An Najaf al Ashraf, Iraq
An Najaf al Ashraf, Iraq

The University of Kufa is an Iraqi university located in Najaf, Iraq. It was founded in 1987 and comprises 12 colleges. The College of Medicine was established a decade earlier and attached to Mustansiriya University. In 1989, the College of Arts was established with only two departments: the Arabic Language Department and the Department of History. In 1991, the regime of Saddam Hussein closed the university after an uprising in March 1991, but two years later it was re-opened. Wikipedia.

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Hadi A.-H.A.,University of Kufa | Jaffat H.S.,University of Kufa
International Journal of PharmTech Research | Year: 2016

Aluminum compounds are used in many pharmaceuticals. Antacid as aluminum hydroxide [Al (OH)3] was tested for its effects on the sperm parameters and testis of rats at dosage of 18 mg/kg/day. Mature male rats were treated orally for 30 days. The sperm parameters in epididymis were counted and testes were examined. Results obtained showed that Al(OH)3 caused significant (P < 0.05) decrease in sperm concentration, sperm motility percent and sperm viability percent compared to the control group, while abnormal sperm morphology percent were increased. In addition, the exposure of rats to Al(OH)3 caused obvious histopathological changes in the testes. It can be concluded that high antacid intake for long period can be effective on reproductive system. © 2016, Sphinx Knowledge House. All Rights Reserved.


Nasir A.S.,University of Kufa | Jaffat H.S.,University of Kufa
International Journal of PharmTech Research | Year: 2016

The present study suggested the therapeutic effect of turmeric (Curcuma longa) extract against oxidative stress induced by lithium carbonate (Li2CO3) are studied. The experiment is designed on fifty male rats spread randomly into 5 groups of 10 animals in each group. Thefirstgroup is received normal saline as normal control, the second and third groups are given lithium carbonate only at dose 4 and 8 mg/kg for induction of oxidative state on rats, While the fourth group is received lithium carbonate at dose 4 mg/kg with turmeric extract (curcuminoids) at dose 1 g for 1 kg of diet and the fifth group is received lithium carbonate at dose 8 mg/kg with turmeric extract (curcuminoids) at dose 1 g for 1 kg of diet. Results showed that oral administration of turmeric extract in rats with oxidative state by Li2CO3 increase the red blood corpuscles (RBCS), haemoglobin concentration (Hb), packed cell volume (PCV) and decrease the white blood cells (WBCS), erythrocyte sedimentation rate (ESR).At the same time, the results appear increase dopamine level and decrease serotonin level in groups administrated lithium carbonate and curcuminoids. In conclusion: turmeric has beneficial effect against side effects induced by Li2CO3 in rats. © 2016, Sphinx Knowledge House. All rights reserved.


Nasir A.S.,University of Kufa | Jaffat H.S.,University of Kufa
International Journal of PharmTech Research | Year: 2016

The antioxidant effect of turmeric (Curcuma longa) extract against side effects induced by lithium carbonate (Li2CO3) were studied. The experiment was carried out on fifty male rats distributed randomly into 5 groups of 10 animals in eachgroup.The (1) group was kept as a normal control was received normal saline, rats of group (2) and (3) were given only lithium carbonate only in a dose 4 and 8 mg/kg for induction of oxidative state on rats, While other groups (4) was received lithium carbonate at dose 4 mg/kg with turmeric extract at dose 1 g for 1 kg of diet and groups (5) was received lithium carbonate at dose 8 mg/kg with turmeric extract at dose 1 g for 1 kg of diet. Results showed that oral administration of turmeric extract in rats with oxidative state by Li2CO3 decrease the lipid profile parameters and increase antioxidant enzymes. Conclusively: treatment by turmeric extract was produce a protective effect against oxidative stress by Li2CO3 in the male rats. © 2016, Sphinx Knowledge House. All rights reserved.


