Liverpool, United Kingdom
Liverpool, United Kingdom

The University of Liverpool is a public university based in the city of Liverpool, England. Founded in 1881 as a university college, it is also one of the six original "red brick" civic universities. It comprises three faculties organised into 35 departments and schools.It is a founding member of the Russell Group of research-intensive universities, the N8 Group for research collaboration and the University Management school is AACSB accredited.The university has produced nine Nobel Prize winners and offers more than 230 first degree courses across 103 subjects. It was the world's first university to establish departments in Oceanography, civic design, architecture, and biochemistry at the Johnston Laboratories.In 2006 the university became the first in the UK to establish an independent university in China making it the world's first Sino-British university.It has an annual turnover of £410 million, including £150 million for research.Graduates of the University are styled with the post-nominal letters Lpool, to indicate the institution. Wikipedia.

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University of Liverpool | Date: 2015-03-12

A device for applying a compressive force to the uterus, the device comprising a contact portion for contacting the uterus and providing a compressive force thereto, and at least two elongate handles each extending from the contact portion along a respective longitudinal axis. The at least two elongate handles are configured to facilitate insertion of the device into the body and handling of the device from outside the body when inserted. At least a part of the contact portion is configured to be radially moveable relative to the longitudinal axes between a first radial position and a second radial position where the second radial position is radially outward of the first radial position.

University of Liverpool | Date: 2015-04-15

Provided are fusion proteins, polynucleotides and expression vectors with therapeutic utility in the prevention and/or treatment of cancer, as well as medical uses of these agents, and methods of treatment in which they are used. A fusion protein of the invention comprises an amino acid sequence that provides the apoptosis-inducing activity of TRAIL, and a membrane-anchoring amino acid sequence. The amino acid sequence that provides the apoptosis-inducing activity of TRAIL comprises the extracellular domain of TRAIL, or a fragment or variant thereof. A fusion protein comprising an amino acid sequence from TRAIL that is able to induce apoptosis, and a second sequence that anchors the first sequence to the cell membrane, is markedly more effective at reducing viability of TRAIL receptor positive cells than the naturally occurring (wild type) TRAIL protein itself.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETOPEN-01-2016-2017 | Award Amount: 3.99M | Year: 2017

ArrestAD proposes a novel and visionary thinking resulting from the demonstration of the central role of a particular heparan sulfate species at the intracellular level in neurons and in circulating cells in the molecular pathology of Alzheimers disease (AD). AD is a societal challenge for which there is neither prevention nor possible cure. Research in the field has long been refining classic concepts based on the aggregation of A and tau through initial seeding and then spreading. Our vision is different and based on the demonstration that tau abnormal phosphorylation and aggregation is triggered by the interaction of tau with heparan sulfates internalized in neurons and circulating cells only in AD [UPEC R.1; P.1,2]. Based in this new concept, ArrestAD will establish links between AD genetics, disease hallmarks, and altered traffic and intracellular accumulation of heparan sulfates to generate new knowledge underpinning the development of new strategies for detection and treatment of AD. This will open to radically new technologies addressing two major objectives: 1) proving that specific and early diagnosis of AD is possible in circulating cells, and 2) demonstrating that a new class of drug candidates are able to preventing and/or arresting AD-neurodegeneration. To reach these objectives, ArrestAD brings together internationally recognized experts in AD clinics and diagnosis, in heparan sulfate biology, transcriptomics, interactomics, carbohydrate chemistry, enzymology, cell biology, animal experimentation with AD models, and a SME specialized in the development of diagnosis kits using circulating cells. The high-risk character of this joint science and technology research is offset by the multidisciplinary nature of the Consortium and the high socio-economic gain resulting from success. Based in this technology, we will build a diverse portfolio of future projects that will result in a long-term benefit for citizens, economy and society.

Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 4.00M | Year: 2017

Nanowires (NWs) exhibit unique properties that make them potential building blocks for a variety of next generation NanoElectronics devices. Recent advances have shown that NWs with predefined properties can be grown, offering a new paradigm enabling functional device prototypes including: biosensors, solar cells, transistors, quantum light sources and lasers. The critical mass of scientific knowledge gained now needs to be translated into NW technologies for industry. FP7-MC NanoEmbrace (ITN) and FUNPROB (IRSES), made substantial contributions to NW research, producing excellent scientific and technological results (>100 journal papers published) and delivered outstanding training in nanoscience and transferable skills to ESRs. Despite demonstrable scientific and technological advantages of NWs, NW-based technology concepts have not yet been translated into market-ready products, because industry and academia have not worked hand-in-hand to commercialize the research findings. Thus, it is essential that NW research is now directed towards customer-oriented scientific R&D; whilst applying innovative industrial design techniques to ensure rapid translation of the basic technologies into commercial devices. This ambitious challenge requires close collaboration between academia and the nascent NW industry, combining the efforts of scientists and engineers to address market needs. Building upon our previous achievements, a team of leading scientific experts from top institutions in Europe, strengthened by experts in innovative design and industrial partners with an excellent track record of converting cutting edge scientific ideas into market products has formed the INDEED network to address this challenge. To enhance employability, INDEED will train young ESRs to become experts with a unique skill set that includes interdisciplinary scientific techniques, industrial experience through R&D secondments and innovative design skills.

Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.91M | Year: 2017

To ensure a healthy environment for people living and working in buildings, research and engineering in the area of building acoustics is essential. Developments in modern building concepts, such as sustainable low-energy consuming buildings, buildings with lightweight materials and open plan working environments, as well as the need to build in extremely noisy areas, require involvement of acoustic experts in order to successfully (re)design buildings without negatively impacting upon peoples health and well-being. Taking up current and future acoustic challenges requires innovative solutions based on a thorough understanding and mastering of modern methods and tools, as well as a holistic acoustic approach involving acoustic design, products and subjective evaluation. However, in the complex field of building acoustics, research activities typically are not holistic and have become slightly marginalised. As a consequence, there is a lack of building acoustics experts. To meet the future acoustic needs of the built environment, Acoutect is constructed around two objectives: 1) Establish a long-lasting European-wide training programme on building acoustics, 2) Launch an innovative research programme. With these objectives, Acoutect will equip ESRs with skills to ensure acoustic quality of modern and future building concepts, and with excellent perspectives for a career in industry or academia within the area of building acoustics. The training and supervision to reach these objectives is offered by the Acoutect consortium composed of 5 academic and 7 non-academic participants. This consortium comprises various disciplines and sectors within building acoustics and beyond, promoting intersectoral, interdisciplinary and innovative training and mobility of the researchers within the project.

Trayhurn P.,University of Liverpool | Trayhurn P.,The University of Buckingham
Physiological Reviews | Year: 2013

The rise in the incidence of obesity has led to a major interest in the biology of white adipose tissue. The tissue is a major endocrine and signaling organ, with adipocytes, the characteristic cell type, secreting a multiplicity of protein factors, the adipokines. Increases in the secretion of a number of adipokines occur in obesity, underpinning inflammation in white adipose tissue and the development of obesity-associated diseases. There is substantial evidence, particularly from animal studies, that hypoxia develops in adipose tissue as the tissue mass expands, and the reduction in PO2 is considered to underlie the inflammatory response. Exposure of white adipocytes to hypoxic conditions in culture induces changes in the expression of >1,000 genes. The secretion of a number of inflammation-related adipokines is upregulated by hypoxia, and there is a switch from oxidative metabolism to anaerobic glycolysis. Glucose utilization is increased in hypoxic adipocytes with corresponding increases in lactate production. Importantly, hypoxia induces insulin resistance in fat cells and leads to the development of adipose tissue fibrosis. Many of the responses of adipocytes to hypoxia are initiated at PO2 levels above the normal physiological range for adipose tissue. The other cell types within the tissue also respond to hypoxia, with the differentiation of preadipocytes to adipocytes being inhibited and preadipocytes being transformed into leptin-secreting cells. Overall, hypoxia has pervasive effects on the function of adipocytes and appears to be a key factor in adipose tissue dysfunction in obesity. © 2013 the American Physiological Society.

