University of Illinois at Urbana - Champaign

www.illinois.edu
Urbana, IL, United States

The University of Illinois at Urbana–Champaign is a public research-intensive university in the U.S. state of Illinois. A land-grant university, it is the flagship campus of the University of Illinois system. The University of Illinois at Urbana–Champaign is the second oldest public university in the state , and is a founding member of the Big Ten Conference. It is a member of the Association of American Universities and is designated as a RU/VH Research University . The campus library system possesses the second-largest university library in the United States after Harvard University.The university comprises 17 colleges that offer more than 150 programs of study. Additionally, the university operates an extension that serves 2.7 million registrants per year around the state of Illinois and beyond. The campus holds 647 buildings on 4,552 acres in the twin cities of Champaign and Urbana ; its annual operating budget in 2011 was over $1.7 billion. Wikipedia.


Time filter

Source Type

Patent
University of Illinois at Urbana - Champaign | Date: 2017-02-06

Disclosed are nanoparticle compositions comprising nanoparticles prepared from denatured, cross-linked albumin and a therapeutic agent for treating a neutrophil-mediated inflammation, and methods of treating neutrophil-mediated inflammation using the compositions.


Patent
University of Illinois at Urbana - Champaign | Date: 2017-03-22

Biomimetic grafts or implants coated with an osteogenic extracellular matrix and methods for production and use are described.


Patent
University of Illinois at Urbana - Champaign | Date: 2017-03-22

Disclosed is a derivative of amphotericin B (AmB), denoted C2epiAmB, with an improved therapeutic index over amphotericin B, pharmaceutical compositions comprising the AmB derivative, methods of making the AmB derivative and the pharmaceutical composition, and their use in methods of inhibiting growth of a yeast or fungus and treating a yeast or fungal infection. C2epiAmB is an epimer of the parent compound. Specifically, C2epiAmB differs from the parent compound at the C2 stereogenic center on mycosamine. This difference in structure results in (i) retained capacity to bind ergosterol and inhibit growth of yeast, (ii) greatly reduced capacity to bind cholesterol, and (iii) essentially no toxicity to human cells.


Patent
University of Illinois at Urbana - Champaign | Date: 2017-03-07

Tumor stem cells can be obtained by culturing a tumor cell population, and exposing the cultured tumor cell population to free radicals. In certain embodiments, the free radical agent can be a nitric oxide (NO) donor. In one embodiment, the free radical agent can be Diethylenetriamine NONOate (DETA NONOate) or agents that constitutively increase cellular nitric oxide, such as phosphodiesterase inhibitors or L-arginine, or agents that increase NO synthase in the population. The methods can further include inducing stem cells present in the population to expand and/or inducing dedifferentiation of tumor cells into tumor stem cells. Additionally, the present invention provides methods of selecting stem cells from a tumor cell population. Another aspect provides methods of screening for anti-tumor stem cell teherapeutic compounds by providing high nitric oxide (HNO) tumor cells, exposing the HNO cells to at least one compound, assessing one or more indicators of HNO cell health and determining toxicity of the compound to HNO tumor cells.


Patent
University of Illinois at Urbana - Champaign and The Board Of Regents Of The University Of Texas System | Date: 2017-03-09

Compositions comprising Formula (I) can be selectively lethal toward a variety of different cancer cell types. The compositions are useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy.


Patent
Oklahoma Medical Research Foundation and University of Illinois at Urbana - Champaign | Date: 2017-06-28

Hypercoagulable and hyperinflammatory responses can lead to a variety of diseases including but not limited to disseminated intravascular coagulation in sepsis, consumptive coagulopathy in trauma, thrombosis in the postsurgical setting, acute respiratory distress syndrome in lung, and other diseases or conditions. Polyphosphate is accumulated by many infectious microorganisms and may be released by damaged infectious microorganisms. In addition, polyphosphate is found in many organs and is released from activated platelets and mast cells. Polyphosphates activate the intrinsic pathway of coagulation that also induces inflammation. Hypercoagulable and hyperinflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death, which occur in many pathological conditions. As such, polyphosphates can be targeted pharmacologically by inhibitors, such as anti-polyphosphate antibodies, as well as used as biomarkers for diagnosis, prognosis, and treatment response indicators that may be used to provide guidance for alterations in treatment plans.


Patent
University of Illinois at Urbana - Champaign | Date: 2016-11-30

The disclosure generally relates to reactive electrochemical membranes (REMs); and in particular, to asymmetric reactive electrochemical membranes to be used for aqueous separations and membrane fouling regeneration.


Patent
Dow Chemical Company, Rohm, Haas Electronic Materials LLC and University of Illinois at Urbana - Champaign | Date: 2017-07-05

In one aspect, structures (10) are provided that comprise a photonic crystal comprising a dielectric layer (14) comprising therein one or more light-emitting nanostructure materials(16). In a further aspect, structures (10) are provided that comprise a dielectric layer (14) comprising first (16a) and second (16b) sets of light-emitting nanostructure materials (16a, b) at differing depths within the dielectric layer (14).


Patent
University of Illinois at Urbana - Champaign | Date: 2017-01-23

A two-phase metallic alloy comprising precipitates of Ag possessing a volume-averaged diameter of less than about 500 nm dispersed in a matrix selected from the group consisting of Ni, Fe, combinations of Ni with Cu and combinations of Fe with Cu.


Patent
The United States Of America and University of Illinois at Urbana - Champaign | Date: 2017-01-27

The system for cleaning fresh and freshly-cut produce is designed to clean produce as soon as practicable after the produce is cut. As the produce falls downwardly, a spray manifold directs a produce-washing liquid upwardly so that the produce-washing liquid directly sprays and impacts the falling produce. The impact of the produce-washing liquid causes the produce to tumble and the descent of the produce is slowed, and consequently the produce is thoroughly coated and cleaned by the produce-washing liquid. In an alternative embodiment, a suspending fluid (preferably air) is simultaneously directed to the falling produce to slow the descent of the produce and further ensure that the produce is thoroughly washed and directly sprayed by the produce-washing liquid.

Loading University of Illinois at Urbana - Champaign collaborators
Loading University of Illinois at Urbana - Champaign collaborators