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Linares de Riofrío, Spain

Escolano J.,University of Jan | Navarro J.M.,University of Murcia | Lopez J.J.,Multimedia University
Journal of the Acoustical Society of America | Year: 2010

In recent years a model for predicting sound fields in enclosures has been proposed, based on the mathematical theory of diffusion. This model is held to be valid for predicting the late reverberation component of the impulse response, on the basis that sufficient reflection events must occur [Valeau, J. Acoust. Soc. Am. 119, 1504-1513 (2006)]. The present work determines numerically the extent of reflections necessary for the solution of the diffusion equation model to be accurate in quasi-cubic rooms. Some preliminary numerical experiments have been carried out to determine after how many mean-free times of the impulse response, which is obtained by a geometrical-acoustic approach, gives a similar result to the solution obtained from a diffusion equation model. © 2010 Acoustical Society of America.

Chinchilla A.,University of Jan | Lozano E.,University of Jan | Daimi H.,University of Jan | Esteban F.J.,University of Jan | And 3 more authors.
Cardiovascular Research | Year: 2011

Aims Non-coding RNA has been recently demonstrated to be a novel mechanism for modulation of gene expression at the post-transcriptional level. The importance of microRNAs in the cardiovascular system is now apparent. Mutations of distinct microRNAs have provided evidence for fundamental roles of microRNAs during cardiovascular development. However, there is limited information about global microRNA profiles during mouse heart development. In this study, we have gained insight from the expression profiles of microRNAs during mouse ventricular development by microarray and qRT-PCR analysis.Methods and results Our microarray analysis reveals that relatively few microRNAs display either increasing or decreasing expression profiles during ventricular chamber formation. Interestingly, most of the differentially expressed microRNAs display a rather discrete peak of expression at particular developmental stages. Furthermore, we demonstrate that microRNA-27b (miR-27b) displays an overt myocardial expression during heart development and that the transcription factor-encoding gene Mef2c is an miR-27b target. Conclusion Our data present a comprehensive profile of microRNA expression during ventricular maturation, providing an entry point for investigation of the functional roles of the most abundantly and differentially expressed microRNAs during cardiogenesis. © 2010 The Author.

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