Chicago, IL, United States

University of Illinois at Chicago

www.uic.edu
Chicago, IL, United States

The University of Illinois at Chicago, or UIC, is a state-funded public research university located in Chicago, Illinois, United States. Its campus is in the Near West Side community area, adjacent to the Chicago Loop. The second campus established under the University of Illinois system, UIC is also the largest university in the Chicago area, having approximately 28,000 students enrolled in 15 colleges.UIC operates the largest medical school in the United States, and serves as the principal educator for Illinois’ physicians, dentists, pharmacists, physical therapists, nurses and other healthcare professionals. UIC's medical school has research expenditures exceeding $412 million and consistently ranks in the top 50 U.S. institutions for research expenditures.In the 2015 U.S. News & World Report's ranking of colleges and universities, UIC ranked as the 149th best in the "national universities" category. The 2014 Times Higher Education World University Rankings ranked UIC as the 13th best in the world among universities less than 50 years old.UIC competes in NCAA Division I Horizon League as the UIC Flames in sports. The UIC Pavilion is home to all UIC basketball games. It also serves as a venue for concerts. Wikipedia.

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Patent
Johns Hopkins University and University of Illinois at Chicago | Date: 2015-04-22

The present invention provides novel indoleamide compounds for treating tuberculosis, including drug-resistant M-tuberculosis, compositions comprising the indoleamides and methods of using the indoleamides in conjunction with other biologically active agents for the treatment of tuberculosis in a subject in need thereof.


News Article | May 9, 2017
Site: www.eurekalert.org

A natural compound found in grape seed extract could be used to strengthen dentin -- the tissue beneath a tooth's enamel -- and increase the life of resin fillings, according to new research at the University of Illinois at Chicago College of Dentistry. No filling lasts forever, whether it's composite-resin or amalgam. But dentists find amalgam -- a combination of mercury, silver, tin or other materials -- easier to use and less costly. Plus, it can last 10 to 15 years or more. Composite-resin fillings are more aesthetically pleasing because the mixture of plastic and fine glass particles can be colored to match a patient's teeth. However, the fillings typically last only five to seven years. In research published in the Journal of Dental Research, Ana Bedran-Russo, associate professor of restorative dentistry, describes how grape seed extract can make composite-resin fillings stronger, allowing them to last longer. The extract, Bedran-Russo said, can increase the strength of the dentin, which comprises the majority of the calcified extracellular tissue of teeth, forming the layer just beneath the hard external enamel. Dentin is mostly made of collagen, the main structural protein in skin and other connective tissues. Resins have to bind to the dentin, but the area between the two, or the interface, is a weak point, causing restorations to breakdown, Bedran-Russo said. "When fillings fail, decay forms around it and the seal is lost. We want to reinforce the interface, which will make the resin bond better to the dentin," she said. "The interface can be changed through the use of new natural materials." More than 90 percent of adults between the ages of 20 and 64 have cavities, according to a federal report. A cavity is a hole that forms in the tooth when acid produced by bacteria erodes the minerals faster than the tooth can repair itself. The dentist removes the decay, or caries, with a drill and seals the hole with a filling. Secondary caries and margin breakdown are the most frequent causes of failed adhesive restorations, Bedran-Russo said. Despite numerous advances in dental restorative materials, degradation of the adhesive interface still occurs. Bedran-Russo has discovered that damaged collagen can repair itself with a combination of plant-based oligomeric proanthocyanidins -- flavonoids found in most foods and vegetables -- and extracts from grape seeds. Interlocking the resin and collagen-rich dentin provides better adhesion and does not rely on moisture. "The stability of the interface is key for the durability of such adhesive joints, and hence, the life of the restoration and minimizing tooth loss," Bedran-Russo said. One of the possible benefits of using grape seed extract is that it prevents tooth decay, she said. She and Guido Pauli, professor of medicinal chemistry and pharmacognosy in the UIC College of Pharmacy, recently collaborated on another study that showed extract from the root bark of Chinese red pine trees has similar properties to the grape seed extract. Co-authors on the Journal of Dental Research study are Ariene Leme-Kraus, Berdan Aydin, Cristina Vidal, Rasika Phansalkar, Joo-won Nam, James McAlpine, Pauli and Shao-nong Chen, all of UIC. The research was funded by the National Institute of Dental and Craniofacial Research (grant number DE021040), one of the National Institutes of Health.


