The University of Granada is a public university located in the city of Granada that enrolls approximately 80,000 students, thereby becoming the fourth largest university in Spain. UGR also has campuses in Northern Africa , thus being the only European university with campuses in two continents. Founded in 1531 by Emperor Charles V, UGR has almost 500 years of history and it is one of the most famous universities in Spain.According to several rankings, the University of Granada ranks among top ten best Spanish universities and holds first place in Translation and Interpreting studies. In addition, UGR plays a major role in scientific output, placing high in national ranks and being one of the best world universities in computing and mathematics studies. The university has an important heritage thanks to its policy of using buildings of historical and cultural value. The Madrasah of Granada represents one such example. Furthermore, the university has major new facilities committed to innovation, such as the Parque Tecnológico de Ciencias de la Salud.Every year, over 2,000 European students enroll in UGR through the Erasmus Programme, making it the most popular European destination. The university's Center for Modern Languages receives over 10,000 international students each year. UGR also has been recently voted best Spanish university by international students. Wikipedia.
Stichting Vumc and University of Granada | Date: 2015-04-21
Disclosed are small ncRNAs that may be used as biomarkers for classifying the health status of an individual. The disclosure also provides screening methods for identifying ncRNA biomarkers.
Agency: Cordis | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016
Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around the world, to develop a unified multi-level understanding of the brain and diseases, and ultimately to emulate its computational capabilities. The goal is to catalyze a global collaborative effort. During the HBPs first Specific Grant Agreement (SGA1), the HBP Core Project will outline the basis for building and operating a tightly integrated Research Infrastructure, providing HBP researchers and the scientific Community with unique resources and capabilities. Partnering Projects will enable independent research groups to expand the capabilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitious Flagship Objectives.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: PHC-03-2015 | Award Amount: 6.19M | Year: 2016
Understanding mechanisms underlying comorbid disorders poses a challenge for developing precision medicine tools. Psychiatric disorders are highly comorbid, and are among the last areas of medicine, where classification is driven by phenomenology rather than pathophysiology. We will study comorbidity between the most frequent psychiatric conditions, ADHD, mood/anxiety, and substance use disorders, and a highly prevalent somatic disease, obesity. ADHD, a childhood-onset disorder, forms the entry into a lifelong negative trajectory characterized by these comorbidities. Common mechanisms underlying this course are unknown, despite their relevance for early detection, prevention, and treatment. Our interdisciplinary team of experts will integrate epidemiologic/genetic approaches with experimental designs to address those issues. We will determine disease burden of comorbidity, calculate its socioeconomic impact, and reveal risk factors. We will study biological pathways of comorbidity and derive biomarkers, prioritizing two candidate mechanisms (circadian rhythm and dopaminergic neurotransmission), but also leveraging large existing data sets to identify new ones. A pilot clinical trial to study non-pharmacologic, dopamine-based and chronobiological treatments will be performed, employing innovative mHealth to monitor and support patients daily life. Integration of findings will lead to prediction algorithms enhancing early diagnosis and prevention of comorbidity. Finally, we will screen to repurpose existing pharmacological compounds. Integrating complementary approaches based on large-scale, existing data and innovative data collection, we maximize value for money in this project, leading to insight into the mechanisms underlying this comorbidity triad with its huge burden for healthcare, economy, and society. This will facilitate early detection and non-invasive, scalable, and low-cost treatment, creating opportunities for substantial and immediate societal impact.
Agency: Cordis | Branch: H2020 | Program: ECSEL-IA | Phase: ECSEL-02-2014 | Award Amount: 139.30M | Year: 2015
The proposed pilot line project WAYTOGO FAST objective is to leverage Europe leadership in Fully Depleted Silicon on Insulator technology (FDSOI) so as to compete in leading edge technology at node 14nm and beyond preparing as well the following node transistor architecture. Europe is at the root of this breakthrough technology in More Moore law. The project aims at establishing a distributed pilot line between 2 companies: - Soitec for the fabrication of advanced engineered substrates (UTBB: Ultra Thin Body and BOx (buried oxide)) without and with strained silicon top film. - STMicroelectronics for the development and industrialization of state of the art FDSOI technology platform at 14nm and beyond with an industry competitive Power-Performance-Area-Cost (PPAC) trade-off. The project represents the first phase of a 2 phase program aiming at establishing a 10nm FDSOI technology for 2018-19. A strong added value network is created across this project to enhance a competitive European value chain on a European breakthrough and prepare next big wave of electronic devices. The consortium gathers a large group of partners: academics/institutes, equipment and substrate providers, semiconductor companies, a foundry, EDA providers, IP providers, fabless design houses, and a system manufacturer. E&M will contribute to the objective of installing a pilot line capable of manufacturing both advanced SOI substrates and FDSOI CMOS integrated circuits at 14nm and beyond. Design houses and electronics system manufacturer will provide demonstrator and enabling IP, to spread the FDSOI technology and establish it as a standard in term of leading edge energy efficient CMOS technology for a wide range of applications battery operated (consumer , healthcare, Internet of things) or not. Close collaboration between the design activities and the technology definition will tailor the PPAC trade-off of the next generation of technology to the applications needs.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SC1-PM-09-2016 | Award Amount: 6.19M | Year: 2017
