University of Lausannne

Epalinges, Switzerland

University of Lausannne

Epalinges, Switzerland
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The new urban ecology tackles a core question concerning the link between the concepts of ecological footprint and urban quality: how can cities become more «bearable» for nature and how can urban environments become more liveable for the human kind? Focusing on the imaginary, as well on the urban material form, fonctions and usages, sustainable planning lies at the very heart of the question at stake. Our reflection foresees the urban space layout as an evolving structure where allowing dialogue in the planning process is key at all scales of the collective decision-making. This dialogue, subordinate to ethical and political choices, could be considered as an opportunity to enhance sustainable urban development, and is at the centre of our thought.


Charmoy M.,University of Lausannne | Brunner-Agten S.,University of Lausannne | Aebischer D.,University of Lausannne | Auderset F.,University of Lausannne | And 4 more authors.
PLoS Pathogens | Year: 2010

Neutrophils are rapidly and massively recruited to sites of microbial infection, where they can influence the recruitment of dendritic cells. Here, we have analyzed the role of neutrophil released chemokines in the early recruitment of dendritic cells (DCs) in an experimental model of Leishmania major infection. We show in vitro, as well as during infection, that the parasite induced the expression of CCL3 selectively in neutrophils from L. major resistant mice. Neutrophil-secreted CCL3 was critical in chemotaxis of immature DCs, an effect lost upon CCL3 neutralisation. Depletion of neutrophils prior to infection, as well as pharmacological or genetic inhibition of CCL3, resulted in a significant decrease in DC recruitment at the site of parasite inoculation. Decreased DC recruitment in CCL3-/- mice was corrected by the transfer of wild type neutrophils at the time of infection. The early release of CCL3 by neutrophils was further shown to have a transient impact on the development of a protective immune response. Altogether, we identified a novel role for neutrophil-secreted CCL3 in the first wave of DC recruitment to the site of infection with L. major, suggesting that the selective release of neutrophil-secreted chemokines may regulate the development of immune response to pathogens. © 2010 Charmoy et al.


PubMed | University of Lausannne
Type: Journal Article | Journal: PLoS pathogens | Year: 2010

Neutrophils are rapidly and massively recruited to sites of microbial infection, where they can influence the recruitment of dendritic cells. Here, we have analyzed the role of neutrophil released chemokines in the early recruitment of dendritic cells (DCs) in an experimental model of Leishmania major infection. We show in vitro, as well as during infection, that the parasite induced the expression of CCL3 selectively in neutrophils from L. major resistant mice. Neutrophil-secreted CCL3 was critical in chemotaxis of immature DCs, an effect lost upon CCL3 neutralisation. Depletion of neutrophils prior to infection, as well as pharmacological or genetic inhibition of CCL3, resulted in a significant decrease in DC recruitment at the site of parasite inoculation. Decreased DC recruitment in CCL3(-/-) mice was corrected by the transfer of wild type neutrophils at the time of infection. The early release of CCL3 by neutrophils was further shown to have a transient impact on the development of a protective immune response. Altogether, we identified a novel role for neutrophil-secreted CCL3 in the first wave of DC recruitment to the site of infection with L. major, suggesting that the selective release of neutrophil-secreted chemokines may regulate the development of immune response to pathogens.

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