Damascus, Syria

University of Kalamoon

www.uok.edu.sy
Damascus, Syria
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Khattab M.A.,Minia University | Ferenci P.,Medical University of Vienna | Hadziyannis S.J.,Henry Dunant Hospital | Colombo M.,University of Milan | And 9 more authors.
Journal of Hepatology | Year: 2011

HCV has been classified into no fewer than six major genotypes and a series of subtypes. Each HCV genotype is unique with respect to its nucleotide sequence, geographic distribution, and response to therapy. Genotypes 1, 2, and 3 are common throughout North America and Europe. HCV genotype 4 (HCV-4) is common in the Middle East and in Africa, where it is responsible for more than 80% of HCV infections. It has recently spread to several European countries. HCV-4 is considered a major cause of chronic hepatitis, cirrhosis, hepatocellular carcinoma, and liver transplantation in these regions. Although HCV-4 is the cause of approximately 20% of the 170 million cases of chronic hepatitis C in the world, it has not been the subject of widespread research. Therefore, this document, drafted by a panel of international experts, aimed to review current knowledge on the epidemiology, natural history, clinical, histological features, and treatment of HCV-4 infections. © 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.


Background. Many adhesive systems have been investigated as alternatives to conventional bonding methods. Selfetching primers and resin modified glass ionomer cement have been introduced to overcome the disadvantages of acid etching Objectives. To assess the effect of using either a self etching primer (SEP) or a resin modified glass ionomer (RMGI) on shear bond strength and failure type in comparison with conventional methods (CM). Material and Methods. Eighty metal brackets were bonded to buccal surfaces of human upper premolars by the same clinician according to 1of 4 protocols. Group 1, Transbond XT was used with self-etching primer (SEP) Transbond Plus (3M Untiek, Monrovia, Calif). Group 2, resin modified glass ionomer (RMGI) Fuji Ortho LC (GC Crop, Japan). Group 3, light cure resin (LC) Transbond XT (3M Unitek, Monrovia, Calif) were used with 37% phosphoric acid. Group 4, Chemically cure resin (CC) Unite (3M Unitek, Monrovia, Calif) were used with 37% phosphoric acid. The premolars were stored in distilled water for 24 hours at 4oC. Brackets were loaded to failure in Instron machine. Descriptive statistics were calculated. ANOVA, Bonferroni, Kruskal-Wallis tests and Mann- Whitney U were used. Results. The present study indicated that the SEP provided no significantly higher shear bond (10.01 ± 5.46 MPa) than LC adhesive (8.59 ± 4.07 MPa) while RMGI showed the lowest (5.08 MPa). A comparison of the adhesive remnant index (ARI) scores indicated that there was significantly difference between the groups with less residual adhesive remaining on the teeth with SEP and RMGI. Conclusions. SEP produced bond strength clinically accepted with less amount of residual adhesive left on the enamel while RMGI produced unacceptable bond strength. SEP can use successfully in bond orthodontic brackets. © 2016 by Wroclaw Medical University and Polish Dental Society.


Malkaram S.A.,University of Nebraska - Lincoln | Hassan Y.I.,University of Kalamoon | Zempleni J.,University of Nebraska - Lincoln
Advances in Nutrition | Year: 2012

Recent advances in "omics" research have resulted in the creation of large datasets that were generated by consortiums and centers, small datasets that were generated by individual investigators, and bioinformatics tools for mining these datasets. It is important for nutrition laboratories to take full advantage of the analysis tools to interrogate datasets for information relevant to genomics, epigenomics, transcriptomics, proteomics, and metabolomics. This review provides guidance regarding bioinformatics resources that are currently available in the public domain, with the intent to provide a starting point for investigators who want to take advantage of the opportunities provided by the bioinformatics field. © 2012 American Society for Nutrition.


Barah F.A.,University of Kalamoon | Chehada A.G.,University of Kalamoon
Saudi Medical Journal | Year: 2010

Objectives: To examine the current sero-epidemiology of rubella IgG among Syrian females of childbearing age that missed rubella vaccination. Methods: A cross-sectional study examined healthy female students of the Pharmacy College, Kalamoon University, Deratiah, Syria. Ninety sera were collected between March and May 2008, and were subject to rubella specific IgG screening and titration using an enzyme-linked immunosorbent assay-based technique provided by Diamed Eurogen in the Microbiology Laboratory, Faculty of Pharmacy. Results: The quantitative analysis for rubella IgG showed a noticeable variability in the values of antibodies that ranged between 0-363 IU/ml. A total of 77 participants were positive for rubella IgG giving a prevalence of 85.6%, and leaving a relatively high proportion of susceptibility (14.4%) among the tested group. Conclusion: Although most women tested were seropositive for rubella IgG, suggesting a natural virus circulation within the community, screening for protective immunity followed by vaccination to those who missed the regular vaccine program should be enforced to prevent possible rubella congenital syndrome. In addition, adding a second shot of rubella vaccine to those who were subject to the national program of vaccination is a must since the concentration of antibodies may drop below the recommended levels necessary for protection.


