, operations, logistics and supply chain management and the impact of these systems and processes over the end-users and customers. This is to be conceived through the integration of standard and customised solutions for facilitating the collaborative engagement within the agriculture value chain.
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: NFRP-10-2014 | Award Amount: 3.18M | Year: 2016
The present situation of nuclear energy in Europe asks for a continuing effort in the field of Education and Training aimed to assure a qualified workforce in the next decades. In this scenario, the present proposal is aimed at enhancing and networking the Europe-wide efforts initiated in the past decades by different organisations belonging to academia, research centres and industry to maintain and develop Education and Training in the nuclear fields. This will allow consolidating, developing and better exploiting the achievements already reached in the past and to tackle the present challenges in preparing the European workforce in the nuclear fields. The main objectives of the proposal are: 1. SURVEY AND COORDINATION OF NETWORKING IN E&T AND VET IN THE NUCLEAR AREAS 2. DESIGN AND IMPLEMENTATION OF COORDINATED E&T AND VET EFFORTS (Master and Summer Courses for continuous professional development) 3. GENERATIONAL TRANSFER OF EXPERTISE (Sustainable production of educational material) 4. CROSS BORDER TRANSFER OF EXPERTISE (Implementation of ECVET based exchanges among industrial bodies) 5. REINFORCING ETI ACTIONS FOR SHARING AND ENHANCING NUCLEAR SAFETY CULTURE COMPETENCE 6. FACILITATING THE NUCLEAR TRANSITION IN FUSION: COORDINATING THE E&T ACTIONS The European Nuclear Education Network (ENEN), as coordinator of the proposed action, together with the other Participants, is committed to pursue the above objectives, being fully coherent with the ones suggested in the call (NFRP10) and proposed by the SET Plan Roadmap for Education and Training for the nuclear sector, tightening at the same time the links among the different nuclear areas and better coordinating their contributions in the E&T fields. Strict links with the SNE-TP; IGD-TP and MELODI platforms and other relevant associations and bodies (EHRO-N, NUGENIA, EUTERP, IAEA, HERCA, etc.) will be implemented to assure coherence of this effort with similar other efforts going on in Europe.
Agency: European Commission | Branch: H2020 | Program: ECSEL-IA | Phase: ECSEL-18-2015 | Award Amount: 82.27M | Year: 2016
The goal of EnSO is to develop and consolidate a unique European ecosystem in the field of autonomous micro energy sources (AMES) supporting Electronic European industry to develop innovative products, in particular in IoT markets. In summary, EnSO multi-KET objectives are: Objective 1: demonstrate the competitiveness of EnSO energy solutions of the targeted Smart Society, Smart Health, and Smart Energy key applications Objective 2: disseminate EnSO energy solutions to foster the take-up of emerging markets. Objective 3: develop high reliability assembly technologies of shapeable micro batteries, energy harvester and power management building blocks Objective 4: Develop and demonstrate high density, low profile, shapeable, long life time, rechargeable micro battery product family. Objective 5: develop customizable smart recharge and energy harvesting enabling technologies for Autonomous Micro Energy Source AMES. Objective 6: demonstrate EnSO Pilot Line capability and investigate and assess the upscale of AMES manufacturing for competitive very high volume production. EnSO will bring to market innovative energy solutions inducing definitive differentiation to the electronic smart systems. Generic building block technologies will be customizable. EnSO manufacturing challenges will develop high throughput processes. The ENSo ecosystem will involve all the value chain from key materials and tools to many demonstrators in different fields of application. EnSO work scope addresses the market replication, demonstration and technological introduction activities of ECSEL Innovation Action work program. EnSO relates to several of the Strategic Thrusts of ECSEL MASP. EnSO innovations in terms of advanced materials, advanced equipment and multi-physics co-design of heterogeneous smart systems will contribute to the Semiconductor Process, Equipment and Materials thrust. The AMES will be a key enabling technology of Smart Energy key applications.
