The University of Ilorin, also known as Unilorin, is a university in Ilorin, Nigeria. It was established by a decree of the Federal Military Government in 1975 and is a federal government owned tertiary institution of education located in Ilorin, Kwara State, western Nigeria. The ancient city of Ilorin, capital of Kwara State, is about 300 km from Lagos and 500 km from Abuja, the country's administrative capital. In August 2014, the school was ranked as the best university in Nigeria by 4icu. Wikipedia.
White N.J.,Mahidol University |
White N.J.,Center for Tropical Medicine |
Pukrittayakamee S.,Mahidol University |
Hien T.T.,University of Oxford |
And 4 more authors.
The Lancet | Year: 2014
Although global morbidity and mortality have decreased substantially, malaria, a parasite infection of red blood cells, still kills roughly 2000 people per day, most of whom are children in Africa. Two factors largely account for these decreases; increased deployment of insecticide-treated bednets and increased availability of highly effective artemisinin combination treatments. In large trials, parenteral artesunate (an artemisinin derivative) reduced severe malaria mortality by 22·5% in Africa and 34·7% in Asia compared with quinine, whereas adjunctive interventions have been uniformly unsuccessful. Rapid tests have been an important addition to microscopy for malaria diagnosis. Chemopreventive strategies have been increasingly deployed in Africa, notably intermittent sulfadoxine-pyrimethamine treatment in pregnancy, and monthly amodiaquine-sulfadoxine-pyrimethamine during the rainy season months in children aged between 3 months and 5 years across the sub-Sahel. Enthusiasm for malaria elimination has resurfaced. This ambitious but laudable goal faces many challenges, including the worldwide economic downturn, difficulties in elimination of vivax malaria, development of pyrethroid resistance in some anopheline mosquitoes, and the emergence of artemisinin resistance in Plasmodium falciparum in southeast Asia. We review the epidemiology, clinical features, pathology, prevention, and treatment of malaria.
Owoyele B.V.,University Of Ilorin
Journal of medicinal food | Year: 2010
The analgesic and anti-inflammatory activities of Zea mays husk extract (25, 50, 100, and 200 mg/kg of body weight) were investigated in rats. The hot plate and formalin-induced paw licking models were used to assess analgesic effects of the extract, whereas the carrageenan and cotton pellet models were used for the evaluation of anti-inflammatory activity. The extract at 25, 50, 100, and 200 mg/kg body weight significantly (P < .05) reduced pain stimuli and inflammatory activity when compared with the control group. The reductions in paw licking time and granuloma weight in the formalin and cotton pellet models were both dose dependent. Also, the 200 mg/kg doses of the extract produced higher effects compared with indomethacin (5 mg/kg body of weight) in all the tests. These observations suggest that Z. mays husk extract may have analgesic and anti-inflammatory effects that may be due to its tannins and polyphenolic constituents. These results provide scientific validation for the use of Z. mays husk decoction for the treatment of pain and inflammatory conditions in Nigerian folk medicine.
Yussuf A.D.,University Of Ilorin
African journal of psychiatry | Year: 2013
This study was prompted by the heightened concerns about the stress inherent in medical education evident from the incessant requests for suspension of studies due to psychological problems. The objectives of the study were to: (i) survey the students for possible psychological problems at admission, and follow them up till exit for possible changes in morbidity, and (ii) ascertain possible risk factors, and coping strategies. This is a preliminary 2-stage cross-sectional report, which is part of a longitudinal survey. It involves first year medical students of the College of Health Sciences of University of Ilorin between March and April, 2011. Questionnaires used included socio demographic, sources of stress, the general health questionnaire-12 (GHQ-12), Maslach's burnout inventory (MBI), and Brief COPE. Data were analysed using SPSS version 15 at 5% significance level. Chi-square, frequency distributions, Pearson's correlation, Odd ratios, and Confidence Intervals were calculated to determine the levels of risk. 79 students returned completed questionnaires. 12 (15.2%) were ghq-12 cases (i.e., scored ≥ 3). Students who had morbidity were 9 times at risk of being stressed consequent upon 'competing with their peers' and 4 times at risk due to 'inadequate learning materials'. Morbidity was significantly more likely to engender use of 'religion', 4 times less likely to engender use of 'positive reframing' with a trend in the use of 'self blame' as coping strategies. Aside from psychosocial/personal issues in this cohort, academic demand was an additional source of psychological problems thereby causing those who had morbidity to utilize 'religion' and 'positive reframing' to cope. There is therefore an apparent need to incorporate the principle of mental health promotion in medical education.
