Chicago, IL, United States

University of Illinois at Chicago
Chicago, IL, United States

The University of Illinois at Chicago, or UIC, is a state-funded public research university located in Chicago, Illinois, United States. Its campus is in the Near West Side community area, adjacent to the Chicago Loop. The second campus established under the University of Illinois system, UIC is also the largest university in the Chicago area, having approximately 28,000 students enrolled in 15 colleges.UIC operates the largest medical school in the United States, and serves as the principal educator for Illinois’ physicians, dentists, pharmacists, physical therapists, nurses and other healthcare professionals. UIC's medical school has research expenditures exceeding $412 million and consistently ranks in the top 50 U.S. institutions for research expenditures.In the 2015 U.S. News & World Report's ranking of colleges and universities, UIC ranked as the 149th best in the "national universities" category. The 2014 Times Higher Education World University Rankings ranked UIC as the 13th best in the world among universities less than 50 years old.UIC competes in NCAA Division I Horizon League as the UIC Flames in sports. The UIC Pavilion is home to all UIC basketball games. It also serves as a venue for concerts. Wikipedia.

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Johns Hopkins University and University of Illinois at Chicago | Date: 2015-04-22

The present invention provides novel indoleamide compounds for treating tuberculosis, including drug-resistant M-tuberculosis, compositions comprising the indoleamides and methods of using the indoleamides in conjunction with other biologically active agents for the treatment of tuberculosis in a subject in need thereof.

Lazarov O.,University of Illinois at Chicago | Hollands C.,University of Illinois at Chicago
Progress in Neurobiology | Year: 2016

Alzheimer's disease, the most prevalent form of dementia in the elderly, is characterized by progressive memory loss and cognitive dysfunction. It has become increasingly clear that while neuronal cell loss in the entorhinal cortex and hippocampus occurs in Alzheimer's disease, it is preceded by a long period of deficits in the connectivity of the hippocampal formation that contributes to the vulnerability of these circuits. Hippocampal neurogenesis plays a role in the maintenance and function of the dentate gyrus and hippocampal circuitry. This review will examine the evidence suggesting that hippocampal neurogenesis plays a role in cognitive function that is affected in Alzheimer's disease, will discuss the cognitive assessments used for the detection of Alzheimer's disease in humans and rodent models of familial Alzheimer's disease, and their value for unraveling the mechanism underlying the development of cognitive impairments and dementia. © 2016 Elsevier Ltd.

Thulborn K.R.,University of Illinois at Chicago
NeuroImage | Year: 2016

Sodium magnetic resonance (MR) imaging in humans has promised metabolic information that can improve medical management in important diseases. This technology has yet to find a role in clinical practice, lagging proton MR imaging by decades. This review covers the literature that demonstrates that this delay is explained by initial challenges of low sensitivity at low magnetic fields and the limited performance of gradients and electronics available in the 1980s. These constraints were removed by the introduction of 3T and now ultrahigh (≥7. T) magnetic field scanners with superior gradients and electronics for proton MR imaging. New projection pulse sequence designs have greatly improved sodium acquisition efficiency. The increased field strength has provided the expected increased sensitivity to achieve resolutions acceptable for metabolic interpretation even in small target tissues. Consistency of quantification of the sodium MR image to provide metabolic parametric maps has been demonstrated by several different pulse sequences and calibration procedures. The vital roles of sodium ion in membrane transport and the extracellular matrix will be reviewed to indicate the broad opportunities that now exist for clinical sodium MR imaging. The final challenge is for the technology to be supplied on clinical ≥3. T scanners. © 2016 Elsevier Inc.