News Article | May 9, 2017
Site: www.prnewswire.com

Among Arup Chicago's current projects in their portfolio are Chicago Union Station Phase 1A, Illinois Institute of Technology Innovation Center, digital master plans for The Wharf and Union Point new site developments, Nanotechnology and Bioengineering Institute in Monterrey, Mexico and ongoing state-of-the-art owner's representative services for international, enterprise technology giants including Microsoft and Amazon. Named one of Building Design + Construction magazine's "40 Under 40" in 2013, Nicolas is a recognized technical authority and thought leader in the field of electrical engineering. Prior to joining Arup in 2016, she served as an executive consultant to a preeminent Silicon Valley-based tech firm, advising the company's CEO and top management team on domestic and international construction projects and real estate strategies. As part of her considerable career, Nicolas was also active within the Chicago architecture, engineering and real estate community as a Vice President at a large consulting engineering firm. Among the notable projects to which she has contributed are: the Wrigley Field Restoration and Expansion project in Chicago; the 'Moment' high-rise residential building in Chicago's Streeterville neighborhood; the development of downtown Chicago's Block 37 mixed-use urban center; the University of Illinois at Chicago (UIC) Forum and South Campus Mixed-Use Development Superblock; the Department of Homeland Security's St. Elizabeths Campus in Washington D.C.; FKI Tower in Seoul, Korea; and Jeddah Tower in the Kingdom of Saudi Arabia. Nicolas holds Bachelor of Science degrees in electrical engineering and molecular & cellular biology from the University of Illinois at Urbana-Champaign. She was also awarded a graduate fellowship in electrical engineering, theoretical physics, and integrative physiology jointly offered by Stanford University, Princeton University, and UIUC. About Arup Arup provides planning, engineering, design, and consulting services for the most prominent projects and sites in the built environment. Since its founding in 1946, the firm has consistently delivered technical excellence, innovation, and value to its clients, while maintaining its core mission of shaping a better world. Arup opened its first US office more than 30 years ago and now employs 1,400 people in the Americas. The firm's employee-ownership structure promotes ongoing investment in joint research to yield better outcomes that benefit its clients and partners. Visit Arup's website, www.arup.com, and the online magazine of Arup in the Americas, doggerel.arup.com, for more information. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/arup-taps-cierine-nicolas-to-head-its-chicago-office-300454583.html


