Springfield, IL, United States

University of Illinois at Springfield

Springfield, IL, United States

The University of Illinois at Springfield is a public university in Springfield, Illinois, United States. The university was established in 1969 as Sangamon State University by the Illinois General Assembly and became a part of the University of Illinois system on July 1, 1995. As a public liberal arts college, and the newest campus in the University of Illinois system, UIS is a member of the Council of Public Liberal Arts Colleges. UIS is also part of the American Association of State Colleges and Universities and the American Council on Education. The campus' main repository, Brookens Library, holds a collection of nearly 800,000 books and serials- in addition to accessible resources at the University of Illinois at Chicago and University of Illinois at Urbana-Champaign campuses.The University of Illinois at Springfield serves roughly 5,700 students in 23 undergraduate programs, 20 master's programs, and a doctorate in Public Administration. The university was once one of the two upper-division and graduate universities in Illinois, but now accepts freshmen, transfer and graduate students. Wikipedia.

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News Article | May 5, 2017
Site: www.prweb.com

LearnHowToBecome.org, a leading resource provider for higher education and career information, has released its list of the Best Colleges in Illinois for 2017. 50 four-year colleges were ranked, with Northwestern University, University of Chicago, Bradley University, Illinois Institute of Technology and Augustana College taking the top five spots on the list. 49 two-year schools were also selected; Carl Sandburg College, Illinois Central College, Richland Community College, Rend Lake College and Lincoln Land Community College were the top five. A complete list of schools is included below. “The schools on our list have shown that they offer outstanding educational programs that set students up for post-college success,” said Wes Ricketts, senior vice president of LearnHowToBecome.org. “Students exploring higher education options in Illinois can also look to these schools to provide top-quality resources that help maximize the overall educational experience.” To be included on the “Best Colleges in Illinois” list, all schools must be not-for-profit and regionally accredited. Each college is also evaluated metrics including annual alumni earnings, the opportunity for employment services and academic counseling, the selection of degree programs offered, financial aid availability and graduation rates. Complete details on each college, their individual scores and the data and methodology used to determine the LearnHowToBecome.org “Best Colleges in Illinois” list, visit: The Best Four-Year Colleges in Illinois for 2017 include: Augustana College Aurora University Benedictine University Blackburn College Bradley University Chicago State University Concordia University-Chicago DePaul University Dominican University Eastern Illinois University Elmhurst College Eureka College Governors State University Greenville College Illinois College Illinois Institute of Technology Illinois State University Illinois Wesleyan University Judson University Knox College Lake Forest College Lewis University Loyola University Chicago MacMurray College McKendree University Millikin University Monmouth College National Louis University North Central College North Park University Northern Illinois University Northwestern University Olivet Nazarene University Principia College Quincy University Rockford University Roosevelt University Rush University Saint Xavier University Southern Illinois University-Carbondale Southern Illinois University-Edwardsville Trinity Christian College Trinity International University-Illinois University of Chicago University of Illinois at Chicago University of Illinois at Springfield University of Illinois at Urbana-Champaign University of St Francis Western Illinois University Wheaton College The Best Two-Year Colleges in Illinois for 2017 include: Black Hawk College Carl Sandburg College City Colleges of Chicago - Harry S Truman College City Colleges of Chicago - Malcolm X College City Colleges of Chicago - Wilbur Wright College City Colleges of Chicago-Harold Washington College City Colleges of Chicago-Kennedy-King College City Colleges of Chicago-Olive-Harvey College City Colleges of Chicago-Richard J Daley College College of DuPage College of Lake County Danville Area Community College Elgin Community College Frontier Community College Harper College Heartland Community College Highland Community College Illinois Central College Illinois Valley Community College John A Logan College John Wood Community College Joliet Junior College Kankakee Community College Kaskaskia College Kishwaukee College Lake Land College Lewis and Clark Community College Lincoln Land Community College Lincoln Trail College MacCormac College McHenry County College Moraine Valley Community College Morton College Oakton Community College Olney Central College Parkland College Prairie State College Rend Lake College Richland Community College Rock Valley College Sauk Valley Community College Shawnee Community College South Suburban College Southeastern Illinois College Southwestern Illinois College Spoon River College Triton College Wabash Valley College Waubonsee Community College ### About Us: LearnHowtoBecome.org was founded in 2013 to provide data and expert driven information about employment opportunities and the education needed to land the perfect career. Our materials cover a wide range of professions, industries and degree programs, and are designed for people who want to choose, change or advance their careers. We also provide helpful resources and guides that address social issues, financial aid and other special interest in higher education. Information from LearnHowtoBecome.org has proudly been featured by more than 700 educational institutions.