Chronic aortic aneurysms are permanent and localized dilations of the aorta that remain asymptomatic for long periods of time but continue to increase in diameter before they eventually rupture. Left untreated, the patients prognosis is dismal, since the internal bleeding of the rupture brings about sudden death. Although successful treatment cures the disease, the risky procedures can result in paraplegia from spinal cord ischaemia or even death, particularly for aneurysms extending from the thoracic to the abdominal aorta and thus involving many segmental arteries to the spinal cord, i.e. thoracoabdominal aortic aneurysms of Crawford type II. Although various strategies have achieved a remarkable decrease in the incidence of paraplegia, it is still no less than 10 to 20%. However, it has been found that the deliberate occlusion of the segmental arteries to the paraspinous collateral network finally supplying the spinal cord does not increase rates of permanent paraplegia. A therapeutic option, minimally invasive segmental artery coil embolization has been devised which proceeds in a staged way to occlude groups of arteries under highly controlled conditions after which time must be allowed for arteriogenesis to build a robust collateral blood supply. PAPA-ARTiS is a phase II trial to demonstrate that a staged treatment approach can reduce paraplegia and mortality dramatically. It can be expected to have both a dramatic impact on the individual patients quality of life if saved from a wheelchair, and also upon financial systems through savings in; 1) lower costs in EU health care; 2) lower pay-outs in disability insurance (est. at 500k in Year 1), and; 3) loss of economic output from unemployment. Approx. 2500 patients a year in Europe undergo these high risk operations with a cumulative paraplegia rate of over 15%; therefore >100M per year in costs can be avoided and significantly more considering the expected elimination of type II endoleaks.
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.99M | Year: 2017
Sustainable Multi-functional Automated Resilient Transport Infrastructures ETN, will bring together a stimulating platform where the stakeholders of the transport infrastructure sector will work alongside world-wide experts in smartening of systems (developers of high-tech sensors, advanced monitoring equipment, automated structures, etc.,) with direct support from the roads, railways and airports managers. This environment will enable talented graduates to conceive the transport infrastructure network of the future and will provide them with world-wide extended training in each of the four pillars supporting the SMARTI vision: designed to last by maximising recycling and minimizing impact (Sustainable), conceived not for transport purposes only and towards optimisation of land use (Multi-functional), equipped for communicating with managers and users, to allow a more intuitive use and a simplified management (Automated), built to be adaptable to natural and anthropogenic hazards (Resilient). The consortium will combine and share expertise to offer advanced scientific training structured into network-wide thematic taught modules combined with original research supported by secondments that will expose fellows to both academia and industry and will also allow them with the possibility to be award with Doctoratus Europeus. The training programme will be enriched by specific modules to support job creation by enabling the fellows with business, entrepreneurship, communication, project management and other transferrable skills. A tailored Dissemination strategy will evaluate the variety of channels and means appropriate to allow the fellows to be prepared and successful in reaching both scientific and larger public audiences. As a result, SMARTI ETN will create a new generation of highly-skilled and appealing professionals that will be in great demand in this rapidly expanding field and will benefit Europe and developing countries
Soler M.,University of Granada
Biological Reviews | Year: 2014
Coevolutionary theory predicts that the most common long-term outcome of the relationships between brood parasites and their hosts should be coevolutionary cycles based on a dynamic change selecting the currently least-defended host species, given that when well-defended hosts are abandoned, hosts will be selected to decrease their defences as these are usually assumed to be costly. This is assumed to be the case also in brood parasite-host systems. Here I examine the frequency of the three potential long-term outcomes of brood parasite-host coevolution (coevolutionary cycles, lack of rejection, and successful resistance) in 182 host species. The results of simple exploratory comparisons show that coevolutionary cycles are very scarce while the lack of rejection and successful resistance, which are considered evolutionary enigmas, are much more frequent. I discuss these results considering (i) the importance of different host defences at all stages of the breeding cycle, (ii) the role of phenotypic plasticity in long-term coevolution, and (iii) the evolutionary history of host selection. I suggest that in purely antagonistic coevolutionary interactions, such as those involving brood parasites and their hosts, that although cycles will exist during an intermediate phase of the interactions, the arms race will end with the extinction of the host or with the host acquiring successful resistance. As evolutionary time passes, this resistance will force brood parasites to use previously less suitable host species. Furthermore, I present a model that represents the long-term trajectories and outcomes of coevolutionary interactions between brood parasites and their hosts with respect to the evolution of egg-rejection defence. This model suggests that as an increasing number of species acquire successful resistance, other unparasitized host species become more profitable and their parasitism rate and the costs imposed by brood parasitism at the population level will increase, selecting for the evolution of host defences. This means that although acceptance is adaptive when the parasitism rate and the costs of parasitism are very low, this cannot be considered to represent an evolutionary equilibrium, as conventional theory has done to date, because it is not stable. © 2014 Cambridge Philosophical Society.
