Jos, Nigeria
Jos, Nigeria

The University of Jos , abbreviated as Unijos, is a federal university in Jos, Plateau State, central Nigeria. The school offers courses in law, medicine, pharmacy, natural science, social science, the built environment as well as arts and humanities.What became University of Jos was first established in November 1971 as a satellite campus of the University of Ibadan. The first students were admitted in January 1972 as pre-degree students with the first Bachelor of Arts degree program begun in October 1973. In October 1975, then military government under General Murtala Mohammed, established the Unijos as a separate institution. The first Vice-Chancellor of the Unijos was Professor Gilbert Onuaguluchi. Classes began at the newly reorganized University of Jos in October 1976 with 575 students spread over the existing four faculties of Arts and Social science, Education, Natural science and Medical science. Post-graduate programs were added in 1977. By 1978 Faculties of Law and Environmental science were established and the Faculties of Arts and Social science were separated.In 2003, the Carnegie Corporation of New York gave Unijos a US $2 million grant to form its own fundraising department. Wikipedia.

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Okeahialam B.N.,University of Jos
Therapeutic Advances in Drug Safety | Year: 2017

Background: Hypertension as a cardiovascular disease risk factor continues to take a heavy toll on the population despite efforts with containment. Poor control, even among those on treatment, is part of the challenge and results from patient, physician and health system factors. When the problem resides at patient level, adherence is largely responsible. An entity defined as multidrug intolerance (MDI) is hardly considered. A situation when a patient is willing to adhere but is compelled otherwise could frustrate both patient and physician. Encountering a few such cases prompted the author to audit his specialized hypertension service in order to evaluate the burden of MDI and its associations. Methods: Between 7 May and 30 July 2016 (to cover a 12-week cycle which ensured all attendees were captured), all patients attending follow up for blood pressure control had their records evaluated for intolerance to three or more different classes of anti-hypertensives, which defines MDI. Their ages, sex, control state and co-morbidities were extracted from the records. Results: A total of 489 patients with hypertension were seen over the period; 271 (55.4%) of whom were women and 248 (50.7%) were uncontrolled. Overall 15 (3.1%) satisfied the definition of MDI; 10 women and 5 men. All the men with MDI were uncontrolled while 7 out of the 10 women were uncontrolled; with two having premenstrual syndrome as co-morbidity. A total of four patients (three men, one woman) had history suggesting allergy and two (one man, one woman) were on treatment for anxio-depressive illness. Conclusion: MDI does occur in sub-Sahara African patients with hypertension and should be considered before describing hypertension as resistant or considering alternative treatments including device therapy. Staggering doses or trying different formulations could be of benefit. © 2017, © The Author(s), 2017.

The purpose of this work was to evaluate the effect of the extraction process and the potential of okra gum as a suspending agent in pharmaceutical oral formulations containing acetaminophen as a model drug. Clarified mucilage of dried okra was either extracted directly with ethanol 96% (F1) or was first treated with base (F2), acid (F3) or heating in the presence of salt (F4) before extraction with ethanol 96%. The samples were used at 0.5% w/v as suspending agents in acetaminophen acetaminophen suspension to deliver 125 mg/5 mL acetaminophen. A binary mixture of F2 and F4 (1:1) was also used. Similar suspensions of acetaminophen containing either hydroxymethylpropylcellulose (HPMC) or tragacanth gum (TRAGA) were produced. Some physicochemical properties of the formulations were evaluated. The rheological properties of acetaminophen-containing treated okra gums (F2-F5) were generally similar. Changes in viscosity with storage were slower in the F2-F5 formulations as compared with F1. Particle size and particle size distribution were different for all formulations, and hysteresis was a function of time and the suspending agent used. The re-dispersion time of the formulations with treated okra gums was generally shorter than that observed with the untreated okra gum. The use of a binary mixture of F2 and F4 resulted in different physicochemical properties from those of either F2 or F4. The physicochemical properties of the formulations were comparable to those with HPMC and TRAGA. It can thus be concluded that treating okra gum with acid, base or salt impacted better physicochemical properties on an acetaminophen pediatric suspension when they were used as suspending agents.

