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Hong Kong, China

The University of Hong Kong is the oldest tertiary institution in Hong Kong. Its motto is "Sapientia et Virtus" in Latin, meaning "wisdom and virtue", and "明德格物" in Chinese. The medium of instruction in most classes is English. The school adopts the problem-based learning teaching strategy which aims to train students' problem solving skills. It has a great achievement in Humanities, Legal subjects, Political science, Biological science and Medicine. Wikipedia.


Graft-versus-host disease (GVHD) is a lethal complication of allograft transplantation. The current strategy of using immunosuppressive agents to control GVHD may cause general immune suppression and limit the effectiveness of allograft transplantation. Adoptive transfer of regulatory T cells (Treg) can prevent GVHD in rodents, indicating the therapeutic potential of Treg for GVHD in humans. However, the clinical application of Treg-based therapy is hampered by the low frequency of human Treg and the lack of a reliable model to test their therapeutic effects in vivo. Human alloantigen-specific Treg are generated from antigenically-nave precursors in a large scale ex vivo using allogeneic activated B cells as stimulators. Here, a human allogeneic GVHD model is established in humanized mice to mimic GVHD after allograft transplantation in humans. The ex vivo-induced CD8


In one embodiment, provided are a new class of diarylethene-containing photochromic compounds with the incorporation of silicon- or phosphorus-containing heterocycles into the ethene part of the diarylethene backbone that has been shown to be capable of displaying tunable, robust and thermally stable photochromic properties. Also provided are methods for synthesizing these compounds, as well as uses of these compounds as these compounds may be used as the photochromic layer in an optical recording material and other optical functioning devices.


Patent
University of Hong Kong | Date: 2015-05-27

A one-step method for fabricating solidified particles from all-aqueous emulsion droplets involves solidification and drying of the droplets by osmosis. According to this method the fabrication of solidified particles is induced by implementing a high osmotic pressure gradient between the internal phase and external phase of the all-aqueous emulsion. The resultant extraction of water leads to solidification of the emulsion droplets. This approach provides mild conditions for encapsulating bioactive ingredients or other delicate components to conveniently fabricate bio- and cyto-compatible particles because it does not involve the introduction of external energy used in conventional drying. Such conventional external energy inputs are time-consuming, so the method is more efficient.


Annexin A3 (ANAX3) is utilized as a biomarker for the diagnosis and prognosis of hepatocellular carcinoma (HCC) and the utilization of a monoclonal antibody against ANXA3 or antisense polynucleotide against ANXA3 mRNA for the suppression or treatment of HCC, alone or in combination with other HCC treatment. Monoclonal antibody against ANXA3 can be administered for the suppression of tumor growth, metastasis, and chemoresistance.


Patent
University of Hong Kong | Date: 2014-08-13

An optical coherent tomographic imaging system includes means for introducing a 180-degree phase inversion in the interference fringes, and generating a two-peak shape point spread function (PSF) in the frequency domain for the interference-based tomographic imaging system. The system further includes means for achieving sharper resolution than the diffraction-limited spectral bandwidth in the tomographic imaging system through subtracting the two-peak shape from the original Gaussian PSF. Means are provided for removing the ghost fringes in the tomographic imaging system, which is introduced by the self-interference between the different layers of the sample arm. The apparatus is configured to realize the real-time super-resolution swept-source optical coherent tomography (OCT) such that the sensitivity of the system is enhanced by suppressing the noise floor in the frequency domain, as well as removing the ghost fringes.

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