University of Human Arts and science is a private distance learning university with headquarters in Iwatsuki-ku, Saitama, Saitama, Japan, established in 2000. It has a satellite campus in Chiyoda, Tokyo. The predecessor of the school was founded in 1953. Wikipedia.
Shimada H.,Center for Gerontology and Social Science |
Ishii K.,Tokyo Metropolitan University |
Ishiwata K.,Tokyo Metropolitan University |
Oda K.,Tokyo Metropolitan University |
And 3 more authors.
Gait and Posture | Year: 2013
This study evaluated brain activity during unaccustomed treadmill walking using positron emission tomography (PET) and [18F]fluorodeoxyglucose. Twenty-four healthy elderly females (75-82years) participated in this study. Two PET scans were performed after 25min of rest and after walking for 25min at 2.0km/h on a treadmill. Participants were divided into low and high step-length variability groups according to the median coefficient of variation in step length during treadmill walking. We compared the regional changes in brain glucose metabolism between the two groups. The most prominent relative activations during treadmill walking compared to rest in both groups were found in the primary sensorimotor areas, occipital lobe, and anterior and posterior lobe of the cerebellum. The high step-length variability group showed significant relative deactivations in the frontal lobe and the inferior temporal gyrus during treadmill walking. There was a significant relative activation of the primary sensorimotor area in the low step-length variability group compared to the high step-length variability group (P=0.022). Compared to the low step-length variability group, the high step-length variability group exhibited a greater relative deactivation in the white matter of the middle and superior temporal gyrus (P=0.032) and hippocampus (P=0.034) during treadmill walking compared to resting. These results suggest that activation of the primary sensorimotor area, prefrontal area, and temporal lobe, especially the hippocampus, is associated with gait adaptability during unaccustomed treadmill walking. © 2012 Elsevier B.V.
Yamaguchi O.,Nihon University |
Marui E.,University of Human Arts and Sciences |
Kakizaki H.,Asahikawa University |
Homma Y.,University of Tokyo |
And 9 more authors.
BJU International | Year: 2014
Objective To evaluate the efficacy and safety of the β3- adrenoceptor agonist mirabegron, in a Japanese population with overactive bladder (OAB). Patients and Methods This randomised, double-blind, placebo-controlled phase III study enrolled adult patients experiencing OAB symptoms for ≥24 weeks. Patients with ≥ 8 micturitions/24=h and ≥1 urgency episode/24=h or ≥1 urgency incontinence episode/24=h were randomised to once-daily placebo, mirabegron 50=mg or tolterodine 4=mg (as an active comparator, without testing for non-inferiority of efficacy and safety) for 12 weeks. The primary endpoint was the change in the mean number of micturitions/24=h from baseline to final assessment. Secondary endpoints included micturition variables related to urgency and/or incontinence and quality-of-life domain scores on the King's Health Questionnaire. Safety assessments included adverse events (AEs), post-void residual urine volume, laboratory variables, vital signs and 12-lead electrocardiogram. Results A total of 1139 patients were randomised to receive placebo (n = 381), mirabegron 50=mg (n = 380) or tolterodine 4=mg (n = 378). Demographic and baseline characteristics were similar among the treatment groups. At final assessment, mirabegron was significantly superior to placebo in terms of mean [sd] change from baseline in number of micturitions/24=h (-1.67 [2.212] vs -0.86 [2.354]; P < 0.001) and mean [sd] change from baseline in number of urgency episodes/24=h (-1.85 [2.555] vs -1.37 [3.191]; P = 0.025), incontinence episodes/24=h (-1.12 [1.475] vs -0.66 [1.861]; P = 0.003), urgency incontinence episodes/24=h (-1.01 [1.338] vs -0.60 [1.745]; P = 0.008), and volume voided/micturition (24.300 [35.4767] vs 9.715 [29.0864] mL; P < 0.001). The incidence of AEs in the mirabegron group was similar to that in the placebo group. Most AEs were mild and none were severe. Conclusions Mirabegron 50=mg once daily is an effective treatment for OAB symptoms, with a low occurrence of side effects in a Japanese population. © 2014 The Authors. BJU International © 2014 BJU International.
PubMed | Seigakuin University, University of Human Arts and Sciences and Japan National Institute of Biomedical Innovation
Type: | Journal: Geriatrics & gerontology international | Year: 2017
The National Health and Nutrition Survey, Japan, has annually monitored two indicators of physical activity in adults. They are contrasting in the association with age; the prevalence of exercise habit is lower and step counts are higher among younger participants. The present study aimed to examine the effects of rapid aging of the Japanese population and the lower participation rate among younger adults on the short-term trend of two indicators of physical activity using tabulated data.The prevalence of exercise habit and step counts by age groups (20years) from 2003 to 2010 were estimated using tabulated data from the National Health and Nutrition Survey by calculating sex-specific means weighted by age-specific Japanese population data for each year (population-weighted estimates) and for a fixed year (2005; age-standardized estimates). Linear regression analyses were used to test the statistical significance of their trends.Statistically significant increasing trends in the prevalence of exercise habit were observed for the crude means (P=0.029), the population-weighted estimates (P=0.007) and the age-standardized estimates (P=0.016) only in men. Statistically significant decreasing trends in the step counts were observed for the crude means (P=0.006 in men and P=0.033 in women) and the population-weighted estimates (P=0.008 in men and P=0.049 in women) both in men and women, but for the age-standardized estimates (P=0.039) only in men.The effects of rapid aging of the Japanese population and the lower participation rate among younger adults on the short-term trend are not small, and age-standardization is necessary to observe even the short-term trend of physical activity data. Geriatr Gerontol Int 2017; : -.
