Hong Kong, China
Hong Kong, China

The University of Hong Kong is the oldest tertiary institution in Hong Kong. Its motto is "Sapientia et Virtus" in Latin, meaning "wisdom and virtue", and "明德格物" in Chinese. The medium of instruction in most classes is English. The school adopts the problem-based learning teaching strategy which aims to train students' problem solving skills. It has a great achievement in Humanities, Legal subjects, Political science, Biological science and Medicine. Wikipedia.


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The subject invention pertains to methods, and related compositions, for treating or inhibiting liver cancer, comprising administering an effective amount of sorafenib; and an inhibiting agent selected from a CD47 inhibiting agent, a NF-B inhibiting agent, and combination thereof.


Annexin A3 (ANAX3) is utilized as a biomarker for the diagnosis and prognosis of hepatocellular carcinoma (HCC) and the utilization of a monoclonal antibody against ANXA3 or antisense polynucleotide against ANXA3 mRNA for the suppression or treatment of HCC, alone or in combination with other HCC treatment. Monoclonal antibody against ANXA3 can be administered for the suppression of tumor growth, metastasis, and chemoresistance.


On field ionization under ambient conditions is described and applied on both ionization and desorption of various chemicals and biochemical present on the surface of materials in solid, liquid or gas states. The Atmospheric Pressure Megavolt Electrostatic Field Ionization Desorption (APME-FID) method generates ions directly from the surface of samples connected to a high electrical voltage at megavolt conditions. Megavolt electrostatic potential is generated and gradually accumulated directly on the sample surface by a Van de Graaff generator without causing damage to the sample. Therefore, when coupled with mass spectrometric system, the APME-FID-MS method enables direct detection of analytes on the surface of samples in different sizes and diverse types.


Patent
University of Hong Kong | Date: 2015-08-31

Methods of diagnosis and/or prognosis of malignant disease from pleural effusion samples are disclosed. The methods typically include determining the normalized intensity of one or more biomarkers, such as acetone and 3-hydroxybutyate, in pleural effusion samples using nuclear magnetic resonance (NMR), such as proton NMR (^(1)H-NMR) spectroscopy. Reference values for malignant disease diagnosis using the disclosed biomarkers are provided. Reference values for prognosis of median survival time based on the disclosed biomarkers are also provided.


Patent
University of Hong Kong | Date: 2017-03-01

Methods of diagnosis and/or prognosis of malignant disease from pleural effusion samples are disclosed. The methods typically include determining the normalized intensity of one or more biomarkers, such as acetone and 3-hydroxybutyate, in pleural effusion samples using nuclear magnetic resonance (NMR), such as proton NMR (^(1)H-NMR) spectroscopy. Reference values for malignant disease diagnosis using the disclosed biomarkers are provided. Reference values for prognosis of median survival time based on the disclosed biomarkers are also provided.


Cowling B.J.,University of Hong Kong
Nature communications | Year: 2013

Influenza A viruses are believed to spread between humans through contact, large respiratory droplets and small particle droplet nuclei (aerosols), but the relative importance of each of these modes of transmission is unclear. Volunteer studies suggest that infections via aerosol transmission may have a higher risk of febrile illness. Here we apply a mathematical model to data from randomized controlled trials of hand hygiene and surgical face masks in Hong Kong and Bangkok households. In these particular environments, inferences on the relative importance of modes of transmission are facilitated by information on the timing of secondary infections and apparent differences in clinical presentation of secondary infections resulting from aerosol transmission. We find that aerosol transmission accounts for approximately half of all transmission events. This implies that measures to reduce transmission by contact or large droplets may not be sufficient to control influenza A virus transmission in households.


