Leipzig University , located in Leipzig in the Free State of Saxony, Germany, is one of the oldest universities in the world and the second-oldest university in Germany. Famous alumni include Leibniz, Goethe, Ranke, Nietzsche, Wagner, Angela Merkel, Raila Odinga, Tycho Brahe and nine Nobel laureates are associated with this university.The university was founded on December 2, 1409 by Frederick I, Elector of Saxony and his brother William II, Margrave of Meissen, and originally comprised the four scholastic faculties. Since its inception the university has engaged in teaching and research for over 600 years without interruption. Wikipedia.
University of Leipzig | Date: 2016-07-11
The invention relates to modified antibiotic peptides, in particular derivatives of apidaecin and oncocin, preferably having increased stability, reduced immunoreaction, and improved pharmacokinetics. In the invention, the peptide antibiotics are reversibly protected by means of a linker having the polymer polyethylene glycol (PEG). The peptide linker contains a recognition sequence for trypsin-like serum proteases. In the apidaecin derivatives, the linker and the PEG are bonded to a side chain. In the serum, the linker is cut by serum proteases and PEG is separated off. The released peptide still contains remnants of the linker, which are still bonded to the amino group in the side chain. Astonishingly, said remaining remnants of the linker impair the activity of the antimicrobial peptide only a little or not at all.
University of Leipzig | Date: 2016-12-23
This invention relates to modified antibiotic peptides, particularly for use in medicine. The invention further relates to composite and methods for destroying microorganisms, such as bacteria, viruses or fungi, and to methods for treating microbial infections. The object of the invention is to develop novel antibiotic peptides, particularly having enhanced antibiotic activity and an expanded spectrum of activity against other strains of bacteria, particularly gram-positive bacteria such as Staphylococcus aureus. According to the invention, the object is attained in a first aspect by a peptide according to claim 1.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: EINFRA-9-2015 | Award Amount: 8.22M | Year: 2016
The overall objective of READ is to implement a Virtual Research Environment where archivists, humanities scholars, computer scientists and volunteers are collaborating with the ultimate goal of boosting research, innovation, development and usage of cutting edge technology for the automated recognition, transcription, indexing and enrichment of handwritten archival documents. This Virtual Research Environment will not be built from the ground up, but will benefit from research, tools, data and resources generated in multiple national and EU funded research and development projects and provide a basis for sustaining the network and the technology in the future. This ICT based e-infrastructure will address the Societal Challenge mentioned in Europe in a Changing World namely the transmission of European cultural heritage and the uses of the past as one of the core requirements of a reflective society. Based on research and innovation enabled by the READ Virtual Research Environment we will be able to explore and access hundreds of kilometres of archival documents via full-text search and therefore be able to open up one of the last hidden treasures of Europes rich cultural hertitage.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-11-2015 | Award Amount: 7.42M | Year: 2016
Cancer is the second leading cause of mortality in EU member states with ~90% of all cancer deaths caused by metastatic spread. Despite its significance, measuring metastatic potential as well as potential indicators of therapy efficacy remain unmet clinical challenges. Recently, it has been demonstrated in vitro, that aggressive metastatic cells pull on their surroundings suggesting that metastatic potential could be gauged by measuring the forces exert by tumours. Furthermore, many solid tumours show a significantly increased interstitial fluid pressure (IFP) which prevents the efficient uptake of therapeutic agents. As a result, a reduction in IFP is recognized as a hallmark of therapeutic efficacy. Currently, there is no non-invasive modality that can directly image these forces in vivo. Our objective is the non-invasive measurement of both IFP within tumours as well as the forces they exert on their surrounding environment. This will be used to predict a tumours metastatic potential and importantly, changes in these forces will be used to predict the therapeutic efficacy of drug therapy. To attain this goal, the biomechanical properties of the tumour and its neighbouring tissue will be measured via MR-elastography at various measured deformation states. Resultant images will be used to reconstruct images of the internal and external forces acting on the tumour. We call this novel imaging modality Magnetic Resonance Force (MRF) imaging. We will calibrate MRF via cell cultures and pre-clinical models, and then test the method in breast, liver, and brain cancer patients. Thereby, we will investigate whether MRF data can predict metastatic spread and measure IFP in patients. We will also investigate the potential to non-invasively modulate the force environment of cancer cells via externally applied shear forces with the aim of impacting cell motility and proliferation. This can provide novel mechanism for anticancer therapeutic agents via mechanotransduction.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-09-2016 | Award Amount: 6.19M | Year: 2017
Chronic aortic aneurysms are permanent and localized dilations of the aorta that remain asymptomatic for long periods of time but continue to increase in diameter before they eventually rupture. Left untreated, the patients prognosis is dismal, since the internal bleeding of the rupture brings about sudden death. Although successful treatment cures the disease, the risky procedures can result in paraplegia from spinal cord ischaemia or even death, particularly for aneurysms extending from the thoracic to the abdominal aorta and thus involving many segmental arteries to the spinal cord, i.e. thoracoabdominal aortic aneurysms of Crawford type II. Although various strategies have achieved a remarkable decrease in the incidence of paraplegia, it is still no less than 10 to 20%. However, it has been found that the deliberate occlusion of the segmental arteries to the paraspinous collateral network finally supplying the spinal cord does not increase rates of permanent paraplegia. A therapeutic option, minimally invasive segmental artery coil embolization has been devised which proceeds in a staged way to occlude groups of arteries under highly controlled conditions after which time must be allowed for arteriogenesis to build a robust collateral blood supply. PAPA-ARTiS is a phase II trial to demonstrate that a staged treatment approach can reduce paraplegia and mortality dramatically. It can be expected to have both a dramatic impact on the individual patients quality of life if saved from a wheelchair, and also upon financial systems through savings in; 1) lower costs in EU health care; 2) lower pay-outs in disability insurance (est. at 500k in Year 1), and; 3) loss of economic output from unemployment. Approx. 2500 patients a year in Europe undergo these high risk operations with a cumulative paraplegia rate of over 15%; therefore >100M per year in costs can be avoided and significantly more considering the expected elimination of type II endoleaks.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-31-2016-2017 | Award Amount: 4.00M | Year: 2016
