Universiti Kuala Lumpur is a multi-campus university technical university with its main campus based in Kuala Lumpur, Malaysia. Rated as a Tier-5 "Excellent University" by the Ministry of Higher Education Malaysia in 2009 and 2011, UniKL has 12 institutes spread across 11 campuses throughout Malaysia in Kuala Lumpur, Gombak, Cheras, Bangi, Kajang, Sepang, Taboh Naning, Pasir Gudang, Ipoh, Lumut and Kulim. Wikipedia.
Rajasuriar R.,University of Kuala Lumpur
AIDS | Year: 2017
BACKGROUND:: Aging among HIV-infected individuals on antiretroviral therapy (ART) is a significant clinical challenge however, studies assessing multidimensional aspects of aging are lacking. We characterised ten geriatric conditions (GCs) encompassing multiple functional domains, its health impact and associated risk factors in HIV-infected and age-matched uninfected controls. METHODS:: HIV-infected individuals were recruited from the out-patient clinic in University Malaya Medical Centre, Malaysia and controls from the community. All participants were aged ≥25years, no acute illness and HIV-infected individuals were on stable ART. GCs were assessed and the burden scored as a composite of GCs present in an individual (total score?=?10). Multivariate regression analysis was performed to determine the risk factors and health impact associated with the burden of GCs. RESULTS:: We analysed data from 336 HIV-infected individuals (total HIV+), of whom 172 were matched for age, gender and ethnicity with 172 HIV-uninfected controls (matched subset). In the total HIV+ cohort, median (interquartile range) age was 44 (38–51)years and CD4 T-cell count was 562 (398–737)cells/μl. The burden of GCs was significantly higher in the HIV-infected group compared to controls (p?0.001). With an increasing GC burden, quality of life scores were 2.2-times poorer, health-care utilisation 5-times greater and mortality risk scores 4-times higher in the HIV-infected group compared to matched controls. Both socio-behavioural and HIV-related clinical factors were independently associated with an increasing burden of GC in HIV. CONCLUSIONS:: A high burden of GCs with significant impact on health outcomes, including mortality risk scores are observed among HIV-infected individuals on ART in a resource-limited setting. Copyright © 2017 Wolters Kluwer Health, Inc.
Balamurugan M.,University of Kuala Lumpur
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012
Chitosan is a natural, tough, cationic, biodegradable, and biocompatible polymer obtained from chitin by deacetylation. Chitin is a polysaccharide obtained from exoskeletons of crustaceans and sea insects such as crab, krill, shrimp and crawfish etc. Besides the formerly mentioned resources it is also obtained from some fungi and bacterial cell walls. In recent times chitosan has been far and wide used as a popular formulation excipient due to its inimitable characteristics in the field of pharmaceutical sciences as binding, disintegrating, stabilizing, suspending, tablet coating, and film forming material. Chitosan has been comprehensively investigated for its suitability for its controlled release characteristics in various studies. Oral delivery of genes and peptides by means of different formulations based on chitosan was also investigated in various examinations by the capability of its absorption and penetration enhancing properties. It is possessing tremendous mucoadhesive and inherent anti-microbial properties, so that it can be used as a carrier for novel drug delivery. In addition to the above mentioned reasons, tailoring the controlled release and to improve the therapeutic efficacy of the low molecular weight drug compounds can also be achieved by this polymer and moreover in combination with various polymers is feasible due its compatibility i.e. low chemical reactivity. This brief editorial epitomizes the potential applications of chitosan in novel drug delivery systems.
Wahidin S.,University of Kuala Lumpur |
Idris A.,University of Technology Malaysia |
Shaleh S.R.M.,Universiti Malaysia Sabah
Bioresource Technology | Year: 2013
Illumination factors such as length of photoperiod and intensity can affect growth of microalgae and lipid content. In order to optimize microalgal growth in mass culture system and lipid content, the effects of light intensity and photoperiod cycle on the growth of the marine microalgae, Nannochloropsis sp. were studied in batch culture. Nannochloropsis sp. was grown aseptically for 9days at three different light intensities (50, 100 and 200μmolm-2s-1) and three different photoperiod cycles (24:0, 18:06 and 12:12h light:dark) at 23°C cultivation temperature. Under the light intensity of 100μmolm-2s-1 and photoperiod of 18h light: 6h dark cycle, Nannochloropsis sp. was found to grow favorably with a maximum cell concentration of 6.5×107cellsmL-1, which corresponds to the growth rate of 0.339d-1 after 8day cultivation and the lipid content was found to be 31.3%. © 2012 Elsevier Ltd.