News Article | May 10, 2017
Site: globenewswire.com

Brings More than Two Decades of Financial and Operating Expertise at Leading Retail Companies Will Support Whole Foods Market’s Accelerated Path to Shareholder Value Creation AUSTIN, Texas, May 10, 2017 (GLOBE NEWSWIRE) -- Whole Foods Market, Inc. (NASDAQ:WFM) (“Whole Foods Market” or “the Company”) today announced the appointment of Keith Manbeck as Executive Vice President and Chief Financial Officer (CFO), effective May 17, 2017. Mr. Manbeck will join a leadership team that is implementing an accelerated plan to enhance shareholder value in a dynamic and increasingly competitive marketplace. Mr. Manbeck brings to Whole Foods Market more than 20 years of financial and operational experience at leading companies, most recently serving as Senior Vice President of Digital Finance, Strategy Management and Business Transformation at Kohl’s Corporation since 2014. During his tenure at Kohl’s, Mr. Manbeck helped lead key transformation initiatives, including the company’s development of its digital commerce business. This resulted in three years of double-digit comp growth that outperformed industry peers, along with more than 20% annual sales growth, and over 25% annual profitability growth. Prior to joining Kohl’s, Mr. Manbeck served as Global Vice President and CFO for Nike’s Direct to Consumer business, which under his stewardship delivered significant gross margin expansion. Under Mr. Manbeck’s leadership, which began in 2008, Nike’s Direct to Consumer business grew to over $5 billion in sales with double-digit comp growth each year and profits increasing by more than 30% each year. “Keith’s proven experience will be a great addition to our team,” said John Mackey, Co-Founder and Chief Executive Officer of Whole Foods Market. “Keith has a track record of success at leading retail companies, including Kohl’s and Nike, where he led key transformation initiatives with great results. He is a proven leader who knows how to drive strategic change, while maintaining the culture and values that make a company great. We are confident Keith’s financial and operational expertise will allow him to hit the ground running as we move forward with our plan to improve financial and operational performance.” “I am excited to join Whole Foods Market and help the Company deliver long-term, profitable and sustainable growth,” Mr. Manbeck said. “I have admired Whole Foods Market for many years, both as a customer and as an executive. I share the Company’s commitment to delivering nutritious food, a best-in-class customer experience and value for shareholders. I look forward to working closely with the entire Board and leadership team to implement financial strategies to support the Company’s continued growth and success.” As previously announced on November 2, 2016, Glenda Flanagan will retire as CFO, coincident with Mr. Manbeck’s appointment. Ms. Flanagan will continue to serve the Company in a senior advisor capacity. “On behalf of everyone at Whole Foods Market, we thank Glenda for her countless contributions and years of dedication, impressive work and friendship. Glenda’s title is smaller than her role. As one of the pioneering female CFOs in the Fortune 500, her head and her heart have been integral to the company that we are today. We are lucky to have her continued service and guidance as an advisor,” said Mr. Mackey. In a separate press releases issued today, Whole Foods Market detailed its accelerated path to shareholder value creation, its second quarter 2017 earnings and the appointment of five new independent directors to its Board of Directors. Keith Manbeck is a financial executive with over 20 years of progressive financial leadership experience with marquee companies. He has extensive experience in Consumer Package goods as well as growing direct to consumer brands and businesses. Prior to joining Whole Foods Market, Mr. Manbeck served as Senior Vice President of Digital Finance, Strategy Management and Business Transformation of Kohl’s Corporation since 2014. At Kohl’s, Mr. Manbeck led efforts to optimize operational effectiveness, margin rate and overall expense structure within the omnichannel organization, delivering over 20% annual sales growth and more than 25% annual profit growth during his tenure. He successfully lowered inventory and improved margin in the company’s digital business unit through transformation of buying, planning and allocation organization. He is also credited with delivering significant leverage of shipping and fulfillment expense by evolving inventory allocation and SKU rationalization, increasing inventory turns by 20%. Mr. Manbeck partnered with the cross-functional Kohl’s executive team to develop and execute a three-year technology blueprint to ensure optimal capital allocation. From 2008 until 2014, Mr. Manbeck worked with Nike, Inc. in a number of leadership roles, including as Global Vice President and CFO of the Direct to Consumer business from 2012 to 2014. In this role, Mr. Manbeck managed financial strategy and operations across the globe, delivering double-digit top line growth, expanded gross margin, leveraged expenses and improved profitability by more than 30% each year. As the CFO of Nike’s European retail business, Mr. Manbeck led a turnaround and, by the end of his assignment, the Western Europe division expanded margin and significantly improved profitability. The Central and Eastern European division also saw significant market expansion, positive comp performance and significantly improved profitability. Before joining Nike, Mr. Manbeck spent three years with Victoria’s Secret Stores from 2005 to 2008 as Vice President of Finance and Finance Director. Mr. Manbeck began his career with Pepsi, holding a number of positions over 12 years and ultimately rising to Group Finance Manager – Business Performance Management. He holds an MBA in Finance and Economics from the University of Chicago’s Booth School of Business, an MBA in Strategy and Accounting from the University of Illinois at Chicago and a Bachelor of Arts in Business Management from Augustana College. About Whole Foods Market Founded in 1978 in Austin, Texas, Whole Foods Market is the leading natural and organic foods supermarket, the first national “Certified Organic” grocer, and uniquely positioned as America’s Healthiest Grocery Store™. In fiscal year 2016, the Company had sales of approximately $16 billion and has more than 460 stores in the United States, Canada, and the United Kingdom. Whole Foods Market employs approximately 87,000 team members and has been ranked for 20 consecutive years as one of the “100 Best Companies to Work For” in America by Fortune magazine. For more information, please visit www.wholefoodsmarket.com or @wholefoods on Twitter.