Goncalves V.,University of Kalamoon
Current opinion in obstetrics & gynecology | Year: 2010

PURPOSE OF REVIEW: This review addresses current knowledge about long-term quality of life (QOL) in survivors of gynecological cancer. RECENT FINDINGS: Survivors of gynecological cancer have generally good long-term QOL, equivalent to healthy controls; however, specific deficits are more prevalent than in women without cancer. Ovarian cancer survivors have good QOL, with few physical symptoms. Psychological distress and sexual impairments exist. No differences in QOL occur between survivors of early and advanced stage disease. Cervical cancer survivors treated with radiotherapy reported more QOL impairments than survivors treated with other approaches. There were no differences on sexuality and sexual function among survival time periods. In general, cervical cancer survivors seem to have a positive attitude towards sexuality. Self-esteem is an important psychological variable in the study of long-term QOL. SUMMARY: When considering specific diseases, ovarian and cervical cancers were the most researched. Endometrial cancer was underreported in recent literature. Studies addressing vulvar and vaginal cancers are lacking. Physical, psychosocial and sexuality were the most investigated QOL domains. Advances are observed in current research; however, more rigorous and larger studies are required to further understand long-term QOL. Available findings are crucial to develop interventions to support those at risk for QOL impairments.


Background. Self-etching primer and resin modified glass ionomer has been introduced to counter phosphoric etching disadvantages. Objectives. Evaluation of the bond failure rate of MBT stainless steel brackets bonded with either self etching primer SEP or resin modified glass ionomer RMGI in comparison with conventional methods CM. Material and Methods. 46 patients with complete permanent dentition were involved in this study. A total of 920 Gemini MBT® brackets (3M Unitek, Monrovia, Calif) were bonded using a split-mouth design. For each patient, four adhesives systems were used: self etching primer SEP (Transbond Plus®, 3M, Unitek, USA), resin-modified glass ionomer RMGI (Fuji Ortho® LC, GC Corp, Japan), light cure LC (Transpond XT®, 3M, Unitek, USA) and chemical cure CC (Unite®, 3M, Unitek, USA). All brackets were bonded by the same clinician. Only first-time bracket failures with tooth number and the remnant adhesive on the enamel were recorded through to 12th month of treatment and observation. Significant differences in bracket failure rate with regard to bonding procedure, patient sex, arch site, and tooth type were determined using the chi-square. The adhesive remnant index was used to determine the bond failure interface. Results. The bond failure rates were 7%, 15.7%, 7% and 6.5% for the SEP, RMGI, LC, CC respectively. Significant differences in failure rates were found between the groups. The maximum bond failure sites were at the enamel adhesive interface in SEP and RMGI groups. Conclusions. The clinical study showed that Transbond Plus can be used effectively for bonding brackets, whereas using Fuji Ortho LC is not effective in clinical practice. © Wroclaw Medical University and Polish Dental Society.


Labban L.,University of Kalamoon
JMS - Journal of Medical Society | Year: 2014

Diabetic Foot Ulcers (DFUs) are complex, chronic wounds, which have a major long-term impact on the morbidity, mortality and quality of patients’ lives. Individuals who develop a DFU are at greater risk of premature death, myocardial infarction, and fatal stroke than those without a history of DFU. Unlike other chronic wounds, the development and progression of DFU is often complicated by wide-ranging diabetic changes, such as neuropathy and vascular disease. These, along with the altered neutrophil function, diminished tissue perfusion, and defective protein synthesis that frequently accompany diabetes, present practitioners with specifi c and unique management challenges.Honey has been used for centuries in wound care. Its therapeutic properties are largely attributed to its antimicrobial and antiinfl ammatory activities. This review provides an insight on the mechanisms by which honey affects wound healing. Honey is being used to treat many types of wound, including: traumatic wounds, surgical incision sites, burns, sloughy wounds, and pressure ulcers.The number of publications reporting the use of honey has increased. A great number of studies haves concluded that clinical evidence to support the use of honey in the treatment of superfi cial wounds and burns was of low quality. Other studies suggested that honey improved healing times in mild to moderate superfi cial and partial thickness burns when compared to conventional dressings.This was supported by a meta-analysis of systematic reviews of topical and systemic antimicrobial interventions for wounds. Of 109 evidence based conclusions, robust evidence was found to support the use of topical honey to reduce healing times in burns.Yet, there are many studies which did not indicate the positive result on using honey to treat DFU’s. Therefore, more studies should be carried out in order to make a solid proof for using honey in treatment of DFU’s. © 2015, Regional Institute of Medical Sciences. All rights reserved.