ECHOES is a multi-disciplinary research project providing policy makers with comprehensive information, data, and policy-ready recommendations about the successful implementation of the Energy Union and SET plan. Individual and collective energy choices and social acceptance of energy transitions are analysed in a multi-disciplinary process including key stakeholders as co-constructors of the knowledge. To account for the rich contexts in which individuals and collectives administer their energy choices, ECHOES utilizes three complementary perspectives: 1) individual decision-making as part of collectives, 2) collectives constituting energy cultures and life-styles, and (3) formal social units such as municipalities and states. To reduce greenhouse gas emissions and create a better Energy Union, system change is required. While technological change is a key component in this change, successful implementation of that change relies on the multi-disciplinary social science knowledge that ECHOES produces. Therefore, three broad technological foci which will run as cross-cutting issues and recurrent themes through ECHOES: smart energy technologies, electric mobility, and buildings. All three technology foci address high impact areas that have been prioritised by national and international policies, and are associated with great potential savings in greenhouse gas emissions. ECHOES uniquely comprehensive methodological approach includes a representative multinational survey covering all 28 EU countries plus Norway and Turkey, syntheses of existing data and literature, policy assessments, as well as quantitative experiments, interviews, netnography, focus groups, workshops, site visits and case studies in eight countries. All data collected in the project will be systematised in a built-for-purpose database that will serve both as an analytical tool for the project and as a valuable resource for stakeholders and researchers after the projects lifetime.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETPROACT-01-2016 | Award Amount: 5.82M | Year: 2017
Social media and the digitization of news and discussion fora are having far-reaching effects on the way individuals and communities communicate, organize, and express themselves. Can the information circulating on these platforms be tapped to better understand and analyze the enormous problems facing our contemporary society? Could this help us to better monitor the growing number of social crises due to cultural differences and diverging world-views? Would this facilitate early detection and perhaps even ways to resolve conflicts before they lead to violence? The Odycceus project answers all these questions affirmatively. It will develop the conceptual foundations, methodologies, and tools to translate this bold vision into reality and demonstrate its power in a large number of cases. Specifically, the project seeks conceptual breakthroughs in Global Systems Science, including a fine-grained representation of cultural conflicts based on conceptual spaces and sophisticated text analysis, extensions of game theory to handle games with both divergent interests and divergent mindsets, and new models of alignment and polarization dynamics. The project will also develop an open modular platform, called Penelope, that integrates tools for the complete pipeline, from data scraped from social media and digital sources, to visualization of the analyses and models developed by the project. The platform features an infrastructure allowing developers to provide new plug-ins for additional steps in the pipeline, share them with others, and jointly develop the platform as an open source community. Finally, the project will build two innovative participatory tools, the Opinion Observatory and the Opinion Facilitator, which allow citizens to monitor, visualize and influence the dynamics of conflict situations that involve heterogeneous cultural biases and non-transparent entanglements of multilateral interests.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-09-2016 | Award Amount: 4.95M | Year: 2017
TYPE 1 DIABETES is one of the most COMMON CHRONIC diseases in children with a RAPID increase in number of cases particularly in young children. Type 1 diabetes is associated with LIFE-LONG dependency on insulin administration. POOR glucose control leads to diabetes COMPLICATIONS, e.g. eye, heart, kidney disease, including BRAIN changes in young children. Episodes of VERY LOW glucose levels may be life threatening and are a major complication. The ARTIFICIAL PANCREAS addresses the problem of LOW and HIGH glucose levels by delivering insulin BELOW and ABOVE pre-set amounts according to real-time sensor GLUCOSE levels, combining glucose SENSOR, insulin PUMP, and CONTROL ALGORITHM. The Artificial pancreas promises to TRANSFORM management of type 1 diabetes but EVIDENCE supporting its use during FREE LIVING in YOUNG CHILDREN is MISSING. The project evaluates the biomedical, psychosocial, and cost effectiveness of NOVEL INDIVIDUALISED artificial pancreas in young children aged 1 to 7 years with type 1 diabetes. Following a PILOT (n=24), in the MAIN study (n=94) half of the participants (n=47) will be treated over 12 MONTHS by the ARTIFICIAL PANCREAS and the other half (n=47) by STATE-OF-THE-ART PREDICTIVE LOW GLUCOSE MANAGEMENT insulin pump therapy. Each treatment will last ONE YEAR. QUALITY OF LIFE will be assessed and semi-structured INTERVIEWS conducted to understand the impact on daily life. HEALTH TECHNOLOGY ASSESSMENT will support reimbursement. The project will OPTIMISE artificial pancreas and SPEARHEAD SYSTEM-WIDE improvements in health care quality and health outcomes in YOUNG CHILDERN with TYPE 1 DIABETES who live with the disease LONGEST. By IMPROVING THERAPEUTIC OUTCOMES, the project will CHANGE clinical practice and INFLUENCE national and international treatment guidelines making the artificial pancreas WIDELY ACCEPTABLE as the state-of-art treatment modality in young children.