University of Krkkale

Of, Turkey

University of Krkkale

Of, Turkey
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Titirinli K.,University of Krkkale | Tekin U.,University of Krkkale | Atl F.,University of Krkkale | Onder M.E.,University of Krkkale | And 3 more authors.
Journal of Biomaterials and Tissue Engineering | Year: 2017

Objective: This study aims to evaluate the effect of fibrin, which is formed with an alteration to the standard PRF centrifugation protocol, on the bone formation. The study additionally aims to assess cell-distribution, and to evaluate the effects of alterations in the speed and duration of centrifugation on the changes in cell-distribution and the formation of hard tissue, by making histological investigations. Materials and methods: Ten New Zealand rabbits were used in this experimental animal study. PRF (2700 rpm, 12 min) and APRF (1500 rpm, 14 min) were placed in the standard bone defects that formed in the right corpus of the mandible randomly. No additional material was placed in the left mandible defect, as a control group. Rabbits were sacrificed after two months, the histological evaluation was performed. Results: There were no marked differences between groups in regard to the quantity of bone formation and bone quality. The quantities of new bone formation were (mean) 56.9%, 55%, 42.5%. Discussion: It may be considered that PRF and its variations have positive effects on the new bone tissue and cell number, and may lead to more rapid ossification compared to the unprocessed bone defects. © 2017 American Scientific Publishers All rights reserved.


Engn A.,University of Krkkale | Yaln M.,Inonu University | Lker H.E.,Konya Oral Health Hospital | Ztrk B.,University of Konya | Hakk S.S.,University of Konya
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology | Year: 2011

Objective: The aim of this study was to evaluate the effects of 4 dentin-bonding agents on the cell viability of bovine derived cells. Study design: Cytotoxicity of dentin-bonding agents (G-Bond [GB], Adper Prompt Self-Etch [APSE], Clearfil DC Bond System [CDCB], and Quadrant University-1-Bond [UB]) was analyzed with a dentin barrier test device using 3-dimensional (3D) pulp cell cultures. A commercially available cell culture perfusion chamber was separated into 2 compartments using a 500 μm dentin disk. The 3D cultures were placed on a dentin disk and held in place with a special biocompatible stainless steel holder. Test materials were introduced into the upper compartment in direct contact with the cavity side of the dentin disks according to the manufacturer's instructions. Subsequently, the pulpal part of the perfusion chamber containing the cell cultures was perfused with a medium (2 mL/h). After an exposure period of 24 hours, cell survival was determined by using the MTT assay. Statistical analyses were performed using the Mann-Whitney U test. Results: In the dentin barrier test, cell survival rates of UB and CDCB were similar to the control group (P >.05). However, all other tested materials were cytotoxic for the 3D pulp-derived cell cultures (P <.05). Conclusions: Dentin-bonding agents include biologically active ingredients and may modify pulp cell metabolism when the materials are used in deep cavities in spite of a dentin barrier. If these adhesive agents are used in deep cavities, a biocompatible cavity liner should be used. © 2011 Mosby, Inc.


Basar M.M.,University of Krkkale | Ozkan Y.,Gazi University | Kisa U.,University of Krkkale | Simsek B.,Gazi University
Indian Journal of Geo-Marine Sciences | Year: 2013