Albesharat R.,TU Munich | Ehrmann M.A.,TU Munich | Korakli M.,University of Kalamoon | Yazaji S.,Damascus University | Vogel R.F.,TU Munich
Systematic and Applied Microbiology | Year: 2011

Lactic acid bacteria (LAB) are generally accepted as beneficial to the host and their presence is directly influenced by ingestion of fermented food or probiotics. While the intestinal lactic microbiota is well-described knowledge on its routes of inoculation and competitiveness towards selective pressure shaping the intestinal microbiota is limited. In this study, LAB were isolated from faecal samples of breast feeding mothers living in Syria, from faeces of their infants, from breast milk as well as from fermented food, typically consumed in Syria. A total of 700 isolates were characterized by genetic fingerprinting with random amplified polymorphic DNA (RAPD) and identified by comparative 16S rDNA sequencing and Matrix Assisted Laser Desorption Ionization-Time-Of-Flight Mass Spectrometry (MALDI-TOF-MS) analyses. Thirty six different species of Lactobacillus, Enterococcus, Streptococcus, Weissella and Pediococcus were identified. RAPD and MALDI-TOF-MS patterns allowed comparison of the lactic microbiota on species and strain level. Whereas some species were unique for one source, Lactobacillus plantarum, Lactobacillus fermentum, Pediococcus pentosaceus and Lactobacillus brevis were found in all sources. Interestingly, identical RAPD genotypes of L. plantarum, L. fermentum, L. brevis, Enterococcus faecium, Enterococcus faecalis and P. pentosaceus were found in the faeces of mothers, her milk and in faeces of her babies. Diversity of RAPD types found in food versus human samples suggests the importance of host factors in colonization and individual host specificity, and support the hypothesis that there is a vertical transfer of intestinal LAB from the mother's gut to her milk and through the milk to the infant's gut. © 2011 Elsevier GmbH.


Objectives: To examine the current seroepidemiology of immunoglobulin (Ig)G for herpes simplex virus types 1 and 2 (HSV 1-2), varicella zoster virus (VZV), and cytomegalovirus (CMV) among university females of childbearing age in Syria. Methods: A cross-sectional study was conducted to examine the female students of the Pharmacy College, Kalamoon University, Deratiah, Syria, where 316 sera were collected from October 2009 to November 2010, and subjected to HSV 1-2, VZV, and CMV IgG screening and titration using enzyme-linked immunosorbent assay-based techniques in the Microbiology Laboratory. Results: A total of 164 participants were positive for HSV 1-2 IgG giving a prevalence of 52%, leaving a relatively high proportion of susceptibility among the tested group. For VZV, 91% of the participants (n=287) were positive for its specific IgG, while, regarding CMV, 74.5% (n=235) were positive, and 25.5% were negative for CMV specific IgG. Conclusion: Although most participants were seropositive for herpes viruses IgG, suggesting a natural virus circulation within the community, screening for protective immunity is suggested against HSV, since a relatively high proportion of tested females are still susceptible. In addition, and because of its nasty outcomes during pregnancy, IgG against CMV should also be tested. High percentage of positivity towards VZV could be explained due to introduction of the new vaccine program, and therefore, further analysis during pregnancy is not recommended.


Antibiotic misuse contributes to the growing problem of microbial resistance. To understand the current knowledge and practices regarding antibiotic use among Syrians, we conducted a cross-sectional study of 430 randomly selected adult residents of Kalamoon in the Syrian Arab Republic using a questionnaire. A high proportion (85%) had taken antibiotics in the past 4 weeks and 34% were not aware of the dangers of antibiotics. Of365 participants, only 43% were prescribed the antibiotic by a physician to treat the condition, while 57% used an old prescription or took someone else's advice. Males, younger individuals, and those with low and medium income and lower educational status showed poorer practice and lower knowledge towards antibiotics. Educational efforts are needed to reduce patient demand for antibiotics.

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