Ibrahim M.H.,University of Kuala Lumpur |
Law S.H.,University Putra Malaysia
Renewable and Sustainable Energy Reviews | Year: 2014
The present paper examines the mitigating effect of social capital on the environmental Kuznets curve (EKC) for CO2 emissions using a panel data of 69 developed and developing countries. Adopting generalised method of moments (GMM) estimators, the paper finds evidence substantiating the presence of EKC. Moreover, the evidence suggests that the pollution costs of economic development tend to be lower in countries with higher social capital reservoir. Surprisingly, there is also evidence to indicate that the income threshold point beyond which CO2 emissions decline is higher in countries with higher social capital. These results are robust to addition of alternative controlled variables in the EKC specification. Thus, in addition to policy focus on investments in environmentally friendly technology and on the use of renewable energy, investments in social capital can also mitigate the pollution effects of economic progress. © 2013 Elsevier Ltd.
Yong F.L.,University of Malaya |
Law C.W.,University of Malaya |
Wang C.W.,University of Kuala Lumpur
BMC Cancer | Year: 2013
Background: MicroRNAs (miRNAs) are short, non-coding RNA molecules that act as regulators of gene expression. Circulating blood miRNAs offer great potential as cancer biomarkers. The objective of this study was to correlate the differential expression of miRNAs in tissue and blood in the identification of biomarkers for early detection of colorectal cancer (CRC).Methods: The study was divided into two phases: (I) Marker discovery by miRNA microarray using paired cancer tissues (n = 30) and blood samples (CRC, n = 42; control, n = 18). (II) Marker validation by stem-loop reverse transcription real time PCR using an independent set of paired cancer tissues (n = 30) and blood samples (CRC, n = 70; control, n = 32). Correlation analysis was determined by Pearson's test. Logistic regression and receiver operating characteristics curve analyses were applied to obtain diagnostic utility of the miRNAs.Results: Seven miRNAs (miR-150, miR-193a-3p, miR-23a, miR-23b, miR-338-5p, miR-342-3p and miR-483-3p) have been found to be differentially expressed in both tissue and blood samples. Significant positive correlations were observed in the tissue and blood levels of miR-193a-3p, miR-23a and miR-338-5p. Moreover, increased expressions of these miRNAs were detected in the more advanced stages. MiR-193a-3p, miR-23a and miR-338-5p were demonstrated as a classifier for CRC detection, yielding a receiver operating characteristic curve area of 0.887 (80.0% sensitivity, 84.4% specificity and 83.3% accuracy).Conclusion: Dysregulations in circulating blood miRNAs are reflective of those in colorectal tissues. The triple miRNA classifier of miR-193a-3p, miR-23a and miR-338-5p appears to be a potential blood biomarker for early detection of CRC. © 2013 Yong et al.; licensee BioMed Central Ltd.
Ee R.,University of Kuala Lumpur
Sensors (Basel, Switzerland) | Year: 2014
Quorum sensing is a unique bacterial communication system which permits bacteria to synchronize their behaviour in accordance with the population density. The operation of this communication network involves the use of diffusible autoinducer molecules, termed N-acylhomoserine lactones (AHLs). Serratia spp. are well known for their use of quorum sensing to regulate the expression of various genes. In this study, we aimed to characterized the AHL production of a bacterium designated as strain RB-25 isolated from a former domestic waste landfill site. It was identified as Serratia fonticola using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry analysis and this was confirmed by 16S ribosomal DNA sequencing. High resolution triple quadrupole liquid chromatography-mass spectrometry analysis of S. fonticola strain RB-25 spent culture supernatant indicated the existence of three AHLs namely: N-butyryl-L-homoserine lactone (C4-HSL), N-hexanoyl-L-homoserine lactone (C6-HSL) and N-(3-oxohexanoyl) homoserine-lactone (3-oxo-C6 HSL). This is the first report of the production of these AHLs in S. fonticola.
