Helsinki, Finland
Helsinki, Finland

The University of Helsinki is a university located in Helsinki, Finland since 1829, but was founded in the city of Turku in 1640 as the Royal Academy of Turku, at that time part of the Swedish Empire. It is the oldest and largest university in Finland with the widest range of disciplines available. Around 36,500 students are currently enrolled in the degree programs of the university spread across 11 faculties and 11 research institutes.As of August 1, 2005, the University complies with the standards of the Europe-wide Bologna Process and offers Bachelor, Master, Licenciate, and Doctoral degrees. Admission to degree programmes is usually determined by entrance examinations, in the case of bachelor degrees, and by prior degree results, in the case of master and postgraduate degrees. Entrance is particularly selective . It has been ranked a top 100 university in the world according to the 2012 QS, Times Higher Education and the Academic Rankings of World Universities.The university is bilingual, with teaching provided both in Finnish and Swedish. Teaching in English is extensive throughout the university at Master, Licentiate, and Doctoral levels, making it a de facto third language of instruction.Remaining true to its traditionally strong Humboldtian ethos, the University of Helsinki places heavy emphasis on high-quality teaching and research of a top international standard. It is a member of various prominent international university networks, such as Europaeum, UNICA, the Utrecht Network, and is a founding member of the League of European Research Universities. Wikipedia.

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Patent
University of Helsinki | Date: 2015-06-30

Disclosed is a method for generating an estimation of earths gravity. The method includes: obtaining one or more acceleration data values and one or more orientation data values over a period of time; generating magnitude of orientation change from the orientation data values; determining a stability value based on the acceleration data values and the magnitude of orientation change; comparing the determined stability value to a threshold value; and generating an estimation of earths gravity over the period of time on the basis of the acceleration data values if the comparison indicates that the determined stability value is below the threshold value. Also disclosed is an apparatus implementing the method.


Patent
University of Helsinki | Date: 2017-08-09

The present invention relates to the field of wood rosin and resin acid derivatives and more particularly to abietane-type diterpenoids as well as different uses thereof. Furthermore, the present invention relates to methods of coating surfaces, preventing, reducing or inhibiting bacterial biofilm formation, and treating or preventing disorders caused by microbial growth and viability as well as bacterial colonization.


Patent
University of Helsinki | Date: 2015-05-18

The present invention relates to adenoviral vectors, wherein the viral capsid has been coated with polypeptides, which are capable of stimulating a peptide-specific immune response in a subject and uses thereof. Furthermore, the present invention relates to methods of treating diseases, e.g. cancer, by adenoviral vectors which have been coated by polypeptides causing peptide-specific immune response. Also the present invention relates to a method of coating adenoviral vectors by specific peptides as well as to a method of identifying those peptides suitable for coating the capsid of an adenoviral vector.


Patent
University of Helsinki | Date: 2017-03-29

The present invention relates to adenoviral vectors, wherein the viral capsid has been coated with polypeptides, which are capable of stimulating a peptide-specific immune response in a subject and uses thereof. Furthermore, the present invention relates to methods of treating diseases, e.g. cancer, by adenoviral vectors which have been coated by polypeptides causing peptide-specific immune response. Also the present invention relates to a method of coating adenoviral vectors by specific peptides as well as to a method of identifying those peptides suitable for coating the capsid of an adenoviral vector.


Patent
University of Helsinki | Date: 2017-05-17

The invention relates to a method for generating an estimation of earths gravity. The method comprises: obtaining (210) one or more acceleration data values and one or more orientation data values over a period of time; generating (220) magnitude of orientation change from the orientation data values; determining (230) a stability value based on the acceleration data values and the magnitude of orientation change; comparing (240) the determined stability value to a threshold value; and generating (250) an estimation of earths gravity over the period of time on the basis of the acceleration data values if the comparison indicates that the determined stability value is below the threshold value. The invention also relates to an apparatus implementing the method.