News Article | May 10, 2017
Site: globenewswire.com

Brings More than Two Decades of Financial and Operating Expertise at Leading Retail Companies Will Support Whole Foods Market’s Accelerated Path to Shareholder Value Creation AUSTIN, Texas, May 10, 2017 (GLOBE NEWSWIRE) -- Whole Foods Market, Inc. (NASDAQ:WFM) (“Whole Foods Market” or “the Company”) today announced the appointment of Keith Manbeck as Executive Vice President and Chief Financial Officer (CFO), effective May 17, 2017. Mr. Manbeck will join a leadership team that is implementing an accelerated plan to enhance shareholder value in a dynamic and increasingly competitive marketplace. Mr. Manbeck brings to Whole Foods Market more than 20 years of financial and operational experience at leading companies, most recently serving as Senior Vice President of Digital Finance, Strategy Management and Business Transformation at Kohl’s Corporation since 2014. During his tenure at Kohl’s, Mr. Manbeck helped lead key transformation initiatives, including the company’s development of its digital commerce business. This resulted in three years of double-digit comp growth that outperformed industry peers, along with more than 20% annual sales growth, and over 25% annual profitability growth. Prior to joining Kohl’s, Mr. Manbeck served as Global Vice President and CFO for Nike’s Direct to Consumer business, which under his stewardship delivered significant gross margin expansion. Under Mr. Manbeck’s leadership, which began in 2008, Nike’s Direct to Consumer business grew to over $5 billion in sales with double-digit comp growth each year and profits increasing by more than 30% each year. “Keith’s proven experience will be a great addition to our team,” said John Mackey, Co-Founder and Chief Executive Officer of Whole Foods Market. “Keith has a track record of success at leading retail companies, including Kohl’s and Nike, where he led key transformation initiatives with great results. He is a proven leader who knows how to drive strategic change, while maintaining the culture and values that make a company great. We are confident Keith’s financial and operational expertise will allow him to hit the ground running as we move forward with our plan to improve financial and operational performance.” “I am excited to join Whole Foods Market and help the Company deliver long-term, profitable and sustainable growth,” Mr. Manbeck said. “I have admired Whole Foods Market for many years, both as a customer and as an executive. I share the Company’s commitment to delivering nutritious food, a best-in-class customer experience and value for shareholders. I look forward to working closely with the entire Board and leadership team to implement financial strategies to support the Company’s continued growth and success.” As previously announced on November 2, 2016, Glenda Flanagan will retire as CFO, coincident with Mr. Manbeck’s appointment. Ms. Flanagan will continue to serve the Company in a senior advisor capacity. “On behalf of everyone at Whole Foods Market, we thank Glenda for her countless contributions and years of dedication, impressive work and friendship. Glenda’s title is smaller than her role. As one of the pioneering female CFOs in the Fortune 500, her head and her heart have been integral to the company that we are today. We are lucky to have her continued service and guidance as an advisor,” said Mr. Mackey. In a separate press releases issued today, Whole Foods Market detailed its accelerated path to shareholder value creation, its second quarter 2017 earnings and the appointment of five new independent directors to its Board of Directors. Keith Manbeck is a financial executive with over 20 years of progressive financial leadership experience with marquee companies. He has extensive experience in Consumer Package goods as well as growing direct to consumer brands and businesses. Prior to joining Whole Foods Market, Mr. Manbeck served as Senior Vice President of Digital Finance, Strategy Management and Business Transformation of Kohl’s Corporation since 2014. At Kohl’s, Mr. Manbeck led efforts to optimize operational effectiveness, margin rate and overall expense structure within the omnichannel organization, delivering over 20% annual sales growth and more than 25% annual profit growth during his tenure. He successfully lowered inventory and improved margin in the company’s digital business unit through transformation of buying, planning and allocation organization. He is also credited with delivering significant leverage of shipping and fulfillment expense by evolving inventory allocation and SKU rationalization, increasing inventory turns by 20%. Mr. Manbeck partnered with the cross-functional Kohl’s executive team to develop and execute a three-year technology blueprint to ensure optimal capital allocation. From 2008 until 2014, Mr. Manbeck worked with Nike, Inc. in a number of leadership roles, including as Global Vice President and CFO of the Direct to Consumer business from 2012 to 2014. In this role, Mr. Manbeck managed financial strategy and operations across the globe, delivering double-digit top line growth, expanded gross margin, leveraged expenses and improved profitability by more than 30% each year. As the CFO of Nike’s European retail business, Mr. Manbeck led a turnaround and, by the end of his assignment, the Western Europe division expanded margin and significantly improved profitability. The Central and Eastern European division also saw significant market expansion, positive comp performance and significantly improved profitability. Before joining Nike, Mr. Manbeck spent three years with Victoria’s Secret Stores from 2005 to 2008 as Vice President of Finance and Finance Director. Mr. Manbeck began his career with Pepsi, holding a number of positions over 12 years and ultimately rising to Group Finance Manager – Business Performance Management. He holds an MBA in Finance and Economics from the University of Chicago’s Booth School of Business, an MBA in Strategy and Accounting from the University of Illinois at Chicago and a Bachelor of Arts in Business Management from Augustana College. About Whole Foods Market Founded in 1978 in Austin, Texas, Whole Foods Market is the leading natural and organic foods supermarket, the first national “Certified Organic” grocer, and uniquely positioned as America’s Healthiest Grocery Store™. In fiscal year 2016, the Company had sales of approximately $16 billion and has more than 460 stores in the United States, Canada, and the United Kingdom. Whole Foods Market employs approximately 87,000 team members and has been ranked for 20 consecutive years as one of the “100 Best Companies to Work For” in America by Fortune magazine. For more information, please visit www.wholefoodsmarket.com or @wholefoods on Twitter.


