Hong Kong, China
Hong Kong, China

The University of Hong Kong is the oldest tertiary institution in Hong Kong. Its motto is "Sapientia et Virtus" in Latin, meaning "wisdom and virtue", and "明德格物" in Chinese. The medium of instruction in most classes is English. The school adopts the problem-based learning teaching strategy which aims to train students' problem solving skills. It has a great achievement in Humanities, Legal subjects, Political science, Biological science and Medicine. Wikipedia.


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The subject invention pertains to methods, and related compositions, for treating or inhibiting liver cancer, comprising administering an effective amount of sorafenib; and an inhibiting agent selected from a CD47 inhibiting agent, a NF-B inhibiting agent, and combination thereof.


Annexin A3 (ANAX3) is utilized as a biomarker for the diagnosis and prognosis of hepatocellular carcinoma (HCC) and the utilization of a monoclonal antibody against ANXA3 or antisense polynucleotide against ANXA3 mRNA for the suppression or treatment of HCC, alone or in combination with other HCC treatment. Monoclonal antibody against ANXA3 can be administered for the suppression of tumor growth, metastasis, and chemoresistance.


On field ionization under ambient conditions is described and applied on both ionization and desorption of various chemicals and biochemical present on the surface of materials in solid, liquid or gas states. The Atmospheric Pressure Megavolt Electrostatic Field Ionization Desorption (APME-FID) method generates ions directly from the surface of samples connected to a high electrical voltage at megavolt conditions. Megavolt electrostatic potential is generated and gradually accumulated directly on the sample surface by a Van de Graaff generator without causing damage to the sample. Therefore, when coupled with mass spectrometric system, the APME-FID-MS method enables direct detection of analytes on the surface of samples in different sizes and diverse types.


Patent
University of Hong Kong | Date: 2015-08-31

Methods of diagnosis and/or prognosis of malignant disease from pleural effusion samples are disclosed. The methods typically include determining the normalized intensity of one or more biomarkers, such as acetone and 3-hydroxybutyate, in pleural effusion samples using nuclear magnetic resonance (NMR), such as proton NMR (^(1)H-NMR) spectroscopy. Reference values for malignant disease diagnosis using the disclosed biomarkers are provided. Reference values for prognosis of median survival time based on the disclosed biomarkers are also provided.


Patent
University of Hong Kong | Date: 2017-03-01

Methods of diagnosis and/or prognosis of malignant disease from pleural effusion samples are disclosed. The methods typically include determining the normalized intensity of one or more biomarkers, such as acetone and 3-hydroxybutyate, in pleural effusion samples using nuclear magnetic resonance (NMR), such as proton NMR (^(1)H-NMR) spectroscopy. Reference values for malignant disease diagnosis using the disclosed biomarkers are provided. Reference values for prognosis of median survival time based on the disclosed biomarkers are also provided.


High-quality non-stoichiometric NiO_(x )nanoparticles are synthesized by a facile chemical precipitation method. The NiO_(x )film can function as an effective p-type semiconductor or hole transport layer (HTL) without any post-treatments, while offering wide temperature applicability from room-temperature to 150 C. For demonstrating the potential applications, high efficiency is achieved in organic solar cells using NiO_(x )HTL. Better performance in NiO_(x )based organic light emitting diodes is obtained as compared to devices using PEDOT:PSS. The solution-processed NiO_(x )semiconductors at room temperature can favor a wide-range of applications of large-area and flexible optoelectronics.


Patent
University of Hong Kong | Date: 2016-11-18

Novel and advantageous insulator discs with embedded resonator coils are provided. By linking the insulator discs in a series using an appropriate mechanical mechanism, the insulator discs form an insulator or insulator string for a high power transmission line system. The resonator coils embedded inside the insulator discs therefore form a series of relay resonators that can be used for wireless power transfer through the principle of near-field magnetic coupling and resonance. The insulator string can provide the simultaneous functions of voltage insulation and wireless power transfer over the length of the string. Applications include, but not limited to, wireless power transfer in a high-voltage environment such as that encountered in high-voltage power transmission line systems.


The present invention provides a method for evaluation of risk and progression of autoimmune diabetes in mammalian subjects. The method includes measuring the enzymatic activities and/or protein concentrations of neutrophil elastase and proteinase 3 in a subject and comparing the measured levels of these proteases to respective reference levels.


Patent
University of Hong Kong | Date: 2016-11-29

The present disclosure relates to the design and generation of stapled helical peptides that perturb protein-protein interactions (PPIs). The methods disclosed herein for preparing stapled peptides involve providing a peptide having a first amino acid that is functionalized with a salicylaldehyde ester side group and a second amino acid functionalized with a 1,2-hydroxyl amine side group; reacting the first and second amino acids to generate an N,O-benzylidene acetal moiety; and performing acidolysis of the resultant N,O-benzylidene acetal moiety to generate the stapled peptide. In many forms, the stapled helical peptides described herein are not hydrophobic.


Interpreting the genetic variants located in the regulatory regions, such as enhancers and promoters, is an indispensable step to understand molecular mechanism of complex traits. Recent studies show that genetic variants detected by genome-wide association study (GWAS) are significantly enriched in the regulatory regions. Therefore, detecting, annotating and prioritizing of genetic variants affecting gene regulation are critical to our understanding of genotype-phenotype relationships. Here, we developed a web server GWAS3D to systematically analyze the genetic variants that could affect regulatory elements, by integrating annotations from cell type-specific chromatin states, epigenetic modifications, sequence motifs and cross-species conservation. The regulatory elements are inferred from the genome-wide chromosome interaction data, chromatin marks in 16 different cell types and 73 regulatory factors motifs from the Encyclopedia of DNA Element project. Furthermore, we used these function elements, as well as risk haplotype, binding affinity, conservation and P-values reported from the original GWAS to reprioritize the genetic variants. Using studies from low-density lipoprotein cholesterol, we demonstrated that our reprioritizing approach was effective and cell type specific. In conclusion, GWAS3D provides a comprehensive annotation and visualization tool to help users interpreting their results. The web server is freely available at http://jjwanglab.org/gwas3d.

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