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Kuala Lumpur, Malaysia

Universiti Kuala Lumpur is a multi-campus university technical university with its main campus based in Kuala Lumpur, Malaysia. Rated as a Tier-5 "Excellent University" by the Ministry of Higher Education Malaysia in 2009 and 2011, UniKL has 12 institutes spread across 11 campuses throughout Malaysia in Kuala Lumpur, Gombak, Cheras, Bangi, Kajang, Sepang, Taboh Naning, Pasir Gudang, Ipoh, Lumut and Kulim. Wikipedia.

Wahidin S.,University of Kuala Lumpur | Idris A.,University of Technology Malaysia | Shaleh S.R.M.,Universiti Malaysia Sabah
Bioresource Technology | Year: 2013

Illumination factors such as length of photoperiod and intensity can affect growth of microalgae and lipid content. In order to optimize microalgal growth in mass culture system and lipid content, the effects of light intensity and photoperiod cycle on the growth of the marine microalgae, Nannochloropsis sp. were studied in batch culture. Nannochloropsis sp. was grown aseptically for 9days at three different light intensities (50, 100 and 200μmolm-2s-1) and three different photoperiod cycles (24:0, 18:06 and 12:12h light:dark) at 23°C cultivation temperature. Under the light intensity of 100μmolm-2s-1 and photoperiod of 18h light: 6h dark cycle, Nannochloropsis sp. was found to grow favorably with a maximum cell concentration of 6.5×107cellsmL-1, which corresponds to the growth rate of 0.339d-1 after 8day cultivation and the lipid content was found to be 31.3%. © 2012 Elsevier Ltd. Source

Ibrahim M.H.,University of Kuala Lumpur | Law S.H.,University Putra Malaysia
Renewable and Sustainable Energy Reviews | Year: 2014

The present paper examines the mitigating effect of social capital on the environmental Kuznets curve (EKC) for CO2 emissions using a panel data of 69 developed and developing countries. Adopting generalised method of moments (GMM) estimators, the paper finds evidence substantiating the presence of EKC. Moreover, the evidence suggests that the pollution costs of economic development tend to be lower in countries with higher social capital reservoir. Surprisingly, there is also evidence to indicate that the income threshold point beyond which CO2 emissions decline is higher in countries with higher social capital. These results are robust to addition of alternative controlled variables in the EKC specification. Thus, in addition to policy focus on investments in environmentally friendly technology and on the use of renewable energy, investments in social capital can also mitigate the pollution effects of economic progress. © 2013 Elsevier Ltd. Source

Yong F.L.,University of Malaya | Law C.W.,University of Malaya | Wang C.W.,University of Kuala Lumpur
BMC Cancer | Year: 2013

Background: MicroRNAs (miRNAs) are short, non-coding RNA molecules that act as regulators of gene expression. Circulating blood miRNAs offer great potential as cancer biomarkers. The objective of this study was to correlate the differential expression of miRNAs in tissue and blood in the identification of biomarkers for early detection of colorectal cancer (CRC).Methods: The study was divided into two phases: (I) Marker discovery by miRNA microarray using paired cancer tissues (n = 30) and blood samples (CRC, n = 42; control, n = 18). (II) Marker validation by stem-loop reverse transcription real time PCR using an independent set of paired cancer tissues (n = 30) and blood samples (CRC, n = 70; control, n = 32). Correlation analysis was determined by Pearson's test. Logistic regression and receiver operating characteristics curve analyses were applied to obtain diagnostic utility of the miRNAs.Results: Seven miRNAs (miR-150, miR-193a-3p, miR-23a, miR-23b, miR-338-5p, miR-342-3p and miR-483-3p) have been found to be differentially expressed in both tissue and blood samples. Significant positive correlations were observed in the tissue and blood levels of miR-193a-3p, miR-23a and miR-338-5p. Moreover, increased expressions of these miRNAs were detected in the more advanced stages. MiR-193a-3p, miR-23a and miR-338-5p were demonstrated as a classifier for CRC detection, yielding a receiver operating characteristic curve area of 0.887 (80.0% sensitivity, 84.4% specificity and 83.3% accuracy).Conclusion: Dysregulations in circulating blood miRNAs are reflective of those in colorectal tissues. The triple miRNA classifier of miR-193a-3p, miR-23a and miR-338-5p appears to be a potential blood biomarker for early detection of CRC. © 2013 Yong et al.; licensee BioMed Central Ltd. Source

Chan S.C.,University of Kuala Lumpur
Singapore Medical Journal | Year: 2012

Introduction This study aimed to determine the views of Malaysian interns and their supervisors on whether undergraduate clinical skills training adequately equipped them for internship and their suggestions for improvement. Methods Pre-tested questionnaires covering demographic characteristics, the participants' views on clinical skills training (communication, history taking, physical examination, diagnosis, patient management and procedures) and their suggestions for improvement were sent to all interns and their supervisors through the hospital directors. Data compiled was analysed to determine any significant association. Results Out of the 32 hospitals with interns, 22 participated in the study. 521 completed questionnaires (350 interns, 171 supervisors) were analysed. The majority of interns felt that their undergraduate clinical skills training was adequate in all the aspects studied. The majority of supervisors, however, felt that it was grossly inadequate to poor in the areas of communication: breaking bad news (77% supervisors versus 13% interns), dealing with angry patients (75% versus 20%), giving information (59% versus 3%), communicating with patients' families (53% versus 7%); adult resuscitation: intubation (72% versus 23%), defibrillation (77% versus 31%), use of drugs (62% versus 19%); and all aspects of child resuscitation. This was statistically significant (p < 0.05). Suggestions for improvement included more clinical exposure, communication skills workshop and monitoring of logbooks. Conclusion This study suggests that there are deficiencies, particularly in communication and resuscitation skills training, in undergraduate clinical skills training. In-depth studies are required to identify ways to improve training. Source

Ee R.,University of Kuala Lumpur
Sensors (Basel, Switzerland) | Year: 2014

Quorum sensing is a unique bacterial communication system which permits bacteria to synchronize their behaviour in accordance with the population density. The operation of this communication network involves the use of diffusible autoinducer molecules, termed N-acylhomoserine lactones (AHLs). Serratia spp. are well known for their use of quorum sensing to regulate the expression of various genes. In this study, we aimed to characterized the AHL production of a bacterium designated as strain RB-25 isolated from a former domestic waste landfill site. It was identified as Serratia fonticola using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry analysis and this was confirmed by 16S ribosomal DNA sequencing. High resolution triple quadrupole liquid chromatography-mass spectrometry analysis of S. fonticola strain RB-25 spent culture supernatant indicated the existence of three AHLs namely: N-butyryl-L-homoserine lactone (C4-HSL), N-hexanoyl-L-homoserine lactone (C6-HSL) and N-(3-oxohexanoyl) homoserine-lactone (3-oxo-C6 HSL). This is the first report of the production of these AHLs in S. fonticola. Source

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