Genoa, Italy

University of Genoa

www.unige.it
Genoa, Italy

The University of Genoa is one of the largest universities in Italy. Located in Liguria on the Italian Riviera, the university was founded in 1481. It currently has about 40,000 students, 1,800 teaching and research staff and about 1,580 administrative staff. Wikipedia.

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The present invention concerns a radical innovation of the CMC contactor (Combined Membranes Contactor) with capillary membranes which is the subject matter of the patent application WO 2012/042553. The new contactor is composed by modules which are easily stackable and can be produced in an industrial way. The invention concerns also an integrated plant for air conditioning utilising the CMC improved according to the invention. The plant integrates a hybrid plant operating with liquid desiccants and heat exchange batteries placed in series/parallel. The integrated plant is provided with a thermovector fluid flow switching valve in order to implement with higher energetic efficiency also the winter heating besides the conditioning in the intermediate and summer seasons.


A tyrosine kinase inhibitor (TKI) for use in a method for the treatment of cancer in a patient, wherein the method comprises subjecting the patient to reduced caloric intake, i.e a daily caloric intake reduced by 10-100%, including starvation, for a period of 24-190 hours and administering the tyrosine kinase inhibitorto the patient during such period; the tyrosine kinase inhibitor is preferably selected among Lapatinib, Crizotinib, Gefitinib, Erlotinib, Afatinib and Regorafenib.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: GV-02-2016 | Award Amount: 9.56M | Year: 2016

The UPGRADE project aims to support the transition to a high efficient, cleaner and affordable powertrain technology systems, based on Spark Ignited GDI (Gasoline Direct Injection) approach, suitable for future Light Duty applications. The project also includes a deep analysis of the phenomenon of the formation of the nanoparticles in relationship to the engine design and its operating conditions and, with regard to the after-treatment solutions, the study and development of new Gasoline Particulate Filter (GPF) technologies. To increase the engine efficiency under Real Driving conditions, the following steps will be carried out: - address stoichiometric combustion approach on the small size engine and lean-burn combustion approach on the medium size one - study and develop the best combinations of technologies, including advanced VVA/VVT capabilities, advanced boosting system (including electrically assisted booster operations), EGR (Exhaust Gas Recirculation) and thermal management systems - Explore and implement advanced fuel injection (direct) and ignition system supported by new dedicated control strategies that will be integrated in the ECU (Engine Control Unit) software. In order to demonstrate the call overall targets (15% improvement on CO2 emissions based on the WLTP cycle and compliancy with post Euro 6 RDE standards) the project will see the realization of two full demonstrator vehicles: one B-segment vehicle, equipped with the small downsized stoichiometric engine, and one D/E vehicle equipped with the medium size lean-burn engine. The vehicle will be fully calibrated and assessed by independent testing, according to on road test procedures, using the available best representative PEMS (Portable Emission Measurement System) technology and considering also PN measurement below 23 nm diameter.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: MG-4.3-2015 | Award Amount: 11.43M | Year: 2016

Most maritime products are typically associated with large investments and are seldom built in large series. Where other modes of transport benefit from the economy of series production, this is not the case for maritime products which are typically designed to refined customer requirements increasingly determined by the need for high efficiency, flexibility and low environmental impact at a competitive price. Product design is thus subject to global trade-offs among traditional constraints (customer needs, technical requirements, cost) and new requirements (life-cycle, environmental impact, rules). One of the most important design objectives is to minimise total cost over the economic life cycle of the product, taking into account maintenance, refitting, renewal, manning, recycling, environmental footprint, etc. The trade-off among all these requirements must be assessed and evaluated in the first steps of the design process on the basis of customer / owner specifications. Advanced product design needs to adapt to profound, sometimes contradicting requirements and assure a flexible and optimised performance over the entire life-cycle for varying operational conditions. This calls for greatly improved design tools including multi-objective optimisation and finally virtual testing of the overall design and its components. HOLISHIP (HOLIstic optimisation of SHIP design and operation for life-cycle) addresses these urgent industry needs by the development of innovative design methodologies, integrating design requirements (technical constraints, performance indicators, life-cycle cost, environmental impact) at an early design stage and for the entire life-cycle in an integrated design environment. Design integration will be implemented in practice by the development of integrated design s/w platforms and demonstrated by digital mock-ups and industry led application studies on the design and performance of ships, marine equipment and maritime assets in general.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SFS-10b-2015 | Award Amount: 5.41M | Year: 2016

The overarching goal of VIVALDI is to increase the sustainability and competitiveness of the European shellfish industry by improving the understanding of bivalve diseases and by developing innovative solutions and tools for the prevention, control and mitigation of the major pathogens affecting the main European farmed shellfish species: Pacific oyster (Crassostrea gigas), mussels (Mytilus edulis and M. galloprovincialis), European flat oyster (Ostrea edulis), clams (Venerupis philipinarum) and scallops (Pecten maximus ). The project addresses the most harmful pathogens affecting either one or more of these shellfish species: the virus OsHV-1, Vibrio species including V. aestuarianus, V. splendidus, V. harveyi and V. tapetis, as well as the parasite Bonamia ostreae. The project is committed to provide practical solutions based on the most advanced knowledge. VIVALDI will dissect the disease mechanisms associated with pathogen virulence and pathogenesis and host immune responses, develop in vivo and in vitro models, and apply omic approaches that will help the development of diagnostic tools and drugs against pathogen targets, and breeding programmes in a collaborative effort with industrial partners. The proposal will include a global shellfish health approach, recognising that cultured bivalves are often exposed to several pathogens simultaneously, and that disease outbreaks can be due to the combined effect of two or more pathogens. The proposal will also investigate advantages and risks of the used of disease-resistant selected animals in order to improve consumer confidence and safety. VIVALDI will be both multi- and trans-disciplinary. In order to cover both basic and applied levels from molecules to farm, the proposal will integrate partners with a broad range of complementary expertises in pathology and animal health, epidemiology, immunology, molecular biology, genetics, genomics and food safety.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: PHC-16-2015 | Award Amount: 6.00M | Year: 2016