Mezher M.N.,University of Kufa
International Journal of PharmTech Research | Year: 2016

This work was directed to get a comparison between the conventional methods ELISA commonly used in lab study for detection of viral hepatitis B and viral DNA by PCR. Thirty plasma samples were collected from patients referred to the Babylon GIT Center in Merjan Teaching Hospital. Those patients were already suffering from viral hepatitis B, or newly diagnosed as being infected with HBV and diagnosed after blood donation and a screening of their family members. Patients were segregated according to age, gender, disease duration. Viral antigenæmia (serum HBs Ag.) was estimated by ELISA technique, while HBV viral DNA was detected after extraction of plasma DNA by Real-Time PCR. Detection of viral revealed 6 (20%) cases with undetectable viral load in their plasma, indicating either, the virus load was below the detectable level of the PCR Kit, or false positive by ELISA, assuming that detection of viral DNA carries a high rate of specificity and sensitivity. Comparison between DNA copies and the level of HBs Ag. Revealed that most instances of high HBs Ag. Demonstrate a high viral load of DNA copies. © 2016, Sphinx Knowledge House. All rights reserved.


In this study, new biopolymer nanocomposites have been prepared. Fatty nitrogen compounds (FNCs); fatty amide (FA), fatty hydroxamic acid (FHA), and carbonyl difatty amide (CDFA), which were synthesized from palm oil, have been used as one of organic compounds to modify natural clay (sodium montmorillonite). The clay modification was carried out by stirring the clay particles in an aqueous solution of FA, FHA, and CDFA by which the clay layer distance increases from 1.23 to 2.71, 2.91 and 3.23 nm, respectively. The modified clay was then used in the preparation of the polylactic acid/epoxidized palm oil (PLA/EPO) blend nanocomposites. The interaction of the modifier in the clay layer was characterized by X-ray diffraction (XRD), and Fourier transform infrared (FTIR). Elemental analysis was used to estimate the presence of FNCs in the clay. The nanocomposites were synthesized by melt blending of the modified clay and PLA/EPO blend at the weight ratio of 80/20. The nanocomposites were then characterized using XRD, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and tensile properties measurements. The XRD and TEM results confirmed the production of nanocomposites. PLA/EPO modified clay nanocomposites show higher thermal stability and significant improvement of mechanical properties in comparison with those of the PLA/EPO blend. © 2011 Pleiades Publishing, Ltd.


Hussein A.H.,University of Kufa
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2015

Objectives: Okra (Abelmoschus Esculentus) is one of the world wide distributed plants used mostly as a food in most civilizations, its fruit characterized by sticky materials tears from it upon fruit cutting, this sticky material could be beneficial in matrix formation and sustained release tablets formulation. Methods: Fresh okra was collected and macerated in different extracting systems in variable ratios. The extracts were dried and collected. Selected extracts were granulated and compressed into tablets using the tablet machine. The formulated tablets were characterized in terms of hardness, friability disintegration and other gross findings, Extract from HCl and NaoH (OE 7 and8) were selected to prepare SR tablet of pentoxifylline (PTX); the same tests were performed in addition to measure the rate of PTX release from the tablet over ten hours. Results: Results obtained shows a promising retardation polymer as the tablets has an elegant shape and texture without chips or cracks, and not friable (FHCl 1 loses 0.03% of its weight after friability testing), tablet strength is acceptable since tablets resist breaking strength more than 200 Newtons, in addition, time needed for tablet disintegration about 175 minutes as found in F NaoH 3. Fortunately, the prepared tablets show a slow release of PTX following zero order kinetic (90% released in eight hours in a constant rate about 10% per hour). Conclusions: These results show the emerging of novel retardant for SR preparation obtained from natural plant okra. © 2015, International Journal of Pharmacy and Pharmaceutical Sciences. All rights reserved.


Al-Mulla E.A.J.,University of Kufa
Advanced Materials Research | Year: 2012

In this study, difatty acyl urea (DFAU), synthesized from palm oil, and natural clay (sodium montmorillonite) were used to prepare organoclay (OMMT). The clay modification was carried out by stirring the clay particles in an aqueous solution of DFAU at which the clay layer thickness increased from 1.25 to 2.82. This OMMT was then used for nanocomposite production to improve the property balance of poly(lactic acid) (PLA) by solution casting process. The nanocomposite was characterized using various apparatuses. The X-ray diffraction (XRD) and transmission electron microscopy (TEM) results confirmed the production of nanocomposite. PLA modified clay nanocomposite shows higher thermal stability and significant improvement of mechanical properties in comparison with pure PLA. The use of DFAU as a modifier will reduce the dependence on petroleum-based surfactant. In addition to its applications such as films and textile fibers, this nanocomposite represents a good candidate to produce disposable packaging because they have good mechanical, thermal properties, fabricability and processability.