Maren S.,Texas A&M University | Phan K.L.,University of Illinois at Chicago | Liberzon I.,University of Michigan
Nature Reviews Neuroscience | Year: 2013

Contexts surround and imbue meaning to events; they are essential for recollecting the past, interpreting the present and anticipating the future. Indeed, the brain's capacity to contextualize information permits enormous cognitive and behavioural flexibility. Studies of Pavlovian fear conditioning and extinction in rodents and humans suggest that a neural circuit including the hippocampus, amygdala and medial prefrontal cortex is involved in the learning and memory processes that enable context-dependent behaviour. Dysfunction in this network may be involved in several forms of psychopathology, including post-traumatic stress disorder, schizophrenia and substance abuse disorders. © 2013 Macmillan Publishers Limited. All rights reserved.

Jun J.-I.,University of Illinois at Chicago | Lau L.F.,University of Illinois at Chicago
Nature Reviews Drug Discovery | Year: 2011

Members of the CCN family of matricellular proteins are crucial for embryonic development and have important roles in inflammation, wound healing and injury repair in adulthood. Deregulation of CCN protein expression or activities contributes to the pathobiology of various diseases ĝ€" many of which may arise when inflammation or tissue injury becomes chronic ĝ€" including fibrosis, atherosclerosis, arthritis and cancer, as well as diabetic nephropathy and retinopathy. Emerging studies indicate that targeting CCN protein expression or signalling pathways holds promise in the development of diagnostics and therapeutics for such diseases. This Review summarizes the biology of CCN proteins, their roles in various pathologies and their potential as therapeutic targets. © 2011 Macmillan Publishers Limited. All rights reserved.

Stephanov M.A.,University of Illinois at Chicago
Physical Review Letters | Year: 2011

We point out that the quartic cumulant (and kurtosis) of the order parameter fluctuations is universally negative when the critical point is approached on the crossover side of the phase separation line. As a consequence, the kurtosis of a fluctuating observable, such as, e.g., proton multiplicity, may become smaller than the value given by independent Poisson statistics. We discuss implications for the beam energy scan program at RHIC at BNL. © 2011 American Physical Society.

Aggarwal S.K.,University of Illinois at Chicago
Progress in Energy and Combustion Science | Year: 2014

Spray ignition represents a critical process in numerous propulsion and energy conversion devices. Compared to a gaseous mixture, ignition in a spray is significantly more complex, as the state of ignition in the latter case can be defined by three distinct ignition modes namely, droplet ignition, droplet cluster ignition, and spray ignition. Ignition for an individual droplet represents the appearance of a flame surrounding the droplet or in the wake region, with a dimension on the order of droplet diameter. The cluster or group ignition refers tothe ignition aroundor inside a droplet cloud, while the spray ignition implies the appearance of aglobal flame witha characteristic dimension few ordersof magnitude larger than adroplet. In all three modes, ignition is preceded by the evaporation of fuel droplets, formation of a combustible gaseous fuel-air mixture, and initiation of chemical reactions producing sufficient radical species. The identification of the dominant ignition mode for given two-phase properties represents a problem of significant fundamental and practical importance. Research dealing with laminar and turbulent spray ignition has been reviewed by Aggarwal [1] and Mastorakos [2], respectively, while Annamalai and Ryan [3] have provided a review of droplet group combustion/ignition. In the present review, we discuss experimental, theoretical, and computational research dealing with individual droplet ignition. Topics include the quasi-steady and unsteady models for the ignition of a fuel droplet in a stagnant environment, the droplet ignition in a high-pressure environment, the convective effects on droplet ignition, and multicomponent fuel droplet ignition. Studies dealing with the two-stage and NTC ignition behavior for a droplet are also discussed. Finally, relationship between the droplet ignition mode to droplet cluster and spray ignition modes is briefly described. Potential topics for further research are outlined. © 2014 Elsevier Ltd. All rights reserved.