AUTOSTEM will develop closed, scaleable and automated systems for therapeutic cell manufacture. The project vision is a donor-to-patient system where all aspects of processing, from tissue harvest to patient delivery are fully closed and aseptic. The process will involve new methods of biological cell selection from marrow, fat or other tissues, bioreactors to achieve scale and media formulations that are fully xeno-free. Process monitoring will utilise remote sensing and the automated retrieval of cells for microscopy, flow cytometry, karyotyping, differentiation or other tests. The final product will be a cryobag containing a specified cell dose, ready for thawing and clinical delivery. AUTOSTEM will be the factory of the future for therapeutic cell manufacturing. This system could ultimately be scaled for hospital-based use to produce autologous cells or at industrial scale for allogeneic therapy. It will achieve consistent cell production, minimise contamination, maximise scale and reduce cost of goods, thus enabling routine clinical use of cell therapies. The consortium will be a partnership of academic centres and industry with expertise across the disciplines relevant to the research and development goals. It will also include expertise in GMP and regulatory compliance and in healthcare economic analysis.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-14-2016 | Award Amount: 2.08M | Year: 2017

The groundbreaking objective of CARESSES is to build culturally competent care robots, able to autonomously re-configure their way of acting and speaking, when offering a service, to match the culture, customs and etiquette of the person they are assisting. By designing robots that are more sensitive to the users needs, CARESSES innovative solution will offer elderly clients a safe, reliable and intuitive system to foster their independence and autonomy, with a greater impact on quality of life, a reduced caregiver burden, and an improved efficiency and efficacy. The need for cultural competence has been deeply investigated in the Nursing literature. However, it has been totally neglected in Robotics. CARESSES stems from the consideration that cultural competence is crucial for care robots as it is for human caregivers. From the users perspective, a culturally appropriate behavior is key to improve acceptability; from the commercial perspective, it will open new avenues for marketing robots across different countries. CARESSES will adopt the following approach. First, we will study how to represent cultural models, how to use these models in sensing, planning and acting, and how to acquire them. Second, we will consider three (physically identical) replicas of a commercial robot on the market and integrate cultural models into them, by making them culturally competent. Third, we will test the three robots, customized for three different cultures, in the EU (two cultural groups) and Japan (one cultural group), on a number of elderly volunteers and their informal caregivers. Evaluation will be conducted through quantitative and qualitative investigation. To achieve its groundbreaking objective, CARESSES will involve a multidisciplinary team of EU and Japanese researchers with a background in Transcultural Nursing, AI, Robotics, Testing and evaluations of health-care technology, a worldwide leading company in Robotics and a network of Nursing care homes.


The weDRAW project comes from the renewed neuroscientific understanding of the role of communication between sensory modalities during development: specific sensory systems have specific roles to learn specific concepts. Starting from these results, in weDRAW we will develop an multisensory technology and three serious games that will exploit the best modality for learning arithmetic and geometrical concepts. In particular weDRAW: - will provide the elements to the teacher to determine which is the best modality (visual, audio or haptic) to teach each specific concepts to the students; - will provide the technology to exploit the best sensory signal; - will permit to teach different concepts together. This will be possible by using a multisensory approach, that will open a new teaching/learning channel, personalized for each student, based on multisensory interactive technology (i.e., audio, tactile, motor and visual), including a serious game platform. - will show that it is possible to learn arithmetical concepts from multisensory rhythm exploration and music and geometrical concepts from body movement and multisensory drawing. - will permit a deeper learning of Science and Mathematics combined with Arts improving creative capacities of learners. Besides application to typical children, a major goal and output of this project consists of applying the proposed multisensory approach and technologies to two specific populations: visually impaired and dyslexic children. In particular, dyslexic children have problems with rhythm, whereas visually impaired children have problems with space and geometry. With weDRAW we expect to improve the spatial and temporal impairments of these two groups of children braking down social barriers.


A scientific review informed about the characteristics of basic compounds and materials used in industrial and technological chemistry. The review emphasized on the the properties of liquid bases, the characterization, and use of solid bases. The contribution was intended to emphasize the linkage between the chemical knowledge of acid-base interactions and the engineering of chemical processes, along with their environmental impact. It also provided evidence of trends aimed at improving process safety and limiting environmental pollution when they were related to the increased use of solid basic materials.


Natural killer (NK) cells may capture the CCR7 chemokine receptor from allogeneic CCR7(+) cells by trogocytosis and acquire migrating properties in response to lymph node chemokines. This event is negatively regulated by inhibitory killer Ig-like receptors (KIRs) and NKG2A. In this study, we analyzed the role of the HLA-C2-specific activating receptor KIR2DS1 in the process of CCR7 uptake by NK cells interacting with different allogeneic CCR7(+) cells. Co-incubation of KIR2DS1(+) fresh NK cells or NK-cell clones with HLA-C2(+) CCR7(+) lymphoblastoid cell lines resulted in increased CCR7 uptake. Remarkably, KIR2DS1 expression represented a major advantage for acquiring CCR7 from HLA-C2(+) allogeneic dendritic cells (DCs) and T-cell blasts. These findings have important implications in haploidentical hematopoietic stem cell transplantation in which donor-derived (alloreactive) KIR2DS1(+) NK cells, upon CCR7 acquisition, become capable of migrating toward lymph nodes, where they may kill patient DCs and T cells, preventing graft-versus-host and host-versus-graft reactions.

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