The University of Glasgow is the fourth-oldest university in the English-speaking world and one of Scotland's four ancient universities. The university was founded in 1451 and is often ranked in the world's top 100 universities in tables compiled by various bodies. In 2013, Glasgow moved to its highest ever position, placing 51st in the world and 9th in the UK in the QS World University Rankings.In common with universities of the pre-modern era, Glasgow educated students primarily from wealthy backgrounds, but was also, with the University of Edinburgh, a leading centre of the Scottish Enlightenment during the 18th century. The University became a pioneer in British higher education in the 19th century by also providing for the needs of students from the growing urban and commercial middle classes. Glasgow served all of these students by preparing them for professions: the law, medicine, civil service, teaching, and the church. It also trained smaller but growing numbers for careers in science and engineering. In 2007, the Sunday Times ranked it as "Scottish University of the Year." The university is a member of the Russell Group which represents the highest-ranked public research-based universities in the UK. It is also a member of Universitas 21, the international network of research universities.Originally located in the city's High Street, since 1870 the main University campus has been located at Gilmorehill in the West End of the city. Additionally, a number of university buildings are located elsewhere, such as the University Marine Biological Station Millport on the Island of Cumbrae in the Firth of Clyde and the Crichton Campus in Dumfries.Glasgow has departments of Law, Medicine, Veterinary Medicine, and Dentistry. Its submission to the most recent UK university research assessment was one of the broadest in the UK. Glasgow's financial endowment is the fifth largest among UK universities.Alumni or former staff of the University include philosopher Francis Hutcheson, engineer James Watt, economist Adam Smith, physicist Lord Kelvin, surgeon Joseph Lister, 1st Baron Lister, seven Nobel laureates, two British Prime Ministers, several leaders of Britain's and Scotland's major political parties, and numerous leading figures from legal, scientific and business professions. Entry to the university is highly competitive; applications for each place on many of its courses run into double figures, and successful entrants have on average almost 485 UCAS points. This ranks as the 11th highest among UK higher education institutions . Wikipedia.
University of Glasgow | Date: 2017-01-12
This invention relates to methods and systems for measuring T cell diversity. It is particularly related to methods of identifying T cell receptor (TCR) pairs and their relative frequencies and finds particular use in antigen-specific T cell populations and other T cell populations with limited polyclonality. An exemplary embodiment of the invention provides a method estimating the clonal composition of a T cell population, the method including the steps of: obtaining a plurality of samples from said population, each sample containing a plurality of T cells; sequencing the CDR3 and CDR3 regions of each of those samples; calculating, for every and chain found in common in at least one of the samples, an association score which reflects the likelihood of pairing between each of those chains; repeatedly, for a randomly selected subset of said samples, determining, from the calculated association scores, the most likely pairs in each of said selected samples and selecting those pairs as candidate pairs; comparing the number of instances that each of said candidate pairs appears in all of said repeats to a threshold and selecting those pairs whose instances exceed said threshold as true pairs; estimating, from the frequency of co-existence of and chains in each of said samples and the sample size of said sample, the frequency of each of said true pairs; and discriminating, amongst said pairs, between possible dual T cell receptors or two clones which share a common chain.
University of Glasgow | Date: 2017-07-05
An acceleration measuring device is disclosed, for use as a gravimeter or gradiometer for example. The device has a support and a proof mass, connected to each other by at flexures allowing displacement of the proof mass relative to the support. The support defines a space for displacement of the proof mass. The device is configured so that the modulus of the gradient of the force-displacement curve of the proof mass decreases with increasing displacement, for at least part of the force-displacement curve. This is the so-called anti-spring effect. The resonant frequency of oscillation of the proof mass is determined at least in part by the orientation of the device relative to the direction of the force due to gravity. The proof mass is capable of oscillating with a resonant frequency of 10 Hz or less. The proof mass has a mass of less than 1 gram.
University of Glasgow | Date: 2015-06-26
A method of treating a particle beam is disclosed, of interest in particular for mass spectrometry for ^(14)C. A particle beam including positive ions is passed through a charge exchange cell containing a target gas. The target gas is electrically insulating at room temperature and pressure. At least some of the positive ions of the particle beam are converted to negative ions by interaction with the target gas. The particle beam incident at the charge exchange cell includes molecules and/or molecular ions which interact with the target gas to reduce the concentration of molecules as a result of repeated collisions with particles of the target gas. A corresponding mass spectrometry system is also disclosed.
