University of Ioannina is a university lying in the plains 5 km southwest of Ioannina, Greece. The campus is linked to the town by Greek National Road 5. It now hosts over 20,000 students in 17 faculties . The university was founded in 1964, as a charter of the Aristotle University of Thessaloniki and became an independent university in 1970. University of Ioannina is one of the leading academic institutions in Greece. Wikipedia.
Christou G.A.,University of Ioannina
The Journal of endocrinology | Year: 2014
Adiponectin is secreted by the adipose tissue and is downregulated in states of obesity and insulin resistance. There is a growing body of evidence indicating that adiponectin has renoprotective effects and protects against the development of albuminuria in rodent experiments. Adiponectin crossing the glomerular filtration barrier possibly inhibits inflammation, fibrosis and oxidative stress in kidneys through activation of AMP-activated protein kinase. Moreover, microalbuminuria is a well established early sign of progressive cardiovascular and renal disease, even in subjects with preserved glomerular filtration rate. Studies investigating the relationship between serum adiponectin levels and urinary albumin excretion rate (UAE) have yielded conflicting data and the mechanisms underlying the interplay between adiponectin and albuminuria remain to be elucidated. This article constitutes a critical review attempting to clarify any remaining confusion about this matter. Furthermore, this article examines the clinical significance of adiponectin-albuminuria interplay, suggesting that adiponectin is possibly involved in the development of albuminuria that is associated with obesity, diabetes and cardiovascular disease and may mediate, at least in part, the actions of medical treatments that influence UAE, such as angiotensin-converting-enzyme inhibitors, angiotensin II receptor blockers, thiazolidinediones, fenofibrate and diet. Further studies to investigate more thoroughly the renoprotective role of adiponectin in the human setting should be carefully planned, focusing on causality and the possible influence of adiponectin on the development of albuminuria in specific clinical settings.
Tsipis A.C.,University of Ioannina
Coordination Chemistry Reviews | Year: 2014
An overview of recent progress in DFT application to coordination chemistry is presented. Some recent applications that best illustrate the promise of DFT in a number of very active areas of coordination chemistry, such as catalysis (mechanistic studies), bonding (electronic and bonding character) electronic spectroscopy (absorption and emission spectra) and heavy-nucleus NMR spectroscopy are reviewed. Particular emphasis was given to the practical aspects that may be interesting for experimentalists that wish to employ DFT alongside to their experimental work. General instructions of how to select the proper DFT computational protocol for a particular study are outlined. © 2014 Elsevier B.V.
Evangelou E.,University of Ioannina |
Ioannidis J.P.A.,Stanford University
Nature Reviews Genetics | Year: 2013
Meta-analysis of genome-wide association studies (GWASs) has become a popular method for discovering genetic risk variants. Here, we overview both widely applied and newer statistical methods for GWAS meta-analysis, including issues of interpretation and assessment of sources of heterogeneity. We also discuss extensions of these meta-analysis methods to complex data. Where possible, we provide guidelines for researchers who are planning to use these methods. Furthermore, we address special issues that may arise for meta-analysis of sequencing data and rare variants. Finally, we discuss challenges and solutions surrounding the goals of making meta-analysis data publicly available and building powerful consortia. © 2013 Macmillan Publishers Limited.
Prodromidis M.I.,University of Ioannina
Electrochimica Acta | Year: 2010
This review outlines the theoretical background of impedimetric biosensors and presents different types of impedimetric immunosensors along with the instrumental approaches that have been so far proposed in the literature for the evaluation of their performance. The electrode assemblies have been classified in four main categories with respect to the electrode material, the type of the insulating layer and the immobilization platform that have been used for their construction. Additionally, some selected works on recent developments in immunosensors, which are based on polymer degradation phenomena, magnetic nanobeads, etc. as well as strategies for the amplification of the measuring signals, are also presented. © 2009 Elsevier Ltd. All rights reserved.
Gerothanassis I.P.,University of Ioannina
Progress in Nuclear Magnetic Resonance Spectroscopy | Year: 2010
Some of the basic principles and applications of oxygen-17 NMR spectroscopy are discussed. Researchers have significant efforts to provide information about the experimental aspects and the theoretical background that is essential to the understanding of 17O NMR and a wide range of applications with specific emphasis on those that demonstrate the unique potential of this nucleus. Emphasis is placed on the presentation of work that has demonstrated the benefits of employing 17O NMR in studies of chemical and biochemical systems. An effort is also made to define unexplored areas where 17O NMR can provide structural and dynamic information which is difficult or impossible to obtain using other techniques. Bloch's phenomenological theory to demonstrate that the spin of 17O is determined by comparing the signal amplitude and width of both oxygen-17 and deuterium nuclei whose spin is known.