Uthman M.M.,University Of Ilorin
The Cochrane database of systematic reviews | Year: 2013
Mycobacterium avium complex (MAC) infection is a common complication of advanced acquired immunodeficiency syndrome (AIDS) disease and is an independent predictor of mortality and shortened survival. To determine the effectiveness and safety of interventions aimed at preventing MAC infection in adults and children with HIV infection. We searched MEDLINE, EMBASE, and The Cochrane Library (search date December 2012). Randomised controlled trials comparing different strategies for preventing MAC infection in HIV-infected individuals. Two reviewers independently assessed trial eligibility and quality, and extracted data. Where data were incomplete or unclear, a third reviewer resolved conflicts and/or trial authors were contacted for further details. Development of MAC infection and survival were compared using risk ratios (RR) and 95% confidence intervals (CI). The quality of evidence has been assessed using the GRADE methodology. Eight studies met the inclusion criteria. Placebo-controlled trials: There was no statistically significant difference between clofazimine and no treatment groups in the number of patients that developed MAC infection (RR 1.01; 95% CI 0.37 to 2.80). Rifabutin (one study; RR 0.48; 95% CI 0.35 to 0.67), azithromycin (three studies; RR 0.37; 95% CI 0.19 to 0.74) and clarithromycin (one study; RR 0.35; 95% CI 0.21 to 0.58) were more effective than placebo in preventing the development of MAC infection. There was no statistically significant difference between those treated with clofazimine (one study; RR 0.98; 95% CI 0.41 to 2.32), rifabutin (one study RR 0.91; 95% CI 0.78 to 1.05), azithromycin (three studies, pooled RR 0.96; 95% CI 0.69 to 1.32) and placebo in number of reported deaths. One study found that the risk of death was reduced by 22% in patients treated with clarithromycin compared to those treated with placebo (RR 0.78; 95% CI 0.64 to 0.96). Monotherapy vs. monotherapy: Patients treated with clarithromycin (RR 0.60; 95% CI 0.41 to 0.89) and azithromycin (RR 0.60; 95% CI 0.40 to 0.89) were 40% less likely to develop MAC infection than those treated with rifabutin. There was no statistically significant difference between those treated with clarithromycin (RR 0.98; 95% CI 0.83 to 1.15), azithromycin (RR 0.98; 95% CI 0.77 to 1.24) and rifabutin in the number of reported deaths. Combination therapy versus monotherapy: There was no statistically significant difference between patients treated with a combination of rifabutin and clarithromycin and those treated with clarithromycin alone (RR 0.74; 95% CI 0.46 to 1.20); and those treated with combination of rifabutin and azithromycin and those treated with azithromycin alone (RR 0.59; 95% CI 1.03). Patients treated with a combination of rifabutin plus clarithromycin were 56% less likely to develop MAC infection than those treated with rifabutin alone (RR 0.44; 95% CI 0.29 to 0.69). Patients treated with a combination of rifabutin plus azithromycin were 65% less likely to develop MAC infection than those treated with rifabutin alone (RR 0.35; 95% CI 0.21 to 0.59). There was no statistically significant difference in the number of reported deaths in all the four different comparisons of prophylactic agents. Based on limited data, azithromycin or clarithromycin appeared to be a prophylactic agent of choice for MAC infection. Further studies are needed, especially direct comparison of clarithromycin and azithromycin. In additions, studies that will compare different doses and regimens are needed.
Bello J.O.,University Of Ilorin
Urology | Year: 2014
Duplications of the urethra are rare, but the congenital posterior urethroperineal fistula (CUPF) is an even rarer anomaly. CUPF resembles type II A2, Y-duplication described by Effmann but differs significantly because it has a normal functional dorsal urethra and a ventral hypoplastic accessory urethra. Excision or fulguration of the accessory urethra results in the resolution of patient's symptoms. The 25th case in English literature is reported with a review of literature; the addition of CUPF to Effmann classification as "type II A2, Y-hypoplastic ventral urethra" is proposed. © 2014 Elsevier Inc.
