Liège, Belgium
Liège, Belgium

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Helgadottir A.,DeCODE Genetics Inc. | Helgadottir A.,University of Iceland | Gretarsdottir S.,DeCODE Genetics Inc. | Thorleifsson G.,DeCODE Genetics Inc. | And 92 more authors.
Journal of the American College of Cardiology | Year: 2012

The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis or thrombosis. The 2 LPA variants were combined and examined as LPA scores for the association with ischemic stroke (and TOAST [Trial of Org 10172 in Acute Stroke Treatment] subtypes) (effective sample size [n e] = 9,396); peripheral arterial disease (n e = 5,215); abdominal aortic aneurysm (n e = 4,572); venous thromboembolism (n e = 4,607); intracranial aneurysm (n e = 1,328); CAD (n e = 12,716), carotid intima-media thickness (n = 3,714), and angiographic CAD severity (n = 5,588). LPA score was associated with ischemic stroke subtype large artery atherosclerosis (odds ratio [OR]: 1.27; p = 6.7 × 10 4), peripheral artery disease (OR: 1.47; p = 2.9 × 10 14), and abdominal aortic aneurysm (OR: 1.23; p = 6.0 × 10 5), but not with the ischemic stroke subtypes cardioembolism (OR: 1.03; p = 0.69) or small vessel disease (OR: 1.06; p = 0.52). Although the LPA variants were not associated with carotid intima-media thickness, they were associated with the number of obstructed coronary vessels (p = 4.8 × 10 12). Furthermore, CAD cases carrying LPA risk variants had increased susceptibility to atherosclerotic manifestations outside of the coronary tree (OR: 1.26; p = 0.0010) and had earlier onset of CAD (1.58 years/allele; p = 8.2 × 10 8) than CAD cases not carrying the risk variants. There was no association of LPA score with venous thromboembolism (OR: 0.97; p = 0.63) or intracranial aneurysm (OR: 0.85; p = 0.15). LPA sequence variants were associated with atherosclerotic burden, but not with primarily thrombotic phenotypes. © 2012 American College of Cardiology Foundation.


Rosanova M.,University of Milan | Rosanova M.,University of Liège | Gosseries O.,University of Liège | Casarotto S.,University of Milan | And 9 more authors.
Brain | Year: 2012

Patients surviving severe brain injury may regain consciousness without recovering their ability to understand, move and communicate. Recently, electrophysiological and neuroimaging approaches, employing simple sensory stimulations or verbal commands, have proven useful in detecting higher order processing and, in some cases, in establishing some degree of communication in brain-injured subjects with severe impairment of motor function. To complement these approaches, it would be useful to develop methods to detect recovery of consciousness in ways that do not depend on the integrity of sensory pathways or on the subject's ability to comprehend or carry out instructions. As suggested by theoretical and experimental work, a key requirement for consciousness is that multiple, specialized cortical areas can engage in rapid causal interactions (effective connectivity). Here, we employ transcranial magnetic stimulation together with high-density electroencephalography to evaluate effective connectivity at the bedside of severely brain injured, non-communicating subjects. In patients in a vegetative state, who were open-eyed, behaviourally awake but unresponsive, transcranial magnetic stimulation triggered a simple, local response indicating a breakdown of effective connectivity, similar to the one previously observed in unconscious sleeping or anaesthetized subjects. In contrast, in minimally conscious patients, who showed fluctuating signs of non-reflexive behaviour, transcranial magnetic stimulation invariably triggered complex activations that sequentially involved distant cortical areas ipsi-and contralateral to the site of stimulation, similar to activations we recorded in locked-in, conscious patients. Longitudinal measurements performed in patients who gradually recovered consciousness revealed that this clear-cut change in effective connectivity could occur at an early stage, before reliable communication was established with the subject and before the spontaneous electroencephalogram showed significant modifications. Measurements of effective connectivity by means of transcranial magnetic stimulation combined with electroencephalography can be performed at the bedside while by-passing subcortical afferent and efferent pathways, and without requiring active participation of subjects or language comprehension; hence, they offer an effective way to detect and track recovery of consciousness in brain-injured patients who are unable to exchange information with the external environment. © 2012 The Author.