Bueno C.,University of Granada
Blood | Year: 2013
Mixed-lineage leukemia (MLL)-AF4 fusion arises prenatally in high-risk infant acute pro-B-lymphoblastic leukemia (pro-B-ALL). In human embryonic stem cells (hESCs), MLL-AF4 skewed hematoendothelial specification but was insufficient for transformation, suggesting that additional oncogenic insults seem required for MLL-AF4-mediated transformation. MLL-AF4+ pro-B-ALL expresses enormous levels of FLT3, occasionally because of activating mutations, thus representing a candidate cooperating event in MLL-AF4+ pro-B-ALL. Here, we explored the developmental impact of FLT3 activation alone, or together with MLL-AF4, in the hematopoietic fate of hESCs. FLT3 activation does not affect specification of hemogenic precursors but significantly enhances the formation of CD45(+) blood cells, and CD45(+)CD34(+) blood progenitors with clonogenic potential. However, overexpression of FLT3 mutations or wild-type FLT3 (FLT3-WT) completely abrogates hematopoietic differentiation from MLL-AF4-expressing hESCs, indicating that FLT3 activation cooperates with MLL-AF4 to inhibit human embryonic hematopoiesis. Cell cycle/apoptosis analyses suggest that FLT3 activation directly affects hESC specification rather than proliferation or survival of hESC-emerging hematopoietic derivatives. Transcriptional profiling of hESC-derived CD45(+) cells supports the FLT3-mediated inhibition of hematopoiesis in MLL-AF4-expressing hESCs, which is associated with large transcriptional changes and downregulation of genes involved in hematopoietic system development and function. Importantly, FLT3 activation does not cooperate with MLL-AF4 to immortalize/transform hESC-derived hematopoietic cells, suggesting the need of alternative (epi)-genetic cooperating hits.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: YOUNG-3-2015 | Award Amount: 2.50M | Year: 2016
Most European Lifelong Learning (LLL) policies have been designed to create economic growth and, at the same time, guarantee social inclusion (EC 2010). First, we will study how different LLL policies are compatible with each other in terms of their orientations and objectives and how each policy considers the needs of young adults. Second, we will research the intended and unintended effects of policies on young adults. In this regard, we will look into relevant social developments such as life course de-standardisation processes and into an emerging new political economy of skills. Third, we will generate new knowledge about regional and local policymaking, with particular attention to actors, dynamics, and trends. By focusing on their regional/local context, we will elucidate the interaction and complementarity of LLL policies with other sectors of society, thus contributing to a better understanding of current fragmentation and discrepancies, in order to set parameters for future decision-making support systems. The project will first contribute new knowledge of the impact of LLL policies on young adults life courses, yielding insights on the conditions, strategies, and necessities for policies to become effective. In addition, it will provide insights on the innovations and potentials they unlock, in particular with view to informal and non-formal learning to better address vulnerable groups. Second, the project contributes to a better understanding of the structural relationships and functional match between education/training and the labour market sectors. Third, the project will provide a thorough review of regional policies and initiatives in the countries studied, laying bare distinct dynamics and trends, but also mismatches and redundancies. In particular, the project aims at identifying successful programmes in terms of sustainable solutions in integrating labour market with, social inclusion as well as their transferability to other contexts.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: ICT-25-2015 | Award Amount: 4.54M | Year: 2016
REMINDER aims to develop an embedded DRAM solution optimized for ultra-low-power consumption and variability immunity, specifically focused on Internet of Things cut-edge devices. The objectives of REMINDER are: i) Investigation (concept, design, characterization, simulation, modelling), selection and optimization of a Floating-Body memory bit cell in terms of low power and low voltage, high reliability, robustness (variability), speed, reduced footprint and cost. ii) Design and fabrication in FDSOI 28nm (FD28) and FDSOI 14nm (FD14) technology nodes of a memory matrix based on the optimized bit-cells developed. Matrix memory subcircuits, blocks and architectures will be carefully analysed from the power-consumption point of view. In addition variability tolerant design techniques underpinned by variability analysis and statistical simulation technology will be considered. iii) Demonstration of a system on chip application using the developed memory solution and benchmarking with alternative embedded memory blocks. The eventual replacement of Si by strained Si/SiGe and III-V materials in future CMOS circuits would also require the redesign of different applications, including memory cells, and therefore we also propose the evaluation of the optimized bit cells developed in FD28 and FD14 technology nodes using these alternative materials. The fulfilment of the objectives above will also imply the development of: i) New techniques for the electrical characterization of ultimate CMOS nanometric devices. This will allow us to improve the CMOS technology by boosting device performance. ii) New behavioural models, incorporating variability effects, to reach a deep understanding of nanoelectronics devices iii) Advanced simulation tools for nanoelectronic devices for state of the art, and emerging devices. iv) Extreme low power solutions The consortium supporting this proposal is ideally balanced with 2 industrial partners, 2 SMEs, 2 research centers and 3 universities.