In this study, different organoclays (OMMTs) were prepared using various fatty nitrogen compounds (FNCs) and natural clay, sodium montmorillonite (MMT). The clay modification was carried out by stirring the clay particles in an aqueous solution of fatty amides (FA), fatty hydroxamic acids (FHA), and carbonyl difatty amides (CDFA). These OMMTs were then used for nanocomposites production to improve the property balance of poly(lactic acid) (PLA) by solution casting process. All sets of OMMTs and nanocomposites were characterized using various apparatuses. In the nanocomposites, where the clay surface is pretreated with FA, FHA and CDFA, the basal spacing of the clay increased to 2.94, 3.26 and 3.80 nm, respectively The X-ray diffraction (XRD) and transmission electron microscopy (TEM) results confirmed the production of nanocomposites. PLA modified clay nanocomposites show higher thermal stability and significant improvement of mechanical properties in comparison with pure PLA. © 2011 The Korean Fiber Society and Springer Netherlands.


Al-Hakeim H.K.,University of Kufa | Al-Rammahi D.A.,University of Kufa | Al-Dujaili A.H.,University of Kufa
Journal of Affective Disorders | Year: 2015

Major depressive disorder (MDD) and schizophrenia are associated with inflammatory processes. Studies have shown that these disorders exhibit increase in the level of one or more proinflammatory markers. However, these studies did not exclude patients with obvious inflammation (i.e., CRP>6 mg/L). Therefore, a comprehensive study should include those inflammatory disorders. In the present study, the inflammatory natures of MDD and schizophrenia were investigated. To achieve this goal, serum levels of interleukin-6 (IL-6), interleukin-18 (IL-18), tumor necrosis factor alpha (TNFα), and soluble interleukin 2 receptor (sIL-2R) in depressed and schizophrenic patients were obtained and compared with those of the control group. Results showed a significant increase (p<0.05) in serum levels of IL-6, IL-18, TNFα, and sIL-2R in MDD and schizophrenic patients compared with the control group. Also patients with schizophrenia group showed higher levels of the inflammatory markers than MDD and control groups. The current study concluded that the immunological response in the MDD and schizophrenic patients groups was significantly stimulated. These disorders may be considered an inflammatory disorder because of elevated levels of proinflammatory cytokines in spite of lacking an overt inflammation. Furthermore results of this study suggested the possibility of the use of anti-inflammatory drugs as adjuvant therapy in schizophrenic and depressive disorders. © 2015 Elsevier B.V. All rights reserved.


Al-Mulla E.A.J.,University of Kufa
Korean Journal of Chemical Engineering | Year: 2011

Clay modification was carried out by treatment of fatty nitrogen compounds (FNCs); fatty hydrazide (FH), hydroxy methyl fattyamide (HMFA), and difatty acyl thiourea (DFAT) were synthesized from vegetable oils with a sodium montmorillonite (MMT) as natural clay. This process was accomplished by stirring the clay particles in an aqueous solution of FH, HMFA, and DFAT, by which the clay layer thickness increased from 1.23 to 2.69, 2.89 and 3.21 nm, respectively. The modified clay was then used in the preparation of the polylactic acid/epoxidized palm oil (PLA/ EPO) blend nanocomposites. The interaction of the modifier in the clay layer was characterized by X-ray diffraction (XRD) and Fourier transform infrared (FTIR). Elemental analysis was used to estimate the presence of FNCs in the clay. The nanocomposites were synthesized by solution casting of the modified clay and a PLA/EPO blend at the weight ratio of 80/20, which has the highest elongation at break. The nanocomposites were then characterized using XRD, transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and tensile properties measurements. Improvement in mechanical properties of the FH-MMT, HMFA-MMT, and DFAT-MMT nanocomposites was obtained when 2% of the DFAT-MMT and 3% of both FH-MMT and HMFA-MMT loadings were used. PLA/EPO modified clay nanocomposites show higher thermal stability in comparison with those of the PLA/EPO blend. The XRD and TEM results confirmed the production of nanocomposites. © 2010 Korean Institute of Chemical Engineers, Seoul, Korea.

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