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 2.05M | Year: 2016
In this project we aim to train early-stage researchers in what is referred to as an outstanding challenge in solid mechanics: developing novel solutions for the analysis and design of aerospace and defense structures subjected to extreme loading conditions. Structural elements used in these sectors are frequently subjected to a large variety of unusually severe thermo-mechanical solicitations. One easily realizes that this type of structures (e.g. components for satellites) has to be designed to sustain extreme temperatures, which may vary hundred degrees in short periods of time, and extreme mechanical loadings like hypervelocity impacts. New specific structural solutions are constantly developed to fulfill such requirements, which place these industrial sectors in the forefront of the technological innovation. Hereby, aerospace and defense industries constitute the natural meeting point between academia and entrepreneurial fabric. A deep understanding of the response of structures under the aforementioned sharp solicitations is mandatory for design purposes. Unfortunately, not even today is easy to find researchers in the labour market with such specific (and complicated) understanding. Aerospace and defence industries require highly-qualified technical staff capable of developing research and innovation within the framework of structural mechanics. This is the precise context where our proposal lies. We intend to form a consortium composed of 3 academic beneficiaries and 2 industrial beneficiaries which aims at developing specific training for early-stage researchers within the field of aerospace and defense structures subjected to severe thermo-mechanical loads. The leitmotif of this ITN is to train creative and innovative researchers ready to face structural-engineering challenges which arise in the vanguard of technological innovation.
Weissman K.J.,University of Lorraine
Nature Chemical Biology | Year: 2015
The modular polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) are among the largest and most complicated enzymes in nature. In these biosynthetic systems, independently folding protein domains, which are organized into units called 'modules', operate in assembly-line fashion to construct polymeric chains and tailor their functionalities. Products of PKSs and NRPSs include a number of blockbuster medicines, and this has motivated researchers to understand how they operate so that they can be modified by genetic engineering. Beginning in the 1990s, structural biology has provided a number of key insights. The emerging picture is one of remarkable dynamics and conformational programming in which the chemical states of individual catalytic domains are communicated to the others, configuring the modules for the next stage in the biosynthesis. This unexpected level of complexity most likely accounts for the low success rate of empirical genetic engineering experiments and suggests ways forward for productive megaenzyme synthetic biology.
Caro G.,University of Lorraine
Annual Review of Earth and Planetary Sciences | Year: 2011
The discovery of small 142Nd anomalies in early Archean rocks has brought about a revolution in our understanding of early planetary differentiation processes. 142Nd is a radiogenic isotope produced by the decay of now-extinct 146Sm in crustal and mantle reservoirs. Given that 142Nd heterogeneities can be produced only prior to 4.2 Gya, this short-lived chronometer provides selective information on the very early evolution of primordial silicate reservoirs. This information is particularly crucial for Earth, where the fingerprints of the earliest crustal formation processes have been almost entirely erased from the geological record. This article reviews the history of the field, from the pioneering applications of the 147Sm- 143Nd and 146Sm- 142Nd systems to ancient crustal rocks, to the more recent insights gained from application of 146Sm- 142Nd to meteorites and lunar samples. Copyright © 2011 by Annual Reviews. All rights reserved.
Agency: European Commission | Branch: H2020 | Program: ERC-ADG | Phase: ERC-ADG-2015 | Award Amount: 2.81M | Year: 2017
Light elements such as hydrogen and nitrogen present large isotope variations among solar system objects and reservoirs (including planetary atmospheres) that remain unexplained at present. Works based on theoretical approaches are model-dependent and do not reach a consensus. Laboratory experiments are required in order to develop the underlying physical mechanisms. The aim of the project is to investigate the origins of and processes responsible for isotope variations of the light elements and noble gases in the Solar System through an experimental approach involving ionization of gaseous species. We will also investigate mechanisms and processes of isotope fractionation of atmophile elements in planetary atmospheres that have been irradiated by solar UV photons, with particular reference to Mars and the early Earth. Three pathways will be considered: (i) plasma ionisation of gas mixtures (H2-CO-N2-noble gases) in a custom-built reactor; (ii) photo-ionisation and photo-dissociation of the relevant gas species and mixtures using synchrotron light; and (iii) UV irradiation of ices containing the species of interest. The results of this study will shed light on the early Solar System evolution and on processes of planetary formation.