Agency: European Commission | Branch: FP7 | Program: CP-FP-SICA | Phase: HEALTH.2010.2.4.1-4 | Award Amount: 4.78M | Year: 2011

Chronic hepatitis B virus (HBV) infection affects 350 million people worldwide and 25-30% of these individuals will die as a result of their infection mainly as a results of hepatocellular carcinoma HCC. Liver cirrhosis, high viral load and dietary exposure to aflatoxin are recognised as risk factors for hepatocellular carcinoma amongst HBV carriers. However, these variables do not account for all cases of HCC and decompensated cirrhosis is rarely ever seen in West Africa suggesting that advanced liver fibrosis may not be an important risk factor in this population. A large case control study on HCC will be used to evaluate the importance of liver fibrosis and other established risk factors in West Africa and to explore other potential oncogenic determinants. The case-control study will generate serum, urine and DNA samples for proteomic, metabonomic and genomic analysis to identify biomarkers and aetiological agents for HCC. Effective treatment for HBV infection is now available in the developed world but treatment programmes have not been developed for resource poor settings even though some of the effective medication is now available at low cost for HIV management. A trial of HBV treatment in a group of carefully selected high risk patients will be conducted to demonstrate that the incidence of HCC can be reduced in this population as has been observed in Asian patients. The treatment trial will also be used to evaluate the efficacy of screening by ultrasound for early tumours which can be treated with percutaneous alcohol injection. This comprehensive programme therefore aims to reveal novel aetiological factors for HCC, identify and evaluate biomarkers and demonstrate the efficacy of selective antiviral therapy to prevent HCC

Anzaku A.S.,Bingham University | Musa J.,University of Jos
Archives of Gynecology and Obstetrics | Year: 2013

Objective: The study aimed at determining the prevalence and associated risk factors for gestational diabetes mellitus (GDM) among antenatal women attending the Jos University Teaching Hospital (JUTH), Jos, Nigeria. Methods: A cross-sectional study was done between February and April 2009 among 265 pregnant women enrolled from the antenatal clinic of JUTH. Screening was done between 24 and 28 weeks' gestation with a 50 g, 1-h glucose challenge test (GCT). Those with plasma glucose concentration >7.8 mmol/l were then given 75 g oral glucose tolerance test (OGTT) to confirm the diagnosis of GDM. Plasma glucose measurements were performed with glucose oxidase method. GDM was diagnosed according to the WHO criteria. All relevant data including demographic information, obstetric history, and risk factors for GDM, GCT and OGTT results were collected and analyzed using Epi Info version 3.5.1, CDC, Atlanta, USA. Results: Of the 265 pregnant women enrolled, 253 subjects were eligible for screening out of which, 28 (11.1 %) had positive GCT >7.8 mmol/l. The prevalence of GDM was 8.3 % (21/253); 95 % CI 5.2-12.4. The pattern of glucose tolerance in the study population indicated that 232 (91.7 %) had normal glucose tolerance, 6.7 % had impaired glucose tolerance (IGT) while 1.6 % had overt diabetes. Previous history of fetal macrosomia was independently associated with GDM (adjusted OR 11.1; 95 % CI 2.93-42.12, P = 0.0004). Conclusion: The prevalence of GDM was relatively high among our antenatal population. Women with previous history of fetal macrosomia have a higher likelihood of having GDM and should be screened. © 2012 Springer-Verlag Berlin Heidelberg.

Apetrei C.,University of Jos | Rodriguez-Mendez M.L.,University of Valladolid | De Saja J.A.,University of Valladolid
Electrochimica Acta | Year: 2011

An amperometric biosensor was constructed by immobilization of enzyme, tyrosinase, in an electrochemically synthesized phosphate ion-doped polypyrrole film on a Pt disk electrode. The tyrosinase maintains its bioactivity well within the polypyrrole thin film. A clearly defined reduction current proportional to the phenolic compounds concentration was observed in cyclic voltammetry, which attributed to the reduction of enzymatically produced quinone at the electrode surface. Phenolic compounds were quantitatively estimated in aqueous medium by the direct electrochemical reduction of enzymatically liberated quinone species at -0.05 V by chronoamperometry. For the all six phenolic compounds analyzed, the kinetics of the enzymatic reaction fitted into a Michaelis-Menten type kinetics, as demonstrated by the h parameter close to 1 obtained from the Hill's plot. The sensitivity followed the decreasing order catechol > phenol > 2-bromophenol > 2-chlorophenol > 2-iodophenol > 2-fluorophenol. The greater value of Imax and the lowest KMapp was found for catechol. The detection limits were in the range of 0.84-8.54 μM. The lowest detection limits were found for catechol and the highest for 2-fluorophenol. © 2011 Elsevier Ltd.