Xhauflaire-Uhoda E.,University Hospital of Lige | Pierard G.E.,University Hospital of Lige | Quatresooz P.,University Hospital of Lige
American Journal of Clinical Dermatology | Year: 2010

Skin capacitance is an electrical property measurable at the level of the stratum corneum. Values are related to the moisture content of the tissue. Using the silicon image sensor technology, it has recently become possible to measure capacitance at 50μm intervals on the skin surface. The resulting nonoptical picture corresponds to skin capacitance imaging. This novel tool for dermatologists highlights with precision the hollow skin surface patterns, including dermatoglyphics, the patterns of the shallow skin lines, and wrinkles. The topographic heterogeneity in skin surface hydration is made visible. In addition, the sweat gland and follicular openings are disclosed. Skin disorders induced by surfactants or presenting as hyperkeratotic areas, including some neoplasms, may show typical aspects. It is concluded that skin capacitance imaging brings added value to the clinical assessment performed by dermatologists. © 2010 Adis Data Information BV. All rights reserved.


Izumo M.,St. Marianna University School of Medicine | Suzuki K.,St. Marianna University School of Medicine | Moonen M.,University Hospital of Lige | Kou S.,St. Marianna University School of Medicine | And 8 more authors.
European Journal of Echocardiography | Year: 2011

Aims: Exercise may dramatically change the extent of functional mitral regurgitation (MR) and left ventricular (LV) geometry in patients with chronic heart failure (CHF). We hypothesized that dynamic changes in MR and LV geometry would affect exercise capacity.Methods and resultsThis study included 30 CHF patients with functional MR who underwent symptom-limited bicycle exercise stress echocardiography and cardiopulmonary exercise testing for quantitative assessment of MR (effective regurgitant orifice; ERO), and pulmonary artery systolic pressure (PASP). LV sphericity index was obtained from real-time three-dimensional echocardiograms. The patients were stratified into exercised-induced MR (EMR; n 10, an increase in ERO by <13 mm2) or non-EMR (NEMR; n 20, an increase in ERO by <13 mm2) group. At rest, no differences in LV volume and function, ERO, and PASP were found between the two groups. At peak exercise, PASP and sphericity index were significantly greater (all P < 0.01) in the EMR group. The EMR group revealed lower peak oxygen uptake (peak VO2; P 0.018) and greater minute ventilation/carbon dioxide production slope (VE/VCO2 slope; P 0.042) than the NEMR group. Peak VO2 negatively correlated with changes in ERO (r -0.628) and LV sphericity index (r -0.437); meanwhile, VE/VCO2 slope was well correlated with these changes (r 0.414 and 0.364, respectively). A multivariate analysis identified that the change in ERO was the strongest predictor of peak VO2 (P 0.001). ConclusionDynamic changes in MR and LV geometry contributed to the limitation of exercise capacity in patients with CHF. © The Author 2010.


Pierard-Franchimont C.,University Hospital of Lige | Pierard G.E.,University Hospital of Lige
Journal of Biomedicine and Biotechnology | Year: 2012

In recent years, the treatment of moderate to severe psoriasis has benefited from the development of targeted biologicals. Assessing this new class of drugs calls for precise modalities of severity/improvement ratings of the disease. Bioengineering-driven dermometrology aims at improving objective and quantitative assessments of disease severity and treatment efficacy. Skin capacitance mapping/imaging is one of those emerging methods. Among its clinical applications, psoriasis capacitance mapping (PCM) was introduced in order to assess both skin scaliness and water trapping inside the stratum corneum (inflammatory serum deposits) on lesional skin. PCM was used for assessing the therapeutic effects of ustekinumab on target lesions of 5 psoriatic patients. The reduction in the inflammatory dampness of the stratum corneum was conveniently seen after a 1-month ustekinumab treatment. The present pilot study suggests that PCM could be used as a fast and convenient method for assessing the anti-inflammatory efficacy of ustekinumab and other biotherapies. Copyright © 2012 Claudine Piérard-Franchimont and Gérald E. Piérard.


Nickers P.,University Hospital of Lige | Nickers P.,Center Oscar Lambret | Hermesse J.,University Hospital of Lige | Deneufbourg J.-M.,University Hospital of Lige | And 2 more authors.
Radiotherapy and Oncology | Year: 2010

Purpose: To calculate the α/β of prostate adenocarcinoma. Materials and methods: From January 1997 to December 2005, 328 patients were treated consecutively with external beam radiotherapy and brachytherapy boost. The patients with at least one of the following adverse prognostic factors were included: PSA > 10 ng/ml, Gleason score ≥ 7, T ≥ 2B. A total EQD2 of 80 Gy was delivered uniformly within the same timeframe. Prior to August 2002, the patients were treated to low-dose-rate brachytherapy using 192Ir (n = 201), and those treated thereafter received a high-dose-rate brachytherapy boost (n = 127). The equivalency of dose was established using the incomplete repair model, with generally accepted α/β ratio of 3 Gy, and half-time for repair of sublethal damage (HTR) of 1.5 h. Results: In a Cox proportional hazards model, the two groups displayed no difference (HR: 0.99, 95% CI: 0.87-1.1, p = 0.98) in biochemical control. Analyzing using the linear quadratic model, the data fit well an α/β ratio of 3.41 Gy (95% CI: 2.56-4.26) and the recently published HTR of 1.9 h (95% CI: 1.4-2.4), but also an α/β of 5.87 Gy (95% CI: 4.67-7.07) and the more widely established HTR of 1.5 h. Conclusions: Unlike the previously published data, calculation of the α/β ratio from consecutive patients and using a uniform treatment duration points to higher values than 2.5 Gy. © 2010 Elsevier Ireland Ltd. All rights reserved.


