University of Itajai Valley

Itajaí, Brazil

University of Itajai Valley

Itajaí, Brazil

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Odebrecht C.,Grande Rio University | Bergesch M.,Grande Rio University | Rorig L.R.,University of Itajai Valley | Abreu P.C.,Grande Rio University
Estuaries and Coasts | Year: 2010

A long-term study (monthly sampling, 1992 to 2007) was conducted in the surf zone of Cassino Beach, Southern Brazil, in order to detect possible natural and/or anthropogenic disturbances. Surface water temperature (6-29°C) was the only parameter with predictable seasonal variation; salinity (14-38) was inversely related to rainfall (3.1-485.2 mm month -1) and low values followed extreme precipitation periods in 1997/1998 and 2002/2003 (El Niño years). Asterionellopsis glacialis and chlorophyll a presented high concentrations and peak frequency until 1998, when an intense mud deposition occurred with concomitant extreme rainfall. It affected the surf zone and beach, changing the hydrology and dissolved inorganic nutrient availability. Six phytoplankton species groups were recognized with distinct responses to this mud deposition. We conclude that large-scale climatic changes, like El Niño Southern Oscillation, in conjunction with human activities significantly altered the phytoplankton ecology of the highly dynamic Cassino Beach surf zone. © Coastal and Estuarine Research Federation 2009.

Sobieranski A.C.,Harvard University | Sobieranski A.C.,Federal University of Santa Catarina | Inci F.,Stanford University | Tekin H.C.,Stanford University | And 8 more authors.
Light: Science and Applications | Year: 2015

In this paper, an irregular displacement-based lensless wide-field microscopy imaging platform is presented by combining digital in-line holography and computational pixel super-resolution using multi-frame processing. The samples are illuminated by a nearly coherent illumination system, where the hologram shadows are projected into a complementary metal-oxide semiconductor-based imaging sensor. To increase the resolution, a multi-frame pixel resolution approach is employed to produce a single holographic image from multiple frame observations of the scene, with small planar displacements. Displacements are resolved by a hybrid approach: (i) alignment of the LR images by a fast feature-based registration method, and (ii) fine adjustment of the sub-pixel information using a continuous optimization approach designed to find the global optimum solution. Numerical method for phase-retrieval is applied to decode the signal and reconstruct the morphological details of the analyzed sample. The presented approach was evaluated with various biological samples including sperm and platelets, whose dimensions are in the order of a few microns. The obtained results demonstrate a spatial resolution of 1.55 mm on a field-of-view of ≈30 mm2. © 2015 CIOMP. All rights reserved.

Fileto R.,Federal University of Santa Catarina | Kruger M.,University of Itajai Valley | Pelekis N.,University of Piraeus | Theodoridis Y.,University of Piraeus | Renso C.,CNR Institute of Neuroscience
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2013

Movement understanding frequently requires further information and knowledge than what can be obtained from bare spatio-temporal traces. Despite recent progress in trajectory data management, there is still a gap between the spatio-temporal aspects and the semantics involved. This gap hinders trajectory analysis benefiting from growing collections of linked data, with well-defined and widely agreed semantics, already available on the Web. This article introduces Baquara, an ontology with rich constructs, associated with a system architecture and an approach to narrow this gap. The Baquara ontology functions as a conceptual framework for semantic enrichment of movement data with annotations based on linked data. The proposed architecture and approach reveal new possibilities for trajectory analysis, using database management systems and triple stores extended with spatial data and operators. The viability of the proposal and the expressiveness of the Baquara ontology and enabled queries are investigated in a case study using real sets of trajectories and linked data. © Springer-Verlag 2013.

PubMed | Federal University of Paraná, University of Itajai Valley and State University of Ponta Grossa
Type: | Journal: Journal of ethnopharmacology | Year: 2015

GB-2a is a I3-naringenin-II8-eriodictyol compound isolated from Garcinia gardneriana (Planchon & Triana) Zappi, a plant used in folk medicine for the treatment of skin disorders.In the search for new depigmenting agents, this study was carried out to investigate the in vitro effects of GB-2a isolated from G. gardneriana (Planchon & Triana) Zappi in B16F10 melanoma cells.The effects of GB-2a were evaluated through determination of melanin biosynthesis in B16F10 melanoma cells in comparison with the reference drug kojic acid (500M). In parallel, the GB-2a effect was assessed in a cell viability assay. Mushroom tyrosinase activity assays were conducted to verify the effect of this enzyme. In order to ascertain the nature of enzyme inhibition on tyrosinase, kinetics analysis of the GB-2a was performed with L-tyrosine and L-3,4-dihydroxyphenylalanine (L-DOPA) substrates.The results showed that GB-2a biflavonoid significantly inhibited the melanin content, without reducing cell viability. GB-2a also showed a strong antityrosinase activity in the mushroom tyrosinase assay. GB-2a inhibited the tyrosinase activity, exerting a mixed inhibition. For the L-tyrosine substrate the inhibition was in non-competitive mode and for L-DOPA it was in uncompetitive mode.GB-2a biflavonoid promoted inhibition on tyrosinase activity and reduced melanin biosynthesis in B16F10 cells, which suggests great potential for medical and cosmetic uses as a depigmenting agent.

