Pandey R.M.,All India Institute of Medical Sciences |
Agrawal A.,University of Rajasthan |
Misra A.,Fortis Rajan Dhall Hospital |
Vikram N.K.,All India Institute of Medical Sciences |
And 6 more authors.
Indian Heart Journal | Year: 2013
Background & objectives: There is poor knowledge and behaviors regarding chronic diseases related nutritional and lifestyle factors among women in low income countries. To evaluate efficacy of a multilevel population-based intervention in improving knowledge and practices for related factors we performed a study in India. Methods: Population based study among women 35-70 years was performed in four urban and five rural locations. Stratified sampling was performed and we enrolled 4624 (rural 2616, urban 2008) of eligible 8000 women (58%). Demographic details, medical history, diet, physical activity and anthropometry were recorded and blood hemoglobin, glucose and total cholesterol determined. Knowledge and behaviors regarding diet in chronic diseases were inquired in a randomly selected 100 women at each site (n = 900). A systematic multilevel population based intervention (using posters, handouts, street plays, public lectures, group lectures and focused group discussions) was administered over 6 months at each site. The questionnaire was re-administered at the end in random 100 women (n = 900) and differences determined. Descriptive statistics are reported. Comparison of parameters before and after intervention was assessed using Mann Whitney test. Results: Prevalence (%) of chronic disease related lifestyles and risk factors in rural/urban women, respectively, was illiteracy in 63.6/29.4, smoking/tobacco use 39.3/18.9, high fat intake 93.6/93.4, high salt intake 18.2/12.6, low physical activity 59.5/70.2, overweight/obesity 22.5/45.6, truncal obesity 13.0/44.3, hypertension 31.6/48.2, hypercholesterolemia 13.5/27.7, and diabetes in 4.3/15.1 percent. Composite chronic diseases knowledge at baseline vs after intervention increased significantly in overall (32.0 vs 62.0), rural (29.0 vs 63.5) and urban (39.5 vs 60.5) groups (p < 0.001). Significant increase in knowledge regarding diet in hypertension, diabetes, heart disease and anemia as well as importance of dietary proteins, fats, fibres and fruits was observed (p < 0.001). There was insignificant change in most of the practices regarding intake of low fat, high protein, high fibre diet except sieving the flour which declined significantly (80.1 vs 53.6, p < 0.001). Conclusions: A short-term multilevel population-wide intervention among women in rural and urban locations in India increased chronic disease knowledge but failed to influence practices. © 2012, Cardiological Society of India. All rights reserved.
Chakrabarty S.,Central Sericultural Research and Training Institute |
Saha A.K.,Central Sericultural Research and Training Institute |
Manna B.,Central Sericultural Research and Training Institute |
Manna B.,University of Kolkata |
Bindroo B.B.,Central Sericultural Research and Training Institute
Indian Silk | Year: 2012
Among different types of silkworms produced commercially, eri is highly resistant to pebrine in comparison to other silkworms. The authors discuss here about the disease and its symptoms and morphology, besides the extent of cocoon crop loss.
Ishimaru D.,Medical University of South Carolina |
Zuraw L.,The Citadel |
Ramalingam S.,Medical University of South Carolina |
Ramalingam S.,SASTRA University |
And 7 more authors.
Journal of Biological Chemistry | Year: 2010
The antiapoptotic Bcl-2 protein is overexpressed in a variety of cancers, particularly leukemias. In some cell types this is the result of enhanced stability of bcl-2 mRNA, which is controlled by elements in its 3′-untranslated region. Nucleolin is one of the proteins that binds to bcl-2 mRNA, thereby increasing its half-life. Here, we examined the site on the bcl-2 3′-untranslated region that is bound by nucleolin as well as the protein binding domains important for bcl-2 mRNA recognition. RNase footprinting and RNA fragment binding assays demonstrated that nucleolin binds to a 40-nucleotide region at the 5′ end of the 136-nucleotide bcl-2 AU-rich element (AREbcl-2). The first two RNA binding domains of nucleolin were sufficient for high affinity binding to AREbcl-2. In RNA decay assays, AREbcl-2 transcripts were protected from exosomal decay by the addition of nucleolin. AUF1 has been shown to recruit the exosome to mRNAs. When MV-4-11 cell extracts were immunodepleted of AUF1, the rate of decay of AREbcl-2 transcripts was reduced, indicating that nucleolin and AUF1 have opposing roles in bcl-2 mRNA turnover. When the function of nucleolin in MV-4-11 cells was impaired by treatment with the nucleolin-targeting aptamer AS1411, association of AUF1 with bcl-2 mRNA was increased. This suggests that the degradation of bcl-2 mRNA induced by AS1411 results from both interference with nucleolin protection of bcl-2 mRNA and recruitment of the exosome by AUF1. Based on our findings, we propose a model that illustrates the opposing roles of nucleolin and AUF1 in regulating bcl-2 mRNA stability. © 2010 by The American Society for Biochemistry and Molecular Biology, Inc.
Savina E.,James Madison University |
Coulacoglou C.,FTT Society |
Sanyal N.,University of Kolkata |
Zhang J.,CAS Institute of Psychology
School Psychology International | Year: 2012
The present study investigated externalizing and internalizing behaviours in Greek (n = 599), Russian (n = 596), Indian (n = 571), and Chinese (n = 376) 7- to-12-year-old children. The Fairy Tale Test was used to measure impulsive and motivated aggression, fear of aggression, anxiety, and depression. The results indicated culture-specific patterns of the aforementioned behaviours. Greek children demonstrated the highest levels of impulsive and motivated aggression, while Russian children had the highest fear of aggression. Chinese children appeared to be most anxious among other cultural groups. Both Russian and Indian children were more depressed than their Greek and Chinese counterparts. Gender and age difference were obtained only for impulsive aggression. Regardless of culture, boys scored higher compared to girls; and 7- to 8-year-old children demonstrated higher level of impulsive aggression than older children. The obtained results are interpreted in light of contextual differences in child socialization in four cultures; suggestions for school psychology practices are offered. © The Author(s) 2011.
Gupta A.D.,University of Kolkata |
Mukhopadhyay B.C.,SAIL Bokaro Steel Plant
InterCeram: International Ceramic Review | Year: 2013
The Bokaro Steel Plant of the Bokaro Steel Authority of India Ltd. (BSL-SAIL) is India's largest flat steel producer. It has five 2000-2500 m 3 capacity (useful volume) blast furnaces for production of hot metal. These furnaces are currently producing 11,550 mt of processed metal on a daily basis. The five furnaces are operated at a top pressure of 1.0-1.65 kg/cm2, with average productivity of 1.55 mt/m3/day of hot metal at a temperature of 1480-1510°C. In the Bokaro Steel Plant, each blast furnace (BF) has twin cast houses offset from each other by 180°. To increase the productivity of the BFs, there is continual demand for ever higher throughput of hot metal tonnage from the cast house through the main trough, metal runners and other parts of the plant, and a desire to move to hotter metal temperatures. The throughput and operational life of BF troughs and runners depends on the characteristics of their refractory components, lining design, installation, and maintenance and operating regimes. The paper describes the details of refractory-related operating parameters, product (Al 2O3-SiC-C) characteristics, trough/ runner material reactions in contact with iron, slag and air/slag interfaces, installation techniques, and causes of lining wear and other critical issues. New generation Al2O3-SiC-C low moisture castables with varied SiC content were also created and tested for strength and slag resistance.