Lau L.F.,University of Illinois at Chicago
Cellular and Molecular Life Sciences | Year: 2011

CCN1 (CYR61) is a dynamically expressed, multifunctional matricellular protein that plays essential roles in cardiovascular development during embryogenesis, and regulates inflammation, wound healing and fibrogenesis in the adult. Aberrant CCN1 expression is associated with myriad pathologies, including various cancers and diseases associated with chronic inflammation. CCN1 promotes diverse and sometimes opposing cellular responses, which can be ascribed, as least in part, to disparate activities mediated through its direct binding to distinct integrins in different cell types and contexts. Accordingly, CCN1 promotes cell proliferation, survival and angiogenesis by binding to integrin αvβ 3, and induces apoptosis and senescence through integrin α6β1 and heparin sulfate proteoglycans. The ability of CCN1 to trigger the accumulation of a robust and sustained level of reactive oxygen species underlies some of its unique activities as a matrix cell-adhesion molecule. Emerging studies suggest that CCN1 might be useful as a biomarker or therapeutic target in certain diseases. © 2011 Springer Basel AG.

BACKGROUND–: Intramyocardial triglyceride (TG) turnover is reduced in pressure overloaded, failing hearts, limiting availability of this rich source of long-chain fatty acids (LCFAs) for mitochondrial β-oxidation and nuclear receptor activation. This study explored two major dietary fats, palmitate and oleate, in supporting endogenous TG dynamics and peroxisome proliferatoractivated receptor-α (PPAR-α) activation in sham-operated (SHAM) and hypertrophied (transverse aortic constriction, TAC) rat hearts.METHODS AND RESULTS–: Isolated SHAM and TAC hearts were provided media containing carbohydrate with either C-palmitate or C-oleate for dynamic C NMR spectroscopy and endpoint LC/MS of TG dynamics. With palmitate, TAC hearts contained 48% less TG versus SHAM (P=0.0003), while oleate maintained elevated TG in TAC, similar to SHAM. TG turnover in TAC was greatly reduced with palmitate (TAC: 46.7±12.2 nmol/g dw/min; SHAM: 84.3±4.9; P=0.0212), as was β-oxidation of TG. Oleate elevated TG turnover in both TAC 140.4±11.2) and SHAM (143.9±15.6), restoring TG oxidation in TAC. PPAR-α target gene transcripts were reduced by 70% in TAC with palmitate, while oleate induced normal transcript evels. Additionally, mRNA levels for PGC-1α and PGC-1β in TAC hearts were maintained by oleate. With these metabolic effects, oleate also supported a 25% improvement in contractilityover palmitate with TAC (P=0.0202).CONCLUSIONS–: The findings link reduced intracellular lipid storage dynamics to impaired PPAR-α signaling and contractility in diseased hearts, consistent with a rate-dependent lipolytic activation of PPAR-α In decompensated hearts, oleate may serve as a beneficial energy substrate versus palmitate by upregulating TG dynamics and nuclear receptor signaling. © 2014 by the American College of Cardiology Foundation and the American Heart Association, Inc.

Agency: NSF | Branch: Standard Grant | Program: | Phase: Campus Cyberinfrastrc (CC-NIE) | Award Amount: 499.75K | Year: 2017

The sizes of scientific datasets are growing exponentially across all scientific disciplines due to several factors such as improved scientific instrumentation, social media and decreasing costs of storage. To extract real value from these geographically distant datasets, researchers need to have access to these datasets at high speeds which is typically not possible with traditional campus networks. The University of Illinois at Chicago (UIC) is building HPRNet, a high performance research network providing last mile connectivity for over 31 research projects. HPRNet not only improves the ongoing research productivity, but also sets the stage for future innovations and collaborations. UIC is a public university and minority serving institution (MSI) in the heart of Chicago area where HPRNet significantly impacts the research training of underrepresented groups. The project team is working with other NSF and institutionally funded minority training programs on campus to ensure access to HPRNet resources.

For HPRNets deployment, 13 locations are identified at UIC where 10 to 40 Gigabit uplinks to regional, national and international R&E networks are established. HPRNet builds on the Science DMZ model that works in concert with the current campus research network (CRN) and a special data storage system known as Data Transfer Node (DTN) to deliver high-performance and reliable network paths for data-intensive applications, including high-volume bulk data transfer, remote experiment and/or instrumentation control, cloud computing, data-mining and advanced visualization.

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