Neto S.L.M.,National Institute for Space Research | Neto S.L.M.,Federal University of Santa Catarina | von Wangenheim A.,Federal University of Santa Catarina | Pereira E.B.,National Institute for Space Research | Comunello E.,University of Itajai Valley
Journal of Atmospheric and Oceanic Technology | Year: 2010

The current work describes the use of multidimensional Euclidean geometric distance (EGD) and Bayesian methods to characterize and classify the sky and cloud patterns present in image pixels. From specific images and using visualization tools, it was noticed that sky and cloud patterns occupy a typical locus on the red-green-blue (RGB) color space. These two patterns were linearly distributed parallel to the RGB cube's main diagonal at distinct distances. A characterization of the cloud and sky patterns EGD was done by supervision to eliminate errors due to outlier patterns in the analysis. The exploratory data analysis of EGD for sky and cloud patterns showed a Gaussian distribution, allowing generalizations based on the central limit theorem. An intensity scale of brightness is proposed from the Euclidean geometric projection (EGP) on the RGB cube's main diagonal. An EGD-based classification method was adapted to be properly compared with existing ones found in related literature, because they restrict the examined color-space domain. Elimination of this limitation was considered a sufficient criterion for a classification system that has resource restrictions. The EGD-adapted results showed a correlation of 97.9% for clouds and 98.4% for sky when compared to established classification methods. It was also observed that EGD was able to classify cloud and sky patterns invariant to their brightness attributes and with reduced variability because of the sun zenith angle changes. In addition, it was observed that Mie scattering could be noticed and eliminated (together with the reflector's dust) as an outlier during the analysis. Although Mie scattering could be classified with additional analysis, this is left as a suggestion for future work. © 2010 American Meteorological Society.

PubMed | c Lychnoflora Pesquisa e Desenvolvimento em Produtos Naturais LTDA and University of Itajai Valley
Type: Journal Article | Journal: Pharmaceutical biology | Year: 2016

The aerial parts of Sphagneticola trilobata (L.) Pruski (Asteraceae) are popularly used to treat topical inflammation, but have not been fully investigated.To identify polar compounds in S. trilobata extracts and develop a new topical phytomedicine based on the kaurenoic acid (KA) content while monitoring and demonstrating its topical anti-inflammatory activity.Ethanol spray-dried extract of S. trilobata was analysed by LC-MS while the KA content from semisolid was analysed by LC-UV. The extent of ear edema induced by applying 20L of croton oil (2.5%), arachidonic acid (AA; 2mg/ear) and decanoylphorbol-13-acetate (TPA; 2.5mg/ear) in mice was used to evaluate the biological activity of the semisolids, which were applied 30min before the phlogistic agents.Eight phenylpropanoids and four oleanane-type triterpenoid saponins were identified, majority of them reported for the first time in this species, in addition to KA. The semisolid containing 1.0% of dried extract reduced the ear edema induced by croton oil [77.24.5%; ID50=0.49 (0.28-0.87%)], TPA (81.52.4%) and AA (39.16.9%), with decreasing effect at higher KA concentrations. This was accompanied by neutrophil migration inhibition as investigated by biochemical and histological assays.The anti-inflammatory effects were (at least in part) due to the interference in protein kinase C (PKC) activation, AA-cascade products and neutrophil migration inhibition, demonstrating the efficacy of the folk topical usage of this plant. The results support the development of a novel topical anti-inflammatory phytomedicine properly standardized to treat inflammatory dermatological diseases.

Corra A.X.R.,University of Itajai Valley | Tiepo E.N.,University of Itajai Valley | Somensi C.A.,University of Itajai Valley | Sperb R.M.,University of Itajai Valley | Radetski C.M.,University of Itajai Valley
Journal of Environmental Engineering | Year: 2010

Batch ozone-photocatalytic oxidation (O3 /UV/ TiO2) and biological remediation by macroalgae were performed in a laboratory-scale reactor to evaluate the efficiency of these processes in the degradation of contaminants and/or decrease in the ecotoxicity of produced waters of petroleum refineries. The effectiveness of the hybrid advanced oxidation process followed by biological treatment was evaluated through the physicochemical time-course analysis and ecotoxicological tests. The results showed that after 5 min of treatment the O3 /UV/ TiO2 combination was very effective and phenol concentration decreased by 99.9%, sulfide by 53.0%, COD by 37.7%, O&G by 5.2%, and ammonia by 1.9%. The following reductions in contaminants were obtained after 60 min of oxidation treatment: phenols 99.9%, O&G 98.2%, sulfide 97.2%, COD 89.2%, and ammonia 15%. The acute toxicity tests with the bacterium Vibrio fischeri (Lumistox) and the fish Poecilia vivipara showed a high toxicity of the raw effluents (E (L) C50 <1.55% for both species), while after 60 min of treatment effluents showed lower acute toxicity toward bacteria (E C50 =30.9%), but toxicity toward fish remained high (E C50 =1.9%). Additional wastewater biotreatment with macroalgae Ulva spp. for wastewater depuration showed a significant toxicity reduction (E C50 =89.2% for bacteria and E C50 =85.7% for fish), which was due to the biosorption/transformation of metals and ammonia compounds during the biological treatment. Thus, the physicochemical results showed that a combination of O3 /UV/ TiO 2 for 10 min followed by macroalgae depuration seems to be a good option for cost effective treatment of produced water streams. © 2010 ASCE.