This invention relates to bioassay method wherein the presence of a specific soluble antibody in a sample of a bodily fluid, preferably plasma or serum, of an animal, including human, is qualitatively and/or quantitatively determined. The method employs, a first group labelled with an energy donor and a second group labelled with an energy acceptor; the first group, or second group, comprising an antigen of the soluble antibody and the second group, or first group, respectively, comprising a Fab binding moiety capable of binding to a Fab region of antibodies of said animal. The donor and the acceptor form an energy transfer pair capable of energy transfer. The invention further comprises a kit for the bioassay method.


This invention relates to bioassay method wherein the presence of a specific soluble antibody in a sample of a bodily fluid, preferably plasma or serum, of an animal, including human, is qualitatively and/or quantitatively determined. The method employs, a first group labelled with an energy donor and a second group labelled with an energy acceptor; the first group, or second group, comprising an antigen of the soluble antibody and the second group, or first group, respectively, comprising a Fab binding moiety capable of binding to a Fab region of antibodies of said animal. The donor and the acceptor form an energy transfer pair capable of energy transfer. The invention further comprises a kit for the bioassay method.


Porkka-Heiskanen T.,University of Helsinki
Current Opinion in Neurobiology | Year: 2013

Research on sleep homeostasis aims to answer the question: how does the brain measure the duration and intensity of previous wakefulness in order to increase the duration and intensity of subsequent sleep? The search of regulatory factors has identified a number of potential molecules that increase their concentration in waking and decrease it during sleep. These factors regulate many physiological functions, including energy metabolism, neural plasticity and immune functions and one molecule may participate in the regulation of all these functions. The method to study regulation of sleep homeostasis is experimental prolongation of waking, which is used also to address the question of physiological purpose of sleep: prolonging wakefulness provokes symptoms that tell us what goes wrong during lack of sleep. The interpretation of the role of each identified factor in the regulation of sleep/sleep homeostasis reflects the theoretical background concept of the research. Presently three main concepts are being actively studied: the energy (depletion) hypothesis, the neural plasticity hypothesis and the (immune) defense hypothesis. © 2013 Elsevier Ltd.


Karpova N.N.,University of Helsinki
Neuropharmacology | Year: 2014

Brain-derived neurotrophic factor (BDNF) is a key mediator of the activity-dependent processes in the brain that have a major impact on neuronal development and plasticity. Impaired control of neuronal activity-induced BDNF expression mediates the pathogenesis of various neurological and psychiatric disorders. Different environmental stimuli, such as the use of pharmacological compounds, physical and learning exercises or stress exposure, lead to activation of specific neuronal networks. These processes entail tight temporal and spatial transcriptional control of numerous BDNF splice variants through epigenetic mechanisms. The present review highlights recent findings on the dynamic and long-term epigenetic programming of BDNF gene expression by the DNA methylation, histone-modifying and microRNA machineries. The review also summarizes the current knowledge on the activity-dependent BDNF mRNA trafficking critical for rapid local regulation of BDNF levels and synaptic plasticity. Current data open novel directions for discovery of new promising therapeutic targets for treatment of neuropsychiatric disorders. This article is part of the Special Issue entitled 'BDNF Regulation of Synaptic Structure, Function, and Plasticity'. © 2013 Elsevier Ltd. All rights reserved.


Pyykko P.,University of Helsinki
Chemical Reviews | Year: 2012

Quantum electrodynamics (QED) is the orders of magnitude below the Dirac-level relativistic effects and, being small, thus indirectly verifies the soundness of the latter. For neutral or nearly neutral systems, beyond Li, only one order-of-magnitude improvement of the computational accuracy, mainly the treatment of electron correlation with adequate basis sets, is estimated to separate the QED effects from being observed in head-on comparisons of theory and experiment. If the zero-point oscillations of the EM field are modified by objects ranging from molecules to macroscopic bodies, this leads to Casimir forces between them. The width of the chosen self-energy (SE) potential is arbitrary and could range from nuclear dimensions to much more diffuse values. Reviews on the finite nuclear charge distributions and their inclusion in quantum chemistry show that an explicit, quantum-mechanical description of both the nucleus and the electrons, is required.

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