Falaye B.J.,University Of Ilorin
Journal of Mathematical Physics | Year: 2012
This study presents the solutions of three dimensional Klein-Gordon equation for the spherically and non-spherically harmonic oscillatory ring-shaped potentials within the framework of asymptotic iteration method. Using the method of variable separation, this study obtains the radial and angular equations. And then the bound states energy eigenvalues and corresponding eigenfunctions are obtained analytically. © 2012 American Institute of Physics.
Falaye B.J.,University Of Ilorin
Central European Journal of Physics | Year: 2012
The asymptotic iteration method is employed to calculate the any ℓ-state solutions of the Schrödinger equation with the Eckart potential by proper approximation of the centrifugal term. Energy eigenvalues and corresponding eigenfunctions are obtain explicitly. The energy eigenvalues are calculated numerically for some values of ℓ and n. Our results are in excellent agreement with the findings of other methods for short potential ranges. © 2012 Versita Warsaw and Springer-Verlag Wien.
Falaye B.J.,University Of Ilorin
Few-Body Systems | Year: 2012
The asymptotic iteration method is employed to calculate the any ℓ-state solutions of the Schrödinger equation with the hyperbolical potential by proper approximation to the centrifugal term. Energy eigenvalues and corresponding eigenfunction are obtain analytically. The energy eigenvalues are computed numerically for some values of ℓ and n. Our results are in good agreement with the findings of other methods for short potential range. A straightforward extension to the s-wave (ℓ = 0) and σ o = 1 cases are also presented. © 2012 Springer-Verlag.
Falaye B.J.,University Of Ilorin
Few-Body Systems | Year: 2012
The relativistic Klein-Gordon equation with equal scalar and vector spherically asymmetrical singular oscillators is solved using the asymptotic iteration method. The energy eigenvalues equation and the corresponding wave functions are obtain explicitly. It was found that the asymptotic iteration method provides the closed-forms for the energy eigenvalues as well as the eigenfunctions. The non-relativistic limit c → ∞ of the energy spectrum, where c is the speed of light, have also been discussed. © 2012 Springer-Verlag.
Yakubu M.T.,University Of Ilorin
Journal of Andrology | Year: 2012
The present study was aimed at investigating the effects of the crude alkaloids isolated from Chromolaena odorata leaves on the hormonal and spermatogenic indices of male rats. The alkaloids obtained from C odorata leaves using standard methods were administered to male rats for 60 days at the doses of 250, 500, and 1000 mg/kg body weight. Thin-layer chromatographic analysis of the alkaloid mixture produced 8 spots, 3 of which were alkaloids with Rf values of 0.41, 0.49, and 0.55 as confirmed by the formation of orange color and creamy precipitates with both Dragendorff and Mayer reagents, respectively. The alkaloids were represented in the extract by a yield of 20.28 g, corresponding to a percentage yield of 90.05% of the total extract of 22.52 g. The final body weights of both the control and alkaloid-treated animals increased significantly (P <.05) compared with their respective body weights before treatment. The alkaloids significantly decreased (P <.05) the testes-body weight ratio; the concentrations of testicular total protein, glycogen, sialic acid, and cholesterol; and the activities of γ-glutamyl transferase, acid phosphatase, and alkaline phosphatase. The serum luteinizing hormone and follicle-stimulating hormone levels, as well as testicular and serum testosterone levels, also decreased significantly (P <.05). There were decreases in the sperm count, motility, and density, as well as morphological changes in the sperm cells. The pH and whitish-gray color of the semen were not significantly affected. All of the doses of the alkaloids increased the total mean number of sperm cell abnormalities, with the secondary type predominating over the primary spermcell abnormality. The alterations in the levels of the hormones and secretory and synthetic constituents of the testes and the spermatotoxic effects by the alkaloids from C odorata leaves may be due to nonavailability or deprivation of testosterone to the target organ. This lack of testosterone may have consequential effects on the reproductive process of the male rat. © American Society of Andrology.