Tam A.Y.-Y.,University of Hong Kong | Yam V.W.-W.,University of Hong Kong
Chemical Society Reviews | Year: 2013

Amongst the areas of supramolecular chemistry, low molecular weight gelators (supramolecular gels) have been considered to be one of the most interesting soft and smart materials due to their ability to construct polymeric structures from small molecules through non-covalent interactions. Recently, metal centres have been incorporated into organic-based gelators that can integrate the interesting and unique properties of metal complexes into gelator molecules that can hardly be achieved by pure organic compounds. In this review, we will give a summary of the recent developments on metallogels and their interesting properties originating from the metal centres. © 2013 The Royal Society of Chemistry.


Interpreting the genetic variants located in the regulatory regions, such as enhancers and promoters, is an indispensable step to understand molecular mechanism of complex traits. Recent studies show that genetic variants detected by genome-wide association study (GWAS) are significantly enriched in the regulatory regions. Therefore, detecting, annotating and prioritizing of genetic variants affecting gene regulation are critical to our understanding of genotype-phenotype relationships. Here, we developed a web server GWAS3D to systematically analyze the genetic variants that could affect regulatory elements, by integrating annotations from cell type-specific chromatin states, epigenetic modifications, sequence motifs and cross-species conservation. The regulatory elements are inferred from the genome-wide chromosome interaction data, chromatin marks in 16 different cell types and 73 regulatory factors motifs from the Encyclopedia of DNA Element project. Furthermore, we used these function elements, as well as risk haplotype, binding affinity, conservation and P-values reported from the original GWAS to reprioritize the genetic variants. Using studies from low-density lipoprotein cholesterol, we demonstrated that our reprioritizing approach was effective and cell type specific. In conclusion, GWAS3D provides a comprehensive annotation and visualization tool to help users interpreting their results. The web server is freely available at http://jjwanglab.org/gwas3d.


Chesi G.,University of Hong Kong
IEEE Transactions on Automatic Control | Year: 2010

Numerous tasks in control systems involve optimization problems over polynomials, and unfortunately these problems are in general nonconvex. In order to cope with this difficulty, linear matrix inequality (LMI) techniques have been introduced because they allow one to obtain bounds to the sought solution by solving convex optimization problems and because the conservatism of these bounds can be decreased in general by suitably increasing the size of the problems. This survey aims to provide the reader with a significant overview of the LMI techniques that are used in control systems for tackling optimization problems over polynomials, describing approaches such as decomposition in sum of squares, Positivstellensatz, theory of moments, Plya's theorem, and matrix dilation. Moreover, it aims to provide a collection of the essential problems in control systems where these LMI techniques are used, such as stability and performance investigations in nonlinear systems, uncertain systems, time-delay systems, and genetic regulatory networks. It is expected that this survey may be a concise useful reference for all readers. © 2006 IEEE.


Zhao G.,University of Hong Kong
Gondwana Research | Year: 2015

The Jiangnan Orogen is considered as a continent-continent collisional belt resulting from the closure of a Meso-Neoproterozoic ocean separating the southeastern margin of the Yangtze Block from the northwestern margin of the Cathaysia Block. Recent data indicate the existence of early Neoproterozoic (1000-825. Ma) volcanic arc assemblages on both sides of the orogen, suggesting that the ocean lithosphere between the Yangtze and Cathaysia blocks must have undergone divergent double-sided subduction during the period of 1000-825. Ma. The divergent double subduction eventually resulted in the closure of the ocean basin at ~. 825. Ma, leading to the soft collision of the Yangtze and Cathaysia blocks to form the Jiangnan Orogen, without involvement of continental deep subduction, high-grade metamorphism of continental crust and uplift/exhumation of high-grade metamorphic rocks. Shortly after the collision, the initial detachment of the ocean lithosphere from the overlying crust and sedimentary sections induced underplating of mantle magmas, triggering partial melting of accretionary-wedge strata to form some peraluminous (S-type) granites in the period 825-815. Ma. Finally, the sinking of the oceanic slab pulled down the overlying strata to form some basins in which the Banxi Group and its equivalent strata including bimodal volcanic rocks were formed in the period 815-750. Ma. © 2014 International Association for Gondwana Research.

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