Brewer G.J.,University of Illinois at Springfield
Experimental Gerontology | Year: 2010

Harman's free radical theory of aging posits that oxidized macromolecules accumulate with age to decrease function and shorten life-span. However, nutritional and genetic interventions to boost anti-oxidants have generally failed to increase life-span. Furthermore, the free radical theory fails to explain why exercise causes higher levels of oxyradical damage, but generally promotes healthy aging. The separate anti-aging paradigms of genetic or caloric reductions in the insulin signaling pathway is thought to slow the rate of living to reduce metabolism, but recent evidence from Westbrook and Bartke suggests metabolism actually increases in long-lived mice. To unify these disparate theories and data, here, we propose the epigenetic oxidative redox shift (EORS) theory of aging. According to EORS, sedentary behavior associated with age triggers an oxidized redox shift and impaired mitochondrial function. In order to maintain resting energy levels, aerobic glycolysis is upregulated by redox-sensitive transcription factors. As emphasized by DeGrey, the need to supply NAD+ for glucose oxidation and maintain redox balance with impaired mitochondrial NADH oxidoreductase requires the upregulation of other oxidoreductases. In contrast to the 2% inefficiency of mitochondrial reduction of oxygen to the oxyradical, these other oxidoreductases enable glycolytic energy production with a deleterious 100% efficiency in generating oxyradicals. To avoid this catastrophic cycle, lactate dehydrogenase is upregulated at the expense of lactic acid acidosis. This metabolic shift is epigenetically enforced, as is insulin resistance to reduce mitochondrial turnover. The low mitochondrial capacity for efficient production of energy reinforces a downward spiral of more sedentary behavior leading to accelerated aging, increased organ failure with stress, impaired immune and vascular functions and brain aging. Several steps in the pathway are amenable to reversal for exit from the vicious cycle of EORS. Examples from our work in the aging rodent brain as well as other aging models are provided. © 2010 Elsevier Inc. All rights reserved.

Elble R.J.,University of Illinois at Springfield
Current Neurology and Neuroscience Reports | Year: 2013

Classic essential tremor is a clinical syndrome of action tremor in the upper limbs (at least 95 % of patients) and less commonly the head, face/jaw, voice, tongue, trunk, and lower limbs, in the absence of other neurologic signs. However, the longstanding notion that essential tremor is a monosymptomatic tremor disorder is being challenged by a growing literature describing associated disturbances of tandem walking, personality, mood, hearing, and cognition. There is also epidemiologic, pathologic, and genetic evidence that essential tremor is pathophysiologically heterogeneous. Misdiagnosis of essential tremor is common because clinicians frequently overlook other neurologic signs and because action tremor in the hands is caused by many conditions, including dystonia, Parkinson disease, and drug-induced tremor. Thus, essential tremor is nothing more than a syndrome of idiopathic tremulousness, and the challenge for researchers and clinicians is to find specific etiologies of this syndrome. © 2013 Springer Science+Business Media New York.

Bartke A.,University of Illinois at Springfield
Experimental Gerontology | Year: 2011

Longevity of mice can be increased by spontaneous or experimentally induced mutations that interfere with the biosynthesis or actions of growth hormone (GH), insulin-like growth factor 1 (IGF-1), or insulin in the adipose tissue. The effects of GH resistance and deficiency of GH (along with thyrotropin and prolactin) on aging and lifespan are the most pronounced and best established of these mutations. Potential mechanisms linking these endocrine deficits with delayed aging and extended longevity include increased stress resistance, alterations in insulin and mammalian target of rapamycin (mTOR) signaling and metabolic adjustments.Physiological relationships deduced from the extreme phenotypes of long-lived mouse mutants appear to apply broadly, encompassing genetically normal ("wild-type") mice and other mammalian species. The role of GH in the control of human aging continues to be hotly debated, but recent data indicate that reduced somatotropic signaling provides protection from cancer and other age-related diseases and may promote old age survival. © 2010 Elsevier Inc.