Schoninger L.M.R.,University of Itajai Valley | Dall'Oglio R.C.,University of Itajai Valley | Sandri S.,University of Itajai Valley | Rodrigues C.A.,University of Itajai Valley | Burger C.,University of Itajai Valley
Basic and Clinical Pharmacology and Toxicology | Year: 2010

This study evaluates the effect of complex cross-linked chitosan iron-(III) (CH-FeCL) polymer as phosphate binder in renal failure induced by alloxan (150 mg/kg, i.p.) in rats. The animals (male and female) were divided into four groups and received the treatment once a day for 15 days: (i) control group, which received a single injection of saline (3 ml/kg, i.p.) and normal diet; (ii) alloxan group, which received only a dose of alloxan and normal diet; (iii) phosphate (PO4) group, which received diet supplemented with phosphate 1.2%; and (iv) CH-FeCL group, which received diet supplemented with phosphate 1.2% + CH-FeCL 0.5% (0.054% Fe elemental). It was observed that the CH-FeCL treatment did not alter body-weight, relative weight of the organs and haematological parameters in the treated and control groups for both sexes. However, a decrease in serum phosphorus level of the CH-FeCL group was observed after 15 days, compared with the phosphate group in both sexes. The serum iron concentration of the CH-FeCL group did not differ from the control group in either sex. CH-FeCL polymer decreases intestinal phosphate absorption in rats with renal failure and is promising for the treatment of phosphate retention in patients with renal failure. © 2010 Nordic Pharmacological Society.

Busato W.F.S.,University of Itajai Valley | Bettega L.B.,University of Itajai Valley
Journal of Endourology | Year: 2010

Background and Purpose: Renal cysts are the most common form of renal mass with a prevalence of 35% in people older than 50 years. Several techniques are used to manage symptomatics cysts, from sclerotherapy to open surgery. We present a safe and minimally invasive therapeutic alternative: Percutaneous endocystolysis (PE). Patients and Methods: Between 1995 and 2008, 32 patients were treated for large symptomatic Bosniak type I and II renal cysts with the PE technique. Percutaneous access was obtained by direct puncture guided by fluoroscopy or ultrasonography, percutaneous dilation, and placement of a 28F Amplatz sheath; then a 26F resectoscope with a rollerball electrode was introduced into the interior of the cyst and the whole internal surface was inspected and cauterized. After cauterization, a 20F Foley catheter was placed inside the cyst. Patients were discharged the next day, and the catheter was removed in the outpatient facility after 7 to 10 postoperative days. The variables of age, cyst volume, operative time, and length of hospital stay were statistically analyzed using the Pearson linear correlation coefficient. Results: Clinical follow-up ranged from 4 to 162 months (mean 76 mos). Percutaneous access to the cyst was obtained by blind puncture in 7 (21.8%) patients, aided by fluoroscopy in 12 (37.5%) patients, and guided by ultrasonography in 13 (40.7%) patients. Clinical improvement was observed in all patients with a success rate of 100%. The length of hospital stay was 21.7 ± 8.5 hours (range 9-48 h). The operative time was 41.8 ± 19.7 minutes (range 12-94 min). There was a low complication rate associated with the transparenchymatous PE procedure. Conclusion: PE is a safe, minimally invasive, and effective technique for the management of large symptomatic renal cysts and is associated with high success rates and low complication rates in long-term follow-up. © 2010, Mary Ann Liebert, Inc.

PubMed | University of Itajai Valley
Type: Journal Article | Journal: Basic & clinical pharmacology & toxicology | Year: 2012

Chalcones represent an important group of natural or synthetic compounds with a variety of biological activities including antinociceptive and anti-inflammatory ones. The aim of this work was the synthesis of a new benzofuranone compound and evaluation of its antinociceptive potential in mice. The new benzofuranone 4 was synthesized from chalcone 3. The antinociceptive activity of 4 was determined by writhing, formalin, capsaicin, and glutamate and hot-plate tests. Compound 4 caused potent and dose-related inhibition against the writhing test with ID 6.1 (5.1-7.6) mol/kg, i.p., being about 15 times more active than the reference drugs, acetyl salicylic acid and acetaminophen. It was also effective in a dose-dependent manner in significantly reducing the painful stimulus in both phases of formalin, in the capsaicin and in the glutamate test with ID values of 27.3 (24.5-30.6) and 18.9 (18.5-19.4) mol/kg (first and second phase), 12.6 (9.8-16.2) and 24.5 (20.4-29.6) mol/kg respectively. The results showed that the studied compound exhibits both central and peripheral antinociceptive activities and might be further used as a model to obtain new and more potent analgesic drugs.

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