Leicester, United Kingdom

University of Leicester

www.le.ac.uk
Leicester, United Kingdom

The University of Leicester is a research-led university based in Leicester, England. The main campus is a mile south of the city centre, adjacent to Victoria Park and Wyggeston and Queen Elizabeth I College. The university has established itself as a leading research-led university and has been named University of the Year of 2008 by the Times Higher Education. Wikipedia.


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Patent
University of Leicester | Date: 2016-11-10

Genetically modified mammals are described which lack the mannan binding lectin associated serine protease MASP-2, together with methods and constructs for their production. Such mammals are useful as models for disorders of the complement system, and in the identification of treatments for such disorders. Also described are mammals which lack the associated protein MAp19; such mammals may also lack MASP-2.


Patent
University of Leicester | Date: 2017-02-08

A method for assessing the electrical function of a heart, a method for determining a subjects need for the implantation of an implantable cardioverter defibrillator or the need for administration of an anti-arrhythmic agent, and apparatus for assessing the function of the heart and a computer program product. The methods and products involve analysis of ECG.


Patent
Omeros Corporation and University of Leicester | Date: 2016-11-09

In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a human subject suffering from TMA associated with hematopoietic stem cell transplant. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.


Patent
University of Leicester | Date: 2017-02-22

This invention relates to a method for analysing a liquid when inside a container in order to detect counterfeiting or adulteration of the liquid, the container being at least partially transparent to visible light. The method comprises the steps of: (a) measuring a first transmission spectrum through the container and the liquid at a first orientation of the container which defines a first optical path length through the liquid, (b) measuring a second transmission spectrum through the container and the liquid at a second orientation of the container which defines a second optical path length through the liquid, the second optical path length being different from the first optical path length, and the second spectrum at least partially overlapping with the first spectrum,(c) calculating the ratio (R()) of the first and second spectral intensities at each wavelength in the area of overlap, and(d) comparing this ratio (R()) to a reference measurement of the ratio for a non-counterfeit and unadulterated sample of the liquid being tested.


Patent
University of Leicester | Date: 2017-04-12

There is provided the use of at least one ionic liquid as a soldering/brazing flux. There is also provided a method of soldering a metal comprising applying a solder/braze comprising a flux to a surface of the metal and heating said metal to a desired soldering/brazing temperature, wherein the soldering/brazing flux comprises one or more ionic liquids.


Patent
Omeros Corporation and University of Leicester | Date: 2016-12-07

In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.


Patent
Omeros Corporation and University of Leicester | Date: 2016-12-07

In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact.


Patent
University of Leicester | Date: 2017-04-05

The invention relates to senescent cell biomarkers and the uses thereof. The invention also extends to methods and kits for detecting senescence, and drug conjugates and pharmaceutical compositions for killing senescent cells.


Patent
University of Leicester and University of Northampton | Date: 2017-02-22

The invention provides a process for tanning a substrate using at least one ionic liquid. The at least one ionic liquid can be used in at least one of the following tanning steps: tanning, re-tanning, preservation, liming, pickling, impregnation, lubrication, dyeing, fatliquoring or finishing.


An apparatus (10) for structured illumination microscopy (SIM) comprises a pulsed femtosecond MiTai laser (11) operable to generate a pulsed beam. The beam pulses are directed on to a specimen (12) via an optical arrangement including a beam steering apparatus comprising a pair of acousto-optic deflectors AODx, AODy, each operable to vary the deflection angle of the beam in response to variation in the frequency of an applied acoustic deflection signal,and an acousto-optic modulator AOM. The frequency of the acoustic deflection signals applied to the AODs and/or the frequency of the acoustic compensation signal applied to the AOM in the present invention is dynamically modulated. This dynamic modulation can increase the effective AODxy scan angle in each direction by about 4 mrads (equivalent to a 15% increase in the area of the field of view). Furthermore, dynamic modulation of the compensation frequency also improves the evenness of the illumination over the field of view.

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