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Granada, Spain

Rhimou B.,University of Southern Brittany | Rhimou B.,Abdelmalek Essaadi University | Hassane R.,Abdelmalek Essaadi University | Jose M.,University of Grenade | Nathalie B.,University of Southern Brittany
African Journal of Biotechnology | Year: 2010

The antibacterial activity of extracts from 26 marine Rhodophyceae (8 Ceramiales, 7 Gelidiales, 9 Gigartinales, 1 Bonnemaisoniales and 1 Rhodymeniales) was studied to assess their potential in the pharmaceutical industry. Their bioactivity was analysed from crude methanolic extracts of dried samples against three gram-positive bacteria and two gram-negative bacteria using the disc diffusion technique. The samples were collected from Gibraltar and the Moroccan Mediterranean coast. Of the macroalgae analysed, 96% of extracts were active against at least one of the five test microorganisms. Staphylococcus aureus was the most susceptible microorganism. Methanolic extracts of all seaweed extracts tested in the present study exhibited a broad spectrum of antibacterial activity with inhibition diameters ranging from 10 to 35 mm. An extract of Hypnea musciformis exhibited high antibacterial activity against all the bacteria tested. The results of the present study confirmed the potential use of seaweed extracts as a source of antibacterial compounds. © 2010 Academic Journals.

Romero M.D.C.,University of Grenade | Valero A.,University of Grenade | Martin-Sanchez J.,University of Grenade | Navarro-Moll M.C.,University of Grenade
Phytomedicine | Year: 2012

The increase in diagnosed cases of anisakiasis and the virtual absence of effective treatments have prompted the search for new active compounds against Anisakis L 3 larvae. The biocidal efficacy against different pathogens shown by various essential oils (EO) led us to study the Matricaria chamomilla EO and two of its main components (chamazulene and α-bisabolol) against the L 3 larvae of Anisakis type I. The activity of M. chamomilla EO, chamazulene and α-bisabolol was established by in vitro and in vivo experiments. The EO (125 μg/ml) caused the death of all nematodes, which showed cuticle changes and intestinal wall rupture. In the in vivo assays, only 2.2% ± 1.8 of infected rats treated with M. chamomilla EO showed gastric wall lesions in comparison to 93.3% ± 3.9 of control. Chamazulene was ineffective, while α-bisabolol showed a high activity to that of the EO in vitro tests but proved less active in vivo. These findings suggest that the larvicidal activity may result from the synergistic action of different compounds of M. chamomilla EO. Neither of the tested products induces irritative damage in the intestinal tissues. In conclusion, M. chamomilla EO is a good candidate for further investigation as a biocidal agent against Anisakis type I. © 2012 Elsevier GmbH. All rights reserved.

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