University of Glasgow | Date: 2017-08-09
The invention relates to the treatment of bacterial respiratory infections using the bacterially-originating antibiotics known as pyocins. In particular, the invention provides the use of S-type pyocins, administered by pulmonary administration, for the treatment of such infections.
University of Glasgow | Date: 2017-07-19
The present invention provides a method for the generation of hydrogen, where the method comprises the step of reducing a mediator, such as a polyoxometallate, at a working electrode to yield a reduced mediator and generating oxygen at a counter electrode; and contacting the reduced mediator with a catalyst, such as a Pt, Rh, Pd, Mo or Ni containing catalyst, thereby to oxidise the reduced mediator to yield hydrogen.
University of Glasgow | Date: 2017-05-03
A method of treating a particle beam is disclosed, of interest in particular for mass spectrometry for 14C. A particle beam including positive ions is passed through a charge exchange cell containing a target gas. The target gas is electrically insulating at room temperature and pressure. At least some of the positive ions of the particle beam are converted to negative ions by interaction with the target gas. The particle beam incident at the charge exchange cell includes molecules and/or molecular ions which interact with the target gas to reduce the concentration of molecules as a result of repeated collisions with particles of the target gas. A corresponding mass spectrometry system is also disclosed.
Johnson P.C.D.,University of Glasgow
Methods in Ecology and Evolution | Year: 2014
1. Nakagawa & Schielzeth extended the widely used goodness-of-fit statistic R2 to apply to generalized linear mixed models (GLMMs). However, their R2 GLMM method is restricted to models with the simplest random effects structure, known as random intercepts models. It is not applicable to another common random effects structure, random slopes models. 2. I show that R2 GLMM can be extended to random slopes models using a simple formula that is straightforward to implement in statistical software. This extension substantially widens the potential application of R2 GLMM. © 2014 The Author.
Todd A.J.,University of Glasgow
Nature Reviews Neuroscience | Year: 2010
Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception. The dorsal horn provides numerous potential targets for the development of novel analgesics and is thought to undergo changes that contribute to the exaggerated pain felt after nerve injury and inflammation. Despite its obvious importance, we still know little about the neuronal circuits that process sensory information, mainly because of the heterogeneity of the various neuronal components that make up these circuits. Recent studies have begun to shed light on the neuronal organization and circuitry of this complex region. © 2010 Macmillan Publishers Limited. All rights reserved.
Farrugia L.J.,University of Glasgow
Journal of Applied Crystallography | Year: 2012
The WinGX suite provides a complete set of programs for the treatment of small-molecule single-crystal diffraction data, from data reduction and processing, structure solution, model refinement and visualization, and metric analysis of molecular geometry and crystal packing, to final report preparation in the form of a CIF. It includes several well known pieces of software and provides a repository for programs when the original authors no longer wish to, or are unable to, maintain them. It also provides menu items to execute external software, such as the SIR and SHELX suites of programs. The program ORTEP for Windows provides a graphical user interface (GUI) for the classic ORTEP program, which is the original software for the illustration of anisotropic displacement ellipsoids. The GUI code provides input capabilities for a wide variety of file formats, and extra functionality such as geometry calculations and ray-traced outputs. The programs WinGX and ORTEP for Windows have been distributed over the internet for about 15 years, and this article describes some of the more modern features of the programs. © 2012 International Union of Crystallography. Printed in Singapore-all rights reserved.
Kennedy P.G.E.,University of Glasgow
The Lancet Neurology | Year: 2013
Human African trypanosomiasis, or sleeping sickness, is caused by infection with parasites of the genus Trypanosoma, transmitted by the tsetse fly. The disease has two forms, Trypanosoma brucei (T b) rhodesiense and T b gambiense; and is almost always fatal if untreated. Despite a recent reduction in the number of reported cases, patients with African trypanosomiasis continue to present major challenges to clinicians. Because treatment for CNS-stage disease can be very toxic, diagnostic staging to distinguish early-stage from late-stage disease when the CNS in invaded is crucial but remains problematic. Melarsoprol is the only available treatment for late-stage T b rhodesiense infection, but can be lethal to 5% of patients owing to post-treatment reactive encephalopathy. Eflornithine combined with nifurtimox is the first-line treatment for late-stage T b gambiense. New drugs are in the pipeline for treatment of CNS human African trypanosomiasis, giving rise to cautious optimism. © 2013 Elsevier Ltd.