The aim of the present study was to investigate serum homocysteine levels in patients with erectile dysfunction and to evaluate the relationship between serum homocysteine levels and response to the standard 50 mg phosphodiesterase 5 inhibitor treatment. Twenty-eight erectile dysfunction patients having normal vascular parameter according to Penile Doppler Ultrasonography and twenty healthy subjects were enrolled in the study. All subjects filled The International Index of Erectile Function (IIEF) questionnaire. A total of 4-6 doses of phosphodiesterase 5 inhibitor (sildenafil 50 mg) were given to patients. Later, they were divided into two groups as sildenafil responder and non-responder. Serum homocysteine levels were compared in groups based on sildenafil response. Compared with healthy subject, higher homocysteine levels were observed in patients with erectile dysfunction (p = 0.005), especially in sildenafil non-responder group (p = 0.005). There was significant negative correlation between homocysteine and IIEF scores in group responder to sildenafil treatment (r = -0.698, p = 0.008). Mean IIEF scores of patients with non-responder to sildenafil 50 mg were lower than those of controls (p = 0.0001), but mean IIEF scores of patients with responders approached values observed in control subjects (p = 0.002). The results indicated that measurement of serum homocysteine levels could be used as a marker for the evaluation of efficacy of phosphodiesterase 5 inhibitor and the selection of efficacious alternative therapies. © 2013, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.


Baydemir N.A.,University of Krkkale | Demirbas Y.,University of Krkkale | Gozutok S.,Abant Izzet Baysal University | Karoz A.M.,University of Krkkale
Caryologia | Year: 2015

C- and Ag-NOR banding of the least weasel, Mustela nivalis, from the central and Mediterranean regions of Turkey was examined for the first time in this study. The chromosome set was composed of 18 biarmed and three acrocentric autosome pairs. The X chromosome was a medium-sized submetacentric, while the Y was a small metacentric. A distinct secondary constriction was observed on the juxta centromeric region of the long arm of an autosome that was negatively C-banded. Large heterochromatic C-blocks, stained densely, were detected in six biarmed pairs, while ones stained faintly were recorded in four biarmed autosome pairs. Active NORs were located in the secondary constriction of the acrocentric autosome. The numbers of C-banded autosomes of Turkish specimens were similar to those reported previously from the Palearctic region. © 2015 Dipartimento di Biologia Evoluzionistica, Università di Firenze.


This study was carried out to investigate fleece qualities of Malya ewes and rams and effect of age (14 months age, 26 months age, 38 months age, 50 months age and 62 months age and older) and sex (ewe and ram) on fleece traits. The data were collected from 100 head ewes and 50 head rams raised at Malya State farm and were analyzed by using least squares method. The least squares means was calculated for greasy fleece weight (2.90±0.08 kg), clean wool percentage (50.05±0.69%), tenacity (18.72±0.52 Cn/Tex), fiber elasticity (31.17±0.43%), fiber diameter (26.66 ±0.19 um), staple length (H) (31.88±0.46 mm), and staple length (B) (47.67±0.72 mm), medullated fiber rate (23.52±0.73%), comfort factor (78.04±1.14%), and opacity (75.67±0.11%). Effect of age on all fleece traits was significant (P<0.001-P<0.05) except for fiber elasticity. Effect of sex on all fleece traits was significant (P<0.001-P<0.05) except for fiber diameter, tenacity and comfort factor. It can be generally concluded that younger and rams have higher fleece yield and fleece quality than older and ewes and fleece quality of Malya sheep was between textile and carpet industry and is closely similar to textile type wool. © 2015 University of Agriculture. All Rights Reserved.


PubMed | University of Krkkale
Type: Journal Article | Journal: Indian journal of pediatrics | Year: 2012

To evaluate the changes in heart rate variability (HRV) in newborns with hypoxic-ischemic encephalopathy (HIE).Twenty-two newborns (14 boys, 8 girls) with moderate or severe HIE and 24 term neonates with similar gestational and postnatal age for control were included in this study. Normalized low and high frequency components of HRV and their ratio were evaluated for 24-h in newborns with HIE and control subjects.The newborns with hypoxic-ischemic encephalopathy had significantly lower normalized low frequency (LFn) and low frequency (LF) / high frequency (HF) values and higher normalized high frequency (HFn) values when compared with the control babies. In addition, when the cases with severe HIE are compared with those of moderate HIE, decreased LFn, LF/HF values and also increased HFn values were present in the severe cases.HIE is associated with reduced sympathetic nervous system activity, and increased parasympathetic nervous system activity and these activities also correlate with the severity of the disease.

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