Leeds, United Kingdom
Leeds, United Kingdom

The University of Leeds is a British Redbrick university located in the city of Leeds, West Yorkshire, England. Wikipedia.


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Patent
Mayo Foundation For Medical Education And Research and University of Leeds | Date: 2015-03-19

This document provides methods and materials for treating cancer. For example, methods and materials for treating cancer using combinations of antigens are provided. For example, VSV vectors designed to express a GNAQ antigen, a TYRP1 antigen, and an N-RAS antigen can be used to reduce the number of cancer cells (e.g., uveal melanoma cells) within a mammal (e.g., a human). In some cases, VSV vectors designed to express a BRAF antigen, a TOPO-lla antigen, and a YB-I antigen can be used to reduce the number of cancer cells (e.g., skin melanoma cells) within a mammal (e.g., a human). The composition can comprise less than 50 separate nucleic acid molecules.


Patent
Mayo Foundation For Medical Education And Research and University of Leeds | Date: 2015-03-19

This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided. In general, one aspect of this document features a composition comprising, or consisting essentially of, nucleic acid encoding HIF-2a, SOX-10, C-MYC, and TYRP-1, wherein the composition comprises less than 100 separate nucleic acid molecules.


Patent
University of Leeds | Date: 2015-04-16

There is described variegin for use as a medicament in the treatment of disease or condition characterised in that the variegin is administered in an amount of at least about 0.1 mg/kg (mass of drug compared to mass of patient).


Patent
University of Leeds | Date: 2017-01-04

The present invention is concerned with a dye system for application to a substrate, the dye system comprising: (a) at least one dye precursor; (b) an oxidising agent; and (c) a catalyst, wherein the catalyst is a homogenous catalyst or a heterogeneous catalyst. Preferably, the catalyst comprises at least one metal-containing compound. The invention also envisages a method for the coloration of a substrate, the method comprising treating the substrate with the dye system of the invention. In preferred embodiments of the invention, the substrate comprises human hair, natural or synthetic polymers, or textile fibres. In further preferred embodiments, the at least one dye precursor is an organic precursor, the at least one metal derivative for use as a catalyst comprises at least one inorganic metal compound or at least one metal complex comprising at least one organic ligand, and the oxidising agent is hydrogen peroxide.


Patent
University of Leeds | Date: 2017-02-22

There is described variegin for use as a medicament in the treatment of disease or condition characterised in that the variegin is administered in an amount of at least about 0.1 mg/kg (mass of drug compared to mass of patient).


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: IoT-01-2016 | Award Amount: 25.43M | Year: 2017

Automated driving is expected to increase safety, provide more comfort and create many new business opportunities for mobility services. The market size is expected to grow gradually reaching 50% of the market in 2035. The IoT is about enabling connections between objects or things; its about connecting anything, anytime, anyplace, using any service over any network. There is little doubt that these vehicles will be part of the IoT revolution. Indeed, connectivity and IoT have the capacity for disruptive impacts on highly and fully automated driving along all value chains towards a global vision of Smart Anything Everywhere. In order to stay competitive, the European automotive industry is investing in connected and automated driving with cars becoming moving objects in an IoT ecosystem eventually participating in BigData for Mobility. AUTOPILOT brings IoT into the automotive world to transform connected vehicles into highly and fully automated vehicle. The well-balanced AUTOPILOT consortium represents all relevant areas of the IoT eco-system. IoT open vehicle platform and an IoT architecture will be developed based on the existing and forthcoming standards as well as open source and vendor solutions. Thanks to AUTOPILOT, the IoT eco-system will involve vehicles, road infrastructure and surrounding objects in the IoT, with a particular attention to safety critical aspects of automated driving. AUTOPILOT will develop new services on top of IoT to involve autonomous driving vehicles, like autonomous car sharing, automated parking, or enhanced digital dynamic maps to allow fully autonomous driving. AUTOPILOT IoT enabled autonomous driving cars will be tested, in real conditions, at four permanent large scale pilot sites in Finland, France, Netherlands and Italy, whose test results will allow multi-criteria evaluations (Technical, user, business, legal) of the IoT impact on pushing the level of autonomous driving.


Hardie M.J.,University of Leeds
Chemical Society Reviews | Year: 2010

New chemistry of the cyclic molecular host cyclotriveratrylene (CTV) includes applications such as in sensors and separations; in self-organised materials such as gels, liquid crystals, dendritic systems, and self-assembled monolayers; and in metallo-supramolecular chemistry. This tutorial review covers aspects of CTV chemistry interest to supramolecular, coordination and host-guest chemists as well as those interested in self-organised systems. © 2010 The Royal Society of Chemistry.


Plane J.M.C.,University of Leeds
Chemical Society Reviews | Year: 2012

This review discusses the magnitude of the cosmic dust input into the earth's atmosphere, and the resulting impacts from around 100 km to the earth's surface. Zodiacal cloud observations and measurements made with a spaceborne dust detector indicate a daily mass input of interplanetary dust particles ranging from 100 to 300 tonnes, which is in agreement with the accumulation rates of cosmic-enriched elements (Ir, Pt, Os and super-paramagnetic Fe) in polar ice cores and deep-sea sediments. In contrast, measurements in the middle atmosphere - by radar, lidar, high-flying aircraft and satellite remote sensing - indicate that the input is between 5 and 50 tonnes per day. There are two reasons why this huge discrepancy matters. First, if the upper range of estimates is correct, then vertical transport in the middle atmosphere must be considerably faster than generally believed; whereas if the lower range is correct, then our understanding of dust evolution in the solar system, and transport from the middle atmosphere to the surface, will need substantial revision. Second, cosmic dust particles enter the atmosphere at high speeds and undergo significant ablation. The resulting metals injected into the atmosphere are involved in a diverse range of phenomena, including: the formation of layers of metal atoms and ions; the nucleation of noctilucent clouds, which are a sensitive marker of climate change; impacts on stratospheric aerosols and O 3 chemistry, which need to be considered against the background of a cooling stratosphere and geo-engineering plans to increase sulphate aerosol; and fertilization of the ocean with bio-available Fe, which has potential climate feedbacks. © The Royal Society of Chemistry 2012.


This tutorial review discusses the structural and electronic consequences of the Jahn-Teller effect in transition metal complexes, focussing on copper(ii) compounds which tend to be the most studied. The nature of a Jahn-Teller distortion in molecular complexes and extended lattices can be manipulated by application of pressure or temperature, by doping a molecule into a host lattice, or simply by molecular design. Many of these results have been achieved using compounds with a trans-[CuX4Y2] coordination sphere, which seems to afford copper centres that are particularly sensitive to their environment. Jahn-Teller distortions lead to some unusual phenomena in molecular magnetism, and are important to the functionality of important classes of conducting and superconducting ceramics. © 2013 The Royal Society of Chemistry.


Halcrow M.A.,University of Leeds
Chemical Society Reviews | Year: 2011

Spin-crossover compounds are becoming increasingly popular for device and sensor applications, and in soft materials, that make use of their switchable colour, paramagnetism and conductivity. The de novo design of new solid spin-crossover compounds with pre-defined switching properties is desirable for application purposes. This challenging problem of crystal engineering requires an understanding of how the temperature and cooperativity of a spin-transition are influenced by the structure of the bulk material. Towards that end, this critical review presents a survey of molecular spin-crossover compounds with good availability of crystallographic data. A picture is emerging that changes in molecular shape between the high- and low-spin states, and the ability of a lattice to accommodate such changes, can play an important role in determining the existence and the cooperativity of a thermal spin-transition in the solid state (198 references). © 2011 The Royal Society of Chemistry.

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