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Hamburg, Germany

The University of Hamburg is a comprehensive university in Hamburg, Germany. It was founded on 28 March 1919, having grown out of the previous General lecture system and the Colonial Institute of Hamburg as well as the Akademic Gymnasium. In spite of its relatively short history, six Nobel Prize Winners and serials of scholars are affiliated to the university. University of Hamburg is the biggest research and education institution in Northern Germany and one of the most extensive universities in Germany. The main campus is located in the central district of Rotherbaum, with affiliated institutes and research centres spread around the city state. Wikipedia.

Albino S.,University of Hamburg
Reviews of Modern Physics | Year: 2010

The description of inclusive production of single unpolarized light hadrons using fragmentation functions in the framework of the factorization theorem is reviewed. The factorization of observables into perturbatively calculable quantities and these universal fragmentation functions are summarized and some improvements beyond the standard fixed order approach are discussed. The extraction of fragmentation functions for light charged (π⊃±, K⊃±, and p.p̄) and neutral (KS0 and Λ/ Λ̄) hadrons using these theoretical tools is discussed through global fits to experimental data from reactions at various colliders, in particular from accurate e⊃+ e⊃- reactions at the Large Electron-Position Collider (LEP), and the subsequent successful predictions of other experimental data, such as data gathered at Hadron Electron Ring Accelerator (HERA), the Tevatron, and the Relativistic Heavy Ion Collider (RHIC), from these fitted fragmentation functions as allowed by factorization universality. These global fits also impose competitive constraints on αs (MZ). Emphasis is placed on the need for accurate data from pp (p̄) and ep reactions in which the hadron species is identified in order to constrain the separate fragmentation functions of the gluon and each quark flavor for each hadron species. © 2010 The American Physical Society. Source

Janka G.E.,University of Hamburg
Annual Review of Medicine | Year: 2012

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome in which an uncontrolled and ineffective immune response, triggered in most cases by infectious agents, leads to severe hyperinflammation. Familial forms of HLH (FHL), which are increasingly found also in adolescents and adults, are due to genetic defects leading to impaired function of natural killer cells and cytotoxic T cells. These mutations occur either in the perforin gene or in genes important for the exocytosis of cytotoxic granules. Cytotoxic granules contain perforin and granzymes, which induce apoptosis upon entering (infected) target cells. Additionally, perforin is important for the downregulation of the immune response. Acquired forms of HLH are encountered in association with (usually) viral infections, autoinflammatory/autoimmune diseases, malignant diseases, and acquired immune deficiency states (e.g., after organ transplantation). Treatment of HLH includes immune-suppressive and immune-modulatory agents, cytostatic drugs, and biological response modifiers. For patients with FHL, stem cell transplantation is indicated and can be curative. © 2012 by Annual Reviews. All rights reserved. Source

Hasenkamp J.,University of Hamburg
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2012

Current observations of the cosmic microwave background could confirm an increase in the radiation energy density after primordial nucleosynthesis but before photon decoupling. We show that, if the gravitino problem is solved by a light axino, dark (decoupled) radiation emerges naturally in this period leading to a new upper bound on the reheating temperature T R≲10 11GeV. In turn, successful thermal leptogenesis might predict such an increase. The Large Hadron Collider could endorse this opportunity. At the same time, axion and axino can naturally form the observed dark matter. © 2011 Elsevier B.V. Source

Guse A.H.,University of Hamburg
Science Signaling | Year: 2012

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca 2+-releasing second messenger that might regulate different ion channels, including the ryanodine receptor, two-pore channels, and TRP-ML1 (transient receptor potential channel, subtype mucolipin 1), a Ca2+ channel localized to lysosomes. New evidence suggests that a 22- and 23-kilodalton pair of proteins could be the receptor for NAADP. Labeling of NAADP binding proteins was independent of overexpression or knockout of two-pore channels, indicating that two-pore channels, although regulated by NAADP, are not the NAADP receptors. I propose that NAADP binding proteins could bind to different ion channels and thus may explain how NAADP regulates diverse ion channels. Source

Allogeneic hematopoietic stem cell transplantation (SCT) is well accepted as a curative treatment approach for younger patients with myelodysplastic syndrome (MDS) and has become one of the most frequent indications for allogeneic SCT as reported to the Center for International Blood and Marrow Transplant Research. However, MDS patients are usually elderly with a median age of approximately 75 years at diagnosis. Large register studies have confirmed the feasibility of the procedure in elderly MDS patients; and in the register of the European Group for Blood and Marrow Transplantation, one-third of the allogeneic transplant procedures for MDS were performed in 2010 in patients older than 60 years. Despite its curative potential, its role in the treatment of elderly MDS patients is less defined. Because of the inherent complications of the transplantation leading to treatment-related mortality and the risk of relapse, a careful calculation of the benefit for each patient is mandatory, taking into account comorbidities, disease status, donor selection, and effective nontransplant therapies. Prospective multicenter studies are needed to define optimal intensity of the conditioning regimen, timing of transplantation within a treatment algorithm, including drug-based therapies, and posttransplant strategies to reduce the risk of relapse. © 2012 by The American Society of Hematology. Source

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