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Kinshasa, Democratic Republic of the Congo

The University of Kinshasa , was one of three universities, along with University of Kisangani and University of Lubumbashi, created following the division of the National University of Zaire . It is located in Kinshasa.The university had an enrollment of 26,186 and a faculty and research staff of 1,530 in the 2006-2007 academic year, and currently has ten academic divisions. Wikipedia.

Pakasa N.M.,University of Kinshasa
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia | Year: 2011

Renal structural abnormalities in HIV/AIDS infected patients have been infrequently and incompletely reported in patients from sub-Saharan Africa. We report an immune complex glomerulonephritis with "lupus-like" features in a ten-year-old HIV+ boy who was evaluated at the University Hospital of Kinshasa. The light microscopic examination of the renal biopsy displayed a predominantly membranoproliferative glomerulonephritis with prominent focal segmental necrotizing injury, numerous wire-loops, and a spiky membranous nephropathy. In addition, there were prominent tubular injury, microcysts filled with periodic acid-Schiff (PAS) positive casts, edema and an inflammatory infiltrate of the interstitium, features of a classic HIV-associated nephropathy (HIVAN). Electron microscopy revealed large subendothelial, intra-membranous, subepithelial and mesangial deposits. The combination of these findings, while being consistent with lupus nephritis WHO grade IV/V, the tubulointerstitial HIVAN-like changes and the absence of clinical evidence of lupus disease favored an HIV-associated immune complex glomerulonephritis with "lupus-like features". Source

Kaimbo Wa Kaimbo D.,University of Kinshasa
Journal Francais d'Ophtalmologie | Year: 2012

Purpose: To determine the frequency of pseudoexfoliation syndrome (PEX) in Congolese patients and its association with cataract and glaucoma. Methods: We performed a cross-sectional and descriptive analysis of the data from patients diagnosed with PEX. Data were collected between February 2005 and June 2008 in a general practice of ophthalmology in Kinshasa. Patients aged 50 or above who attended the general practice of ophthalmology were included in the study. Each patient underwent complete ophthalmic evaluation, including visual acuity testing, slit-lamp biomicroscopy, applanation tonometry, gonioscopy, and ophthalmoscopy. The diagnosis of PEX was based on presence of typical pseudoexfoliation material on the anterior lens surface and/or the pupillary margin in either or both eyes. Results: Of 2142 patients seen during the study period, 37 (59 eyes) had PEX in either eye, for a frequency of 1.73%. The mean (±SD) age of the patients with PEX was 70.40 years ± 8 (range: 57-87 years). The frequency of PEX had a tendency to increase with age: 0.50% of patients aged 50-59 years had PEX, whereas 7.29% of those aged more or equal to 80 years were affected (P < 0.0001), with a female predominance (2.18% of women versus 1.22% of men, P = 0.035). PEX was bilateral in 22 (59.46%) of 37 patients (74.58% of eyes). Bilateral PEX was found more often in females (16 patients over 22, 72.72%) than in males (six patients over 15, 40%) (P = 0.05). PEX was significantly associated with cataract (P = 0.002) and glaucoma (P < 0.001). Conclusion: Despite the limitations inherent in a clinic-based study, this investigation provides an indication of the frequency of PEX in Central Africa. This shows that Congolese patients have a low frequency of PEX (1.73%), inferior to that of black people in South Africa (12.1-16%). This study confirms that PEX is an age-related condition and is associated with cataract and glaucoma, as in other races. © 2011 Elsevier Masson SAS. Source

Memvanga P.B.,Catholic University of Louvain | Memvanga P.B.,University of Kinshasa | Preat V.,Catholic University of Louvain
European Journal of Pharmaceutics and Biopharmaceutics | Year: 2012

β-Arteether, an effective artemisinin derivative, is used in the treatment of malaria but available only as an intramuscular injection. The objective of this work was to develop lipid-based formulations for oral administration of β-arteether. Self-emulsifying drug delivery systems (SEDDSs) of low cost and with accessible excipients (groundnut or sesame oil, Maisine 35-1, Tween 80 or Cremophor EL, and absolute ethanol) were formulated. In 250 ml of simulated gastric medium, 1 g of these SEDDS solubilized the daily dose of β-arteether and formed lipid droplets of average size 80-250 nm. No toxicity against Caco-2 intestinal cells was observed. Using a mouse model, the efficacy of these arteether lipid formulations against Plasmodium berghei was evaluated. A daily dose of 24 mg/kg for 4 days led to complete cure for more than 45 days in 100% of treated mice and had an antimalarial efficacy comparable to that of an intramuscular oily solution of arteether and significantly higher than that of an oily solution of β-arteether given orally at the same dose. In conclusion, lipid-based drug delivery systems constitute a promising approach for the oral administration of β-arteether. © 2012 Elsevier B.V. All rights reserved. Source

Mvitu Muaka M.,University of Kinshasa | Longo-Mbenza B.,Walter Sisulu University
African Health Sciences | Year: 2012

Background: Diabetic Retinopathy (DR) remains a common and one of the major causes of blindness in the developed and western societies. The same situation is shown in emerging economic areas (5,6). In sub-Saharan Africa (SSA) however, the issues of visual disability due to diabetes mellitus (DM) are overshadowed by the presence of the prevalent and common nutritional deficiency diseases and eye infections Objective: This clinic-based study was conducted to determine whether diabetic retinopathy is independently related to visual disability in black patients with diabetes mellitus (DM) from Kinshasa, Congo. Methods: A total of 299 urban patients with DM and low income including 108 cases of visual disability and matched for time admission and DM type to 191 controls, were assessed. Demographic, clinical, and ophthalmic data were assessed using univariate and multivariate analyses. Results: Age >60 years, female sex, presence of diabetic retinopathy (DR), proliferative DR, shorter DM duration, glaucoma, macular oedema, diabetic nephropathy were the univariate risk factors of visual disability. Using logistic regression model, visual disability was significantly associated with female sex and diabetic retinopathy. Conclusion: The risk of visual disability is 4 times higher in patients with diabetic retinopathy and 2 times higher in females with DM. Therefore, to prevent further increase of visual disability, the Congolese Ministry of Health should prioritize the eye care in patients with DM. Source

Tshimanga R.M.,University of Kinshasa | Hughes D.A.,Rhodes University
Water Resources Research | Year: 2014

Gaps in hydrological information of the Congo Basin increase uncertainties in understanding hydroclimatic processes in the basin, and consequently the risks associated with decision making for major water resources development plans. There is also uncertainty about the predictions of future climate and land use change. These challenges make it essential to explore possible approaches to close the information gaps. Some of the gaps can be filled using hydrological simulation models, which if they prove practical, can be established with available data, but generate sufficiently reliable information for management purposes. This paper discusses the results of applying a semidistributed rainfall-runoff model which was established for the whole Congo Basin, using the available historical data, with an ultimate goal of understanding processes of runoff generation as well as assessing the impacts of future climate and land use changes on water resources availability, including options for water resources development in the basin. Issues of water resources assessment in the basin, approaches used to address them and some directions for future research are discussed. It is noted that the hydrological model applied in this study for the Congo Basin is able to capture the timing and magnitude of high and low flows satisfactorily, irrespective of the subbasins are located in headwater areas, downstream areas or at the outlets of regions strongly affected by wetlands and lakes. There remain a number of opportunities to improve the methods used for water resources assessment within the basin. Key Points A semidistributed hydrological model is presented for the Congo Basin The model adequately simulates the dominant processes of the basin hydrology The paper addresses some of the challenges of prediction in the Congo Basin © 2014. American Geophysical Union. All Rights Reserved. Source

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