Mainjot A.K.,University Hospital of Lige | Mainjot A.K.,University of Paris Descartes | Schajer G.S.,University of British Columbia | Vanheusden A.J.,University Hospital of Lige | Sadoun M.J.,University of Paris Descartes
Dental Materials | Year: 2011

Objectives: Mismatch in thermal expansion properties between veneering ceramic and metallic or high-strength ceramic cores can induce residual stresses and initiate cracks when combined with functional stresses. Knowledge of the stress distribution within the veneering ceramic is a key factor for understanding and predicting chipping failures, which are well-known problems with Yttria-tetragonal-zirconia-polycrystal based fixed partial dentures. The objectives of this study are to develop a method for measuring the stress profile in veneering ceramics and to compare ceramic-fused-to-metal compounds to veneered Yttria-tetragonal-zirconia-polycrystal ceramic. Methods: The hole-drilling method, often used for engineering measurements, was adapted for use with veneering ceramic. Because of the high sensitivity needed in comparison with industrial applications, a high sensitivity electrical measurement chain was developed. Results: All samples exhibited the same type of stress vs. depth profile, starting with compressive at the ceramic surface, decreasing with depth and becoming tensile at 0.5-1.0 mm from the surface, and then becoming slightly compressive again. The zirconia samples exhibited a stress depth profile of larger magnitude. Significance: The hole drilling method was shown be a practical tool for measuring residual stresses in veneering ceramics. © 2010 Academy of Dental Materials.


Mainjot A.K.,University Hospital of Lige | Mainjot A.K.,University of Paris Descartes | Schajer G.S.,University of British Columbia | Vanheusden A.J.,University Hospital of Lige | Sadoun M.J.,University of Paris Descartes
Dental Materials | Year: 2011

Objectives: The manufacture of dental crowns and bridges generates residual stresses within the veneering ceramic and framework during the cooling process. Residual stress is an important factor that control the mechanical behavior of restorations. Knowing the stress distribution within the veneering ceramic as a function of depth can help the understanding of failures, particularly chipping, a well-known problem with Yttria-tetragonal-zirconia-polycrystal based fixed partial dentures. The objective of this study is to investigate the cooling rate dependence of the stress profile in veneering ceramic layered on metal and zirconia frameworks. Methods: The hole-drilling method, often used for engineering measurements, was adapted for use with veneering ceramic. The stress profile was measured in bilayered disc samples 20 mm in diameter, with a 0.7 mm thick metal or Yttria-tetragonal-zirconia-polycrystal framework and a 1.5 mm thick veneering ceramic. Three different cooling procedures were investigated. Results: The magnitude of the stresses in the surface of the veneering ceramic was found to increase with cooling rate, while the interior stresses decreased. At the surface, compressive stresses were observed in all samples. In the interior, compressive stresses were observed in metal samples and tensile in zirconia samples. Significance: Cooling rate influences the magnitude of residual stresses. These can significantly influence the mechanical behavior of metal-and zirconia-based bilayered systems. The framework material influenced the nature of the interior stresses, with zirconia samples showing a less favorable stress profile than metal. © 2011 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.


Thulkar S.,All India Institute of Medical Sciences | Namur G.,University Hospital of Lige | Hustinx R.,University Hospital of Lige | Bhalla A.S.,All India Institute of Medical Sciences | Kumar R.,All India Institute of Medical Sciences
PET Clinics | Year: 2011

Computed tomography (CT) is the primary noninvasive imaging modality for staging of non-small cell lung cancer. Magnetic resonance imaging compliments CT in tumor staging in specific situations. [18F]Fluorodeoxyglucose positron emission tomography/CT is useful in detecting additional regional nodal and distant metastatic sites of disease, thereby reducing the number of unnecessary surgeries. However, noninvasive imaging modalities lack sufficient accuracy for nodal staging in all cases and, hence, preoperative lymph node sampling with invasive techniques such as mediastinoscopy, thoracoscopy, and fine-needle aspiration cytology guided by endobronchial ultrasound or endoscopic ultrasound is frequently required in selected patients. © 2011 Elsevier Inc. All rights reserved.

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