Orisaremi T.C.,University of Jos
African journal of reproductive health | Year: 2012

The study investigated how unequal gender relations inhibit the attainment of women's reproductive rights. It examined whether women can choose if and when to marry, who to marry/have sex with, ability to negotiate sex with spouse, and their access to family planning. Based on theoretical orientation from gender-sexuality framework, this paper employed the qualitative research design. The main respondents were female and male of various sociodemographic groups who were engaged through in-depth interviews and focus group discussion sessions. Findings show wide scale abuses of Tarok women's reproductive rights. Most of these abuses may be traced to traditional male-centred socio-cultural structures and patriarchy that help guarantee the immunity of male violators. It is concluded that in the context of unequal gender relations and dominance of patriarchy, the attainment of women's reproductive rights is a major challenge which has profound implications for life and death.

Mandong B.M.,University of Jos
Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria | Year: 2013

In areas of parasitic endemicity, the occurrence of cancer that is not frequent may be linked with parasitic infection. Epidemiological correlates between some parasitic infections and cancer is strong, suggesting a strong aetiological association. The common parasites associated with human cancers are schistosomiasis, malaria, liver flukes (Clonorchis sinenses, Opistorchis viverrini). To review the pathology, literature and methods of diagnosis. Literature review from peer reviewed Journals cited in PubMed and local journals. Parasites may serve as promoters of cancer in endemic areas of infection.

Puscasu G.,University of Jos | Codres B.,University of Jos
International Journal of Neural Systems | Year: 2011

A new approach for nonlinear system identification and control based on modular neural networks (MNN) is proposed in this paper. The computational complexity of neural identification can be greatly reduced if the whole system is decomposed into several subsystems. This is obtained using a partitioning algorithm. Each local nonlinear model is associated with a nonlinear controller. These are also implemented by neural networks. The switching between the neural controllers is done by a dynamical switcher, also implemented by neural networks, that tracks the different operating points. The proposed multiple modelling and control strategy has been successfully tested on simulated laboratory scale liquid-level system. © 2011 World Scientific Publishing Company.

Auta A.,University of Jos
North American Journal of Medical Sciences | Year: 2012

Background: Malaria constitutes a major health problem, with children and pregnant women being the most vulnerable to its morbidity and mortality. Aim: To determine the demographic factors associated with the use of insecticide-treated nets among children and pregnant women in Nigeria. Materials and Methods: The study was based on data drawn from the Nigeria Demographic and Health Survey 2008 on the use of insecticide-treated nets among women and children. The survey was conducted in 34070 households and a total of 10,724 women aged 15-49 years participated in the survey. Data were entered into Minitab version 15 and the chi-square test for independence was performed to show association between variables. Results: The results revealed that 49.8% of children and 44% of pregnant women present in households that owe insecticide-treated nets slept under them on the night before the survey. Sleeping under an insecticide-treated nets among children was associated with (P<0.05) the age of a child, geopolitical zone, and wealth quintile while the use of insecticide-treated nets among pregnant women was associated with the education level and wealth quintile of households. Conclusion: The study demonstrated that some demographic factors are associated with the use of ITNs among children and pregnant women in Nigeria.

Ngwuluka N.C.,University of Jos
Preventive Medicine | Year: 2012

Human longevity and healthy ageing though controversial require extended investigations. Some studies have shown that ageing can be managed by reducing the amounts of free radicals the cells are exposed to. Oxidative stress has been shown to be combated by antioxidants and plant sources are known to generate antioxidants that are efficacious and low in toxicity. This review aims to enlighten on antioxidants from Bombax buonopozense and Bombax malabaricum for prevention, reversal or delay of age-related diseases. Furthermore, it advocates for more studies to enable the shift from research to commercial applications of the antioxidants as nutraceuticals in age management. © 2011 Elsevier Inc..

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