Stephanov M.A.,University of Illinois at Chicago
Physical Review Letters | Year: 2011

We point out that the quartic cumulant (and kurtosis) of the order parameter fluctuations is universally negative when the critical point is approached on the crossover side of the phase separation line. As a consequence, the kurtosis of a fluctuating observable, such as, e.g., proton multiplicity, may become smaller than the value given by independent Poisson statistics. We discuss implications for the beam energy scan program at RHIC at BNL. © 2011 American Physical Society.


Aggarwal S.K.,University of Illinois at Chicago
Progress in Energy and Combustion Science | Year: 2014

Spray ignition represents a critical process in numerous propulsion and energy conversion devices. Compared to a gaseous mixture, ignition in a spray is significantly more complex, as the state of ignition in the latter case can be defined by three distinct ignition modes namely, droplet ignition, droplet cluster ignition, and spray ignition. Ignition for an individual droplet represents the appearance of a flame surrounding the droplet or in the wake region, with a dimension on the order of droplet diameter. The cluster or group ignition refers tothe ignition aroundor inside a droplet cloud, while the spray ignition implies the appearance of aglobal flame witha characteristic dimension few ordersof magnitude larger than adroplet. In all three modes, ignition is preceded by the evaporation of fuel droplets, formation of a combustible gaseous fuel-air mixture, and initiation of chemical reactions producing sufficient radical species. The identification of the dominant ignition mode for given two-phase properties represents a problem of significant fundamental and practical importance. Research dealing with laminar and turbulent spray ignition has been reviewed by Aggarwal [1] and Mastorakos [2], respectively, while Annamalai and Ryan [3] have provided a review of droplet group combustion/ignition. In the present review, we discuss experimental, theoretical, and computational research dealing with individual droplet ignition. Topics include the quasi-steady and unsteady models for the ignition of a fuel droplet in a stagnant environment, the droplet ignition in a high-pressure environment, the convective effects on droplet ignition, and multicomponent fuel droplet ignition. Studies dealing with the two-stage and NTC ignition behavior for a droplet are also discussed. Finally, relationship between the droplet ignition mode to droplet cluster and spray ignition modes is briefly described. Potential topics for further research are outlined. © 2014 Elsevier Ltd. All rights reserved.