Mohd Jani J.,RMIT University |
Mohd Jani J.,University of Kuala Lumpur |
Leary M.,RMIT University |
Subic A.,RMIT University |
Materials and Design | Year: 2014
Shape memory alloys (SMAs) belong to a class of shape memory materials (SMMs), which have the ability to 'memorise' or retain their previous form when subjected to certain stimulus such as thermomechanical or magnetic variations. SMAs have drawn significant attention and interest in recent years in a broad range of commercial applications, due to their unique and superior properties; this commercial development has been supported by fundamental and applied research studies. This work describes the attributes of SMAs that make them ideally suited to actuators in various applications, and addresses their associated limitations to clarify the design challenges faced by SMA developers. This work provides a timely review of recent SMA research and commercial applications, with over 100 state-of-the-art patents; which are categorised against relevant commercial domains and rated according to design objectives of relevance to these domains (particularly automotive, aerospace, robotic and biomedical). Although this work presents an extensive review of SMAs, other categories of SMMs are also discussed; including a historical overview, summary of recent advances and new application opportunities. © 2013 Elsevier Ltd.
Shaharudin S.H.,University of Kuala Lumpur
Alternative therapies in health and medicine | Year: 2011
A cross-sectional studywas carried out to determine the prevalence of complementary and alternative medicine (CAM) use by breast cancer survivors. A descriptivesurveydesignwasdeveloped. Information on sociodemographic characteristics, cancer clinical treatment history, and use of CAM were obtained through a modified self-administered questionnaire from 116 Malay breast cancer survivors aged 21 to 67 years who were 2 years postdiagnosis and currently undergoing follow-up treatment at breast cancer clinics at Hospital Kuala Lumpur and Universiti Kebangsaan Malaysia Medical Centre. Data suggest that 64% of the participants were identified as CAM users; dietary supplements were the most common form used, followed by prayer and Malay traditional medicine. Within the wide range of dietary supplements, multivitamins were most often taken followed by spirulina, vitamin C, evening primrose oil, and herbal products. Contrary to other findings, the CAM users were found to be older, had secondary education levels, and were from middle-income households. However, there was no significant difference between CAM users and nonusers in this study. Family members played an important role as the main source of information along with doctors/health care providers, friends, and printed materials/mass media. The reasons participants gave for using CAM were mainly to assist in healing the body's inner strength, to cure cancer, and to reduce stress. Only half of the participants consulted with their physicians regarding the safety of CAM use. The participants began to use CAM while undergoing clinical treatments. Most of the participants used CAM for more than a year. About RM100 to RM149 (31.88 USD to 47.50 USD at press time) were spent monthly on CAM by 32% of the participants. The CAM use was found to be effective and beneficial for patients' disease states, and they were contented with the usage of the CAM therapies. Multivariate analysis revealed that thedecision to use or not to use CAM was not dependent on sociodemographic background or cancer clinical treatment history. CAM was commonly used by breast cancer survivors as a coping mechanism to battle the disease.
Sapawe N.,University of Kuala Lumpur
New Journal of Chemistry | Year: 2015
A HY zeolite supported by highly dispersed electrogenerated iron oxide nanoparticles (EGFe2O3/HY) was prepared by a facile electrochemical method and has been characterized using XRD, TEM, BET, UV-vis/DRS, and XPS. The formation of EGFe2O3 nanoparticles with a size of <30 nm, well distributed on the surface of HY, led to enhanced catalytic activity for the decolorization of organic dyes such as methylene blue (MB), congo red (CR), and methyl orange (MO) under sunlight irradiation. The MB dye shows the highest decolorization (99.9%) followed by CR (96.4%) and MO (91.3%). Kinetics study signifies that the reaction follows pseudo first-order kinetics, and the rate constants was determined using the Langmuir-Hinshelwood model which gave values of KR = 0.48 mg L-1 h-1, KLH = 3.83 L mg-1 for MB; KR = 0.39 mg L-1 h-1, KLH = 1.78 L mg-1 for CR; and KR = 0.29 mg L-1 h-1, KLH = 0.13 L mg-1 for MO. No dissolution of EGFe2O3 ions was detected during the photoreaction. The catalyst was stable with a slight decrease of decolorization (<13%) after five cycling runs. Good performance of the decolorization of simulated dyes was observed with nearly complete mineralization as measured by COD and TOC removal. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2015.
Al Joudi F.S.,University of Kuala Lumpur
Indian Journal of Medical Research | Year: 2014
Human mammaglobin is a member of the uteroglobin proteins family that has recently been tested as a specific marker for breast cancer. While low levels may be seen in normal breast tissue, expression is increased dramatically in breast cancer and is correlated with higher grade. Detection in blood and body fluids is also correlated with cancer metastasis, and its levels with prognosis. This promises to be a useful screen for early detection of breast cancer, especially in high risk individuals. Mammoglobin has also been used for immunotherapeutic targeting of breast cancer cells. However, there are some controversies regarding its diagnostic efficacy and prognostic value, which warrant further study.