Pirmohamed M.,University of Liverpool
Annual Review of Genomics and Human Genetics | Year: 2014

Drug response varies between individuals owing to disease heterogeneity, environmental factors, and genetic factors. Genetic factors can affect both the pharmacokinetics and pharmacodynamics of a drug, leading to changes in local and systemic drug exposure and/or changes in the function of the drug target, altering drug response. Several pharmacogenetic biomarkers are already utilized in clinical practice and have been shown to improve clinical outcomes. However, a large number of other biomarkers have never made it beyond the discovery stage. Concerted effort is needed to improve the translation of pharmacogenetic biomarkers into clinical practice, and this will involve the use of standardized phenotyping and genotyping strategies, collaborative work, multidisciplinary approaches to identifying and replicating associations, and cooperation with industry to facilitate translation and commercialization. Acceptance of these approaches by clinicians, regulators, patients, and the public will be important in determining future success. Copyright © 2014 by Annual Reviews. All rights reserved.

Vallabhaneni S.R.,University of Liverpool
Circulation | Year: 2012

Background-Fenestrated endovascular repair of abdominal aortic aneurysms has been proposed as an alternative to open surgery for juxtarenal and pararenal abdominal aortic aneurysms. At present, the evidence base for this procedure is predominantly limited to single-center or single-operator series. The aim of this study was to present nationwide early results of fenestrated endovascular repair in the United Kingdom. Methods and Results-All patients who underwent fenestrated endovascular repair between January 2007 and December 2010 at experienced institutions in the United Kingdom(>10 procedures) were retrospectively studied by use of the GLOBALSTAR database. Site-reported data relating to patient demographics, aneurysm morphology, procedural details, and outcome were recorded. Data from 318 patients were obtained from 14 centers. Primary procedural success was achieved in 99% (316/318); perioperative mortality was 4.1%, and intraoperative target vessel loss was observed in 5 of 889 target vessels (0.6%). The early reintervention (<30 days) rate was 7% (22/318). There were 11 deaths during follow-up; none were aneurysm-related. Survival by Kaplan-Meier analysis was 94% (SE 0.01), 91% (0.02), and 89% (0.02) at 1, 2, and 3 years, respectively. Freedom from target vessel loss was 93% (0.02), 91% (0.02), and 85% (0.06), and freedom from late secondary intervention (>30 days) was 90% (0.02), 86% (0.03), and 70% (0.08) at 1, 2, and 3 years. Conclusions-In this national sample, fenestrated endovascular repair has been performed with a high degree of technical and clinical success. Late survival and target vessel patency are satisfactory. These results support continued use and evaluation of this technique for juxtarenal aneurysms, but illustrate the need for a more robust evidence base. © 2012 American Heart Association, Inc.

Bro-Jorgensen J.,University of Liverpool
Trends in Ecology and Evolution | Year: 2010

The ubiquity of multiple signalling is a long-standing puzzle in the study of animal communication: given the costs of producing and receiving signals, why use more than a single cue? Focusing on sexually selected signals, I argue that dynamic variation in selection pressures can often explain why multiple signals coexist. In contrast to earlier research, which has taken a largely static view of the world, new insights highlight how fluctuations in ecological and social environments, as well as non-equilibrium dynamics intrinsic to coevolutionary systems, can maintain both multiple redundant and non-redundant signals. Future challenges will include identifying the circumstances under which environmental fluctuations lead to multiple signalling, and the consequences of such fluctuations for speciation in multiple-signalling species. © 2009 Elsevier Ltd. All rights reserved.

De Magalhaes J.P.,University of Liverpool
Nature Reviews Cancer | Year: 2013

The ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities. Understanding the links between cancer and ageing is therefore more important than ever. How the interplay of ageing-associated changes affects cancer initiation and progression is complex, however, and some ageing processes probably foster cancer development whereas others hinder it, possibly in a tissue-specific manner. In the emerging age of cancer, how can our growing understanding of the biology of ageing inform cancer biology? © 2013 Macmillan Publishers Limited. All rights reserved.

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