Lau L.F.,University of Illinois at Chicago
Cellular and Molecular Life Sciences | Year: 2011

CCN1 (CYR61) is a dynamically expressed, multifunctional matricellular protein that plays essential roles in cardiovascular development during embryogenesis, and regulates inflammation, wound healing and fibrogenesis in the adult. Aberrant CCN1 expression is associated with myriad pathologies, including various cancers and diseases associated with chronic inflammation. CCN1 promotes diverse and sometimes opposing cellular responses, which can be ascribed, as least in part, to disparate activities mediated through its direct binding to distinct integrins in different cell types and contexts. Accordingly, CCN1 promotes cell proliferation, survival and angiogenesis by binding to integrin αvβ 3, and induces apoptosis and senescence through integrin α6β1 and heparin sulfate proteoglycans. The ability of CCN1 to trigger the accumulation of a robust and sustained level of reactive oxygen species underlies some of its unique activities as a matrix cell-adhesion molecule. Emerging studies suggest that CCN1 might be useful as a biomarker or therapeutic target in certain diseases. © 2011 Springer Basel AG.


BACKGROUND–: Intramyocardial triglyceride (TG) turnover is reduced in pressure overloaded, failing hearts, limiting availability of this rich source of long-chain fatty acids (LCFAs) for mitochondrial β-oxidation and nuclear receptor activation. This study explored two major dietary fats, palmitate and oleate, in supporting endogenous TG dynamics and peroxisome proliferatoractivated receptor-α (PPAR-α) activation in sham-operated (SHAM) and hypertrophied (transverse aortic constriction, TAC) rat hearts.METHODS AND RESULTS–: Isolated SHAM and TAC hearts were provided media containing carbohydrate with either C-palmitate or C-oleate for dynamic C NMR spectroscopy and endpoint LC/MS of TG dynamics. With palmitate, TAC hearts contained 48% less TG versus SHAM (P=0.0003), while oleate maintained elevated TG in TAC, similar to SHAM. TG turnover in TAC was greatly reduced with palmitate (TAC: 46.7±12.2 nmol/g dw/min; SHAM: 84.3±4.9; P=0.0212), as was β-oxidation of TG. Oleate elevated TG turnover in both TAC 140.4±11.2) and SHAM (143.9±15.6), restoring TG oxidation in TAC. PPAR-α target gene transcripts were reduced by 70% in TAC with palmitate, while oleate induced normal transcript evels. Additionally, mRNA levels for PGC-1α and PGC-1β in TAC hearts were maintained by oleate. With these metabolic effects, oleate also supported a 25% improvement in contractilityover palmitate with TAC (P=0.0202).CONCLUSIONS–: The findings link reduced intracellular lipid storage dynamics to impaired PPAR-α signaling and contractility in diseased hearts, consistent with a rate-dependent lipolytic activation of PPAR-α In decompensated hearts, oleate may serve as a beneficial energy substrate versus palmitate by upregulating TG dynamics and nuclear receptor signaling. © 2014 by the American College of Cardiology Foundation and the American Heart Association, Inc.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: Campus Cyberinfrastrc (CC-NIE) | Award Amount: 499.75K | Year: 2017

The sizes of scientific datasets are growing exponentially across all scientific disciplines due to several factors such as improved scientific instrumentation, social media and decreasing costs of storage. To extract real value from these geographically distant datasets, researchers need to have access to these datasets at high speeds which is typically not possible with traditional campus networks. The University of Illinois at Chicago (UIC) is building HPRNet, a high performance research network providing last mile connectivity for over 31 research projects. HPRNet not only improves the ongoing research productivity, but also sets the stage for future innovations and collaborations. UIC is a public university and minority serving institution (MSI) in the heart of Chicago area where HPRNet significantly impacts the research training of underrepresented groups. The project team is working with other NSF and institutionally funded minority training programs on campus to ensure access to HPRNet resources.

For HPRNets deployment, 13 locations are identified at UIC where 10 to 40 Gigabit uplinks to regional, national and international R&E networks are established. HPRNet builds on the Science DMZ model that works in concert with the current campus research network (CRN) and a special data storage system known as Data Transfer Node (DTN) to deliver high-performance and reliable network paths for data-intensive applications, including high-volume bulk data transfer, remote experiment and/or instrumentation control, cloud computing, data-mining and advanced visualization.

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