Medicine and, Spain
Medicine and, Spain

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Martin-Martin L.M.,University Granade | Valenza-Demet G.,University Granade | Ariza-Vega P.,University Granade | Ariza-Vega P.,Virgen Of Las Nieves Hospital | And 6 more authors.
Clinical Rehabilitation | Year: 2014

Objective: To examine the effectiveness of an occupational therapy intervention program in reducing emotional distress in informal caregivers of hip fracture patients. Design: Single-blind randomized controlled trial. Setting: A public Trauma and Rehabilitation Hospital in Granade, Spain. Participants: A total of 186 caregivers and their care recipients with hip fracture (93 in each group) were allocated to an intervention group or a control group using a block system. Intervention: An occupational therapy intervention during patient hospitalization focused on patient handling by caregivers and ergonomic treatment for both. Main measures: The Goldberg General Health Questionnaire was used to measure emotional distress and psychological well-being. The Goldberg Anxiety and Depression Scale was used to measure caregiver affective illness. Results: Among informal caregivers, emotional distress decreased to a greater extent in the intervention group than in the control group from the first assessment to the six-month follow-up (intervention group: 4.16 (SD 4.57) to 2.81 (SD 2.93); control group: 4.61 (SD 4.57) to 4.24 (SD 4.30)), showing significant differences at the first, third and sixth month. As regards anxiety levels, significant differences were only found at the third month (1.54 (SD 2.09) vs. 2.35 (SD 2.53) in the intervention and control groups, respectively (p < 0.05)), although the intervention group always showed lower levels from the first month. Although depression levels decreased in both groups, the decrease was also greater in the intervention group. Conclusion: Occupational therapy training for caregivers of hip fracture patients helps to significantly reduce emotional distress, anxiety and depression in caregivers. © The Author(s) 2014.


Salto R.,University of Granade | Vilchez J.D.,University of Granade | Cabrera E.,University of Granade | Guinovart J.J.,University of Barcelona | Giron M.D.,University of Granade
FEBS Letters | Year: 2014

The balance between the rates of protein synthesis and degradation in muscle is regulated by PI3K/Akt signaling. Here we addressed the effect of ERK activation by sodium tungstate on protein turnover in rat L6 myotubes. Phosphorylation of ERK by this compound increased protein synthesis by activating MTOR and prevented dexamethasone-induced protein degradation by blocking FoxO3a activity, but it did not alter Akt phosphorylation. Thus, activation of ERK by tungstate improves protein turnover in dexamethasone- treated cells. On the basis of our results, we propose that tungstate be considered an alternative to IGF-I and its analogs in the prevention of skeletal muscle atrophy. © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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