Bartke A.,University of Illinois at Springfield
Trends in Endocrinology and Metabolism | Year: 2011

Growth hormone (GH) affects somatic growth, sexual maturation, body composition and metabolism, as well as aging and longevity. Mice lacking GH or GH receptor outlive their normal siblings and exhibit symptoms of delayed aging associated with improved insulin signaling and increased stress resistance. Beneficial effects of eliminating the actions of GH are counterintuitive but conform to the concept of antagonistic pleiotropy. Evolutionary selection for traits promoting early-life fitness and reproductive success could account for post-reproductive deficits. Reciprocal relationships between GH signaling and longevity discovered in mutant mice apply also to normal mice, other mammalian species, and perhaps humans. This review summarizes the present understanding of the multifaceted relationship between somatotropic signaling and mammalian aging. © 2011.

Sachdeva M.,University of Illinois at Springfield | Mo Y.-Y.,University of Illinois at Springfield
Cancer Research | Year: 2010

MicroRNAs are important gene regulators that could play a profound role in tumorigenesis. Our previous studies indicate that miR-145 is a tumor suppressor capable of inhibiting tumor cell growth both in vitro and in vivo. In this study, we show that miR-145 exerts its function in a cell-specific manner. Although miR-145 inhibits cell growth in MCF-7 and HCT-116 cells, it has no significant effect on cell growth in metastatic breast cancer cell lines. However, miR-145 significantly suppresses cell invasion in these cells; in contrast, the antisense oligo against miR-145 increases cell invasion. miR-145 is also able to suppress lung metastasis in an experimental metastasis animal model. This miR-145-mediated suppression of cell invasion is in part due to the silencing of the metastasis gene mucin 1 (MUC1). Using luciferase reporters carrying the 3′-untranslated region of MUC1 combined with Western blot and immunofluorescence staining, we identify MUC1 as a direct target of miR-145. Moreover, ectopic expression of MUC1 enhances cell invasion, which can be blocked by miR-145. Of interest, suppression of MUC1 by miR-145 causes a reduction of β-catenin as well as the oncogenic cadherin 11. Finally, suppression of MUC1 by RNAi mimics the miR-145 action in suppression of invasion, which is associated with downregulation of β-catenin and cadherin 11. Taken together, these results suggest that as a tumor suppressor, miR-145 inhibits not only tumor growth but also cell invasion and metastasis. ©2010 AACR.

Illingworth K.D.,University of Illinois at Springfield
The Journal of bone and joint surgery. American volume | Year: 2013

Total joint arthroplasty is one of the most common and most successful orthopaedic procedures. Infection after total joint arthroplasty is a devastating problem that expends patient, surgeon, and hospital resources, and it substantially decreases the chances of a successful patient outcome. Postoperative infection affects approximately 1% to 7% of all total joint arthroplasties, at a cost of approximately $50,000 per infection. Decreasing postoperative periprosthetic joint infection is of the utmost importance for the total joint arthroplasty surgeon. Preoperative, perioperative, intraoperative, and postoperative measures to minimize infection and optimize patient outcomes in total joint arthroplasty are discussed. Preoperative measures include management of patients colonized by Staphylococcus aureus, nutritional optimization, and management of medical comorbidities. Perioperative measures include skin preparation and prophylactic antibiotics. Intraoperative measures include body exhaust suits, laminar flow, ultraviolet light, operating-room traffic control, surgical suite enclosures, anesthesia-related considerations, and antibiotic-loaded bone cement. Postoperative measures include continued antibiotic prophylaxis, blood transfusions, hematoma formation and wound drainage, duration of hospital stay, and antibiotic prophylaxis for future invasive procedures.