Ikeda N.,Japan National Institute of Biomedical Innovation |
Okuda N.,University of Human Arts and Sciences |
Tsubota-Utsugi M.,Japan National Institute of Biomedical Innovation |
Nishi N.,Japan National Institute of Biomedical Innovation
Journal of Epidemiology | Year: 2016
Background: National surveys have demonstrated a long-term decrease in mean energy intake in Japan, despite the absence of a decrease in the prevalence of overweight and obesity. We aimed to examine whether total energy intake of survey respondents is associated with completion of an in-person review of dietary records and whether it affects the trend in mean energy intake. Methods: We pooled data from individuals aged 20-89 years from the National Nutrition Surveys of 1997-2002 and the National Health and Nutrition Surveys of 2003-2011. We conducted a linear mixed-effects regression to estimate the association between total energy intake and the lack of an in-person review of semi-weighed household dietary records with interviewers. As some respondents did not have their dietary data confirmed, we used regression coefficients to correct their total energy intake. Results: Compared with respondents completing an in-person review, total energy intake was significantly inversely associated with respondents not completing a review across all sex and age groups (P < 0.001). After correction of total energy intake for those not completing a review, mean energy intake in each survey year significantly increased by 2.1%-3.9% in men and 1.3%-2.6% in women (P < 0.001), but the decreasing trend in mean energy intake was sustained. Conclusions: Total energy intake may be underestimated without an in-person review of dietary records. Further efforts to facilitate completion of a review may improve accuracy of these data. However, the increasing proportion of respondents missing an in-person review had little impact on the decreasing mean caloric intake. © 2015 Nayu Ikeda et al.
Smith C.L.,University of Human Arts and Sciences |
Bell M.A.,Williams College
Developmental Psychobiology | Year: 2010
Stability in frontal brain electrical activity (i.e., electroencephalographic or EEG) asymmetry at 10 and 24 months was examined with respect to maternal ratings of internalizing and externalizing behaviors at 30 months in a sample of 48 children. Children with stable left frontal EEG asymmetry during infancy were rated higher in externalizing behaviors by their mothers, whereas children with stable right frontal EEG asymmetry were rated higher in internalizing behaviors. These findings highlight the need to focus on the early stability in physiological measures that may be implicated later in developing behavioral problems. © 2009 Wiley Periodicals, Inc.
Furukawa K.,Seijoh University |
Suzuki H.,University of Human Arts and Sciences |
Fukuda J.,University of Human Arts and Sciences
Journal of Rehabilitation Medicine | Year: 2012
Objective: To observe the real-time muscle activity of bilateral hands while subjects draw circles under 2 conditions: with and without using Ramachandran's mirror-box. Subjects: A total of 24 healthy volunteers. Methods: Subjects drew 4 circles sequentially using their dominant hand with the other hand at rest, both with and without looking at a mirror image. Circles were marked by 8 dots on the paper, which subjects connected up to draw the shape. The activity of the bilateral first dorsal interosseus muscles was recorded using surface electromyography. Results: Muscle activity of the dominant hand remained constant during each task. In contrast, muscle activity of the non-dominant hand increased under the condition of watching the image in the mirror, but was low under the non-watching condition. Furthermore, muscle activity of the non-dominant hand increased over the duration of the task. However, wide variation between subjects was observed under the mirror-image condition. Conclusion: Increased muscle action potential of the nondominant hand may be induced by the circle drawing task of the dominant hand during Ramachandran's mirror-box therapy, which supports previous observations of increased brain activity caused by watching a mirror image. © 2012 The Authors.
Uchiyama K.,Jikei University School of Medicine |
Nakamura M.,Jikei University School of Medicine |
Odahara S.,Jikei University School of Medicine |
Koido S.,Jikei University School of Medicine |
And 5 more authors.