The reproducibility of pre-clinical research is an important concern that is now being voiced by constituencies that include the National Institutes of Health, the pharmaceutical industry, Congress, the public and the scientific community. An important facet of performing and publishing well-controlled reproducible pre-clinical research is to stabilize and more completely define the environment of the animal subjects. Scientists who use rodents in research generally recognize the importance of maintaining a stable animal environment. However, despite a theoretical and general awareness of these issues, many may lack a true appreciation of how significantly even seemingly minor variations in the environment can affect research outcomes. The purpose of this article is to help investigators gain a more comprehensive and substantiated understanding of the potentially significant impact of even seemingly minor environmental changes on the animals and the data. An important caveat to this article is that the examples presented were selected from a very large literature, admittedly in order to illustrate certain points. The goal of this article is not to provide an overview of the entire literature on how the environment affects rodents but rather to make preclinical scientists more aware of how these factors can potentially influence the experimental data and contribute to poor reproducibility of research. © 2015.

Corona J.,University of Illinois at Springfield
The Journal of bone and joint surgery. American volume | Year: 2013

Literature guiding the management of early-onset scoliosis consists primarily of studies with a low level of evidence. Evaluation of clinical equipoise (i.e., when there is no known superiority among treatment modalities) allows for prioritization of research efforts. The objective of this study was to evaluate areas of clinical uncertainty among pediatric spine surgeons regarding the treatment of early-onset scoliosis. Fourteen experienced pediatric spine surgeons participated in semistructured interviews to identify clinical variables that influence decision making in the treatment of early-onset scoliosis. A series of case scenarios of 315 patients with idiopathic and neuromuscular early-onset scoliosis was then developed to be representative of those encountered in clinical practice. Using an online survey, eleven surgeons selected their choice of eight treatment options for each case scenario. Associations between case characteristics and treatment choices were assessed with chi-square and logistic regression analysis. Participants then reviewed the areas of treatment uncertainty identified in the survey, nominated additional research questions of interest, and ranked their interest to further explore the identified research questions. Collective equipoise was identified in numerous scenarios in the survey spanning a range of ages and magnitudes of scoliosis, and additional questions were identified during the nominal group technique. Areas that had the greatest clinical uncertainty included the management of patients who have finished treatment with a growing-rod, timing of rod-lengthening intervals, and indications for spine-based and rib-based proximal instrumentation anchors. The use of rib anchors compared with spine-based anchors was ranked highly for consideration in future clinical trials. Variability in decision making with regard to the optimum treatment of certain subsets of patients with early-onset scoliosis reflects gaps in the available evidence. Structured consensus methods identified priorities for higher levels of research in this area of scoliosis. Higher-level studies, including randomized trials, should focus on answering the questions highlighted in this report.

Bartke A.,University of Illinois at Springfield
Philosophical Transactions of the Royal Society B: Biological Sciences | Year: 2011

Studies of the effects of single-gene mutations on longevity in Caenorhabditis elegans, Drosophila melanogaster and Mus musculus identified homologous, highly conserved signalling pathways that influence ageing. In each of these very distantly related species, single mutations which lead- directly or indirectly-to reduced insulin, insulin-like growth factor (IGF) or insulin/IGF-like signalling (IIS) can produce significant increases in both average and maximal lifespan. In mice, most of the life-extending mutations described to date reduce somatotropic (growth hormone (GH) and IGF-1) signalling. The reported extensions of longevity are most robust in GH-deficient and GH-resistant mice, while suppression of somatotropic signalling 'downstream' of the GH receptor produces effects that are generally smaller and often limited to female animals. This could be due to GH influencing ageing by both IGF-1-mediated and IGF-1-independent mechanisms. In mutants that have been examined in some detail, increased longevity is associated with various indices of delayed ageing and extended 'healthspan'. The mechanisms that probably underlie the extension of both lifespan and healthspan of these animals include increased stress resistance, improved antioxidant defences, alterations in insulin signalling (e.g. hypoinsulinaemia combined with improved insulin sensitivity in some mutants and insulin resistance in others), a shift from pro- to anti-inflammatory profile of circulating adipokines, reduced mammalian target of rapamycin-mediated translation and altered mitochondrial function including greater utilization of lipids when compared with carbohydrates. © 2011 The Royal Society.

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