Inflammatory Bowel Diseases | Year: 2010
Background: N-3 polyunsaturated fatty acids (PUFA) are considered important pharmaconutrients for modulating mucosal immunity and therapeutic responses in patients with inflammatory bowel disease (IBD). We investigated the influence of diet therapy involving the use of an "n-3 PUFA food exchange table" (n-3DP) on the fatty acid composition of the erythrocyte membranes of IBD patients and its remission-maintaining effects. Methods: We analyzed the fatty acid composition of the erythrocyte membrane before and after n-3DP intervention in 20 initial-onset IBD patients who had not undergone any dietary intervention. We then analyzed it again and evaluated disease activity after 12-18 months intervention in 230 IBD patients (168 ulcerative colitis, 62 Crohn's disease; follow-up group) in whom n-3DP was introduced after remission had been achieved. The follow-up group was divided into remission and relapse groups. Results: In the 20 initial-onset patients, the mean n-3/n-6 ratio significantly increased after intervention (0.41 ± 0.16 versus 0.70 ± 0.20; P < 0.001). In the follow-up group the ratio in the remission group (n = 145) was significantly higher than that in the relapse group (n = 85) (0.65 ± 0.28 versus 0.53 ± 0.18; P < 0.001). The ratio significantly decreased in those who suffered a relapse after the beginning of treatment (P < 0.01). Conclusions: N-3DP significantly increased the erythrocyte membrane n-3/n-6 ratio in IBD patients, and this ratio was significantly higher in the remission group, suggesting that n-3DP alters the fatty acid composition of the cell membrane and influences clinical activity in IBD patients. © 2010 Crohn's & Colitis Foundation of America, Inc.
Yamashita M.,University of Human Arts and Sciences |
Kudo C.,East Japan Railway Co.
Nursing and Health Sciences | Year: 2014
Following the Great East Japan earthquake (the Big Quake) that hit the northeastern parts of Japan on March 11, 2011, aid was dispatched from multiple levels of organizations including the Japanese Nurses Association (JNA). Evidence indicates that the JNA did not play an effective role in the aid efforts, since the professional organization had pulled out and stopped sending nursing personnel from the end of April 2011. In view of the way that things were handled in terms of aid efforts immediately, a year, or two years after the Big Quake occurred, the authors of this paper have identified issues related to nurse's role at the time of the disaster. By looking back at what happened, we have gained insights into how to prepare for future disasters. © 2014 Wiley Publishing Asia Pty Ltd.
Kagitani F.,Tokyo Metropolitan Institute for Neuroscience |
Kagitani F.,University of Human Arts and Sciences |
Uchida S.,Tokyo Metropolitan Institute for Neuroscience |
Hotta H.,Tokyo Metropolitan Institute for Neuroscience
Autonomic Neuroscience: Basic and Clinical | Year: 2010
Acupuncture has been used for analgesia, for treating visceral function disorders and for improving motor functions. It is well established that stimulation of the skin and muscles, either electrically or with noxious or non-noxious stimuli, induces a variety of somato-motor and autonomic responses. This strongly suggests that acupuncture acts by exciting cutaneous and/or muscular afferent nerve fibers. A question of considerable scientific and practical interest is what kinds of somatic afferent fibers are stimulated by acupuncture and are involved in its effects. There are several types of afferent fiber: thick myelinated Aα and Aβ (group I and II), thin myelinated Aδ (group III) and thinner unmyelinated C (group IV) fibers. In recent studies we have tried to establish which ones of these types of somatic afferent fiber are stimulated by acupuncture. In this article we first review the experimental evidence showing that the effects of acupuncture are mediated by the activation of afferent nerve fibers innervating the skin and muscles. Secondly, we discuss what types of afferent nerve fiber are activated by electrical acupuncture, and what types are involved in its effects on somato-motor functions and on visceral functions. Finally, we present some new findings based on recordings from single afferent nerve fibers excited by manual acupuncture. © 2010 Elsevier B.V.
PubMed | University of Human Arts and Sciences and Chapman University
Type: | Journal: Frontiers in physiology | Year: 2017
Myokines are specialized cytokines that are secreted from skeletal muscle (SKM) in response to metabolic stimuli, such as exercise. Interleukin-15 (IL-15) is a myokine with potential to reduce obesity and increase lean mass through induction of metabolic processes. It has been previously shown that IL-15 acts to increase glucose uptake in SKM cells. However, the downstream signals orchestrating the link between IL-15 signaling and glucose uptake have not been fully explored. Here we employed the mouse SKM C2C12 cell line to examine potential downstream targets of IL-15-induced alterations in glucose uptake. Following differentiation, C2C12 cells were treated overnight with 100 ng/ml of IL-15. Activation of factors associated with glucose metabolism (Akt and AMPK) and known downstream targets of IL-15 (Jak1, Jak3, STAT3, and STAT5) were assessed with IL-15 stimulation. IL-15 stimulated glucose uptake and GLUT4 translocation to the plasma membrane. IL-15 treatment had no effect on phospho-Akt, phospho-Akt substrates, phospho-AMPK, phospho-Jak1, or phospho-STAT5. However, with IL-15, phospho-Jak3 and phospho-STAT3 levels were increased along with increased interaction of Jak3 and STAT3. Additionally, IL-15 induced a translocation of phospho-STAT3 from the cytoplasm to the nucleus. We have evidence that a mediator of glucose uptake, HIF1, expression was dependent on IL-15 induced STAT3 activation. Finally, upon inhibition of STAT3 the positive effects of IL-15 on glucose uptake and GLUT4 translocation were abolished. Taken together, we provide evidence for a novel signaling pathway for IL-15 acting through Jak3/STAT3 to regulate glucose metabolism.